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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 2,170 Documents
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Immature teratoma of the urinary bladder Indriwati Indriwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 35, No 3 (2003)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A three year old female with immature teratoma of the urinary bladder was reported. The cell differentiation theory should be considered as an important alternative theory in the histogenesis of extragonadal immature teratoma. Extragonadal immature teratoma can be differentiated from extrarenal Wilm's tumor by a proper histopatological examination particularly in view of the presence of neuroepithelial tissue.Key words : bladder immature teratoma - extrarenal Wilm's tumor -cell dedifferentiation theory
The association between diabetic autonomic neuropathy with thiamine deficiency Samekto Wibowo Samekto Wibowo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 31, No 03 (1999)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Background: Autonomic neuropathy is a kind of diabetes mellitus complication. Parasympathetic neuropathy occurs first, and then it is followed by sympathetic neuropathy. Autonomic nerves are widely distributed in many organs and systems, including cardiovascular, gastrointestinal, urogenital, thermoregulation, and ocular organs. Therefore, the involvement of those organs will produce certain clinical symptoms related to the functions of the internal organs. On the other hand, thiamine status influences the condition of nerve fibers. Thiamine deficiency may produce nerve impairment.Objective: To discover the association between diabetic autonomic neuropathy with thiamine deficiency. Methods: Diabetes mellitus cases of Sardjito Central General Hospital were involved in this study. Schellong test was used to diagnose autonomic neuropathy. Thiamine status was measured in The Nutrition and Food Laboratory of Gadjah Mada University by determining transketolase enzyme activity as done by Ismadi. Results: One hundred and forty subjects were involved in this study. Eleven subjects (7.9%) suffered from autonomic neuropathy. Thiamine deficiency occured in 60% of autonomic neuropathy subjects. Among the subjects without autonomic neuropathy, 55.6% suffered from thiamine deficiency. The difference was not significant (p> 0.05). Odds Ratio 1,2; 95%Cl 0.32-4,46.Conclusions: Thiamine deficiency was more prominent among diabetic autonomic neuropathy subjects. Nevertheless, diabetic autonomic neuropathy had no significant association (p > 0.05) OR 1.2; 95% CI 0.32-4.46) with thiamine deficiency.Key words: diabetes mellitus - thiamine deficiency - autonomic neuropathy - diabetic autonomic neuropathy - postural hypotension
Medical Biotechnology : Its Impact on Society's Teuku Jacob Teuku Jacob
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 04 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Karangan ini memberi pandangan bioanthropologis tentang dampak sosial bioteknologi medis. Dimulai dengan definisi bioteknologi dalam arti luas dan sempit, lalu diteruskan dengan tinjauan tentangcara, balk yang modern maupun yang tradisional, kemudian diakhiri dengan uraian tentang dampak biososial, ekologis, evolusioner, demografis, ekonornis, politis, militer, hukum, sosiokultural dan agama, yangdapat men imbulkan perubahan-perubahan mendasar4alam masyarakat dunia.Di antara cara-cara bioteknologi yang disinggung adalah eufenetika, eugenetika, transplantasi dan substitusi organ, genoteknologi dan teknologi reproduksi. Ke dalam yang terakhir termasuk peijodohan terpimpin, pengendalian pembuahan, pembuahan anumerta, dan in vitro, fusi embryo dan pencangkokan nukleus, hybridisasi sel dan klonasi. Di antara cara-cara tradisional dikemukakan system Itasca, pengebirian, pengguguran, infantisida, perjodohan terpimpin dan manipulasi lingkungan.Diingatkan tentang dampak negatif yang merugikan manusia dan ekos-ystemnya, karena alchimya aspekteknologis kehidupan tidal( dapat di pisah kan dari aspek-aspek politis,sosial dan ethis.Key Words: biotechnology - euphenics - eugenics - reproductive technology -- guided mating
