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Armeida Dwi Ridhowati Madjid
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Alchemy : Journal of Chemistry
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 20861710     EISSN : 24606871     DOI : http://dx.doi.org/10.18860/al
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology
ALCHEMY: Journal of Chemistry (eISSN 2460-6871) is a scientific journal that focus on chemistry. This journal publishes a scientific article that cover research and review articles. Research topics for this journal such as natural science, physical chemistry, inorganic chemistry, organic chemistry, environment, biochemistry, marine, energy and other related-sciences. ALCHEMY: Journal of Chemistry also accepts article about halal products and chemistry on Islamic perspectives.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 203 Documents
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Antifungal Activity Test of the Ethanol Extract of Kaembu-embu (Blumea balsamifera) Leaves Against the Fungus C. albicans Growth Nasriadi Dali Wela; Arniah Dali Wela; Seniwati Dali; Armadi Chairunnas; Hilda Ayu Melvi Amalia; Sri Ayu Andini Puspitasari
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.10954

Abstract

AbstractResearch on the antifungal activity test of ethanol extract of Kaembu-embu (Blumea balsamifera) leaves against the fungus C. albicans growth was carried out. The aim of this study was to examine the antifungal activity of ethanol extracts of Kaembu-embu (Blumea balsamifera) leaves on the growth of the fungus C. albicans. The ethanol extract of Kaembu-embu (Blumea balsamifera) leaves was obtained through maceration method. The ethanol extract of Kaembu-embu (Blumea balsamifera) leaves was tested for antifungal activity by liquid and solid dilution methods in determining minimum inhibitory concentration (MIC) and minimum kill concentration (MKC). The results of the antifungal activity of the ethanol extract of Kaembu-embu (Blumea balsamifera) leaves on the growth of the fungus C. albicans by the liquid dilution method showed the MIC value of 25 ppm and MKC value of 500 ppm. While the results of the antifungal activity of the ethanol extract of Kaembu-embu (Blumea balsamifera) leaves on the growth of the fungus C. albicans by solid dilution method showed the MIC value of 5 ppm with inhibitory ability of 50.13% of media control and a MKC value of 250 ppm.
Fabrication and Characterization of Ibuprofen and Ceftriaxone loaded Electrospun Cellulose Acetate Nanofiber Layers as a Model of Targeted Drug Delivery System Novrynda Eko Satriawan; Junaidi Khotib; Muhamad Nasir; A. H. Zaidan
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.15502

Abstract

This study aims to study the process of fabricating and characterization nanofibers based on cellulose acetate polymer filled with ceftriaxone and ibuprofen using the electrospinning method as a model for a targeted drug delivery system. Cellulose acetate has been successfully fabricated into nanofibers using the electrospinning method and filled with ceftriaxone and ibuprofen. The resulting nanofibers have an average diameter in the range of 412.5 – 558.5 nm under the conditions of the electrospinning process, namely 22 kV voltage, 15 cm distance, and flow rate. 0.005 mL/min using acetone/DMAc (2:1). Based on the data generated from the FTIR test, homogeneity, and drug release test, it is known that the resulting nanofibers, namely cellulose acetate, cellulose acetate-ceftriaxone, and cellulose acetate-ibuprofen, have good morphological characteristics, homogeneity, and release rate so that they have the potential to be used as a targeted drug delivery system
Aktivitas Imunostimulan Ekstrak Metanol Biji Kurma (Phoenix dactylifera) secara In Silico Terhadap Reseptor GIF dan COX-2 serta Uji In Vitro melalui Proliferasi Sel Limfosit Mencit Siti Warnasih; Tamimah Shafwatul Ishlah; Dianda Namira Azzahra; Gita Syahputra
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.14076

