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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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Herpes simplex encephalitis (A review) Satiti Retno Pudjiati, Herning Setijowati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008)
Publisher : Universitas Gadjah Mada

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Abstract

Herpes simplex encephalitis (HSEI is an inflammation of the brain caused by herpes simpleks virus (HSVI. HSE includes serious types. HSE can influence all age group, but most common in those under 20 and over 40 years old. Clinical diagnosis based on clinical presentation, laboratory examination of cerebrospinal fluid (CSFI, even by computerized tomography scan (CT-scan)/magnetic resonance imaging (MRII, electro encephalogram (EEGI is difficult that resulted in nonspecific diagnosis. Polymerase chain reaction (PCRI, and brain biopsy are the best diagnostic test. The main treatment of HSE is non spesific i.e. acyclovir. An early management may decrease the risk of mortality from 80% - 25%. While without treatment the mortality.can reach 70-80% and the prognosis might unfavourable.Key words: encephalitis - HSE - CSF - CT-scan - MRI - EEG
Body Constitution, grip stregth, and Vital Capacity of Children 15 to 18 Years in Samigaluh Highland and Galur Lowland Kulonprogo Yogyakarta Janatin Hastuti, Janatin Hastuti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 01 (2007)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Growth of children at age of 15 to 18 years old has an important influence on providing body constitution in their adult. Grip strength and vital capacity express functional effort of organs or parts of the body. Therefore, it certainly relates to the shape and size of the body or the body constitution. Different environment in highland and lowland affects the body constitution and functional capacity in growth period.ObJective: The aims of this research were to know the differences of body constitution, grip strength, and vital capacity of 15-18 year old children in Samigaluh highland and Galur lowland in Kulonprogo, Yogyakarta Province, and the relationship between body constitution, grip strength, and vital capacity of both populations. Methods: The research was done on 422 boys and girls of 1 5-18 years, which consisted of 152 children living in Samigaluh and 270 children living in Galur Kulonprogo. The children were examined with respect to body weight, height, grip strength of right and left hands, and vital capacity. Body Mass was Index then calculated from weight and height. Statistical analysis of three way ANOV A, t-test, Pearson product moment correlation, and linear regression were used.Results: Body constitution, grip strength, and vital capacity of boys differed significantly from girls. Boys were heavier and taller than girls. Grip strength and vital capacity were also greater in boys. Children living in Galur were heavier and taller than those living in Samigaluh, but they were similar in vital capacity. Grip strength was different at age of 15-16 years. There was no difference in Body Mass Index between boys and girls, as well as between Samigaluh children and Galur children.Conclusions: Body constitution, grip strength, and vital capacity of boys and girls were different significantly, also between Samigaluh and Galur children as well. Concerning Samigaluh children were shorter and lighter, it was said that Samigaluh children have better physical performance. Grip strength and vital capacity of 1 5 to 1 8 year old children living in Samigaluh highland and Galur lowland were stronger affected by body constitution than by age.Key words: body constitution; grip strength; vital capacity; 1 5-18 year old boys and girls
The combination effect of triamcinolone acetonide and tamoxifen citrate on fibroblast populated collagen lattice contractions Yohanes Widodo Wirohadidjojo, Agung Pranoto Satiti RetnoPudjiati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 02 (2008)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Keloid is caused by fibroblast hyperproliferation stimulated by transforming growth factor-IH ITGF-131 I, and it is usually treated with triamcinolone acetonide (TAl, which has the ability to inhibit TGF131 synthesis. However, the clinical results is still unsatisfied. Another drug that may inhibit keloid fibroblast TGF-131 synthesis is tamoxifen citrate (TCI, but the effect of the combination on keloid fibroblast activities has never been published.Objective: To find out the effect of combined triamcinolone acetonide and tamoxifen citrate on fibroblast keloid activities in vitro.Methods: It was a parallel post-test only study. The third passage keloid fibroblasts were isolated from a patient with keloid, cultivated in collagen lattice, and treated with several combinations of 5, 10, and 20 pM TA and 10, and 20 pM TC. Lattice contractions were measured based on digital image using scion image.Results: Among TA groups, the best inhibition of lattice contraction was found among 20 pM treated group and among TC groups. The best inhibition of lattice contraction was found among 20 pM TC. The best combination was found in the combination of 20 pM TA plus 20 pM TC.Conclusion: The result indicated that a combination of triamcinolone acetonide and tamoxifen citrate had a significant role in suppressing fibroblast activity, better than triamcinolone acetonid or tamoxifen citrate alone.Key words: tamoxifen - triamcinolone - collagen lattice - keloid fibroblast.
The Evaluation of Vaginal Hysterectomy Using Spinal Anaesthesia Ibnu Pranoto, Ibnu Pranoto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 39, No 02 (2007)
Publisher : Universitas Gadjah Mada

