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All Journal Medula Journal of Islamic Medicine Jurnal Ilmu Kedokteran dan Kesehatan JFM (Jurnal Farmasi Malahayati) Organisms: Journal of Biosciences JOURNAL OF Pharmacy and Tropical Issues
Marcellia, Selvi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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KAJIAN PUSTAKA: EFEKTIVITAS EKSTRAK TANAMAN SEBAGAI LARVASIDA DALAM PENGENDALIAN NYAMUK Marcellia, Selvi; Septiani, Linda; Berawi, Khairunnisa; Oktavia Ningtias, Nabila; Qanita Arindia, Naifa Hana
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 3 (2024): Volume 11 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i3.13461

Abstract

Abstrak: Kajian Pustaka: Efektivitas Ekstrak Tanaman Sebagai Larvasida Dalam Pengendalian Nyamuk. Nyamuk merupakan vektor penyakit tertentu yang dapat menyebabkan kesakitan hingga kematian pada individu yang terpapar gigitannya. Larvasida merupakan salah satu upaya yang dapat dilakukan dalam mengendalikan larva nyamuk. Banyak penelitian telah menunjukkan adanya potensi larvasida dalam berbagai ekstrak tanaman. Melalui uji fitokimia ditemukan kandungan senyawa dalam ekstrak tanaman tersebut yang berpotensi sebagai larvasida yaitu flavonoid, tanin, saponin, alkaloid, terpenoid, dan steroid. Senyawa-senyawa tersebut didapatkan oleh tanaman dari proses biosintesis yang merupakan sistem pertahanan diri alami pada tanaman. Ekstrak tanaman yang telah diuji antara lain ekstrak kulit buah limus, ekstrak daun duwet, ekstrak biji kelor, ekstrak daun kemangi, ekstrak daun jelatang, ekstrak daun salam, dan ekstrak daun bidara. Ekstrak kulit buah limus merupakan ekstrak yang paling efektif. Setiap tanaman di dunia ini memiliki potensi sebagai larvasida yang sangat bermanfaat dalam pengendalian nyamuk.
LITERATURE REVIEW: EKSTRAK MAKROALGA SEBAGAI ANTIMALARIA Adisa, Mutiara Putri; Septiani, Linda; Marcellia, Selvi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 3 (2024): Volume 11 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i3.13402

Abstract

Abstrak: Literature Review: Ekstrak Makroalga sebagai Antimalaria. Malaria adalah penyakit akibat infeksi parasit Plasmodium sp yang diperantarai oleh nyamuk betina Anopheles sp melalui gigitannya. Kasus malaria cukup tinggi di Indonesia. Upaya dalam mengendalikan kasus malaria di Indonesia perlu dilakukan dengan mengembangkan penelitian terkait antimalaria. Tujuan studi ini adalah merangkum beberapa hasil penelitian tentang ekstrak makroalga yang berpotensi sebagai antimalaria dan memberikan informasi dasar sebagai  referensi penelitian lebih lanjut. Penelitian ini menggunakan metode studi literatur untuk memperoleh informasi dari beberapa jurnal penelitian. Eksplorasi sumber daya alam di Indonesia dengan meneliti potensi antimalaria dari bahan-bahan alami dapat dilakukan untuk memaksimalkan pemanfaatannya. Umumnya penelitian terkait potensi makroalga sebagai antimalaria dilakukan dengan melakukan ekstraksi pada makroalga yang diteliti. Ekstrak makroalga tersebut diuji terhadap parasit Plasmodium sp. Potensi antimalaria diduga terkandung dalam senyawa pada makroalga.  Makroalga memiliki kandungan senyawa metabolit sekunder yaitu alkaloid, flavonoid, saponin, tanin, dan terpenoid. Senyawa tersebut berperan dalam menghambat pertumbuhan dan perkembangan Plasmodium sp yang merupakan parasit penyebab malaria. Makroalga yang memiliki potensi antimalaria antara lain Euchema cottonii, Sargassum sp, dan Sargassum duplicatum.
UJI AKTIVITAS ANTIFUNGI TERHADAP CANDIDA ALBICANS EKSTRAK METANOL KULIT BAWANG MERAH (ALLIUM CEPA L.) Setiya, Kusumaningtiyas Putra; Tutik, Tutik; Marcellia, Selvi
JFM (Jurnal Farmasi Malahayati) Vol 7, No 1 (2024)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v7i1.8702

