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Alchemy : Journal of Chemistry
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 20861710     EISSN : 24606871     DOI : http://dx.doi.org/10.18860/al
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology
ALCHEMY: Journal of Chemistry (eISSN 2460-6871) is a scientific journal that focus on chemistry. This journal publishes a scientific article that cover research and review articles. Research topics for this journal such as natural science, physical chemistry, inorganic chemistry, organic chemistry, environment, biochemistry, marine, energy and other related-sciences. ALCHEMY: Journal of Chemistry also accepts article about halal products and chemistry on Islamic perspectives.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 203 Documents
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Pemetaan Komponen Metabolit Sekunder Utama dari Tanaman Berkhasiat terhadap Paru paru menurut Al-Qanun fi at-Tibb 2 karya Ibnu Sina djamain, nelly suryani; Nurkholiza, Zahara Faiziah; Saibi, Yardi Yardi; Betha, Ofa Suzanti; Dahlizar, Sabrina Sabrina; Dillasari, Estu Mahanani
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.21469

Abstract

Al-Qanun fii at-Tibb 2 is a medical text book by Ibn Sina, which contains monographs of various natural materials, especially plants that have properties for organs including the lungs. In this book there is no data regarding the secondary metabolite content of these plants and this study aims to conduct a literature review of the main secondary metabolite components of these plants. and see the correlation between the major components and their efficacy on the lungs. This research was conducted using the literature review method through various databases by extracting from 124 scientific journals information about 58 plants that are efficacious for lung organs according to Al Qanun Fi'l Tibb and data has been produced in the form of the content of the main secondary metabolites of these plants, namely flavonoids, terpenes, tannins, lignans., saponins, anthraquinones, glucosinolates, phenolic acids, sekoiridoids, steroids, and alkaloids as the major components. Based on the results of this review, the main components of secondary metabolites are known to have reported beneficial bioactivities in the treatment of the respiratory system and lung organ.
Sediaan Gel dari Kombinasi Ekstrak Buah Gandaria (Bouea macrophylla Griff.) dan Ekstrak Belimbing Wuluh (Averhoa bilimbi L) dan Bioaktivitasnya Jayantie, Dhyneu Dwi; Khaerunnisa, Arini; Renaldy, Renaldy; Suryani, Nani; Rudiana, Tarso
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.23451

Abstract

Melanin is the main pigment thfunctions to protect the skin from exposure to ultraviolet light, excessive melanin synthesis can cause skin hyperpigmentation. A. bilimbi and B. macrophylla fruits have bioactive compounds such as phenolics, flavonoids that function as antioxidants and tyrosinase inhibitors. This study aims to formulate a gel preparation of a combination of fruit extracts of A. bilimbi and B. macrophylla, test antioxidant activity using the DPPH method, and test tyrosinase inhibition enzymes. Three formulas were made, namely F0 (Basis), FI (50x extract), and FII (100x extract). Physical evaluation includes organoleptic, homogeneity, pH, adhesion, spreadability, viscosity, viscosity and irritation. Test of antioxidant activity and tyrosinase enzyme inhibition. Then the data were analyzed descriptively and statistically. The results of the evaluation of homogeneous preparations, dispersion, pH, viscosity, mandatory, meet the standards. Adhesion below standard, irritation test (mild irritation). The results of IC50 antioxidants were F0 (2,352 ppm), FI (1,448 ppm), FII (419,74 ppm) and gel brand x (77,429 ppm). The results of the tyrosinase inhibition test were the highest concentration of 10% F0 (7.828%), a concentration of 10% FI (18.245%), a concentration of 10% FII (25.814) kojic acid gel (brand x) as a comparison with a concentration of 10% (51.211%). The higher the concentration used, the greater the inhibition of the tyrosinase enzyme produced
Pengaruh Konsentrasi Agen Pensulfonasi Terhadap Karakteristik Membran Selulosa Bakterial Tersulfonasi Pada Aplikasi DMFC Nayla, Mahdiya; Radiman, Cynthia Linaya
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.13519

