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INDONESIA
Jurnal Penelitian Farmasi Indonesia
Published by Universitas Riau
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Decision Sciences, Operations Research & Management Medicine & Pharmacology
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Articles 14 Documents
 1   2 
Isolasi Senyawa dan Uji Aktivitas Anti-inflammasi Ekstrak Metanol Daun Puwar Kincung (Nicolaia speciosa Horan) Fernando, Armon; Suryani, Fitri; Ahmad, Farediah; Sirat, Hasnah M.; Arbain, Dayar
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
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The study of anti-inflammatory activity and isolation of the methanolic extract, hexane and ethyl acetate fractions of the leaves of puwarkincung (Nicolaia speciosa Horan) have been done. Isolation was carried out by extraction, fractionation and multiple column chromatographicmethod, followed by recrystallization technique. Two compounds were isolated and labeled as F4 and S3. F4 was derived from n-hexanefraction as yellowish-white crystals (20 mg) with mp. 55–57 oC and S3 from the ethyl acetate fraction (15 mg) as yellow crystals with mp.68–69 oC. Anti-inflammatory activity of methanolic extract using Paw Edema method showed that the dose 250 and 1000mg/kgbw wereactive as anti inflammatory agents.
Isolasi Katekin dari Gambir (Uncaria gambir (Hunter). Roxb) untuk Sediaan Farmasi dan Kosmetik Rahmawati, Noveri; Bakhtiar, Amri; Putra, Deddi Prima
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
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Study on isolation of catechin from gambier (Uncaria gambier (Hunter). Roxb) for pharmaceutical and cosmetic uses has been conducted.Raw materials of gambier were collected from three different areas including Andalas University Medicinal Plant Garden, Lima Puluh Kotaand Siguntur Pesisir Selatan, West Sumatera. Catechin was isolated from gambier using two methods, namely purification and pre nonpurification. Several evalutions on quality of the obtained catechin was done including descriptions of the catechins, solubility, colorreactions, thin layer chromatography, yield, drying shrinkage, melting point and maximum uptake levels of catechins. The best results forpharmaceutical and cosmetic uses are gambier originated from Siguntur with pre purification method which obtained 56.3% yield and 96.17%levels of catechins.
Optimasi Ekstraksi Triterpenoid Total Pegagan (Centella asiatica (Linn.) Urban) yang Tumbuh di Riau Mora, Enda; Fernando, Armon
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
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Optimization of extraction of total triterpenoid content from pegagan (Centela asiatica (Linn) Urban) originated from three locations inRiau province; kecamatan Siak Hulu, kabupaten Kampar, kecamatan Belilas, kabupaten Pelalawan and kecamatan Tampan kota Pekanbaruwas carried out using soxhlet method. n-Hexane and methanol were used as eluent and 8 grams of active carbon as adsorbent. The resultrevealed that pegagan originated from kabupaten Kampar showed the highest yield with total triterpenoid content of 3.94%, while otherspegagan afforded lower yield; 1.25% for kabupaten pelalawan and 1.91% for kota Pekanbaru.
Sintesis dan Uji Antiinflamasi Senyawa (R)-3-(4-Florofenil)-1-fenil-5-(tiofen-2-il)-4,5-dihidro-1H-pyrazol Serta Pengaruhnya terhadap Kerusakan Lambung Rullah, Kamal; Hasti, Syilfia; Hariani, Destawira; Utama, Putri Bela; Teruna, Hilwan Yuda; Zamri, Adel
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
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An in-vivo anti-inflammatory study of pyrazoline compound synthesized from chalcone has been carried out using Paw Edema method.Compound (R)-3-(4-florofenil)-1-fenil-5-(tiofen-2-il)-4, 5-dihidro-1H-pyrazole was synthesized by milling method in alkaline condition,with no solvent addition and was conducted under room temperature. Characterization of the synthesized compound was determined using1H-NMR and HR-MS spectrometer. As for anti-inflammatory study, suspension of compound (R)-3-(4-florofenil)-1-fenil-5-(tiofen-2-il)-4,5-dihidro-1H-pyrazol was administrated orally to white female mice (Rattus novergicus) with doses 20, 40, 80 mg/kg bw, respectively. Theresult showed that the compound with doses 40 and 80 mg/kg bw exhibited insignificant difference compared with standard drugs Celecoxiband Piroksikam (p>0,05). Futhermore, all doses of compound did not cause any damage of stomach organ of mice, which is given the same“ulcer index” (Iu) with negative control (Iu 2,00). Meanwhile, ulcer index for Celecoxib of Iu 35,99 and Piroksikam of Iu 70,01.
