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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
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Articles 651 Documents
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PERAN INDUKSI TNF-α SERIAL DOSES DALAM PENINGKATAN VEGF DAN PDGF MESENCHYMAL STEM CELLS Putra, Agung; Hutagalung, Ananta; Hasanal, Ihdina Hanifa; Trisnadi, Setyo; Djannah, Durrotul; Cahyono, Erwin Budi; Intan, Yulice Soraya Nur
Majalah Kedokteran Bandung Vol 50, No 2 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1316.352 KB) | DOI: 10.15395/mkb.v50n2.1278

Abstract

Mesenchymal stem cell (MSC) mempunyai kemampuan immunoregulasi dan regenerasi melalui supresi pelepasan mediator proinflamasidan peningkatan molekul proliferasi terutama vascular endothelial growth factor (VEGF) dan platelet-derived growth factor (PDGF). Mesenchymal stem cell yang diaktivasi TNF-? dengan dosis tertentu mampu meningkatkan sekresi VEGF dan PDGF, namun dosis optimal TNF-? yang mampu memaksimalkan ekspresi molekul tersebut belum diketahui secara pasti. Variasi dosis TNF-? digunakan pada penelitian ini dengan tujuan mengetahui dosis optimal, rendah, dan tinggi TNF-? dalam memaksimalkan ekspresi VEGF dan PDGF. Penelitian ini mengunakan post-test only control group design dengan 5 kelompok penelitian, terdiri atas satu kelompok kontrol (K) dan 4 kelompok perlakuan (P) (TNF-?= 5, 10, 40, 80 ng/mL) yang diinduksikan pada MSC dengan inkubasi 24 jam, kemudian kadar PDGF dan VEGF diukur dengan metode ELISA. Penelitian ini dilakukan antara bulan September?November 2017 di Laboratorium Stem Cell and Cancer Research (SCCR), Fakultas Kedokteran, Universitas Islam Sultan Agung, Semarang. Hasil penelitian menunjukkan peningkatan kadar PDGF dan VEGF secara signifikan (p<0,05) dimulai dari dosis TNF-? 5 ng/mL, optimal padadosis 10 ng/mL dan mulai terjadi penurunan pada dosis 40 ng/mL. Induksi TNF-? pada MSC mampu memaksimalkan kadar VEGF dan PDGF pada dosis 10 ng/mL.Kata kunci: MSC, PDGF, TNF-?, VEGF Effect of TNF-? Serial Doses Inducition on Increasing VEGF dan PDGF in Mesenchymal Stem Cells Mesenchymal Stem Cells (MSCs) have immunoregulation and regeneration capabilities through suppression of proinflammatory mediator release and increase of proliferative molecules, particularly the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) TNF-? activated MSC in a certain dose has the ability to increase VEGF and PDGF levels; however, the exact optimum dose of TNF-? to optimize the levels of VEGF and PDGF is unclear. In this study, TNF-? dose variations were used to determine the optimum, low, and high doses of TNF-? in optimizing VEGF and PDGF expression. This was a post-test only control group study with five study groups consisting of one control (K) and four treatment groups(P). The treatment groups were treated with 5, 10, 40 and 80 ng/mL of TNF-? for 24 hours. PDGF and VEGF levels were measured using ELISA. This study was conducted between September?November 2017 at the Stem Cell and Cancer Research Laboratory (SCCR), Faculty of Medicine, Sultan Agung Islamic University, Semarang. The results show significant increased in PDGF and VEGF levels (p<0.05) starting from TNF-? 5 ng/mL as the initiation dose to 10 ng/mL as the optimum dose and reduction was seen starting from 40 ng/mL dose. TNF-induced MSCs have the ability to increase the VEGF and PDGF levels with an optimum dose of 10 ng/mL.Key words: MSC, PDGF, TNF-?, VEGF
Efikasi Fortifikasi Cookies Ubi Jalar untuk Perbaikan Status Anemia Siswi Sekolah Briawan, Dodik; Sulaeman, Aris; Syamsir, Elvira; Herawati, Dian
Majalah Kedokteran Bandung Vol 45, No 4 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Selain suplementasi tablet besi, fortifikasi pangan lokal diperlukan sebagai alternatif program untuk perbaikan status besi. Tujuan penelitian ialah menguji efikasi fortififikasi cookies ubi jalar untuk peningkatan hemoglobin (Hb) pada siswi sekolah. Studi dilakukan dengan desain pre-post intervention study, yang melibatkan 74 siswi SMK Pelita Kabupaten Bogor. Studi dilaksanakan pada bulan Mei–Juli 2012. Cookies ubi jalar difortifikasi dengan 10,5 mg vitamin A, 42 μg vitamin B12, 1,25 g vitamin C, 2 mg asam folat, dan besi fumarat 150 mg per 