Abstract

Dates (Phoenix dactylifera) is one of the plants that very useful, but the date palm seeds that become waste have not been widely used. Based on studies that are known to contain bioactive compounds that can be suspected as antioxidants, antimicrobials and anti-inflammatory. However, research on immunostimulants from dates, especially in silico and in vitro, has not been widely carried out. Therefore, this study aims to determine the potential of date seed bioactive compounds as immunostimulants through in silico against Human Glycosylation-Inhibiting Factor (1GIF) and Human Cyclooxygenase-2 (5IKR) receptors as well as in vitro through the proliferation of lymphocyte cells of male mice (Mus musculus) balb/c strains with the MTT Assay methods. The results of the in silico study showed that 5-O-Caffeoylshikimic Acid had the highest interaction and stability, Gibbs free energy with 1GIF and 5IKR receptors, -6.68 kcal/mol and -8.58 kcal/mol, respectively. This value is known to be higher than the Caffeic Acid as control ligand. The results of in vitro research obtained methanol extract of date seeds at a concentration series of 6.25; 12.5; 25 µg/mL had higher lymphocyte cell proliferation activity which was indicated by an increasing OD value, and at a concentration of 25 μg/mL produces the highest immunostimulant activity. Therefore, date seed extract containing the compound 5-O-Caffeoylshikimic Acid can potentially be an immunostimulant agent.
Pengaruh Konsentrasi Agen Pensulfonasi Terhadap Karakteristik Membran Selulosa Bakterial Tersulfonasi Pada Aplikasi DMFC Mahdiya Nayla; Cynthia Linaya Radiman
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.13519

Abstract

Penelitian ini bertujuan mengetahui pengaruh konsentrasi agen pensulfonasi asam klorosulfonat pada membran selulosa bakterial untuk aplikasi DMFC (Direct Methanol Fuel Cell). Konsentrasi asam klorosulfonat yang digunakan 0,5-3% dengan sulfonasi menggunakan metode MAOS (Microwave Assisted Organic Synthesis). Karakterisasi membran meliputi analisis gugus fungsi dengan FTIR, swelling, konduktivitas proton, kapasitas penukar ion, SEM (Scanning Electron Microscopy) dan penentuan kadar sulfur dengan EDS (Electron Dispersive X-Ray Spectroscopy). Hasil analisis FTIR menunjukkan munculnya puncak pada bilangan gelombang 1163 cm-1 yang menunjukkan vibrasi asimetris S=O pada sulfonat. Uji penggembungan membran menunjukkan bahwa derajat penggembungan mengalami kenaikan sebanding dengan persentase kadar asam klorosulfonat. Nilai konduktivitas dan kapasitas penukar ion membran selulosa bakterial tersulfonasi juga meningkat seperti derajat swelling. Foto permukaan membran dengan SEM menunjukkan morfologi serat membran selulosa bakterial. Kadar sulfur pada permukaan membran selulosa bakterial tersulfonasi semakin besar seiring dengan bertambahnya persentase asam klorosulfonat. Hal ini menunjukkan semakin banyaknya gugus –OH yang tersubstitusi dengan –SO3H pada membran selulosa bakterial tersebut. Sulfonasi membran selulosa bakterial paling baik dengan asam klorosulfonat 3% menghasilkan karakteristik derajat penggembungan 183,54%, konduktivitas 0,052 S/cm, kapasitas penukar ion 3,88 meq/g serta persentase kadar sulfur 0,94%.
Potential Ethanol Exract Kapuk Randu Leaves (Ceiba petandra (L.) Gaertn) as Sunscreen Resi Andela; Damayanti Iskandar; DF Yani
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.13085

