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Contact Name
Armeida Dwi Ridhowati Madjid
Contact Email
armeida@uin-malang.ac.id
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+6281233402334
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alchemy@uin-malang.ac.id
Editorial Address
Fakultas Sains dan Teknologi Universitas Islam Negeri (UIN) Maulana Malik Ibrahim Malang Gedung BJ Habibie Lt 2 Jl. Gajayana 50 Malang 65144 Indonesia
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Kota malang,
Jawa timur
INDONESIA
Alchemy : Journal of Chemistry
ISSN : 20861710     EISSN : 24606871     DOI : http://dx.doi.org/10.18860/al
ALCHEMY: Journal of Chemistry (eISSN 2460-6871) is a scientific journal that focus on chemistry. This journal publishes a scientific article that cover research and review articles. Research topics for this journal such as natural science, physical chemistry, inorganic chemistry, organic chemistry, environment, biochemistry, marine, energy and other related-sciences. ALCHEMY: Journal of Chemistry also accepts article about halal products and chemistry on Islamic perspectives.
Articles 203 Documents
Potensi Energi Listrik dari Microbial Fuel Cell (MFC) Menggunakan Substrat Molase dan Bakteri Pseudomonas sp. Ilmi Wahyuni; Heri Heriyono; Aisyah Aisyah; Maswati Baharuddin; Iswadi Ibrahim Patunrengi
ALCHEMY:Journal of Chemistry Vol 10, No 1 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i1.12154

Abstract

Sugarcane molasses have been reported as potential biomass to produce electricity from its metabolic processes through the microbial fuel cell (MFC) system. However, it is important to improve electrical generation by using both appropriate and readily available substrates and microorganisms. This study aimed to determine the current and potential difference as well as the power density generated from the metabolic process of the molasses substrate. A dual-chamber of MFC was arranged in series to generate electrical current. The anode chamber contained a mixture of molasses substrate, potassium phosphate buffer pH 7, and Pseudomonas sp. The cathode chamber contained 0.2 M KMnO4 electrolyte solution. Measurement of current and potential differences was conducted every 4 hours for 36 hours. The results showed that the maximum current, potential difference, and power density were 1656 mV, 1582 µA, and 1794.37 mW/m2, respectively.Keywords: dual chamber, microbial fuel cell, molasses, Pseudomonas sp.  Molase telah banyak dilaporkan sebagai salah satu sumber energi listrik yang potensial dengan menggunakan sistem microbial fuel cell (MFC). Namun demikian, produksi energi listriknya perlu ditingkatkan dengan menggunakan substrat dan mikroorganisme yang tepat dan mudah diperoleh. Tujuan dari penelitian ini adalah untuk mengetahui arus dan beda potensial serta nilai kerapatan daya yang dihasilkan dari proses metabolisme substrat molase menggunakan bakteri Pseudomonas sp. Penelitian ini menggunakan sistem MFC kompartemen ganda sebanyak dua sel yang dirangkai seri. Ruang anoda berisi campuran substrat molase, buffer kalium fosfat pH 7 dan bakteri Pseudomonas sp. Adapun ruang katoda berisi larutan elektrolit KMnO4 0,2 M. Pengukuran arus dan beda potensial dilakukan setiap 4 jam selama 36 jam. Berdasarkan hasil penelitian yang dilakukan didapatkan nilai arus, beda potensial maksimum dan kerapatan daya masing-masing sebesar 1656 mV, 1582 µA dan 1794,37 mW/m2.Kata kunci: dua sel, microbial fuel cell, molase, Pseudomonas sp
Effect of Stirring Time on Sodium Silicate Synthesis From Mount Kelud Volcanic Ash Isna Nurhidayati; Endang Tri Wahyuni; Nurul Hidayat Aprilita; Sarwendah Ratnawati Hermanto
ALCHEMY:Journal of Chemistry Vol 9, No 2 (2021): ALCHEMY JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v9i2.12600