100 g Cookies sebanyak 40 g diberikan seminggu tiga kali selama dua bulan. Hasil penelitian menunjukkan kadar Hb rata-rata sebelum intervensi 13,4±1,4 g/dL. Setelah intervensi, terdapat perubahan kadar Hb 0,4±1,6 g/dL dan sebanyak 65,2% subjek mengalami kenaikan Hb. Kenaikan Hb ini tidak memengaruhi prevalensi anemia yang sedikit meningkat dari 10,8% menjadi 18,8% dan secara statistik tidak nyata (p>0,05). Simpulan, intervensi fortifikasi cookies ubi jalar selama dua bulan tidak menurunkan prevalensi anemia pada anak sekolah. Disarankan studi berikutnya untuk menambah waktu intervensi dan menggunakan indikator status besi lainnya. [MKB. 2013;45(4):206–12]Kata kunci: Anemia, cookies, fortifikasi, siswi, ubi jalarEfficacy of Fortified Sweet Potato Cookies for Improving Anemia Status in Female StudentsLocal food fortification for improving iron status is one of the alternative programs in addition to iron tablet supplementation. The objective of this study was to analyze the efficacy of fortified sweet potato cookies for improving hemoglobin (Hb) concentrations in female students. The pre-post intervention study was applied to 74 female students of SMK Pelita in Bogor District. The study was conducted from May to July 2012. The sweet potato cookies used were fortified with 10.5 mg vitamin A, 42 μg vitamin B12, 1.25 g vitamin C, 2 mg folic acid, and 150 mg iron fumarate per 100 g cookies. Subjects received 40 g cookies three times a week for two months. The average Hb concentration before intervention was 13.4±1.4 g/dL. After intervention, there was an increase in hemoglobin concentration (mean 0.4±1.6 g/dL). About 65.2% subjects experienced increase in their Hb concentration. However, after the intervention the anemia prevalence slightly increased from 10.8% to 18.8% although this increase is not statistically significant (p>0.05). In conclusion, fortified sweet potato cookies intervention for two months does not reduce anemia prevalence in female students. Further studies are required by extending intervention times and applying other indicators of iron status. [MKB. 2013;45(4):206–12]Key words: Anemia, cookies, fortification, schoolgirls, sweet potato DOI: http://dx.doi.org/10.15395/mkb.v45n4.166
POTENSI GEN ONCOPROTEIN HUMAN PAPILLOMAVIRUS TIPE 16 SEBAGAI KANDIDAT VAKSIN KANKER SERVIKS Taupiqurrohman, Opik; Yusuf, Muhammad; Nuswantara, Sukma; Subroto, Toto
Majalah Kedokteran Bandung Vol 48, No 2 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (24.911 KB) | DOI: 10.15395/mkb.v48n2.761

Abstract

Kanker serviks menduduki peringkat dua besar penyebab kematian pada wanita dengan jumlah penderita meningkat setiap tahunnya. Kanker ini banyak diakibatkan oleh infeksi human papillomavirus (HPV) dan tipe prevalensi terbesar di Indonesia adalah tipe HPV 16. Vaksin HPV telah dikembangkan dan diproduksi secara komersial, namun perlu dicari alternatif lain vaksin dengan basis gen penyandi E (early) protein. Gen E6 dan E7 merupakan onkogen penting pada proses terjadinya kanker serviks. Penelitian ini dilaksanakan di Laboratorium Kimia Komputasi dan Bioinformatika, Universitas Padjadjaran, dari bulan Desember 2015 sampai Februari 2016. Pada studi ini, penemuan kandidat vaksin peptida HPV dilakukan dengan pendekatan imunoinformatika. Analisis in silico HPV tipe 16 menunjukkan bahwa gen E7 merupakan sumber kandidat vaksin yang potensial karena tidak homolog dengan genom manusia dan diprediksi memiliki afinitas yang baik terhadap major histocompability complex (MHC). Hasil analisis in silico menunjukkan bahwa kandidat vaksin HPV dari gen E7 adalah peptida YMLDLQPET dan HVDIRTLEDLLMGTL. [MKB. 2016;48(2):84?91]Kata kunci: HPV tipe 16, imunoinformatika, in silico, kanker serviksHuman Papillomavirus Type 16 Oncoprotein Genes as the Candidate of Cervical Cancer VaccineCervical cancer is the second largest cause of death for Indonesian women, with increasing number of cases every year. This cancer is mostly caused by human papillomavirus (HPV) infection, in which HPV 16 is the most prevalent type in Indonesia. Although HPV vaccine has been developed and commercially available, the other alternative of vaccine based on E (early) gene is required. Genes of E6 and E7 are important oncogenes in the development of cervical