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Abstract

Background. Vaginal hysterectomy can be performed on patient under general or spinal anesthesia. There are some advantages of spinal anesthesia compared to general anesthesia, although some prefer general anesthesia. We have done frequently vaginal hysterectomy using spinal anesthesia and we are reporting our experience.Objective:To know the spinal anethesia efficency compared to general anesthesia in terms of duration of vaginal hysterectomy operation, amount of bleeding and length of stay.Design: Cross sectional descriptive studySetting: Sardjito HospitalMaterials and methods: Patients underwent vaginal hysterectomy in Dr. Sardjito Hospital from March 2005 until February 2007Results: 50 patients underwent vaginal hysterectomy that consisted of 44 patients with spinal anesthesia and 6 patients with general anesthesia. Vaginal hysterectomy with spinal anesthesia had shorter duration of operation (1.93 hours) compared to general anesthesia (1.95 hours). Patients length of stay was shorter with spinal anesthesia (5.8 days) compared to general anesthesia (9 days). The average amount of blood loss in spinal anesthesia was (250.34 mil compared to general anesthesia (625.0 mil.Conclusion: This study suggests that spinal anesthesia reduces length of hospital stay and amount of blood loss in patients with vaginal hysterectomy compared to general anesthesiaKey Words: vaginal hysterectomy, spinal anesthesia, general anesthesia, duration of operation, amount of bleeding and length of stay.
Correlation of interleukin-6 and monocyte count to troponin I in acute coronary syndrome Usi Sukorini, Teguh Triyono Joni Parinding
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 04 (2008)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Acute coronary syndrome (ACS) becomes an important disease, because of its increased prevalence and mortality rates. Makers of systemic inflammation, including interleukin-6 and monocyte count, have been shown to predict future cardiovascular events. However, the association between these inflammatory markers with cardiac injury is still a controversy.Objective: To evaluate the relationship between IL-6 and monocyte count as inflammation markers and troponin I as cardiac injury.Methods: This was a cross-sectional study. Subjects were patients suspected of ACS admitted to the emergency department of Sardjito Hospital Yogyakarta. Diagnoses were performed based on WHO criteria. Troponin I and interleukin-6 levels were measured from sera using sandwich ELISA method (Roche). Monocyte counts were determined by automatic hematology analyzer (Sysmex). Kruskal-Wallis test and Spearmans correlation test were used to assess the difference and correlation between parameters.Results: Sixty one (61) subjects were included in the study. Age of the subjects were 51-60 years, and diagnosed as ST elevation myocardial infarct (STEMI). Significant differences of IL-6 and troponin I levels were determined among unstable angina pectoris (UAP), non-ST elevation myocardial infarct (NSTEMI), and ST elevation myocardial infarct (STEMI) subjects. There was a moderate correlation (r = 0.54; p = 0.001) between troponin I and Interleukin-6, but not with monocyte count.Conclusion: Interleukin-6, but not monocyte count, was correlated with troponin I in acute coronary syndromes.Key words: acute coronary syndrome - interleukin-6 - monocyte count - troponin I
The Combination of suprakeloidal flap and pulsed light heat energy in keloid management: a Case report Dwi retno Adiwinarni, Yohanes Widodo Wirohadidjojo Kristiana Etnawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008)
Publisher : Universitas Gadjah Mada