Abstract

Candida albicans merupakan mikroflora di tubuh manusia yang dapat ditemukan di traktus gastrointestinal, membran mukosa dan kulit. untuk mengetahui ekstrak metanol kulit bawang merah dengan metode ekstraksi refluk memiliki aktivitas antifungi terhadap fungi Candida albicans, tujuan penelitian untuk mengetahui konsentrasi ekstrak metanol kulit bawang merah ( Allium cepa L. ) yang berpengaruh terhadap fungi Candida albicans. Teknik ekstraksi yang digunakan yaitu refluks dan uji aktivitas. Hasil ekstrak diperoleh rendemen sebesar 10%. Hasil skrining fitokimia diperoleh senyawa flavonoid, alkaloid, tanin, saponin.  Hasil penelitian menunjukkan tidak adanya hambatan yang diterima pada fungi Candida albicans pada konsentrasi 5%, 30%, 55%, 80% dan 100%. Ekstrak metanol kulit bawang merah (Allium cepa L) yaitu senyawa flavonoid, alkaloid, saponin dan tannin. Tidak positif mengandung aktifitas antifungi terhadap Candida albicans. tidak ada penghambatan pertumbuhan terhadap fungi Candida albicans. Karena pada penelitian ini hanya dapat membuktikan adanya suatu senyawa metabolit sekunder secara kualitatif tidak secara kuantitatif terhadap antifungi.
Insecticida Test Of Attractive Oil On Clove (Syzygium Aromaticum (L.) Merr. & Perry.) Leaves Against Aedes Aegypti Mosquito Agustin, Rekha Yulia; Marcellia, Selvi; Susanti, Dwi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 10 (2024): Volume 11 Nomor 10
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i10.16035

Abstract

Clove leaves (Syzygium aromaticum (L.) Merr. & Perry.)  have eugenol compounds in essential oils which have the potential as natural insecticides. The purpose of this study was to determine the effectiveness of essential oil insecticides on clove leaves (Syzygium aromaticum (L.) Merr. & Perry.)  in killing Aedes aegypti mosquitoes. This study used the distillation method with air as a solvent. The concentrations of clove leaf essential oil extract used were 0.5%s, 1%, 2.5% and 4%. The results of the LC50 test showed that clove leaf essential oil (Syzygium aromaticum) was effective in killing Aedes aegypti mosquitoes with an LC50 value of 0.993% and was included in the very toxic category. The higher the concentration of essential oils, the greater the killing activity and the lower the LC50 value, the higher the effectiveness in killing Aedes aegypti mosquitoes. It can be concluded from this study that clove leaf essential oil (Syzygium aromaticum (L.) Merr. & Perry.) has effectiveness as a natural insecticide against Aedes aegypti mosquitoes, can be seen from the mortality value in the 55th minute of 100% at a concentration of 4%.
Uji Efektivitas Biolarvasida Pada Minyak Atsiri Daun Tembelekan (Lantana camara) Terhadap Larva Anopheles sp. Sebagai Upaya Pengendalian Vektor Malaria Marcellia, Selvi; Ramdini, Dwi Aulia; Setiawan, Gigih; Septiani, Linda; Setyaningrum, Endah; Rosa, Emantis; Annasya, Benazhir Saninah
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 12 (2024): Volume 11 Nomor 12
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i12.18425