cancer. This study was conducted at the Laboratory of Computational Chemistry and Bioinformatics, Universitas Padjadjaran, from December 2015 to February 2016. In this study, the candidates of HPV peptide vaccine were discovered using immunoinformatics method. In silico-analysis of HPV type 16, it  was shown gene E7 is not homologous with human genome and it is predicted to have a good affinity with major histocompability complex (MHC). Hence, it was proposed as a potential source of peptide vaccine. It is concluded that he candidates forHPV vaccine from E7 peptides are YMLDLQPET  and HVDIRTLEDLLMGTL. [MKB. 2016;48(2):84?91]Key words: Cervical cancer HPV 16, immunoinformatics, in silico
COMPLETE REMISSION OF ACUTE MYELOID LEUKEMIA IN INDUCTION AND CONSOLIDATION CHEMOTHERAPY WITHOUT BONE MARROW TRANSPLANTATION: LESSONS LEARNED FROM GOOD PRESENTATION CASE Sri Hastuti, Tuti; Sumantri, Rachmat; Wijaya, Indra
Majalah Kedokteran Bandung Vol 51, No 1 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2625.916 KB) | DOI: 10.15395/mkb.v51n1.1634

Abstract

Acute myeloid leukemia (AML) is a clinically morphologically and genetically heterogeneous disease with variable responses to therapy. The majority of the patients eventually relapse and succumb to the disease. Therapeutic modalities of induction chemotherapy, consolidation, and bone marrow transplantation are intended to achieve complete remission. Induction therapy with cytarabine and anthracycline remains thestandard of care in AML. Consolidation treatment is necessary to prevent recurrence, which may reach 90% without this treatment. Options for consolidation therapy are conventional chemotherapy and bone marrow transplantation. Bone marrow transplantation represents the only realistic chance of long-term remission in patients with a high cytogenetic risk. The risk of recurrence of AML is determined mainly by the patient?s age and genetic factors. In younger patients, complete remission (CR) rates of ?80% may be achieved, with 5-year overall survival (OS) of 40%. InDr. Hasan Sadikin Hospital Bandung during the period of 2013-2018, 12 cases of LMA underwent chemotherapy. This case study discusses a young patient with AML who has successfully reached complete remission using induction and consolidation chemotherapy without bone marrow transplantation.    Key words: Acute myeloid leukemia, chemotherapy, complete remission Remisi Lengkap Pasca Kemoterapi Induksi dan Konsolidasi Tanpa Transplantasi Sumsum Tulang pada Leukemia Mieloblastik AkutLeukemia mieloblastik akut adalah sekelompok penyakit yang memiliki gejala klinis, morfologi sel darah, kelainan genetik, dan respon terhadap terapi yang sangat bervariasi. Sebagian besar pasien leukemia mieloblastik akut (LMA) biasanya akan mengalami kekambuhan dalam perjalanan penyakitnya. Kejadian kekambuhan dalam 5 tahun sebesar 9% untuk kekambuhan di ekstramedulari dan 29% kekambuhan di sumsum tulang. Tujuan terapi pada LMA adalah mencapai remisi lengkap dan mencegah kekambuhan melalui modalitas kemoterapi dan transplantasi sumsum tulang. Transplantasi sumsum tulang diindikasikan pada pasien LMA dengan risiko sitogenetik yang tinggi. Tingkat remisi lengkap ?80% dapat dicapai, terutama pada pasien yang lebih muda dengan kelangsungan hidup keseluruhan 5 tahun 40%. Di Rumah Sakit Hasan Sadikin Bandung, selama kurun waktu 2013-2018 didapatkan 12 kasus LMA yang menjalani kemoterapi. Pada artikel ini didiskusikan 1 pasien LMA usia muda yang berhasil mencapai remisi lengkap dengan kemoterapi induksi dan konsolidasi tanpa menjalani transplantasi sumsum tulang dengan terapi pendukung yang optimal selama pemberian kemoterapi.Kata kunci : Leukemia mieloblastik akut, kemoterapi, remisi lengkap
Efek Antioksidan Jamur Tiram Putih pada Kadar Malondialdehid dan Kepadatan Permukaan Sel Paru Tikus yang Terpapar Asap Rokok Rahimah, Santun Bhekti; Sastramihardja, Herri S.; Sitorus, Trully Detty
Majalah Kedokteran Bandung Vol 42, No 4