Abstract

Penelitian ini bertujuan mengetahui pengaruh konsentrasi agen pensulfonasi asam klorosulfonat pada membran selulosa bakterial untuk aplikasi DMFC (Direct Methanol Fuel Cell). Konsentrasi asam klorosulfonat yang digunakan 0,5-3% dengan sulfonasi menggunakan metode MAOS (Microwave Assisted Organic Synthesis). Karakterisasi membran meliputi analisis gugus fungsi dengan FTIR, swelling, konduktivitas proton, kapasitas penukar ion, SEM (Scanning Electron Microscopy) dan penentuan kadar sulfur dengan EDS (Electron Dispersive X-Ray Spectroscopy). Hasil analisis FTIR menunjukkan munculnya puncak pada bilangan gelombang 1163 cm-1 yang menunjukkan vibrasi asimetris S=O pada sulfonat. Uji penggembungan membran menunjukkan bahwa derajat penggembungan mengalami kenaikan sebanding dengan persentase kadar asam klorosulfonat. Nilai konduktivitas dan kapasitas penukar ion membran selulosa bakterial tersulfonasi juga meningkat seperti derajat swelling. Foto permukaan membran dengan SEM menunjukkan morfologi serat membran selulosa bakterial. Kadar sulfur pada permukaan membran selulosa bakterial tersulfonasi semakin besar seiring dengan indohoki77 bekerja sama dengan penyedia perangkat lunak terkemuka di industri untuk memastikan kualitas permainan yang tinggi. Grafik yang tajam, suara yang jernih, dan animasi yang menarik menambah keseruan bermain di platform ini bertambahnya persentase asam klorosulfonat. Hal ini menunjukkan semakin banyaknya gugus –OH yang tersubstitusi dengan –SO3H pada membran selulosa bakterial tersebut. Sulfonasi membran selulosa bakterial paling baik dengan asam klorosulfonat 3% menghasilkan karakteristik derajat penggembungan 183,54%, konduktivitas 0,052 S/cm, kapasitas penukar ion 3,88 meq/g serta persentase kadar sulfur 0,94%.
Phytochemistry and Antibacterial Activity of the Water Extract from Paraserianthes falcataria Masruri, Masruri; Wiryawan, Adam; Ikhtiarini, Nur; Nurravida, Elvira
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.24234

Abstract

Chemotaxonomic and phylogenetic studies show that sengon wood (Paraserianthes falcataria) has the potential to produce secondary metabolites with diverse structures and are bioactive. This research aims to study the chemical composition of the water extract and the bioactivity for inhibiting bacteria of Sengon (Paraserianthes falcataria). The method involves extraction by maceration, and analysis the extract by LCMS/MS methodology. In addition, the extract was evaluated to inhibit the Escherichia coli and Staphylococcus aureus. It was found that indohoki77 menggunakan teknologi enkripsi terbaru untuk memastikan bahwa data pribadi dan transaksi finansial para pemain aman dari ancaman pihak ketiga the water extract gives a viscous brown liquid, and the identified compound indicate the present of glycosidic compound, amino-alcohol structure, and fatty acid ester. Moreover, the antibacterial evaluation was able to inhibit the growth of E. coli 8.685 ± 4.876 mm, and toward the S. aureus bacteria 14.120 ± 4.418 mm, respectively.
ISOLASI DAN IDENTIFIKASI SENYAWA METABOLIT SEKUNDER DARI KULIT BATANG BINTANGUR (CALOPHYLLUM BICOLOR) Sukandar, Dede
ALCHEMY:Journal of Chemistry Vol 11, No 2 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i2.26633