Abstract

This study performed the synthesis of sodium silicate from the volcanic ash of Mount Kelud with various stirring time in the sodium silicate synthesis process. Synthesis of sodium silicate was carried out using alkaline extraction at low temperature. This method is based on the solubility of silica under alkaline conditions and is proven to be more effective than the smelting method. The dissolution of silica contained in the volcanic ash of Mount Kelud was carried out using NaOH solution to form a Na2SiO3 solution. This process also studied the effect of stirring time on the amount of dissolved silica, with the stirring time of 0.5; 1; 1.5; 2; 2.5; 3 and 4 hours. The dissolved silica levels were tested using AAS. The amount of dissolved silica increased sharply with the longer length of stirring time, however for a stirring time of more than 2.5 hours, the dissolution was slow. The study revealed that the optimal result time was obtained from the stirring time of 2.5 hours with dissolved silica content of 19.82%. Keywords: volcanic ash, silica, sodium silicate, stirring time
Analisis Sidik Jari Kromatografi Lapis Tipis Tanaman Anting-Anting (Acalypha indica L.) Muhammad Teguh Laksono; Elok Kamilah Hayati
ALCHEMY:Journal of Chemistry Vol 9, No 2 (2021): ALCHEMY JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v9i2.11613

Abstract

Anting-anting plant (Acalypha indica L.) is a plant that the community has used as raw material for herbal medicine. Anting-anting plants contain chemical compounds, so it is difficult to ensure these plants' safety and quality control. The research objective was to validate the method by knowing the stability, specificity, precision, and rigidity of the chromatographic profile of alkaloid compounds in the TLC analysis of the anting-anting extract. Extraction was carried out using ethyl acetate solvent for 20 minutes with a frequency of 42 kHz. The eluent used is cyclohexane: toluene: diethylamine (75:15:10) with Dragendorff reagent. The method of validation was acceptable according to the criteria except for the stability test of the analyte during chromatography. The instability of the analyte is indicated that not all spots form a straight diagonal line. The specificity of the method was carried out by comparing the fingerprint patterns of the leaves of the anting-anting with ekor kucing (Acalypha hibsida Farm.) and teh-tehan plants (Acalypha siamensis). The fingerprint profile showed a yellow stain (Rf = 0.39) on the leaves of the anting-anting, which did not appear in the fingerprint profiles of the two comparison samples. Keywords: anting-anting, fingerprint analysis, thin layer chromatography, method validation Anting-anting (Acalypha indica L.) merupakan tanaman yang telah dimanfaatkan masyarakat sebagai bahan baku obat herbal. Anting-anting mengandung banyak senyawa kimia sehingga sulit menjamin keamanan dan pengendalian mutu dari tanaman tersebut. Penelitian ini dilakukan untuk validasi metode dengan mengetahui kestabilan, spesifitas, presisi, dan ketegaran profil kromatografi senyawa alkaloid pada analisis KLT ekstrak anting-anting. Ekstraksi dilakukan menggunakan pelarut etil asetat selama 20 menit dengan frekuensi 42 kHz. Eluen yang digunakan adalah sikloheksana : toluena : dietilamin (75:15:10) dengan reagen Dragendorff. Validasi metode dapat diterima sesuai kriteria kecuali uji stabilitas analit selama kromatografi. Ketidakstabilan analit ditunjukkan dengan seluruh noda yang dihasilkan tidak membentuk garis diagonal yang lurus. Spesifitas pada metode dilakukan dengan membandingkan pola sidik jari daun anting-anting dengan daun ekor kucing (Acalypha hibsida Farm) dan daun teh-tehan (Acalypha siamensis). Profil sidik jari menunjukkan bahwa terdapat noda berwarna kuning kehijauan (Rf = 0,39) pada daun anting-anting yang tidak muncul pada profil sidik jari kedua sampel pembanding tersebut. Kata kunci: anting-anting, analisis sidik jari, kromatografi lapis tipis, validasi metode
Antioxidant and Cytotoxicity Activities of the Fermentation Extract of the Endophytic Fungi from the Marine Biota of Colt Coral Dede Sukandar; Nina Artanti; Ika Restu Purwanti; Tarso Rudiana; Fitriyanti Fitriyanti
ALCHEMY:Journal of Chemistry Vol 9, No 2 (2021): ALCHEMY JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v9i2.11899