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Radikal bebas asap rokok dapat menyebabkan peroksidasi lipid dan perubahan patologis pada sel paru. Hal ini dapat dicegah oleh senyawa yang terkandung dalam jamur tiram putih (Pleurotus ostreatus), antara lain fenol, vitamin C, selenium, dan ergotien. Penelitian bertujuan untuk melihat efek ekstrak jamur tiram putih pada kadar malondialdehid (MDA) dan nilai surface density (S/V) setelah terpapar asap rokok. Metode penelitian menggunakan rancangan acak lengkap dan sebagai pembanding digunakan vitamin E. Dosis ekstrak etanol jamur tiram putih adalah 250 mg/kgBB dan paparan asap rokok diberikan 30 menit/tikus/hari menggunakan smoking pump. Pada hari ke-11 perlakuan, dilakukan pemeriksaan kadar MDA darah dengan metode thiobarbituric acid assay (TBARS) dan perhitungan nilai S/V paru secara mikroskopis. Penelitian dilakukan pada bulan Juli 2009 di Departemen Farmakologi Klinik Rumah Sakit Hasan Sadikin Bandung. Hasil menunjukkan ekstrak etanol jamur tiram putih mencegah kenaikan kadar MDA darah (0,4667+0,22295 nm/mL) dan efeknya sama baik dengan vitamin E (0,7467+0,24089 nm/mL). Ekstrak etanol jamur juga mencegah penurunan nilai S/V (0,62283+0,47939) dan mempunyai efek yang lebih baik dari vitamin E (0,54683+0,39832), p<0,05. Disimpulkan bahwa ekstrak etanol jamur tiram putih merupakan antioksidan kuat yang lebih baik dibandingkan dengan vitamin E dalam mencegah kerusakan oksidatif akibat paparan asap rokok. [MKB. 2010;42(4):195–202].Kata kunci: Asap rokok, jamur tiram putih, malondiadehid, nilai S/V, radikal bebasAntioxidant Effect of Pleurotus ostreatus on Malondialdehyde Level and Surface Density of Rat Lung Cells Exposed to Cigarette SmokeCigarette smoke-free radicals can cause lipid peroxidation and pathological changes in lung cells. This effect could be prevented by highly active metabolite in Pleurotus ostreatus such us fenol, ascorbid acid, selenium, and ergothiene. This study aimed to analyze the effect of the Pleurotus ostreatus extract on the levels of malondialdehyde (MDA) and surface density (S/V) after exposure to cigarette smoke. The research used completed randomized design and á-tocopherol was used as control group. The dose of Pleurotus ostreatus ethanol extract was 250 mg/kg body weight and cigarette smoke exposure was given in 30 minutes/day for 10 days by smoking pump. Malondialdehyde (MDA) level and lung surface density (S/V) were observed on day 11th. This research was done at Clinical Pharmacology Department, Hasan Sadikin Hospital on July 2009.The result showed that ethanol extract of Pleurotus ostreatus can prevent increasing level of MDA (0.4667+ 0.22295 nm/mL), as good as that of á-tocopherol(0,7467+ 0,24089 nm/mL). Ethanol extract also prevented the reduction of lung S/V (0.62283+0.4793) and it's effect was better from á-tocopherol (0.54683±0.39832), p=<0.05. In conclusion, our data shows that etanolic extract of Pleurotus ostreatus is a strong antioxidant that have better effect than á-tocopherol in preventing oxidative damage of cigarette smoke. [MKB. 2010;42(4):195–202].Key words: Cigarette smoke, free radical, Pleurotus ostreatus, malondyaldehyde, S/V DOI: http://dx.doi.org/10.15395/mkb.v42n4.36
Respons Insulin Like Growth Factor-I Pascalatihan Fisik Sebagai Indikator Peningkatan Densitas Tulang pada Wanita Lanjut Usia Almuktabar, Neng Tine Kartinah
Majalah Kedokteran Bandung Vol 42, No 2
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Latihan fisik merupakan salah satu upaya untuk mencegah osteoporosis pada wanita lanjut usia namun sampai saat ini indikator latihan fisik yang efektif, efisien, dan aman dalam meningkatkan densitas tulang pada wanita lanjut usia di Indonesia masih belum diketahui. Tujuan penelitian untuk mengetahui hubungan respons insulin like growth factor I (IGF-I) pascalatihan fisik, progressive resistance exercise (PRE), dan senam pencegahan osteoporosis (SPO) terhadap densitas tulang. Studi kasus eksperimen desain pretes dan postes dilakukan selama 16 minggu periode April-Juli 2005. Subjek penelitian terdiri 18 wanita lansia, usia 55-65 tahun di Puskesmas Ciwaruga Bandung yang memenuhi kriteria inklusi (usia 55-56 tahun, dan tidak mengkonsumsi obat-obatan yang berpengaruh buruk terhadap densitas tulang). Analisis statistik yang digunakan uji hubungan regresi linier berganda untuk menguji hubungan respons akut dan kronik IGF-I terhadap densitas tulang. Hasil uji regresi linier berganda respons akut dan kronik IGF-I terhadap densitas tulang pada kelompok PRE dan SPO menunjukkan