Abstract

Indonesia merupakan salah satu negara dengan jumlah kasus malaria yang tertinggi di dunia. Penyakit malaria merupakan jenis penyakit yang penularannya melalui gigitan nyamuk Anopheles sp. yang mengandung protozoa Plasmodium sp. Daun lantana (Lantana camara L.) memiliki kandungan senyawa aktif lantadine, minyak atsiri, flavonoid, alkaloid, saponin, dan tannin. Penggunaan biolarvasida merupakan upaya untuk mengurangi preventif Penelitian ini bertujuan untuk mengetahui efektivitas minyak atsiri daun lantana sebagai biolarvasida terhadapvektor penyakit Malaria.Metode yang digunakan pada penelitian ini adalah destilasi untuk proses ekstraksi, dan menghitung jumlah kematian dari larva yang telah diberi perlakuan dengan konsentrasi minyak atsiri daun lantana 0,5%, 0,75%, 1%, 1,25% sehingga didapatkan nilai persen mortalitas dan dilanjutkan dengan menghitungan nilai LC50 dan LC90 menggunakan uji probit. Hasil penelitian menunjukkan bahwa minyak atsiri daun lantana (Lantana camara) efektif sebagai biolarvasida. LC50 yang di dapat yaitu0,505% pada jam ke-21. Untuk uji ANOVA menunjukkan terdapat perbedaan yang signifikan pada masing-masing konsentrasi 0,5%, 0,75%, 1%, 1,25%, control negative dan control positif karena nilai p-value 0,000<0,05. Dari hasil penelitian ini dapat dikatakan bahwa senyawa yang terkandung pada minyak atsiri daun lantana (Lantana camara) berpotensi sebagai biolarvasida terhadap larva Anopheles sp.
Uji Efektivitas Kombinasi Ekstrak Daun Kemangi (Ocimum x africanum Lour.) dan Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Terhadap Larva Aedes aegypti Wati, Ria Widya; Nofita, Nofita; Marcellia, Selvi
Journal of Islamic Medicine Vol 8, No 1 (2024): JOURNAL OF ISLAMIC MEDICINE EDISI MARET 2024
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v8i1.23293

Abstract

Basil leaves and fragrant pandanus leaves have secondary metabolite compounds namely alkaloids, flavonoids, saponins, tannins, and terpenoids that can be natural larvicides. The purpose of this study was to determine the activity, effectiveness and LC50 value of the combination of basil leaf extract (Ocimum x africanum Lour.) and fragrant pandanus leaf (Pandanus amaryllifolius Roxb.) as larvicide of Aedes aegypti mosquitoes. Extraction using maceration method with 96% ethanol solvent. This study used 5 treatments, namely negative control (distilled water), positive control (abate 1%), FI ( Basil leaf extract 1% concentration + fragrant pandan leaves 2% concentration), FII (Basil leaf extract 1,5% concentration + fragrant pandan leaves 1,5% concentration), and FIII (Basil leaf extract 2% concentration + fragrant pandan leaves 1% concentration) each treatment containing 25 Aedes aegypti instar III larvae with 5 repetitions. Data obtained will be analyzed by one way ANOVA test, Post Hoc Test LSD (Least Significance Different) test, and Probit test. The results of the effectiveness test on FIII with a mortality value of 100%, said to be effective in killing Aedes aegypti larvae. The results of the one way ANOVA test showed significant differences in average concentrations, then the results of the LSD Post Hoc Test showed that the FIII concentration had larvicidal effectiveness that was not significantly different from the positive control, this can be seen from the significant value of 1.000 (p>0.05) against the positive control. The probit test results showed an LC50 value of 1.715% which means that the combination of basil leaf extract (Ocimum x africanum Lour.) and fragrant pandanus leaf (Pandanus amaryllifolius Roxb.) has toxic properties as a natural larvicide Keyword : Basil Leaf, Fragrant Pandanus Leaf, Larvicide, Aedes aegypti
The Literatur Review: Hubungan Kadar Hemoglobin terhadap Lama Rawat Inap Pasien Laparotomi: - Buana, Faris Agung; Darwis, Iswandi; Marcellia, Selvi; Susianti, Susianti
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1432