Abstract

Indonesia has the largest and most biodiverse coral reef in the world. Colt coral has not been studied and explored especially endophytic fungi associated with the coral. Endophytic fungi are highly potential for the production of antioxidant and anticancer compounds. This research aimed to study the antioxidant and cytotoxic activities of fermentation extract from endophytic fungi from colt coral. Filtrate and mycelium extracts were obtained from static and shake fermentations of isolate SKF 15. Antioxidant and cytotoxic assays were conducted by free radical scavenger 1,1-diphenyl-2-picrylhydrazyl (DPPH) and AlamarBlue methods, respectively. The result showed that FD extract provided the highest antioxidant activity with inhibition of 49.36% at 200 ppm of DPPH. Variation of fermentation time (3-21 days) demonstrated the highest activity with inhibition of 66.97% for antioxidant assay (7 days) and 81.13% for cytotoxic assay (3 days). FTIR analysis presented the existence of hydroxyl groups O-H (3452.58 cm-1), C=C groups (1668.43 cm-1); C-O hydroxyl group (1230.58 cm -1), and C-H sp3 groups (2941.44 cm-1). Based on LC-MS analysis, FD extract has a mass of m/z 305.63, [M+H]+, predicted as dihydroquercetin (C15H24O7). Keywords: Antioxidant assay, cytotoxic assay, endophytic fungi, colt coral, DPPH method, AlamarBlue method
Optimization Chicken Bones Gelatin Extraction Using Hydrochloric Acid Immersion and Multi-Stage Thermal Treatment Deva Krisna Kadarani; Akyunul Jannah
ALCHEMY:Journal of Chemistry Vol 10, No 1 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i1.13372

Abstract

The growing poultry consumption rate yearly includes chicken with significantly increased amounts of by-products like skin and bones. Chicken bones are unused properly even if the bone is rich in collagen which is the primary material to produce gelatin. Gelatin usually is generated by bovine and porcine, but some health and religious issues have successfully forbid using both resources. Chicken bones could be an alternative material for gelatin production. This research aimed to investigate chicken bones as a substitute resource for gelatin manufacturing using hydrochloric acid submersion in collaboration with multi-stage thermal treatment. Chicken bones were proceeded in several steps such as degreasing, decontamination, resizing, demineralization using a hydrochloric acid immersion (1.50, 3.00, 4.50, and 6.00% v/v) for 24 and 48 hours, addition gelatin extraction using multi-stages thermal process (55, 65, and 75°C) for 4 hours each temperature subsequentially, evaporating, drying, and shaping a gelatin powder. This study produced type A gelatin which investigated yield number, moisture and ash content, gel strength, acidity level, and functional group using Fourier-transform Infrared (FTIR) spectroscopy. The sample gelatin has obtained at least 2% up to 8% yields. The moisture and ash contents were suitable to the commercial specification range, 4-12%, and 0.1-0.4%, respectively. The acid conditioning process has an impact on acidity with pH levels 4.40-5.44. Based on gelatin standards, this study declared that processing chicken bones using 6.00% hydrochloric acid submersion for 24 hours was optimal for gelatin extraction. Those optimal condition has formed gelatin with more than 8% yields. It was considered great gelatin with 260.57 g Bloom of gel strength and 90.18% of emulsion stability. Sample gelatin has a quite reasonable acidity level at 4.5. Protein structures confirmation using the vibration of the best gelatin sample has also shown essential components such as O-H, N-H, and C=O on the FTIR spectrum.Keywords: chicken bones (Gallus domesticus), hydrochloric acid immersion, gel strength, emulsion stability, FTIR spectroscopy
Studi In Silico Potensi Antikanker Senyawa Kaempferida Arif Fadlan; Tri Warsito; Sarmoko Sarmoko
ALCHEMY:Journal of Chemistry Vol 10, No 1 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i1.13317