titik defleksi nilai densitas tulang sebesar 0,88 dan 0,83 g/cm2 (p= 0,000). Persamaan regresi densitas tulang pada kelompok PRE =0,229 - 0,0005 respons akut + 0,00006 respons kronik (p<0,05). Persamaan regresi pada kelompok SPO menunjukan densitas tulang= 0,158 - 0,0002 respons akut + 0,00009 respons kronik (p<0,05). Dapat disimpulkan bahwa PRE lebih efektif dan efisien dibanding SPO.The Response of Insulin Like Growth Factor-I After Having Exercise As an Indicator for Increasing Bone Density in the Elderly WomenPhysical exercise is an effort for preventing osteoporosis in the elderly women. However, some indicators for effective, efficient, and safe physical exercises for increasing bone density in the elderly women in Indonesia are still questioning. The main purpose of research was to identify the response's correlation of IGF-I post-exercise progressive resistance exercise (PRE) and osteoporosis prevention exercise (SPO) on bone density. The experiment with pre-test and post-test design has been done for 16 weeks on April-July 2005. The subjects of this research were 18 elderly women in Ciwaruga Health Community Center (Puskesmas) that met some inclusion criteria (55-65 years old, health, and do not consume medicines which have bad effects to bone density). The multiple regression test used as statistical analysis to identify the correlation of acute and chronic responses of IGF-I on bone density. The multiple regression analysis of acute and chronic responses of IGF-1 on bone density on PRE and SPO group showed a deflection point of bone density as much as 0.88 and 0.83g/cm2 (p= 0.000). The regression model of bone density on PRE group=0.239 - 0.0005 acute response + 0.00006 chronic response (p< 0.05). The regression model on SPO:Bone density= 0.158 - 0.0002 acute response + 0.00009 chronic response (p< 0.05). Conclusion: the safe indicator for initial bone density before doing PRE and SPO exercises are 0.88 g/cm2 and 0.83 g/cm2 respectively. Therefore, PRE is relatively more effective and efficient than SPO because PRE has high exercise intensity that can increase bone density in short duration than SPO. DOI: http://dx.doi.org/10.15395/mkb.v42n2.11
GELOMBANG AUDITORY BRAINSTEM RESPONSE (ABR) PADA ANAK DIBAWAH LIMA TAHUN Wijana, -; Syamsuddin, Alex; Dewi, Yussy Afriani
Majalah Kedokteran Bandung Vol 46, No 3 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (638.986 KB)

Abstract

Auditory brainstem response (ABR) adalah pemeriksaan pendengaran yang reliabel, bertujuan untuk menilai singkronisasi saraf pendengaran perifer. Masalah pendengaran pada saat balita akan memberikan efek pada perkembangan, khususnya  bicara dan bahasa. Deteksi dini merupakan hal yang penting sementara referensi nilai ABR untuk Indonesia saat ini masih belum ada. Penelitian ini bertujuan untuk mengetahui nilai ABR pada anak usia di bawah 5 tahun dengan pendengaran normal. Telah dilakukan penelitian deskriptif potong lintang pada 198 balita, terdiri atas 119 laki-laki dan 79 perempuan berusia antara 3 bulan hingga 5 tahun di Poliklinik Dengar dan Bicara Rumah Sakit Dr. Hasan Sadikin Bandung, pada bulan Desember 2008 hingga Juni 2011, pada semua subjek dilakukan pemeriksaan ABR kemudian dihitung rerata setiap gelombang. Balita perempuan memiliki masa laten absolut gelombang I, III dan V,  serta masa laten antara gelombang I?III, III?V dan I?V lebih pendek secara bermakna dibandingkan dengan balita laki-laki. Masa laten rata-rata gelombang V pada balita laki-laki 6,07 msec±0,39 dan perempuan 5,90 msec±0,34. Kelompok usia 0?1 tahun memiliki masa laten absolut yang paling panjang. Tidak terdapat perbedaan masa laten absolut dan antara gelombang di kedua telinga pada laki-laki maupun perempuan pada usia di bawah lima tahun. Simpulan, masa latent absolut rata-rata gelombang V pada anak perempuan di bawah lima tahun adalah 5,90±0,34 msec, sedangkan pada anak laki-laki 6,07±0,39 msec.Kata kunci: Gelombang ABR, masa laten ablosut, masa laten antar gelombangAuditory Brainstem Response (ABR) Waveforms in The First Five YearsAuditory brainstem response (ABR) is a reliable hearing examination. It reflects the integrity of synchronous neurons firing within the periphery auditory pathways.  