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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 651 Documents
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Correlation between Serum Uric Acid Level and Severity of Coronary Artery Stenosis in Patients with Acute Coronary Syndrome Diding Heri Prasetyo; Sally Aman Nasution; Idrus Alwi; Murdani Abdullah
Majalah Kedokteran Bandung Vol 53, No 1 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n1.2221

Abstract

Acute coronary syndrome (ACS) is a life-threatening disease which remains one of the causes of high morbidity and mortality despite the current advances in treatment. The relationship between the serum uric acid  (SUA) level and ischemic heart disease continues to be controversial and still has not been established as a cardiovascular risk factor. The cooperative interaction between the two factors has not yet fully understood. Prior epidemiological evidence of the causal relationship between the too is still argumentative. Various studies have been done using the same methods; yet, the outcomes were different. This study aimeds to conduct a meta-analysis to synthesize the results of recent studies in order to obtain accurate quantitative data. This systematic study followed the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guideline and studies published in the period of  January 2010 to May 2020 were screened using the Cochrane Library, Ebsco, Medline/PubMed, ProQuest and Science Direct as the sources. Meta-analysis was conducted to synthesize the association between the SUA level and severity of coronary artery stenosis using random effect model to account for possible study heterogeneity. Heterogeneity was assessed using I2 and the meta-analysis was performed using Comprehensive Meta Analysis Version 3 (CMA3) software. Five studies (n = 601 subjects) identified a correlation between serum uric acid level and Gensini score (r = 0.548; p <0.001) in ACS patients. Heterogeneity bias was found in the analysis, whereas publication bias was not found. Thus, the severity of coronary artery stenosis in patients with ACS is positively correlated with serum uric acid level.
Accuracy of SVS-WIfI Classification in Predicting Major Amputation in Critical Limb Ischemic Patients Teguh Marfen Djajakusumah; Rani Septrina; Putie Hapsari; Rendy Susanto
Majalah Kedokteran Bandung Vol 52, No 4 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n4.2029

Abstract

In 2014, The Society for Vascular Surgery revealed a new classification system for Critical Limb Ischemia (CLI) referred as the Society for Vascular Surgery Lower Extremity Threatened Limb Classification System based on Wound, Ischemia, and foot Infection (SVS WIfI). This scoring system was created to stratify major amputations risk within 1 year and benefit of revascularization for the patient. This study aimed to assess the accuracy of SVS WIFi in predicting major amputations in patients with lower limb ischemia underwent revascularization at Department of Surgery, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital in 2016 - 2019. This was a retrospective observational analytic study with cohort design. Patients who fulfilled the inclusion criteria were assessed with SVS WIfI and results after 1 year of revascularization were identified. Data were analyzed statistically using the Chi-square test. 0f 56 subjects, 39 had limb salvage and 17 underwent major amputations within 1 year. In high revascularization benefit group, 31 had limb salvage and 7 underwent amputation. Meanwhile, in moderate-low revascularization benefits group, 8 had limb salvage and 10 underwent amputation. The accuracy of the SVS WIfI recommendation was 73.2%. Therefore, WIfI SVS classification accurately predicts the incidence of major amputations in patients with lower limb ischemia who underwent revascularization. Akurasi Klasifikasi SVS-WIfI dalam Memprediksi Amputasi Mayor pada Pasien Iskemik Tungkai BawahPada tahun 2014, The Society for Vascular Surgery mengemukakan sistem klasifikasi baru untuk CLI yaitu SVS-WIfI. Sistem skoring ini dibuat untuk menstratifikasi risiko amputasi mayor dalam 1 tahun bila dilakukan revaskularisasi pada pasien. Penelitian ini dilakukan untuk melihat akurasi SVS WIfI dalam memprediksi kejadian amputasi mayor pada pasien iskemia tungkai bawah yang menjalani revaskularisasi dan di lakukan di Departemen Ilmu Bedah Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin pada tahun 2016-2019. Penelitian ini merupakan penelitian observasional analitik dengan rancangan retrospective cohort study. Pasien yang memenuhi persyaratan dilakukan penilaian dengan SVS WIfI dan di-follow up selama 1 tahun, hasil hasilnya dianalisis menggunakan tes Chi-square dan dilakukan perhitungan sensitivitas, spesifisitas, dan akurasi. Berdasarkan penelitian yang dilakukan terhadap 56 pasien yang menjalani revaskularisasi, didapatkan sebanyak 39 pasien yang tidak mengalami amputasi mayor dan 17 pasien yang mengalami amputasi mayor dalam 1 tahun. Dari penelitian ini kelompok pasien dengan manfaat revaskularisasi yang tinggi didapatkan 31 pasien tidak mengalami amputasi, sedangkan 7 pasien mengalami amputasi, pada kelompok pasien dengan manfaat revaskularisasi sedang-rendah, 8 pasien tidak mengalami amputasi, sedangkan 10 pasien mengalami amputasi dan didapatkan hasil uji chi square berdasarkan manfaat vaskularisasi dan kejadian amputasi diperoleh nilai P=0,005, dan Akurasi dari rekomendasi SVS WIfI adalah 73,2%. Dari hasil penelitian didapatkan Klasifikasi SVS WIfI akurat dalam memprediksi kejadian amputasi mayor pada pasien iskemia tungkai bawah yang menjalani revaskularisasi.
Correlation between Personal Hygiene, Household Hygiene, and Atopic Dermatitis in Elementary School Children in Indonesia Muhammad Ikhfa Yusril Bahari; Deryne Anggia Paramita
Majalah Kedokteran Bandung Vol 52, No 3 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n3.1971