Abstract

Matahari merupakan sumber cahaya alami yang berperan sangat penting bagi kehidupan untuk fotosintesis tumbuhan serta sebagai sumber vitamin D bagi tubuh. Namun juga berdampak buruk bagi kesehatan kulit jika terpapar dalam jumlah berlebihan. Salah satu alternatif yang dapat digunakan untuk mencegah dampak radiasi sinar matahari yang berlebihan adalah tabir surya. Sehingga dilakukan penelitian untuk mengetahui aktivitas dan nilai SPF (Sun Protection Factor) ekstrak etanol daun kapuk randu (Ceiba petandra (L.) Gaertn) pada konsentrasi 100, 200, 300, 400 dan 500 ppm. Penelitian ini dilakukan secara in vitro menggunakan spektrofotometer UV-Vis pada panjang gelombang 290-320 nm. Hasil pengujian menunjukkan bahwa ekstrak etanol daun kapuk randu memiliki aktivitas proteksi dengan nilai SPF berturut-turut pada konsentrasi 100, 200, 300, 400 dan 500 ppm yaitu 3 (perlindungan minimal); 6. 9 (perlindungan ekstra); 10.4 (perlindungan maksimal); 13.9 (perlindungan maksimum) dan 17,4 (perlindungan ultra). Berdasarkan nilai SPF, ekstrak etanol daun kapuk randu mampu digunakan sebagai bahan aktif tabir surya dengan kandungan senyawa aktif tanin dan flavonoid.Kata kunci: Ceiba Petandra L.Gaertn, Tabir surya, SPF
Pengaruh Surfaktan terhadap Pemisahan Logam Transisi Periode Pertama Menggunakan Metode Emulsion Liquid Membrane Afifah Rana Widianti; Dwi Ratna Setiani; Fauzia Salsabila; Anni Anggraeni; Uji Pratomo; Husein H. Bahti
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15020

Abstract

First row transition metals are heavy metals that are very abundant in their compound form and widely applied in industrial fields because of their unique physical and chemical properties. These industrial activities often produce waste that still contains toxic transition metal. To overcome that problems, the transition metal must be separated by an effective and efficient method, that is the emulsion liquid membrane (ELM) because simultaneous separation process. ELM is a separation method that involves three phases. The determinant of the success of the ELM process is the stability of the emulsion which depends on the concentration and type of the surfactant used. Types of surfactants that can be used in the first row transition metal separation using the ELM method are non-ionic surfactants such as Span 80, a mixture of Span 80-Tween 80 and Polyamine ECA 4360J. Therefore, this review article aims to determine the effect of concentrations and type of that surfactants on emulsion stability and extraction efficiency in the separation of first row transition metals using the ELM method.Keywords: First row transition metals, emulsion liquid membrane, surfactant
Study Natural Compound of Eleutherine americana as a SaR-CoV-2 Therapeutic Agent : In Silico Approach Mokhamat Ariefin; Rizki Rachmad Saputra
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.18018

Abstract

Sar-CoV-2 (COVID-19) has rapidly spread globally where it has killed thousands of individuals and infected almost 1,016,395 others. Numerous people have died as a result of what the World Health Organization (WHO) has deemed a top worldwide health issue, which has also had severe detrimental social and economic impacts. Some Eleutherin americana are said to possess antiviral effects. Children's colds and nasal congestion can be treated with eleutherin americana. Naphthalene, anthraquinone, and naphtoquinone are the three main chemical families that have been identified from E. americana. Eleutherol, hongconin, isoeleutherol, and eleutherin were the compounds that were identified from E. Americana. Drug-receptor interactions are simulated using computational techniques toward 14 compounds isolated from E. americana. The docking method has been validated by redocking the N3 molecule as a native ligand to the Mpro of Sar-CoV-2 (PDB ID: 7BQY) as a receptor protein. The smaller the RMSD value 0.651 Å, the better the pose obtained through the docking process. Compound 12 has a more negative binding energy are showed -8.6 kcal mol-1, regarding to hydrogen bond interaction toward Thr26, His41, Leu141, Asn142, Gly143, Ser144, His163. The stability of the association between the ligand and receptor increases with decreasing binding energy value (∆G). On the other hand, Compounds 11 and 2 are depicted -8.2 kcal mol-1 and -8.1 kcal mol-1 respectively which close to N3 -8.3 kcal mol-1. Undergoing hydrogen bond interaction between 11 with Gly143,Thr26, Leu141, Glu166, Ser144, Cys145, His163, and less hydrogen bond interaction 2 toward Arg188 and Asn 142. Those result resembling hydroxy group have the best interaction with 7BQY. According to fulfilled data from three candidates 2, 11, 12, it can be expected that compound with many hydroxy groups are within realm of possibility as antiviral agent for Sar-CoV-2 through inhibit replication of this virus.
Optimization of Electrocoagulation Conditions in the Degradation Process of Carbofuran Waste (Furadan 3GR) Using Al/Graphite Electrodes Damar Nurwahyu Bima; Kumala Devi; Suhartana Suhartana; Sriyanti Sriyanti
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15360