Hearing impairment on the first five years will cause speech and language delays; therefore, early detection of hearing loss is very important. Nowadays, there is still no ABR value reference in Indonesia. The aim of this study was to establish the ABR values in toddlers with normal hearing.  This was a descriptive cross-sectional study on 198 subjects between the ages of 3 month and 5 years in the period of December 2008 to June 2011 at the Hearing and Speech Clinic, Dr. Hasan Sadikin General Hospital, Bandung. The hearing level were diagnosed by ABR examination in all subjects and the mean of ABR wave was calculated. Girls displayed shorter absolute latency of wave I, III and V, and  interwave latency of I-III, III-V, and I-V compared to boys. The wave V latency in boys was 6.07 msec ±0.39 and 5.90 msec ±0.34 in girls. The 0?1 years old group have the longest absolute and interwave latencies.  There was no significant differences in absolute and interwave latency between both ears in boys and girls. The conclusion of this study is the average wave V latencies in boys and girls are 6.07±0.39 msec and 5.90 ±0.34, respectively.Key words: ABR wave, absolute latency, interwave latency DOI: 10.15395/mkb.v46n3.311
POLA PEMBERIAN ASI DAN DIARE PADA ANAK USIA 6–24 BULAN Wijaya, Dhandi; Dhamayanti, Meita; Gondodiputro, Sharon
Majalah Kedokteran Bandung Vol 49, No 3 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (62.172 KB) | DOI: 10.15395/mkb.v49n3.1118

Abstract

Diare merupakan salah satu penyebab utama kematian anak secara global. Air susu ibu (ASI) diketahui dapat mencegah diare pada anak sehingga World Health Organization merekomendasikan pemberian ASI eksklusif untuk seluruh bayi. Namun, cakupan ASI eksklusif di Indonesia masih rendah sehingga risiko diare pada anak masih tinggi. Penelitian ini bertujuan menilai hubungan pola pemberian ASI dan  diare pada anak usia 6?24 bulan. Penelitian observasional dengan studi potong lintang ini dilakukan tanggal 20 Januari?31 Januari 2017. pada 160 ibu dengan anak usia 6?24 bulan yang mendapat ASI yang datang ke posyandu di Puskesmas Talang Ubi, Kabupaten Penukal Abab Lematang Ilir. yang buka selama penelitian dilakukan, lahir tunggal, aterm, berat badan lahir ?2.500 gram, gizi baik, tidak menderita kelainan kongenital. Data dikumpulkan menggunakan kuesioner untuk mengetahui pola pemberian ASI dan MP ASI serta prevalensi, periode, dan lama diare dalam tiga bulan terakhir. Data dianalisis dengan uji kai-kuadrat, Fisher eksak, Mann-Whitney U, Kruskal-Wallis, ANOVA, serta uji normalitas Kolmogorov Smirnov. Penelitian ini mendapatkan hubungan waktu inisiasi pemberian ASI, ASI eksklusif, lama pemberian ASI, serta frekuensi dan lamanya menyusui dengan prevalensi dan lama diare (p<0,05), tetapi tidak mendapatkan hubungan waktu inisiasi pemberian ASI, pemberian ASI eksklusif, lama pemberian ASI, frekuensi pemberian ASI, dan lama menyusui dengan frekuensi diare (p>0,05). Dapat disimpulkan bahwa pola pemberian ASI dapat menurunkan prevalensi dan mempersingkat lama diare pada anak usia 6?24 bulan. [MKB. 2017;49(3):165?71]Kata kunci: ASI, ASI eksklusif, diare, MP ASI  Breastfeeding Pattern and Diarrhea in Children Aged 6?24 MonthsDiarrhea is one of the leading causes of global childhood mortality. Breast milk was known to have a protective role against childhood diarrhea that the World Health Organization (WHO) recommendeds exclusive breastfeeding for all infants. However, the coverage of exclusive breastfeeding in Indonesia is still small, leading to a higher risk of childhood diarrhea. The aim of this study was to assess the correlation between breastfeeding pattern,  complementary feeding,  prevalence, frequency, and diarrhea duration in children aged 6?24 months. This observational cross-sectional study was conducted in the period of 20 January?31 January 2017 on 160 mothers who brestfed their child who was, at the time of the study, 6?24 months old. These were children who visited the Posyandu (Integrated Health Post) of Talang Ubi Public Health Center (Puskesmas Talang Ubi), Penukal Abab Lematang Ilir district at the time of the study, singleton, full term, birth weight ?2,500 grams, well-nourished, and did not have any congenital abnormalities. Data were obtained through questionnaires that