Abstract

Atopic dermatitis is a chronic inflammatory skin disease characterized by persistent itching and reddening of the skin. In general, infants and children are more susceptible to atopic dermatitis. Many factors are associated with atopic dermatitis, one of which is personal hygiene. Personal hygiene is a condition or practice to maintain or improve personal health by keeping the body and the environment clean. Personal hygiene can influence the surrounding environment, such as by influencing the household hygiene. The purpose of this study was to determine the correlation between personal hygiene, household hygiene, and atopic dermatitis incidence among children who attended Pertiwi Elementary School Medan. This was a cross-sectional study with correlational analysis designed conducted at Pertiwi Elementary School Medan from July to December 2019. Data were collected using a questionnaire and analyzed using the Chi-Square test with p = 0.05 considered significant. Results showed that 28 children (39.4%) had atopic dermatitis, with more girls affected than boys (n=19, 67.9% vs. n=9, 32.1%). The overall household hygiene and cleanliness were good. There is a significant relationship between personal hygiene, household cleanliness, and the incidence of atopic dermatitis (p<0.05). Hubungan Personal Hygiene, Rumah Tangga, dan Dermatitis Atopik pada Anak Sekolah Dasar di IndonesiaDermatitis atopik merupakan suatu penyakit radang kulit kronis yang ditandai dengan munculnya rasa gatal secara terus-menerus dan timbul ruam kulit yang memerah. Pada umumnya bayi dan anak-anak yang lebih rentan terhadap dermatitis atopik. Faktor-faktor yang dikaitkan dengan dermatitis atopik ini salah satunya yaitu personal hygiene. Personal hygiene adalah kondisi atau praktik yang digunakan orang menjaga atau meningkatkan kesehatan dengan menjaga diri mereka dan lingkungan mereka bersih. Faktor ini dapat mempengaruhi berbagai cakupan yang lebih luas seperti dalam kehidupan rumah tangga. Penelitian ini bertujuan mengetahui hubungan personal hygiene dan tingkat kebersihan dalam rumah tangga dengan kejadian dermatitis atopik pada anak-anak di SD Swasta Pertiwi, Medan. Penelitian ini menggunakan desain analitik korelasi dengan pendekatan cross-sectional yang dilaksanakan di SD Swasta Pertiwi Medan dari bulan Juli–Desember 2019. Pengumpulan data dilakukan menggunakan kuesioner dan dianalisis dengan uji chi-square dengan p=0.05 dianggap bermakna. Pada penelitian didapatkan hasil sebanyak 28 orang menderita dermatitis atopik lebih banyak perempuan 19 orang (32,1%) dibanding dengan pria 9 orang (67,9%). Hasil penelitian bahwa personal hygiene dan kebersihan dalam rumah tangga secara keseluruhan dikategorikan baik. Terdapat hubungan antara personal hygiene dan kebersihan dalam rumah tangga dengan kejadian dermatitis atopik (p<0.05).
Retrospective Analysis on Intraoperative Neuromonitoring (IOM) of Potential Nerve Injury in Scoliosis Correction Surgery Omat Rachmat; Dohar AL Tobing; Ilma Fiddiyanti; Rr. Nur Fauziyah; Jenifer Kiem Aviani; Rr. Anisa Siwianti Handayani
Majalah Kedokteran Bandung Vol 53, No 1 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n1.2123