Formulasi Gel Minyak Kulit Kayu Manis (Cinnamomum burmannii Bl) sebagai Sediaan Antinyamuk Lukman, Anita; Susanti, Emma; Oktaviana, Roli
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
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A study on gel formulation of cinnamomum oil as mosquito repellent has been done against Aedes aegypti. This study was aimed to determinethe most effective formula as mosquito repellent from two different concentrations of oil in gel formulation. Two different concentrations12 and 15% of cinnanmomum oil were formulated in to gel form with addition 1% of clove oil as its fixative. The formulation of bothconcentrations of cinnamomum oil resulted good gel formula based on its organoleptic, pH, homogeneity and physically stable. However,both formulas could cause skin irritation. Gel formula with 15% concentration of oil showed the most effective effect against Aedes aegyptiwith six hours of tested period.
Formulasi Sabun Cair dari Ekstrak Batang Nanas (Ananas comosus. L ) untuk Mengatasi Jamur Candida albicans Anggraini, Deni; Rahmides, Wiwik Sri; Malik, Masril
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
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A study on antifungal effect of liquid soap formulation of extract of pineapple stem (Ananas comosus L) has been carried out towardsCandida albicans. Three different concentrations of extract 3; 5 and 7%, were formulated as liquid soap using TEA, stearic acid andglycerine as its soap bases. Several evaluations were examined on the liquid soap formulation including organoleptic examination, determinationof relative density, viscosity, foam test, pH test, and skin irritation test. While antifungal effect test of the obtained formulations was testedon PDA medium. The result revealed that extract of pineapple stem was successfully formulated and physically stable in liquid soap form.The antifungal effect test showed that formula with 7% concentration of extract demonstrated the strongest effect with 21.3 mm diameterof inhibition towards Candida albicans.
Uji Aktivitas Hepatoproteksi dan Toksisitas Akut dari Ekstrak Gambir Terstandarisasi Hasti, Syilfia; Muchtar, Husni; Bakhtia, Amri
Jurnal Penelitian Farmasi Indonesia Vol 1, No 01 (2013)
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Hepatoprotective activity and acute toxicity from extract of gambir (Uncaria gambir. Roxb) was investigated. The animals were groupedinto seven groups which consist of 5 female mice for each group. Mice from group I were only administrated orally with palm oil, 1% frombody weight for two days and 1% of gum suspension orally at day two. Group II were given CCl4 with dose 1.25 ml/kgbw in 10% of palm oilfor two days and gum suspension orally 1 hour after CCl4 given at day two. Group III, IV, V were given CCl4 with dose 1.25 ml/kgbw in 10%of palm oil for two days and followed by administration of gambir suspension orally 1 hour after CCl 4 given at day two with concentrations30; 100 and 300 mg/kgbw, respectively. At day 3, all the blood were taken and were examined its SGOT and SGPT. While the isolated liverwere weighed and the ratio between liver weight and body weight of mice were also observed. Acute toxicity test was conducted using fiveanimal groups consist of 5 female mice and 5 male mice. Each of mice then was given gambir suspension orally with doses of 1; 2; 4; 8 and15 g/kgbw, respectively. LD50 was defined as dose which can cause 50% death of total mice from each group. The result can be concluded thatgambir extract was found to be active as hepatoprotective agent with dose 30; 100 dan 300 mg/kgbw. Futhermore, extract of gambir couldreduced the ratio of liver weight and based on the LD 50 value obtained (24 hours, >15 g/kgbw), gambir was classify as non toxic.
