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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol 15 No 4 (2025): Medula" : 5 Documents clear
Perkembangan Strategi Pengobatan β-Thalassemia Santhi, Komang Ria Yuliana; Sangging, Putu Ristyaning Ayu; Jausal, Anisa Nuraisa; Ismunandar, Helmi
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1663

Abstract

β-thalassemia is an inherited blood disorder caused by mutations in the β-globin gene that reduce or eliminate β-globin chain synthesis, leading to hypochromic microcytic anemia and significant morbidity worldwide. The disorder is prevalent in South Asia, Southeast Asia, the Mediterranean, the Middle East, India, and Africa, with approximately 1.5% of the global population identified as carriers. Severe complications, including iron overload, skeletal deformities, heart failure, and multi-organ damage, contribute to its substantial global health burden. This narrative literature review synthesizes evidence from PubMed, Cochrane, and Google Scholar to examine conventional and emerging therapeutic strategies for β-thalassemia, with particular emphasis on recent advances in gene therapy. Standard management relies on regular blood transfusions and iron chelation, which remain supportive and are associated with long-term complications. Hematopoietic stem cell transplantation is the only established curative treatment, especially effective in pediatric patients with matched HLA donors, although its availability is limited. Novel pharmacologic agents, such as luspatercept and mitapivat, have demonstrated reductions in transfusion requirements and improvements in hemoglobin production. Additional approaches, including fetal hemoglobin induction and modulation of iron metabolism, show encouraging potential. A major breakthrough is CRISPR-based gene therapy using exagamglogene autotemcel (Casgevy), approved by the FDA and EMA in 2024, with phase 3 trials reporting transfusion independence in more than 90% of patients and significant quality-of-life improvements. Despite persistent challenges related to cost, access, and long-term safety, these advances indicate a paradigm shift toward precision medicine with curative potential for β-thalassemia.
Hubungan Hipertensi dengan Penyakit Jantung Koroner (PJK): Tinjauan Pustaka Worocahyo, Avis Meyvika; Kurniati, Intanri; Damayanti, Putri; Susianti, Susianti
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1694

Abstract

Coronary Artery Disease (CAD) is still one of the leading causes of mortality worldwide, including in Indonesia with a steadily rising prevalence. Hypertension is recognized as a major risk factor, as it accelerates atherosclerosis, induces endothelial dysfunction, and promotes cardiac structural changes that ultimately lead to coronary artery narrowing. This study employed a literature review approach by analyzing scientific articles discussing the association between hypertension and CAD in Indonesia. The findings show a significant relationship between hypertension and CAD, with p-values < 0.05 across multiple studies, and hypertensive individuals found to be more than twice as likely to develop CAD compared to normotensive individuals. Pathophysiologically, chronic hypertension contributes to hemodynamic disturbances, cardiac remodeling, endothelial dysfunction, and activation of the renin-angiotensin-aldosterone system (RAAS), thereby accelerating atherosclerosis and triggering myocardial infarction. These results highlight the importance of early detection and effective management of hypertension as essential strategies for preventing cardiovascular complications.
Hubungan IMT Terhadap Kadar Gula Darah Pada Pasien Diabetes Mellitus Tipe 2: Tinjauan Pustaka Afifah, Ighra; Kurniati, Intanri; Marcellia, Selvi; Ramadhian, Muhammad Ricky
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1704

Abstract

Type 2 diabetes mellitus is a chronic metabolic disease with a steadily increasing prevalence globally, including in Indonesia. One of the main risk factors contributing to the development and severity of type 2 diabetes is obesity, clinically measured by Body Mass Index (BMI). Increased BMI is closely associated with impaired glucose metabolism and insulin resistance, which play a key role in the pathogenesis of type 2 diabetes. This study used a literature review approach by examining various studies analyzing the relationship between BMI and blood glucose levels. The results showed that increased BMI is positively correlated with fasting blood glucose, random blood glucose, and HbA1c levels. Individuals with a higher BMI tend to experience more severe glycemic control disorders. Pathophysiologically, increased adipose tissue, especially visceral fat, produces various inflammatory mediators such as TNF-α and IL-6, which disrupt the insulin signaling pathway, reduce glucose uptake by muscle tissue, and trigger hyperglycemia. Furthermore, dysfunction of adipokine hormones such as decreased adiponectin and resistance to leptin contribute to worsening insulin sensitivity
Efektivitas Beberapa Ekstrak Tanaman sebagai Ovisida terhadap Aedes aegypti dalam Pencegahan Demam Berdarah Dengue Septiani, Linda; aflika happy, terza; Graharti, Risti; Andrifianie, Femmy; Setyaningrum, Endah
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1827

Abstract

Dengue Hemorrhagic Fever (DHF) remains a major public health concern, with Aedes aegypti serving as the primary vector. The continuous use of synthetic insecticides has led to resistance development and environmental concerns, highlighting the need for safer and sustainable alternatives. This review aims to evaluate the ovicidal potential of selected plant extracts against Aedes aegypti as an early-stage vector control strategy. A literature review was conducted using relevant national and international publications focusing on plant-based ovicides. The findings indicate that extracts from Piper nigrum L., Ocimum basilicum, Syzygium myrtifolium Walp., Tithonia diversifolia, Acorus calamus L., Solanum lycopersicum, and Euphorbia hirta L. effectively reduce egg hatchability of Aedes aegypti. The ovicidal activity is associated with secondary metabolites such as flavonoids, alkaloids, saponins, tannins, terpenoids, polyphenols, and essential oils, which disrupt egg membranes and inhibit embryonic development in a concentration-dependent manner. These findings suggest that plant extracts possess promising potential as natural ovicides and may serve as a basis for further pharmaceutical development and formulation in sustainable dengue vector control.
Tinjauan Literatur Sistematis: Protokol Kriptografi untuk Menjamin Keamanan dan Privasi Data Genomik Wijaya, Angga; Idris, Mohamad; Septiani, Linda; Pestalozi, George
Medula Vol 15 No 4 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i4.1840

Abstract

precision medicine. However, the static and hereditary nature of genomic data poses significant privacy risks for individuals and their families. This article aims to conduct a systematic literature review of various modern cryptographic protocols designed to protect genomic data. The research method utilizes a Systematic Literature Review (SLR) approach, analyzing relevant literature from 2018 to 2026. The findings indicate that protocols such as Homomorphic Encryption (HE) and Secure Multi-party Computation (SMPC) offer robust protection but face challenges regarding computational efficiency and bandwidth. Differential Privacy (DP) provides an efficient alternative but carries risks of reduced data accuracy. In conclusion, securing genomic data requires hybrid models that integrate algorithmic efficiency with long-term resilience, particularly against quantum computing threats. Aligning these technologies with Indonesia's Personal Data Protection Law (UU PDP) is crucial for building a secure and credible national health data ecosystem.

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