Abstract

Hemoglobin is an important protein in the blood whose job is to transport oxygen to body tissues. Low hemoglobin levels (anemia) in laparotomy patients can affect postoperative recovery time, including the duration of hospitalization. This study aims to evaluate the relationship between pre-operative hemoglobin levels and length of stay in laparotomy patients. Data were obtained from medical records of patients who underwent laparotomy at the hospital, including hemoglobin levels before surgery, length of stay, and additional variables such as Body Mass Index (BMI) and Surgical Apgar Score (SAS). The analysis showed that patients with low hemoglobin levels had a greater risk of experiencing longer hospital stays. This is due to suboptimal oxygen supply to the tissue, thereby slowing wound healing and increasing the risk of complications, such as infection and organ failure. Treating anemia with blood transfusions or iron supplementation has proven effective in increasing hemoglobin levels and speeding up patient recovery, with the average length of stay reduced to less than four days. Apart from hemoglobin levels, factors such as BMI, SAS, level of complexity of surgery, and the patient's health condition also influence the length of treatment. These findings emphasize the importance of monitoring and correcting hemoglobin levels before surgery as a preventive measure to speed recovery, minimize complications, and reduce hospital operational burden, especially in health facilities with limited resources. Further research is needed to determine the most effective clinical interventions in managing anemia in preoperative patients.
Kandungan Senyawa Aktif Metabolit Sekunder dalam Biolarvasida Annasya, Benazhir Saninah; Mutiara, Hanna; Marcellia, Selvi
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1252

Abstract

Larvicide is a compound that can be toxic, inhibit growth and development, affect behavior, affect hormones, inhibit feeding, and act as a larval killer. Larvicide is divided into two types, namely chemical larvicide and biolarvicide. Chemical larvicide is the larvicide most widely used by the community because it has a large substance strength. However, the use of chemical larvicide can cause damage, especially insects become resistant to drugs, in addition to causing environmental pollution because synthetic larvicide is difficult to decompose and causes poisoning in humans. The use of chemical larvicide can cause damage, especially insects become resistant to drugs, in addition to causing environmental pollution because synthetic larvicide is difficult to decompose and causes poisoning in humans. Therefore, a substitute for chemical larvicide in the form of biolarvicide is needed. Biolarvicide can act as a larval killer, attractant, antifertility agent (sterilization tool), biocide, and other forms that minimally cause drug resistance in insects. Biolarvicide comes from plant materials containing active compounds of secondary metabolites such as essential oils, saponins, steroids, terpenoids, tannins, alkaloids, flavonoids, and phenolics that can kill mosquito larvae and are obtained by extraction. This article provides a broader explanation of the content of secondary metabolite compounds in biolarvicide so that it can be more effectively used as a larvicide from natural materials. The contents of the article were obtained through searches of several national and international journals through the search keywords: Biolarvicide, secondary metabolites, and active compounds.
Keberadaan Bakteri Coliform dan Escherichia coli dalam Sumber Air Bersih Sebagai Penyebab Diare pada Rumah Tangga: Literature Review Fathia, Nauriel; Utama, Winda Trijayanthi; Marcellia, Selvi; Carolia, Novita
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1293