Abstract

 Active compounds as therapeutic agents are mainly found in natural products. Kaempferia pandurata from Kaempferia Genus has been used for the treatment of diseases. K. pandurata contains kaempferol (KMP) which exhibits various biological activities such as anticancer. KMP correlates to death-associated protein kinase 1 (DAPK1) relates to tumor suppression and apoptotic and autophagy mediation. This research aims to evaluate the anticancer potential of kaempferide (a methylated KMP at the C4’ position) against DAPK1 in silico. The research was performed through molecular docking to DAPK1 (5AUX and 5AV3), anticancer activity prediction, drug-likeness analysis, and ADMET (absorption, distribution, metabolism, excretion, and toxicology) evaluation. The binding affinity of kaempferide was -8.0 kcal/mol for 5AUX and 5AV3, respectively. The highest anticancer activity of kaempferide was shown against the prostate carcinoma cell line CWR22R. Kaempferide showed no violation to Lipinski-Veber rule and had good ADMET profile. Keywords: in silico, anticancer, kaempferide  Senyawa aktif dengan potensi terapeutik banyak ditemukan dalam bahan alam. Kaempferia pandurata dari genus Kaempferia telah digunakan dalam pengobatan berbagai penyakit. K. pandurata mengandung kaempferol (KMP) dengan aktivitas biologis beragam, salah satunya adalah antikanker. KMP juga dapat berikatan dengan death-associated protein kinase 1 (DAPK1) yang berhubungan dengan penekanan tumor dan mediasi apoptosis dan autofagi. Penelitian ini mempelajari potensi antikanker kaempferida (KMP yang termetilasi pada posisi C4’) terhadap DAPK1 secara in silico. Penelitian dilakukan melalui penambatan molekular terhadap DAPK1 (5AUX dan 5AV3), perkiraan aktivitas antikanker, analisis drug-likeness, dan prediksi ADMET (absorption, distribution, metabolism, excretion, and toxicology). Afinitas ikatan kaempferida masing-masing sebesar -8,0 kkal/mol untuk 5AUX dan 5AV3. Aktivitas antikanker tertinggi kaempferida ditunjukkan terhadap cell line karsinoma prostat CWR22R. Kaempferida tidak melanggar aturan Lipinski-Veber sesuai analisis drug-likeness dan memiliki profil ADMET yang cukup baik. Kata kunci: in silico, antikanker, kaempferida 
A Method of Determining the C/N Ratio from Aerobically Treated Brem Compost Waste Kindriari Nurma Wahyusi; Nur Aini Fauziyah
ALCHEMY:Journal of Chemistry Vol 10, No 1 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i1.12670

Abstract

The preparation of compost from brem waste has been carried out with the aim of utilizing brem waste into more useful materials. In this work, brem waste was collected from UD.Tongkat Mas, Madiun, East Java. Brem waste compost was processed by aerobic method by adding eggshell powder and M-Bio activator. The M-Bio activator solution that was added was varied with the volume of the solution, i.e., 50, 75, 100, 125 and 150ml. Here, we gave the sample nomenclature of CM50, CM75, CM100, CM125, and CM150, respectively, with the numbers on the back side indicating the volume of M-Bio activator added. Observations on brem compost were carried out for 10 days. Every 2 days interval, measurements of the C/N ratio were carried out on the compost. The manufacture of compost has been successfully made (based on SNI Standard 19-7030-2004) and has the best results by adding 100 ml of M-Bio activator (CM100) with a composting time of 10 days, with a C/N ratio of 11.42, and has no odor.
Pengaruh Pemeraman dan Suhu Pada Sintesis Zeolit Y dari Lumpur Susi Nurul Khalifah; Udi Tyas; Saidun Fiddaroini; Suci Amalia
ALCHEMY:Journal of Chemistry Vol 10, No 1 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i1.17334

Abstract

Pemeraman dapat meningkatkan laju nukleasi serta mengurangi periode induksi dan waktu kristalisasi zeolite. Sehingga, pemeraman memiliki peran penting pada proses sintesis zeolite Y. Sintesis zeolite Y dapat dilakukan dari bahan silika yang diekstrak dari lumpur Lapindo. Sintesis dilakukan dengan dan tanpa pemeraman dengan variasu suhu kristalisasi 60, 80 dan 100 oC. Hasil menunjukkan sintesis zeolite Y tanpa waktu pemeraman menghasilkan struktur berfasa amorf dengan suhu kristalisasi tidak mempengaruhi produk hasil reaksi. Sedangkan pemberian waktu pemeraman pada suhu ruang selama 24 jam sebelum kristalisasi dapat meningkatkan kristalinitas dari zeolit Y. Suhu kristalisasi juga mempengaruhi pembentukan zeolit Y, dimana kristalisasi pada suhu 100 oC menghasilkan lebih banyak produk zeolit Y daripada suhu kristalisasi 80 dan 60 oC.
Pengaruh Perlakuan Awal Hidrolisis Ampas Sorgum (Sorghum Bicolor L.) Terhadap Fermentasi Untuk Produksi Bioetanol Sebagai Energi Terbarukan Stevanny Yulia Margarita Nggai; Sefrinus Maria Dolfi Kolo; Yuni Sine
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.13501