Abstract

Iatrogenic spinal injury resulting in paraplegia or paraparesis after surgical correction of scoliosis deformity is a rare complication but is very detrimental to the patient. Intraoperative Neuromonitoring (IOM) has become the gold standard to monitor surgical procedures which has potential risks to damage the spinal cord. This study  aimed to retrospectively analyze the role of IOM in predicting the severity and extent of neurological injury during and after spinal correction surgery in adult idiopathic scoliosis cases related to surgical variables. This was a retrospective cohort study conducted at Dr. Cipto Mangunkusumo National Central Hospital, Fatmawati Central Hospital, and dr. Drajat Prawiranegara General Hospital during the period of 20 March 2018 to 20 August 2019. The primary outcomes were intraoperative monitoring status and post-operative neurological deficits status. Confounder data on scoliosis correction degree, intraoperative hemorrhage, and type of anesthesia used during surgery were retrieved. Chi-Square statistic was used in the analysis. Out of the ninety three patients eligible for this study, twenty two patients was detected as positive in IOM assessment. Four of the patients were found to be positive for post-operative neuromuscular defect. Thereby it can be concluded that IOM procedure can effectively prevent neurological deficits post-surgery with 81.8% specificity and 95.7% sensitivity among thosepositively detected by IOM. Some of the factors that could potentially influence false positive IOM results such as anesthetic used; dosage and administration procedures; magnitude of the scoliosis correction angle; and amount of bleeding during surgery have to be carefully analyzed.
Association between Rainy Season and Diarrhea in 13- to 24-Month-Old Toddlers Jeceline Sutarto; Edward Surjono
Majalah Kedokteran Bandung Vol 52, No 4 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n4.2139

Abstract

Diarrhea is the second leading cause of death in children under five year and is considered a prevailing problem in many developing countries, including in Indonesia. Diarrhea is a multifactorial disease and season is suggested as one of the attributing factors of this disease. This study aimed to identify the association between the rainy season and diarrhea in 13- to 24-month-old toddlers. This was a cross-sectional analytical observational study on medical records of 13- to 24-month-old-toddlers with infectious diarrhea who visited Penjaringan I Sub-district Public Health Center, North Jakarta, Indonesia from 2016 to 2019 that included three cycles of the rainy and dry seasons. Data collection was performed in March 2020 and 286 medical records were included in the study. The relationship between the independent and dependent variables was analyzed using chi-square. Of the total cases, 83 cases occurred in rainy season and 203 cases occurred in dry season (p=0.291). Diarrhea was seen in girls aged13–16 months. There is no significant association between rainy season and diarrhea.Hubungan Musim Hujan dengan Diare pada Balita Usia 13–24 Bulan Diare merupakan penyebab kematian balita nomor dua di dunia yang masih menjadi masalah pada banyak negara berkembang, termasuk Indonesia. Diare adalah sebuah penyakit multifaktorial. Musim merupakan salah satu faktor yang mempengaruhi diare melalui dampaknya pada lingkungan. Penelitian ini bertujuan mengetahui hubungan musim hujan dengan kejadian diare pada usia 13–24 bulan. Penelitian ini merupakan penelitian analitik observasional dengan metode potong lintang. Pengumpulan data dilakukan pada bulan Maret 2020 di Puskesmas Kelurahan Penjaringan I, Jakarta Utara, dengan menggunakan rekam medis periode tahun 2016–2019, yang meliputi masing-masing tiga siklus musim hujan dan musim kemarau. Sampel penelitian adalah usia 13–24 bulan yang didiagnosa dengan diare infeksi. Hubungan antara variabel independen dan dependen diuji menggunakan chi-square. Dari 286 rekam medis yang digunakan, 83 kasus terjadi sewaktu musim hujan dan 203 kasus terjadi sewaktu musim kemarau (p=0,291). Kejadian diare paling tinggi pada perempuan kelompok usia 13–16 bulan. Tidak terdapat hubungan bermakna antara musim hujan dengan kejadian diare.
Survival Analysis of Chronic Kidney Disease Patients with Hemodialysis in West Java. Indonesia, Year 2007 - 2018 Afiatin Afiatin; Dwi Agustian; Kurnia Wahyudi; Pandu Riono; Rully M. A. Roesli
Majalah Kedokteran Bandung Vol 52, No 3 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n3.2124