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Abstract

The role of chronic tissue hypoxia in the keloid patho-mechanism has been widely accepted. Whereas, the pulsed-light heat energy (LHE) has been developed which has the capacity to generate reactive oxygen species on exposed skin. Although the supra keloidal flap technique has a high recurrence rate, it was used because of its capacity to prevent suturing hypoxia, thereby the formation of lager recurrent keloid after surgery.The combination of supra keloidal flap and pulsed light heat energy was done I the treatment of postvaricella keloid on the right ear lobe of a 9 year old girl. The keloid was excised two times a year ago, but observation one month after the surgery showed a recurrent larger keloid. The performance of supra keloidal technique followed by pulsed-light heat energy treatment in dose 2.5 J/cm2, was administered on day 3r
Antenatal and postnatal risk factors of obesity in children age 2-5 years old in Yogyakarta District, Indonesia Yudha Patria, I Ketut Rutin Pastadita Sunartini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Universitas Gadjah Mada

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Abstract

Obesity and overweight have become a health issue throughout the world, with a dramaticincrease in prevalence each year. An obese child is thought to be adorable, but parents are notaware of the health risk it holds. Preventive measures by decreasing the risk factors for obesityare more effective than treating the problem. The aim of this study was to identify the riskfactors of obesity in antenatal and postnatal period in children in Yogyakarta District. This wasan observational study with a case control design. Criteria of obesity were defined according toWHO 2006 growth chart. Subjects were children age 2 to 5 years old that were enrolled inplaygroups in the Yogyakarta Distric with a targeted sample size of 41 children. Parents ofchildren that met the inclusion and exclusion criteria were given questionnaires to fill out. Theresults were analyzed using bivariate analysis and multivariate logistic regression. Thirty fourobese children and 34 non obese children (as control) were explored for the obesity risk factors.Prematurity/gestational age (OR=16; 95%CI=3.27-78.28; p=0.001), passive smoking (OR=5.50;95%CI=1.90-15.96; p=0.001), low birth weight (OR=7.27; 95%CI=1.45-36.47; p=0.008),eating more than 3 times daily (OR=2.19; 95%CI=1.66-2.89; p=0.007), meals that are high inlipid (OR=4.18; 95%CI=1.45-12.02; p=0.007) were shown to be risk factors for obesity inchildren. Factors such as picky eaters (OR=0.16; 95%CI=1.45-12.02; p=0.002), early introductionto solid food (OR=0.29; 95%CI=0.10-0.79; p=0.01), exercise (OR=0.25; 95%CI=0.06-0.32;p=0.04), and watching TV or playing video game under 2 hours daily (OR=0.30; 95%CI=0.09-0.95; p=0.04) were identified as protective factors against obesity. By using the multivariateanalysis, there were only 2 risk factors for obesity i.e. eating more than 3 times daily andprematurity/gestational age and there were only 2 protective factors i.e. exercise and introductionto solid food that remained statistically significant as independent factors influencing obesity inchildren aged 2 to 5 years old in the Yogyakarta District.Keywords: obesity - children age 2 to 5 years old - antenatal - postnatal - risk factors
Serum testosterone level and active caspase-3 of Leydig cells of diabetic Sprague-Dawley male rats after administration of soybean (Glycin max) powder suspension Sri Kadarsih Soejono, Wiyadi Dicky Moch. Rizal
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Universitas Gadjah Mada