The effect of Zingiber officinale's active compounds against microfilariae Brugia malayi in Fells catus, L. Budi Mulyaningsih Budi Mulyaningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 27, No 02 (1995)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Zingiber officinale, Rosa is a well known plant which can be used for the treatment of various diseases, and has been reported as an effective medicinal plant against Dirofilaria immitis in animal. The volatile oil and the pungent of Zingiber officinale, Rosa have been effectively used against larvae stage 3 (L3) B. malayi in vitro study.This study was designed to investigate the effect of the volatile oil and the pungent of Zingiber officinale, Rosc. against microfilariae B. malayi in Fells catus, L..Antifilarial activity of the pungent compound (isolate 1) and the volatile oil were assayed in vivo.The results showed that the volatile oil had the most quantity (rendement 0,5 %) and its activity against microfilariae B. malayi was higher than that of isolate 1, but lower than that of the dietylacarbamasine drug.Key words: microfilariae - volatile oil - the pungent of medicinal plant - B. malayi - Felis caws L
Onset of menarche: differences between urban and rural community in Tangerang District, Banten Province, Indonesia Dewi Darmawati Sunartini Hapsara Suryono Yudha Patria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 02 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The transition of physical and sexual maturation in becoming an adult occurs in adolescenceperiod. This transition runs in parallel with the development of cognitive, emotional, socialcultural and adaptation ability. Girls sexual maturity is marked by first menstruation (menarche)which is the most important phase of reproductive development. The relationship betweenmenarche and growth rate of body height is very close. The menarche occurs when the growthrate of the body height begins to decline. Many factors influence the onset of menarche i.e.physical activity, nutritional intake, socio economic and environmental conditions and availabilityof medical services. These factors vary between rural and urban area. Girls in urban area tend tohave modest life style compared with their counterpart in rural area. The purpose of this studywas to compare the onset of menarche of girls in urban and rural area, and to identify factorsthat influence the onset of menarche. This was a cross sectional study involving 220 girlsstudents of elementary school from both urban and rural area in Tangerang District, BantenProvince. The mean onset of menarche of all subjects was 11.46 ± 0.99 years, while the meanonset of menarche of girls who live in rural area (11.87±0.99 years) was significantly slowerthan girls who live in urban area (11.05±0.80 years) (p=0.01). The birth body weight and birthbody length, physical activity and environment condition significantly influenced the onset ofmenarche. The girls who live in urban areas had an earlier predictor factors to achieve for onsetof menarche than those who live in rural areas (OR: 3.34 [95% CI: 1.911 to 5.823] and aOR:2.95 [95% CI: 1.410 - 6.012]).Keywords: menarche - growth spurt - sexual maturity - urban - rural community
The innocent murmurs Ahmad H. Asdie Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 13, No 02 (1981)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

In this article the innocent murmur includes only those murmurs that are associated with no known abnormality, either structural or physiologic. The term "functional murmur" and "physiologic murmur" are avoided, because they may include even murmurs resulting from dilatadon of valves, heart chamber, and vessels or are associated with acceleration of the circulation.The innocent murmurs are common and are often misinterpreted. Misinterpretation of innocent murmurs may lead to anxiety on the part of both physician and patient, to a prolonged period of unnecessary restriction of physical activity, and perhaps to permanent cardiac neurosis. They may also lead to exclusion of healthy young people from athletic activities, flying, and military service, or to the use of unnecessary prophylactic penicillin. The distinction between an organic murmur and an innocent murmur is enlargement, no history of rheumatic fever; absence of cyanosis, clubbing, and congestive heart failure.KeyWords: innocent murmur - functional murmur- physiologic murmur - venous hum
Keracunan Makanan Bakterial dan Botulisme Ilyas Ilyas
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 6, No 04 (1974)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

kata kunci : keracunan makanan