collected  information on breastfeeding pattern, complementary feeding, and the prevalence, frequency, and diarrhea duration in the last three months . Data were statistically analyzed using chi-square, Fisher?s exact, Mann-Whitney U, Kruskal-Wallis, and ANOVA tests as well as   Kolmogorov Smirnov normality test. This study found the correlation between breastfeeding initiation, exclusive breastfeeding, breastfeeding duration, frequency and duration of lactation, with the prevalence and diarrhea duration (p<0.05), but did not find the correlation between breastfeeding initiation, exclusive breastfeeding, breastfeeding duration, frequency and duration of lactation with diarrhea frequency (p>0,05). Therefore, this study concludes that the pattern of breastfeeding reduces the prevalence of diarrhea and shortens diarrhea duration in children aged 6?24 months. [MKB. 2017;49(3):165?71]Key words: Breastfeeding, complementary feeding, diarrhea, exclusive breastfeeding
Kesesuaian Hasil Pemeriksaan Antibodi Virus Herpes Simpleks Metode Enzyme-Linked Immunofiltration Assay dengan Enzyme-Linked Immunosorbent Assay Immanuel, Victor; Noormartany, Noormartany; Dewi, Nina Susana
Majalah Kedokteran Bandung Vol 44, No 3 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Infeksi virus herpes simpleks (HSV) merupakan infeksi yang disebabkan oleh HSV tipe 1 (HSV-1) dan HSV tipe 2 (HSV-2). HSV-1 biasanya menyebabkan penyakit orofasial, sedangkan HSV-2 biasanya menyebabkan infeksi perigenital. Diagnosis infeksi HSV ditegakkan berdasarkan anamnesis, pemeriksaan fisis, dan laboratorium. Metode deteksi anti-HSV metode enzyme-linked immunosorbent assay (ELISA) memiliki sensitivitas 93–100% dan spesifisitas 95–100%, sedangkan metode enzyme-linked immunofiltration assay (ELIFA) memiliki sensitivitas 83,36–97% dan spesifisitas 83,93–98%. Tujuan penelitian adalah menilai kesesuaian hasil pemeriksaan anti-HSV antara metode ELIFA dan ELISA. Bila terdapat kesesuaian yang baik maka metode ELIFA dapat menggantikan metode ELISA. Penelitian dilakukan di laboratorium klinik RSUP Dr. Hasan Sadikin Bandung sejak bulan Januari–Mei 2011. Rancangan penelitian adalah potong lintang. Subjek penelitian adalah serum penderita tersangka infeksi HSV. Dilakukan analisis statistik untuk menilai agreement Kappa. Sebanyak 66 sampel diperiksa anti-HSV metode ELIFA dan ELISA. Hasil pemeriksaan IgM anti-HSV antara metode ELIFA dan ELISA memiliki kesesuaian baik (p<0,001; K=0,621), hasil pemeriksaan IgG anti-HSV-1 antara metode ELIFA dan ELISA memiliki kesesuaian sedang (p<0,001; K=0,533), dan hasil pemeriksaan IgG anti-HSV-2 antara metode ELIFA dan ELISA memiliki kesesuaian kurang (p=0,006; K=0,260). Simpulan, hanya pemeriksaan IgM anti-HSV metode ELIFA yang memiliki hasil kesesuaian baik dengan metode ELISA, sedangkan pemeriksaan IgG anti-HSV metode ELIFA memiliki kesesuaian sedang atau kurang. [MKB. 2012;44(3):152–8].Kata kunci: IgM anti-HSV, IgG anti-HSV, kesesuaian, metode ELIFA, metode ELISA Agreement of Herpes Simplex Virus Antibody Test Result between Enzymelinked Immunofiltration and Enzyme-linked Immunosorbent Assay MethodsHerpes simplex virus (HSV) infections are very common and are caused by HSV type 1 (HSV-1) and HSV type 2 (HSV-2). HSV-1 being mostly associated with orofacial disease, whereas HSV-2 is usually associated with perigenital infection. Diagnosis of HSV infection is established based on history, physical and laboratory examination. Enzyme-linked immunosorbent assay (ELISA) method to detect anti-HSV has a sensitivity 93–100% and specificity 95–100%, whereas enzyme-linked immunofiltration assay (ELIFA) has a sensitivity 83.36–97% and specificity 83.93–98%. The aim of this study was to assess the agreement of anti-HSV between ELIFA and ELISA methods. This study was conducted in the clinical laboratory RSUP Dr. Hasan Sadikin Bandung since January to May 2011. The study design was cross sectional. Subjects of this study were serum of patients suspected HSV infection. Statistical analysis was performed to assess Kappa agreement. A total of 66 samples were examined anti-HSV using ELIFA and ELISA method. There was good agreement between test results of anti-HSV IgM ELIFA and ELISA method (p<0.001, κ=0.621), moderate agreement between test results of anti- HSV-1 IgG ELIFA and ELISA method (p<0.001, κ=0.533), and fair agreement between test results of anti-HSV-2 IgG ELIFA and ELISA method (p=0.006, κ= 0.260). In conclusions, only the anti-HSV IgM ELIFA method has good agreement with ELISA. DOI: http://dx.doi.org/10.15395/mkb.v44n3.86 