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Abstract

Diabetes mellitus (DM) is known as the main death cause in the world. This disease causes acuteand chronic complication. The common chronic complication on male reproduction system isthe decrease of testosterone level. This hormone is produced in the Leydig cells. Soybeans(Glycin max) has been used in the management of DM to maintain blood glucose level. However,the effect of soybean on serum testosterone level is still unclear. The aim of this study was toevaluate serum testosterone level and caspase-3 active of Leydig cells of diabetic Sprague-Dawley (SD) male rats model induced by streptozotocine (STZ) after oral ingestion of soybeanpowder suspension. This was an experimental study with pre and post test control group design.Thirty SD male rats, aged 11-12 weeks with body weight (BW) of 200-250 g were divided into 5groups with 6 rats in each group. The first group (G1) was normal rat control and the secondgroup (G2) was diabetic rat control. The third to fifth group (G3, G4 and G5) were diabetic rattreatment with oral ingestion of soybean powder suspension that was given once a day during 4weeks with dose of 400; 800 and 1600 mg/kg BW, respectively. The serum testosterone levelwas measured by an ELISA and active caspase-3 of Leydig cells were measured by animmunohistochemistry method. The result showed that the serum testosterone level and activecasapse-3 Leydig cells of diabetic rats model induced by STZ were not significantly differentafter oral ingestion of soybean powder suspension with dose of 400, 800 and 1600 mg/kg BW(p>0.05). In conclusion, soybean powder suspension did not affect the serum testosteronelevel and active caspase-3 Leydig cells in diabetic rats.Keywords: diabetes - soybean - phytoestrogen - testosterone - active caspase-3
Retinal sensitivity changes after retinal surgery between new onset and long-term rhegmatogenous retinal detachment Retno Ekantini, Rose Angela Nurini Agni
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 03 (2008)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Rhegmatous retinal detachment is an emergency case which will had to blindness if it is not managed properly. It could managed mostly by surgery. Many factors influence the success of the management.Objective: To know the difference of central retinal sensitivity changes after retinal surgery in new onset and long-term rhegmatogenous retinal detachment (RRD)Methods: A prospective cohort study. Eyes with RRD which showed anatomically successful surgery were included in this study. RRD developed more than 24 days prior to surgery was considered as long-term RRD. Sample size was calculated based on the assumption that clinically significant central retinal sensitivity change was 5 decibels. Central retinal sensitivity was examined with Goldmann manual kinetic perimetry before and 3 months after surgery.Results: There were 35 eyes included in this study, consisted of 19 new onset RRDs and 16 long-term RRDs. The macula were involved in all of the subjects. The extent of retinal detachment ranged between 4 clock hours and 12 clock hours. PVR was found in 4 eyes. Two eyes (5.7%) underwent scleral buckling (SB), one eye (2.9%) underwent SB and posterior vitrectomy using silicone oil, and 32 eyes (91.4%) underwent SB and posterior vitrectomy using gas. Retinotomy was performed in 2 eyes and internal limiting membrane (lLM) peeling in 1 eye. Three months after the surgery, the mean change of central retinal sensitivity for both groups was 8.60 :I: 6.02 dB (range: -3 dB to + 23 dB), the new RRD was 6.9 :I: 5.57 dB, and the long-term RRD (p= 0.067) was 10.63 :I: 6.07 dB.Conclusion: The difference of central retinal sensitivity changes between new onset and long-term RRD was not significant clinically and statistically. However, both groups showed improvement of central retinal sensitivity.Keywords: retinal sensitivity - new onset rhegmatogenous retinal detachment - long-term rhegmatogenous retinal detachment - Goldmann manual kinetic perimeter
Molecular subtypes and clinicopathological features of breastcancer Irianiwati, Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 01 (2013)
Publisher : Universitas Gadjah Mada

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Abstract

Breast cancer is a heterogeneous disease with regard to morphological spectrum, clinical presentation and response to therapy. Based on immunohistochemistry detection of estrogen receptor, progesterone receptor, Her-2 status, proliferation rate and clusters of basal gene expression, breast cancers can be classified into luminal A, luminal B, basal-like/triple negative, and Her-2 positive. It was suggested that there was a close relationship between molecular subtypes and clinicopathological features of breast cancer, as they are very important to predict prognosis and therapeutic implications. Keywords: molecular subtypes - breast cancer- clinicopathological features -heterogeneity –theraputicimplications  

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