Abstract

Bioethanol has been successfully produced from sorghum (Sorghum bicolor L.) seed dregs as a biofuel to replace fossil fuels. The goal of this study is to find out what sulfuric acid concentration produces sugar content during hydrolysis utilizing microwave and an autoclave. The concentrations of sulfuric acid used in this experiment were 0.5, 1, 2, and 5%. The hydrolysis of sorghum brans is suspended with a sulfuric acid solution, then in the hydrolysis using microwave (temperature 150°C for 30 minutes) and autoclave (pressurized 1 atm temperature 121 °C for 30 minutes). The fermentation using yeast saccharomyces cerevisiae for 5 days. The analyzed through reducing sugar content using UV-VIS, then morphology of sorghum brans using SEM, the density of ethanol using pycnometer, and analysis ethanol levels using GC. The analysis used SEM is sulfuric acid was able to damage the surface structure of sorghum brans. Produced the optimum reducing glucose occurred in hydrolysis using a microwave with a sulfuric acid concentration of 1% is 44,97 gr/L, then using methods autoclave produced the optimum glucose reducing with a sulfuric acid concentration of 5 % is 30,86 g/L. The analysis ethanol used pycnometer is 1,96%. and gas chromatography converting of ethanol was 15.76%.
Karakterisasi Elektrokimia Ekstrak Klorofil dari Daun Salam (Syzgium polyanthum) pada pH Basa sebagai Sensitizer pada Dye Sensitized Solar Cell (DSSC) Indah Tri Wahyuni; Pirim Setiarso
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.14109

Abstract

Chlorophyll is a plant pigment that has the potential to be used as a dye (sensitizer) in DSSC. The performance of DSSC is highly dependent on the wide bandgap of the dye used. This study aims to determine the optimum pH of bay leaf extract in an alkaline condition through an electrochemical analysis. Bay leaves (Syzgium polyanthum) were extracted by maceration method using 96% ethanol solvent with a pH variation from 8 to 13. Bay leaf extract was characterized using UV-Visible spectrophotometry to determine the wavelength absorption. The results showed that the bay leaf extract contains chlorophyll compounds which has absorption wavelengths of 664 nm and 410 nm for chlorophyll-a as well as at the wavelengths 613,5 nm and 466,5 nm for chlorophyll-b. In electrochemical characterization, the optimum pH of bay leaf extract was at pH 13 with a bandgap value is 0,60105 eV.Keywords: Bay leaf, DSSC, electrochemical, chlorophyllKlorofil merupakan pigmen tumbuhan yang berpotensi untuk dimanfaatkan sebagai zat warna (sensitizer) pada DSSC. Kinerja DSSC sangat dipengaruhi oleh sensitifitas lebar bandgap zat warna yang digunakan.  Penelitian ini bertujuan untuk menentukan pH optimum ekstrak daun salam dalam kondisi basa secara elektrokimia. Daun salam (Syzgium polyanthum) diekstraksi dengan metode maserasi menggunakan pelarut etanol 96% dengan variasi pH 8 hingga 13. Ekstrak daun salam dikarakterisasi menggunakan spektrofotometri UV-Visible untuk mengetahui serapan panjang gelombang. Hasil penelitian menunjukkan bahwa ekstrak daun salam mengandung senyawa klorofil yang memiliki serapan panjang gelombang 664 nm dan 410 nm untuk klorofil-a serta pada panjang gelombang 613,5 nm dan 466,5 nm untuk klorofil-b. Pada karakterisasi elektrokimia, pH optimum ekstrak daun salam yaitu pada pH 13 dengan nilai bandgap sebesar 0,60105 eV. Kata kunci : Daun salam, DSSC, elektrokimia, klorofil