Kesehatan Reproduksi Remaja Putri di Pondok Pesantren Sidoarjo Jawa Timur Nisa Mairo, Queen Khoirun; Rahayuningsih, Sri Endah; Purwara, Benny Hasan
Majalah Kedokteran Bandung Vol 47, No 2 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

terkait kesehatan reproduksinya. Remaja lebih banyak menghabiskan waktunya di sekolah. Pondok pesantren merupakan model pendidikan yang bercirikan asrama dengan pola interaksi 24 jam dengan teman sebaya. Penelitian ini bertujuan menganalisis faktor yang berhubungan dengan kesehatan reproduksi remaja putri di pondok pesantren. Penelitian ini dilakukan pada 100 remaja putri Pondok Pesantren Darul Falah Pusat pada kurun waktu September−Oktober 2012 dengan menggunakan kuesioner yang telah teruji validitas dan reliabilitasnya. Variabel pengetahuan, sikap, komunikasi orangtua, komunikasi guru, komunikasi teman sebaya, dan sumber informasi sebagai independen, sedangkan kesehatan reproduksi sebagai dependen. Data dianalisis secara univariabel, bivariabel, dan multivariabel. Hasil penelitian menunjukkan remaja yang bermasalah dalam kesehatan reproduksi sebanyak 68%. Kesehatan reproduksi remaja terdapat hubungan bermakna dengan faktor pengetahuan  (p=0,022),  sikap (p=0,002) dan komunikasi teman sebaya (p<0,001), tetapi tidak terdapat hubungan bermakna terhadap kesehatan reproduksi remaja pada komunikasi orangtua (p=0,655), komunikasi guru (p=0,833), dan sumber informasi (p=0,532). Faktor yang paling berhubungan dengan kesehatan reproduksi remaja putri di pondok pesantren adalah komunikasi teman sebaya (p=0,001). Simpulan, masalah kesehatan reproduksi di pondok pesantren masih tinggi dengan pengetahuan mengenai kesehatan reproduksi masih rendah, sikap terhadap kesehatan reproduksi kurang, dan faktor yang paling berhubungan adalah komunikasi teman sebaya. [MKB. 2015;47(2):77–83]Kata kunci: Kesehatan reproduksi remaja, lingkungan, pengetahuan, pondok pesantren, sikapReproductive Health of Adolescent Girls in Islamic Boarding School Sidoarjo East JavaAbstractReproductive organ maturation process in adolescence is often prone to health issues. Adolescents spend more time in school, especially when they study in an islamic boarding school. Islamic boarding school is an educational model which is characterized by a dorm with 24 hour interaction pattern among peers. This study aimed  to analyze factors associated with adolescent reproductive health in Islamic boarding school female students. This study was conducted on 100 adolescent girls in Darul Falah Center Islamic boarding school during September to October 2012 using questionnaires with proven validity and reliability. Knowledge, attitudes, parent communication, teacher communication, peer communication, source of information were used as the independent variables and reproductive health was used as the dependent variable. All variables were analyzed ini univariabel, bivariable, and multivariable manners. The results of this study show that 68% adolescents had reproductive health problems. There was a significant relationship between knowledge (p=0.022), attitude (p=0.002) and peers communication (p<0.001) factors and  adolescent reproductive health withno significant relationship discovered between the reproductive health of adolescents and parent communication (p=0.655), teacher communication (p=0.833), and sources of information (p=0.532). The most influencing factor associated with reproductive health in adolescent girls Islamic boarding school was peer communications (p=0.001). In conclusions, reproductive health problem in Islamic boarding school remains high with inadequate knowledge of reproductive health and  low attitude towards reproductive health with peer communication as the most influencing factor. [MKB. 2015;47(2):77–83]Key words: Adolescent reproductive health, attitudes, environment knowledge, Islamic boarding school DOI: 10.15395/mkb.v47n2.457

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