Abstract

The prevalence of chronic kidney disease on dialysis or CKD5D is increasing with a significant impact on disease burden in many countries. Patients are usually listed in the national renal registries, which report demographic data, incidence, prevalence, and outcome. The survival rate is an important outcome measure to characterize the impact of treatment in the CKD5 patient population in the national and international renal registries. Indonesian Society of Nephrology (InaSN) has the Indonesian Renal Registry program to collect data that was endorsed to monitor dialysis treatment quality in Indonesia.  IRR releases an annual report, but there is no survival analysis yet.   This study aimed to discover the five-year survival rate of CKD5D patients in West Java between 2007–2018 and its factor based on the IRR database. A retrospective cohort study was performed by gaining all patients' data from the IRR database, then data on all of the patients from West Java province who completed a 5-year follow-up on December 31, 2018.  Kaplan-Meier analysis and Cox proportional hazard's model were used to analyze the risk factors. There were 3,199 data included in this study. In total, the 1, 2, 3, 4, and 5 year survival rates are 82%, 70%, 62%, 58%, and 55 %, respectively.  Patients whose age is above 55 years and with unknown underlying kidney disease have a worse survival rate with a hazard ratio of 1.28 and 1.50, respectively. Further exploration of IRR data will provide better information on dialysis treatment in Indonesia. Ketahanan Hidup Pasien Penyakit Ginjal Kronis dengan Hemodialisis di Jawa Barat Indonesia tahun 2007-2018Prevalensi penyakit ginjal kronis pada dialisis atau PGK5D meningkat dan memberi beban penanganan penyakit di banyak negara. Pasien biasanya terdaftar dalam register ginjal nasional yang melaporkan data demografis, insiden, prevalensi dan luaran klisis. Tingkat ketahanan hidup merupakan parameter penting dalam registrasi ginjal untuk menggambarkan kualitas terapi pada  populasi pasien PGK stadium 5. Perhimpunan Nefrologi Indonesia (Pernefri) memiliki program Registri Ginjal Indonesia yang disebut Indonesian Renal Registry (IRR) untuk mengumpulkan data pasien PGK5D untuk  memantau kualitas pengobatan dialisis di Indonesia. IRR merilis laporan tahunan tetapi belum dilengkapi dengan  analisis ketahanan hidup. Tujuan penelitian ini adalah mengetahui angka ketahanan hidup lima tahun pasien PGK5D di Jawa Barat antara tahun 2007-2018 dan faktor risikonya berdasarkan basis data dari IRR. Studi kohort retrospektif dengan mengambil semua data pasien dari basis data IRR kemudian ditentukan data pasien Jawa Barat yang lengkap dan di follow up selama 5 tahun pada 31 Desember 2018.   Analisis Kaplan-Meier dan model proporsional hazard Cox digunakan untuk menganalisis faktor risiko. Subjek berjumlah 3199 data yang dimasukkan dalam penelitian ini. Kesimpulannya, angka harapan hidup satu, 2, 3, 4, dan 5 tahun berturut-turut adalah 82%, 70%, 62%, 58%, dan 55%. Usia lebih dari 55 tahun dan penyakit ginjal yang mendasari memiliki kelangsungan hidup yang lebih buruk dengan hazard ratio 1,28 dan 1,50. Eksplorasi lebih lanjut dari data IRR akan memberikan informasi yang lebih baik tentang perawatan dialisis di Indonesia.
Comparison of Diagnostic Accuracy of Tuberculosis Spondylitis between Genexpert and Histopathological Examination David Rudianto Salim; Ahmad Ramdan; Gibran Tristan Alpharian
Majalah Kedokteran Bandung Vol 53, No 1 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n1.2234