Association study of LMP-1 expression and promoter methylation status of tumor suppressor gene RASSF1A in nasopharyngeal carcinoma Ageng Brahmadhi Susanna Hilda Hutajulu, Dewi Kartika Harijadi, Rina Susilowati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Nasopharyngeal carcinoma (NPC) is a cancer originating fromnasopharyngeal epithelial tissue. Genetic susceptibility,exposure to carcinogens, and Epstein-Barr virus (EBV) infection are the main factors in NPC development. Latentmembrane protein 1 (LMP-1) is a product of EBV genome, which is able to interact with various intracellular signalingpathways that leads to expression of many proteins, e.g DNA methyltransferase. The increase expression of DNAmethyltransferase could induce hypermetylation of tumor suppressor genes (TSG). Ras-association domain family1A (RASSF1A) is one of TSG that frequently hypermethylated in NPC cases. The aim of this study is to determinethe association between LMP-1 expression and promoter methylation status of RASSF1A in NPC patients. Theresearch subjects were 36 NPC patients of the Dr. Sardjito Hospital, Yogyakarta, Indonesia. Latent membraneprotein 1was stained immunohistochemically using monoclonal antibody OT21C. Ras-association domain family 1Amethylation statuswas examined by methylation specific PCR (MSP) of DNA isolated fromnasopharyngeal brushing.Chi-square analysis was conducted to examine the association between LMP-1 expression and methylation status ofRASSF1A with 95%confidence interval. Latent membrane protein 1 was expressed in 44.4%subjects. The scoresof LMP-1 expression were ranged from 0-8 (average of 1.56±2.16). Ras-association domain family 1A methylatedin 66.7% of subjects. Statistical analysis showed that there was a relationship between LMP-1 expression andmethylation status of RASSF1A (p<0.05). Statistical analysis also showed association between LMP-1 expressionscore and RASSF1A methylation status (p<0.05). It can be concluded that there was an association between theexpression of LMP-1 and RASSF1A methylation status in NPC patients.Keywords: LMP1 - RASSF1A – NPC – hypermethylation - DNA methyltransferase - methylation specific PCR
Filariasis caused by nonperiodic form of Brugia ma/ayi among transmigrants in East Kalimantan. FA Sudjadi FA Sudjadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 30, No 02 (1998)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A new subspecies of sylvanic or human filarial worm, i.e. nonperiodic form of Brugia malayi Lichtenstein, was recently discovered in East Kalimantan, which was highly prevalent among Dayak indigenous people living in the deep forest. This paper reports the filarial infections among transmigrants coming from Java who have been resettled for about 30 years in the UPT (unit of transmigration resettlement) of Petung, Penajam district, Pasir regency. Higher filarial infections were recorded among transmigrants living in hilly parts of the UPT, such as those found in Gunungrejo subvillage, with a micro-filarial rate of 6.3%, clinical rate of 8,1% or filariasis rate of 12,9%, out of 520 people examined. In more swampy areas, such as those found in Kedungrejo subvillage, the parasite Infection rate was much lower, and was recorded only 3,1%, out of 578 people examined. The result of blood or clinical examinations carried out in this research also indicated that male and older Inhabitants or transmigrants who have stayed longer in Kalimantan have a higher risk of Infection.Key words: transmigrants - Brugia malayi - nonperiodic form - sylvanic filaria - mansonia
Rooming-in program in Dr. Sardjito Central General Hospital Asparin Asparin
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 18, No 04 (1986)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

To evaluate the clinical efficacy of rooming-in program, sixty one term-newborn infants with normal deliveries, birth weight 2500-4000 g, Apgar scores 5 minute were studied. The infants were randomly assigned into two groups, 31 rooming-in and 30 not rooming-in group (mother separated from the newborn for 3 days duration). In the third day of life, there were no statistically significant differences in both groups on serum bilirubin levels (p>0.05), cumulative weight loss (p>0.05) and incidence of hyperbilirubinemia (p>0.05). The intensity of hyperbilirubinemia was not related to weight loss (p>0.05). The episode of gastroenteritis was non-existent in the rooming-in group whereas two infants in the not rooming-in group suffered from it. Key Words: rooming-in program - term - newborn infants - unbound bilirubin - cumulative weight loss - hyperbilirubinemia

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