Abstract

Electrocoagulation is one of the electrochemical methods for treating wastewater and separating pollutants. In this research, the electrocoagulation using Al/Graphite electrodes was applied to artistic wastewater containing carbofuran to see the reduction of its chemical oxygen demand(COD). The electrocoagulation process was chosen in this study based on several advantages, including easy to separate between impurities and the sample and a simple operating system. Several parameters such as electrolysis time, variations in electrolyte concentration, and the effect of pH have been investigated for their impact on the electrocoagulation process. The results showed that the proportion of the best reduction in chemical oxygen demand (COD) was 64.40%. The best conditions were an electrolysis time of 60 minutes, an electrolyte concentration of 0.15 M, and a pH of 10. The results also show that the decrease in chemical oxygen demand (COD) dependson those parameters. These results were investigated further by characterization using UV-Vis spectrophotometry and FTIR spectroscopy. The results of the UV-Vis spectrum showed a decrease in intensity at a wavelength of 275 nm. Analysis of the FTIR spectrum between the initial sample and the results of the electrocoagulation showed that there were similar absorption peaks but with much smaller intensity, indicating that the effluent's pollutants have been deposited.Keywords: Electrocoagulation, Carbofuran, Al/Graphite, COD
Pemanfaatan Zeolit Sodium Dodecyl Benzene Sulfonate (Zeolit-SDBS) dari Abu Sekam Padi Sebagai Adsorben Logam Timbal (Pb) Kurnia Ramadani; Sjamsiah Sjamsiah; Putriani Putriani; Syarifah Rabiatul Adawiah
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.17179

Abstract

Zeolit adalah batuan mineral yang tersusun dari silika dan alumina. Sumber silika tertinggi dapat diperoleh dari sekam padi yang merupakan bagian terluar dari gabah hasil panen. Penelitain ini bertujuan untuk mengetahui besarnya daya serap zeolit SDBS dari abu sekam padi  terhadap logam Pb. Metode yang digunakan adalah hidrotermal pada temperatur 120oC. Karakterisasi zeolit sintesis dengan XRD untuk mengetahui kemurnian zeolit dan kristalinitasnya serta analisis hasil adsorpsi menggunakan SSA. Hasil penelitian dengan XRD menunjukkan pada ZS1 terdapat senyawa sodalit, serta ZS2 dan ZS3 terdapat zeolit K, zeolit (K, Ba) G dan L. Hasil adsorpsi dengan Pb menunjukkan tingkat efisiensi sebesar 99,47% (ZS1), 95,78% (ZS2) dan 94,67% (ZS3). Kata kunci: Zeolit-SDBS, sekam padi, logam Pb dan Adsorben.
Isolasi Fungi Tanah Muara Mangrove Desa Katialada Gorontalo dan Skrining Aktivitas Antibakteri terhadap Pseudomonas aeruginosa Arthur Hariyanto Prakoso; Muhammad Zainul Arifin; Saeful Akhmad Tauladani; Gani Asri Muharam; Asia Asia; Ari Satia Nugraha
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15738

Abstract

Pseudomonas aeruginosa is a bacterial pathogen that causes various kinds of infections. The use of antibiotics is usually done to treat the infection. However, Pseudomonas aeruginosa has various resistance abilities that can avoid the efficacy of antibiotics. The emergence of drug resistance events encourages the need for the discovery of new antibiotic drugs, one of which comes from fungals secondary metabolite. Soil fungi from mangrove ecosystems have not been studied much. Interestingly, these soil fungi have unique adaptive responses. This response also affects the secondary metabolites it contains. Knowing this information, mangrove soil samples were cultured on fungi media which were then tested against Pseudomonas aeruginosa through antagonist test and microdilution test. Three fungal cultures with yeast characteristics were obtained and each of the secondary metabolite ethyl acetate extracts of these three fungi had antibacterial activity. The antibacterial activity was indicated by the % inhibition parameter. The terpenoid content in fungal cultures may be responsible for the antibacterial activity against Pseudomonas aeruginosa. This research is an initial screening of the search for new antibiotic candidates, so further research study such as isolation and species determination needs to be done. 

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