Abstract

Water is an essential necessity for humans on Earth. Its role is crucial for daily activities, including household needs, industry, offices, and food production. In Indonesia, each person is estimated to require approximately 30–60 liters of water per day, whereas in developed countries, the demand per person ranges between 60–120 liters per day. The feasibility of water usage is regulated based on quality characteristics, referred to as water quality. One of the key indicators related to household water quality is biological parameters, particularly concerning the presence of coliform bacteria and Escherichia coli. These bacteria have a fecal-oral entry route, meaning that if consumed in excessive amounts, they can cause gastrointestinal diseases, primarily diarrhea. This study aims to examine the impact of coliform and Escherichia coli contamination in household water sources, leading to diarrhea cases. The research method used is a literature review and analysis. The findings indicate that the presence of Escherichia coli in household water sources, especially in areas with poor sanitation, poses a high health risk, particularly increasing the likelihood of diarrhea. Several factors contribute to this contamination, including the proximity of wells to pollution sources, inadequate waste management, and improper well construction that does not meet safety standards. These conditions suggest that environmental sanitation and the distance between water sources and potential contaminants play a significant role in water quality and public health. Through this study, it is expected that the community will be more aware of the importance of maintaining clean water used for household needs to prevent diarrhea-related diseases.
Formulasi sediaan lotion ekstrak daun nangka (Artocarpus Heterophyllus) sebagai repelan terhadap nyamuk aedes aegypti Nofita, Nofita; Triyanti, Yesicha; Marcellia, Selvi
JOURNAL OF Pharmacy and Tropical Issues Vol. 1 No. 2 (2021): December Edition 2021
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR) Kerjasama dengan Ikatan Sarjana Farmasi Indonesia (ISFI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v1i2.96

Abstract

  Pendahuluan: Demam Berdarah Dengue (DBD) merupakan penyakit yang disebabkan oleh virus yang ditularkan melalui gigitan nyamuk Aedes aegypti yang sebelumnya telah terinfeksi oleh virus dengue dari penderita DBD. Ekstrak daun nangka yang mengandung saponin, flavonoid, alkaloid, terpenoid, steroid dan tanin dapat membunuh nyamuk Aedes aegypti. Berdasarkan latar belakang peneliti tertarik untuk melakukan Uji Formulasi Sediaan Lotion  Ekstrak Daun Nangka (Artocarpus heterophyllus) sebagai Repelan Terhadap Nyamuk Aedes aegypti. Tujuan: Untuk mengetahui efek Repelan ekstrak daun nangka (Artocarpus heterophyllus) terhadap nyamuk Aedes aegypti. Metode: Ekstraksi perkolasi dengan berbagai uji diantaranya uji alkaloid, flavonoid, saponin, tanin, steroid, triterpenoid, evaluasi lotion anti nyamuk. Hasil: Konsentrasi ekstrak daun nangka (Artocarpus heterophyllus) dalam sediaan lotion  yang paling efektif sebagai reppelan nyamuk Aedes aegypti yaitu pada konsentrasi 9% dengan daya efektivitas yang hampir sama dengan kontrol positif yaitu 86% pada 30 detik dan per 6 jam diperoleh rata-rata 79,5% dengan nilai uji statistik p < 0,05. Simpulan: Ekstrak daun nangka dalam sediaan lotion  memiliki efektivitas dalam menolak nyamuk.
Co-Authors Adisa, Mutiara Putri Agustin, Rekha Yulia Andrifianie, Femmy Annasya, Benazhir Saninah Bella, Bella Tasya Salsabila Buana, Faris Agung Damayanti, Ervina Dewi Chusniasih Dwi Susanti Endah Setyaningrum, Endah Fathia, Nauriel Hanna Mutiara, Hanna Iswandi Darwis Juniyanti, Anti Revo Khairun Nisa Mardiyah, Izmi Nofita, Nofita Novita Carolia Oktavia Ningtias, Nabila Primasari Pertiwi Purnama, Robby Candra Qanita Arindia, Naifa Hana Ramdini, Dwi Aulia Retnaningsih, Agustina Rizki Purnamasari, Rizki Rosa, Emantis Safitri, Mariska Mulya Salsabila, Bella Tasya Santi, Putri Era Saputri, Gusti Ayu Rai Septiani, Linda Setiawan, Gigih Setiya, Kusumaningtiyas Putra Sukardi Sukardi Susianti, Susianti Suwandayani, Muhammad Ali Shodiqin Triyanti, Yesicha Tutik Tutik Wati, Ria Widya Winahyu, Diah Astika Winda Trijayanthi Utama, Winda Trijayanthi