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Spinal TB is associated with poor functional outcomes. Histopathological examination requires a long waiting times to obtain the results thus impractical for screening and may delay diagnosis. GeneXpert offers rapid tests for prompt screening and diagnosis. This study aimed to assess the diagnostic accuracy of GeneXpert in patients with spinal TB when compared to the histopathology test as the gold standard. This study was performed on patients in the Spine Clinic of the Department of Orthopedic and Traumatology, Dr. Hasan Sadikin General Hospital Bandung who were diagnosed with spinal TB during the period of May 2019–May 2020. Blood samples were collected from the patients and tested using GeneXpert and histopathological assessment. Results demonstrated 34 patients with a positive result and 6 patients with negative results on both diagnostic methods. Twenty nine out of 40 patients (72.5%) had rifampin-sensitive TB. Diagnostic accuracy of GeneXpert, when compared to histopathological examination, is represented by the sensitivity of 88.2%, specificity of 33.3%, positive predictive value of 88.2%, and negative predictive value of 33.3%. High sensitivity results forpatients with spinal TB on GeneXpert suggests that the test is appropriate to be used as a screening method and as a high-yield rapid diagnostic test for patients suspected for spinal TB.
Potential Vector Shelter for Malaria in South Central Timor Regency in Indonesia Nisa Fauziah; Arie Galih Mohamad; Naufal Fakhri Nugraha; Lia Faridah; Jontari Hutagalung
Majalah Kedokteran Bandung Vol 52, No 4 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n4.2092

Abstract

More than half of the areas in East Nusa Tenggara province, a province in the eastern part of Indonesia, are planned to be free from malaria by the end of 2030. However, one of the critical indicators for malaria elimination is still lacking, i.e. vectors’ environment and  breeding place indicators. South Central Timor (SCT) District is one of the areas with the highest Annual Parasite Incidence (API) >2‰ with the majority of the population works as farmers. The purpose of this study was to capture the relationship between environmental factors and the prevalence of malaria. This study was a cross-sectional analytic retrospective study using data from a previous malaria study conducted in August 2013 to September 2014 in 5 sub-districts of SCT district. All respondents were selected using the systematic random sampling approach from the population of healthy people. Data were collected using a standard questionnaire and an observation environment form. Malaria was confirmed through microscopic and Polymerase Chain Reaction (PCR) examinations. Data were then analyzed using the bivariate and multivariate analysis with 95% CI and α:0.05. Of 357 data collected, 35% (125/357) were malaria positive based on PCR examination. Two variables (living nearby lagoon and nearby rice field) were significant (p-value<0.05) as vector shelters for Anopheles sp. Thus, these have to be included as inputs to formulate effective and efficient malaria elimination strategies and programs in 2030. Lokasi Potensial Perkembangbiakan Vektor Malaria di Kabupaten Timor Tengah Selatan, IndonesiaLebih dari setengah Provinsi Nusa Tenggara Timur di Indonesia timur akan menghadapi bebas malaria pada akhir tahun 2030. Namun, salah satu indicator penting untuk eliminasi malaria adalah pengukuran lingkungan dan tempat berkembang biak vector masih kurang. Kabupaten Timor Tengah Selatan adalah daerah dengan salah satu Insidensi Parasit Tahunan tertinggi di Indonesia dan mayoritas penduduknya bekerja sebagai petani. Tujuan dari penelitian ini adalah mencari hubungan antara faktor lingkungan dengan prevalensi malaria. Penelitian ini menggunakan studi potong lintang metode analitik, menggunakan data retrospektif dari penelitian sebelumnya yang dilakukan pada Agustus 2013 hingga September 2014 di 5 kecamatan di Kabupaten Timor Tengah Selatan pada. Responden dipilih secara acak sistematik dari orang sehat. Pengumpulan data dengan kuesioner standar dan formulir observasi lingkungan. Konfirmasi malaria dengan menggunakan metode mikroskopis dan PCR. Data dianalisis dengan bivariat dan multivariate dengan 95% CI dan α: 0,05. Total 357 data dikumpulkan, 35% (125/357) positif malaria dengan pemeriksaan PCR. Dua variabel (dekat dengan laguna dan dekat dengan sawah) signifikan (nilai-p<0,05) sebagai tempat perlindungan vector untuk Anopheles sp. Penelitian ini diharapkan dapat memberikan informasi rinci untuk merumuskan strategi dan program eliminasi malaria pada tahun 2030 yang efektif dan efisien.
Physical Factors in Age-Related Decline Physical Performance among the Older Adults in Bandung Vitriana Vitriana; Irma Ruslina Defi
Majalah Kedokteran Bandung Vol 52, No 3 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v52n3.1992