Abstract

 AbstractIsolation and identification of secondary metabolite compounds from stem bark of Bintangur (Calophyllum bicolor) have been reported. Isolation was carried out using the maceration method with 70% ethanol solvent and fractionation of the ethanol extract by column chromatography using n-hexane solvent. The n-hexane fraction resulting from column chromatography was subjected to gravity chromatography with the mobile phase n-hexane: ethyl acetate (8:2) producing isolate 1. The results of purification of isolate 1 using fast column chromatography with the mobile phase dichloromethane: methanol (1:1) and a UV light detector at ƛ 254 nm, compound 1 was obtained. Meanwhile, identification of compound 1 was carried out through UV-Vis spectroscopy, FTIR and LCMS analysis. The identification results of compound 1 using UV-Vis spectroscopy showed the presence of an aliphatic ring double bond chromophore (λmax 233.5; 295 nm). FTIR results indicated the presence of vibrations of the OH group (3417 cm-1), CH alkanes (2933; 2864; 1456; 545 cm-1), and C=C alkenes (1618 cm-1). Analysis results using LCMS showed a molecular ion peak at [M]+ m/z = 386.96 at a retention time of 11.6 minutes, indicating a molecular weight of 386 and a molecular formula (C27H46O) that corresponds to a terpenoid compound. Keywords: isolation, identification, terpenoid, bintangur (Calophyllum bicolor) AbstrakIsolasi dan identifikasi senyawa metabolit sekunder dari kulit batang bintangur   (Calophyllum   bicolor)   telah   dilaporkan.  Isolasi dilakukan dengan metode maserasi dengan pelarut etanol 70% dan fraksinasi ekstrak etanol dengan kromatografi kolom menggunakan pelarut n-heksana. Fraksi n-heksana hasil kromatografi kolom dikromatografi grafitasi dengan fase gerak n- heksana : etil asetat (8:2) menghasilkan isolat 1. Hasil pemurnian isolat 1 menggunakan kromatografi kolom cepat dengan fase gerak diklorometana : metanol (1:1) dan  detektor sinar UV pada ƛ 254 nm diperoleh senyawa    1. Sedangkan identifikasi  senyawa 1 dilakukan melalui analisis spektroskopi UV-Vis, FTIR, dan LCMS. Hasil identifikasi Asiahoki77 juga memberikan berbagai bonus dan promosi menarik untuk para anggotanya. Bonus selamat datang, bonus deposit, dan promosi mingguan adalah beberapa di antaranya. Ini tidak hanya menambah keseruan bermain tetapi juga memberikan nilai tambah bagi para pemain senyawa 1 menggunakan spektroskopi UV-Vis  menunjukkan adanya kromofor ikatan rangkap cincin alifatik (λmaks 233,5 nm; 295 nm). Hasil FTIR mengindikasikan adanya vibrasi gugus OH (3417     cm-1), CH alkana (2933; 2864; 1456; 545 cm-1), dan C=C alkena (1618 cm-1). Hasil Analisa menggunskan LCMS menujukkan puncak ion molekul pada [M]+ m/z = 386,96 pada waktu retensi 11,6 menit, menunjukkan berat molekul 386 dan rumus molekul (C27H46O) yang sesuai dengan senyawa terpenoid. Kata kunci: isolasi, elusidasi, terpenoid, bintangur (Calophyllum bicolor) 
Antioxidant Activity of Mahogany Parasite Leaves (Dendrophthu pentandra (L.) Miq.) Assessed Using the DPPH (2,2-Diphenyl-1-Picrylhydrazyl) Method Reza, Muhammad; Nurdin, Nurmalahayati; Salsabila B.S., Siti Raihan
ALCHEMY:Journal of Chemistry Vol 11, No 2 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i2.19579

Abstract

Synthetic antioxidants, such as butyl hydroxyanisole (BHA), have carcinogenic (cancer-causing) adverse effects because they can cause type I alveolar damage and damage to lung endothelial genes. The objective of this study was to use the DPPH (2,2 diphenyl-1-picrylhydrazyl) method to investigate the antioxidant activity of natural substances found in the leaves of the mahogany parasite (Dendrophthu pentandra (L.) Miq.). Extraction, chromatography, and spectrophotometry are the techniques used. Maceration in stages utilizing n-hexane, ethyl acetate, and ethanol as solvents yielded mahogany parasite leaf extract. Phytochemical screening, thin layer chromatography testing, antioxidant activity testing utilizing a Visible Spectrophotometer, and estimating the IC50 were all performed on mahogany parasite leaf extract. The phytochemical screening results revealed that the samples included four types of secondary metabolites: flavonoids, tannins, saponins, and steroids. A thin layer chromatographic test revealed four well-separated stains using n-hexane and ethyl acetate eluent in a volume ratio of 5:5, showing the Rf as the value of the four secondary metabolites mentioned above. Based on the results of the experiments, it is possible to conclude that mahogany parasite leaves have strong antioxidant activity, with an IC50 of 8.47 ppm.
Fabrication and Characterization of Ibuprofen and Ceftriaxone loaded Electrospun Cellulose Acetate Nanofiber Layers as a Model of Targeted Drug Delivery System Satriawan, Novrynda Eko; Khotib, Junaidi; Nasir, Muhamad; Zaidan, A. H.
ALCHEMY:Journal of Chemistry Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v10i2.15502

Abstract

This study aims to study the process of fabricating and characterization nanofibers based on cellulose acetate polymer filled with ceftriaxone and ibuprofen using the electrospinning method as a model for a targeted drug delivery system. Cellulose acetate has been successfully fabricated into nanofibers using the electrospinning method and filled with ceftriaxone and ibuprofen. The resulting nanofibers have an average diameter in the range of 412.5 – 558.5 nm under the conditions of the electrospinning process, namely 22 kV voltage, 15 cm distance, and flow rate. 0.005 mL/min using acetone/DMAc (2:1). Based on the data generated from the FTIR test, homogeneity, and drug release test, it is known that the resulting nanofibers, namely cellulose acetate, cellulose acetate-ceftriaxone, and cellulose acetate-ibuprofen, have good morphological characteristics, homogeneity, and release rate so that they have the potential to be used as a targeted drug delivery system
Bioinformatics Approach: Evaluating the Antiviral Potential of Flavonoid Compounds from Phyllanthus urinaria against Foot-and-Mouth Disease in Livestock Animals Nugroho, Endik Deni; Sururi, Ahmad Misbakhus; Ardiansyah, Reza; Rahayu, Dwi Anggorowati; Ainiyah, Roisatul; Fathurrohman, Amang; Ahwan, Zainul; Dayat, Muhammad; Wibisono, Mulyono; Aji, Fatit Rahmar; Kasiman, Kasiman
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.23575