Aktivitas Antioksidan dan Antimikrobial dari Ekstrak Plectranthus amboinicus Teruna, Hilwan Yuda; Jose, Christine
Jurnal Penelitian Farmasi Indonesia Vol 1, No 2 (2013)
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Plectranthus amboinicus or bangun-bangun is a traditional medicinal plant used for postpartum recovery in North Sumatera. The aims ofthis study were to detemine antioxidant and antimicrobial activity of leaves Plectranthus amboinicus. The leaves of Plectranthus amboinicuswere extracted with using n-hexane, ethyl acetate and methanol, successively. The extracts were tested to antioxidant activity assay usingDPPH with two fold dillution tehnique and ascorbic acid was used as standard. The antimicrobial activity was conducted using agar diffusionmethod against Escherichia coli, Staphylococcus aureus and Candida albicans. The Amoxsan used as positive control for antibacterialassay, while ketokenazole was for antifungi test. Extracted solvents were used as negative control. The n-hexane and ethyl acetate extractsdid not show any antioxidant activity. While, the IC 50 free radical DPPH of methanol extract was 90.96 mg/mL and ascorbic acid was 58.792mg/mL. The antimicrobial activity of n-hexane and Amoxsan againts Escherichia coli were 11.95 and 7.53 mm. The inhibition zone againtsStaphylococcus aureus were 11.30 and 11.57 mm. The antimicrobial activity of ethyl acetate and Amoxsan againts Escherichia coli were12.29 and 7.71 mm. The inhibition zone against Staphylococcus aureus were 13.72 and 11.57 mm. The n-hexane and ethyl acetate did notshow any antifungi activity towards Candida albicans. The methanol extract did not show any inhibition zone againts the selectedpathogens.
Uji Parameter Non Spesifik dan Aktivitas Antibakteri Ekstrak Metanol dari Umbi Tanaman Dahlia (Dahlia variabilis) Haryani, Yuli; Muthmainah, Siti; Sikumbang, Saryono
Jurnal Penelitian Farmasi Indonesia Vol 1, No 2 (2013)
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Dahlia variabilis is one of plant that commonly growing in highland hills in Indonesia. The preliminary screening on secondary metabolitesshowed that the presence of flavonoids, phenolics and saponin in methanol extract of this plant’s tuber. Its methanol extract was subjectedto the evaluation of non-specific parameter of extract standardization as well as antimicrobial assay using disc diffusion method againstEscherichia coli and Staphylococcus aureus. The result revealed that the methanol extract contained 25.48±1.63% of water content,4.06±0.15% of ash content, and there was no heavy metal contamination detected. Antibacterial activity assay of three differenceconcentrations of the extract (10; 8 and 2%) demonstrated that extract with 10% of concentration gave the strongest activity against twotested bacterium with diameter of inhibition of 8.67±0.57 and 8.33±0.28 mm against Escherichia coli and Staphylococcus aureus, respectively.
Isolasi dan Karakterisasi Asam Oleat dari Kulit Buah Kelapa Sawit (Elais guinensis Jacq.) Mora, Enda; Selpas, Nandhana
Jurnal Penelitian Farmasi Indonesia Vol 1, No 2 (2013)
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A compound has been isolated from n-hexane extract of fruits skin of palm (Elais guinensis Jacq). Separation of 2 g extract was conductedby using column chromatography with step gradient polarity method and using n-heksana, ethyl acetate and methanol as the eluents. Thisisolated compound is yellow fatty (573.9 mg, 28.96%) which melted at 26-28oC. Based on NMR spectroscopic datas, including, 1H-NMR, 1H-1H COSY, 13C-NMR and DEPT, the compound was suggested as oleic acid.

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