Abstract

The aging process is associated with increased body fat and decreased muscle mass and strength in older adults. This condition is frequently associated with loss of mobility and functions. This study aimed to explore the relationship between physical performance and handgrip strength, body composition, and anthropometry in community-dwelling older adults living in Bandung, West Java Province, Indonesia. A cross-sectional study was performed from December 2015 to June 2016 on community-dwelling older adults above 60 years old who were the members of the West Java Branch of Lembaga Lansia Indonesia, Indonesia, with the ability to walk without an assistive device and to perform hand grip properly as an additional inclusion criterion. Subjects were excluded if they experienced severe cardiorespiratory or vascular abnormalities, used artificial implants, underwent hormone therapy, and had any disease that would affect the accuracy of the variable measurement. A total of 106 subjects (60-85 years old) participated in this study. A significant negative correlation between total body fat and physical performance and a positive correlation between handgrip strength to physical performance were observed among subjects. However, no correlation was found between the anthropometric measurement and physical performance. The total body fat percentage, muscle mass index, and handgrip strength correlate significantly to the physical performance in older adults and may be used as a good indicator to preserve physical function and quality of life in the elderly.Faktor-Faktor Fisik yang Memengaruhi Penurunan Performa Fisik Lanjut Usia di Lembaga Lansia Indonesia Cabang Jawa BaratProses penuaan sering dihubungkan dengan peningkatan lemak tubuh yang disertai dengan berkurangnya massa dan kekuatan otot pada lanjut usia. Kondisi ini sering berkaitan dengan hilangnya kemampuan mobilisasi dan fungsi lainnya. Tujuan penelitian ini adalah melihat hubungan antara performa fisik dengan kekuatan genggam tangan, komposisi tubuh dan antropometri pada komunitas lanjut usia yang tinggal di Bandung, Jawa Barat, Indonesia. Penelitian potong lintang dilakukan periode Desember 2015 sampai dengan Juni 2016 pada lanjut usia yang tinggal dalam komunitas dan merupakan anggota Lembaga Lansia Indonesia Cabang Jawa Barat, berusia lebih dari 60 tahun, serta mampu berjalan tanpa alat bantu dan dapat menggenggam tangan dengan baik. Partisipan dieksklusi bila menderita gangguan kardiorespirasi atau vaskuler yang berat, menggunakan implan artifisial, menjalani terapi hormonal dan mempunyai penyakit yang berpotensi mempengaruhi akurasi penilaian variabel. Dari total 106 partisipan dengan rentang usia 60–85 tahun, ditemukan korelasi negatif antara total lemak tubuh dengan performa fisik, dan korelasi positif antara kekuatan genggam tangan dengan performa fisik, akan tetapi tidak ditemukan hubungan antara komponen antropometri dengan performa fisik. Persentasi total lemak tubuh, indeks massa otot dan kekuatan tangan mempunyai hubungan yang bermakna dengan performa fisik pada lanjut usia dan dapat menjadi indikator yang baik dalam mempertahankan fungsi fisik dan kualitas hidup pada lanjut usia.
Paternity Test Through Kinship Analysis as Forensic Identification Technique Ahmad Yudianto; Fery Setiawan; Reni Sumino
Majalah Kedokteran Bandung Vol 53, No 1 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n1.2154

Abstract

Paternity tests is often faced with the unavailability of information from the father, mother, or child as a comparison in forensic DNA examination process. Therefore, comparisons with information from close family lines are needed, for example from the victim's siblings or the perpetrator if there are no comparisons from parents or siblings. This study was conducted by the Human Genetic Study Group of Airlangga University in its campus from January to April 2020. The aim of the study was to analyze the use of kinship analysis in paternity test through STR CODIS examination on siblings. This was an observational laboratory study with a temporary design. DNA sample extraction level and purity results were measured with the mean DNA sample level of 675±5.35ng/µL, while the purity values ranged from 1.05 to 1.86. The paternity test principle is based on comparison process between the parents’ alleles with the child’s alleles. However, if the parents’ alleles are not available, the siblings’ alleles can be used as a comparison for identification purpose, which is known as kinship analysis. Statistically, full siblings have a 2 alleles accuracy probability of [0.25] 25%, which was the same as not having the same allele or 0 allele, while 1 allele accuracy reached 50%. All CODIS STR loci had the highest percentage of 2 allele sharing. Therefore, it is recommended to use sibling or kinship analysis if both parents are absent.

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