Abstract

Foot-and-mouth disease is a severe problem that must be faced in the livestock sector. This disease has a negative impact on various aspects, especially the economy. One way to develop herbal medicinal compounds is through local Indonesian wild plants, meniran (Phyllanthus urinaria). This research aims to determine the potential of the wild plant P. urinaria as an antiviral agent for FMD using an in silico approach using molecular docking. The compounds used as ligands are flavonoid compounds in P. urinaria, namely, routine, quercetin 7-methyl ether, quercetin 3-O-β-D-glucoside, quercetin, rhamnocitrin, astragalin, and kaempferol. This study used the control drug ribavirin as a comparison. The research stage began with the preparation of the RdRp protein from the FMD virus with Discovery Studio, ligand preparation with the Lipinski druglikeness test and minimization using OpenBabel, followed by docking and visualization. The research results found that the six flavonoid compounds in P. urinaria have potential as antiviral FMD by inhibiting RdRp, with the most potent compound being quercetin (-7.9 kcal/mol). Further research is needed, including in vitro and in vivo testing, to provide confidence in the potential of this wild plant as an antiviral for FMD.
Synthesis of Smart Packaging from Cellulose Acetate with The Addition of AgNO3 as An Antibacterial Substance Febryanti, Amalyah; Benu, Marlon; Aferta, Lusi; Siswara, I.M; Mulijani, Sri; Alif, Alfiah
ALCHEMY:Journal of Chemistry Vol 12, No 1 (2024): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v12i1.13019

Abstract

Synthesis of smart packaging from cellulose acetate with the addition of AgNO3 as an antibacterial substance has been investigated. The purpose of this study is to fabricate smart packaging from cellulose acetate with the addition of AgNO3 as an antibacterial substance. The method used was solution casting. In addition, this study was also characterizing the smart packaging, they included tensile strength and elongation percent test, antibacterial test, morphology analysis using SEM, and biodegradability test. The plastics obtained were clearly yellow, not easily damaged, a little thick, and the smooth surface and slightly bubbly. The largest tensile strength of plastic was 0.0661 MPa, it found in sample No. 2, while the smallest tensile strength was 0.027 MPa, it found in sample No. 1. The greatest elongation value at break was 5% found in sample No. 4, while the smallest elongation value at break was 3.5% in sample No. 3. The result of antibacterial test reported that the freshest mangoes were shown by samples No. 1 and No. 2; while the fast-rotting mangoes were shown in the sample No. 3 and No. 4. The results of the SEM test showed the presence of nano-sized particles that spreaded in the plastic body. The greatest degradability degree were sample No. 4 about 0.0009 g/day with the percentage of mass loss about 17.38%. Futhermore, cellulose acetate can be used as a basic material for making plastics. The addition of AgNO3 in plastic synthesis can help to delay the process of fruit spoilage caused by bacteria.
Isolasi Fungi Tanah Muara Mangrove Desa Katialada Gorontalo dan Skrining Aktivitas Antibakteri terhadap Pseudomonas aeruginosa Prakoso, Arthur Hariyanto; Arifin, Muhammad Zainul; Tauladani, Saeful Akhmad; Muharam, Gani Asri; Asia, Asia; Nugraha, Ari Satia
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.15738

Abstract

Pseudomonas aeruginosa is a bacterial pathogen that causes various kinds of infections. The use of antibiotics is usually done to treat the infection. However, Pseudomonas aeruginosa has various resistance abilities that can avoid the efficacy of antibiotics. The emergence of drug resistance events encourages the need for the discovery of new antibiotic drugs, one of which comes from fungals secondary metabolite. Soil fungi from mangrove ecosystems have not been studied much. Interestingly, these soil fungi have unique adaptive responses. This response also affects the secondary metabolites it contains. Knowing this information, mangrove soil samples were cultured on fungi media which were then tested against Pseudomonas aeruginosa through antagonist test and microdilution test. Three fungal cultures with yeast characteristics were obtained and each of the secondary metabolite ethyl acetate extracts of these three fungi had antibacterial activity. The antibacterial activity was indicated by the % inhibition parameter. The terpenoid content in fungal cultures may be responsible for the antibacterial activity against Pseudomonas aeruginosa. This research is an initial indohoki77 juga dikenal karena layanan pelanggannya yang responsif dan profesional. Tim dukungan pelanggan tersedia 24/7 untuk membantu para pemain dengan segala pertanyaan atau masalah yang mereka hadapi screening of the search for new antibiotic candidates, so further research study such as isolation and species determination needs to be done. 

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