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All Journal Medula Juke Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati Journal Syifa Sciences and Clinical Research (JSSCR) JK Unila (Jurnal Kedokteran Universitas Lampung) Indonesian Community Empowerment Journal Jurnal Pengabdian Masyarakat JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Muhammad Ricky Ramadhian
Fakultas Kedokteran, Universitas Lampung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Bakteriological Quality Of Refill Drinking Water At Refill Drinking Water Depots In Bandar Lampung Ety Apriliana; M Ricky Ramadhian; Meta Gapila
JUKE Unila Vol 4, No 07 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.34 KB)

Abstract

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INHERITED VARIATIONS IN DRUGS EFFECT INDEPENDENT IN PHARMACOKINETIC: POLYMORPHISM IN PHASE II BIOTRANSFORMATION ENZYMES Muhammad Ricky Ramadhian
JUKE Unila Vol 4, No 8 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.959 KB)

Abstract

Phase II enzymes play an important role in the biotransformation of endogenous compounds and xenobiotics to more easily excretable forms as well as in the metabolic inactivation of pharmacologically active substances. The purpose of phase II biotransformation is to perform conjugating reactions. These include glucuronidation, sulfation, methylation, acetylation, glutathione, and amino acid conjugation. In general, the respective conjugates are more hydrophilic than the parent compounds. Polymorphism in Phase II drug metabolism enzymes may have role in diseases, cancer, and others. This review discuss brief about polymorphism in Phase II drug metabolism enzyme. [JuKe Unila 2014; 4(8):254-268]
AKTIVITAS DIURESIS Leucaena leucocephala.L PADA MENCIT JANTAN (Mus musculus) Muhammad Ricky Ramadhian; Khairil Pahmi; Muhammad Taupik
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9894

Abstract

Diuretics are compounds or drugs that can increase urine volume. This study focused on exploring the activity and concentration of ethanol extract of lamtoro leaves (Leucaenaleucocephala L.) as a diuretic in male house mice (Musmusculus) using experimental research. The method used was to observe the physical activity of urine produced for 120 minutes. Lamtoro leaves extraction was done by maceration using solvent ethanol, then phytochemical screening tests. The screening results stated positively contained alkaloids, flavonoids, terpenoids, and tannins. The animals used were 25 house mice, divided into 5 groups. Group 1 was given Na-CMC 1% w/v suspension, group 2 with furosemide suspension 0.0041% w/v, group 3 with 25% w/v lamtoro leaf ethanol extract, group 4, ethanol extract 50% w/l lamtoro leaf , and group 5 was ethanol extract 75% w/v of lamtoro leaves. Urine volume of the house mice was measured at 15, 30, 45, 60, 75, 90, 105, and 120 minutes.
The Effect of Telmisartan on Collagen Percentages by Picrosirius Staining in the Glomerular Renal Organ of 8% NaCl-Induced Rats Khairil Pahmi; M Sidratullah; M Ricky Ramadhian
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.6976

Abstract

Excessive salt consumption is one of the hypertension and kidney disease factors, while telmisartan is one of antihypertensive drugs used in the therapy. Telmisartan not only blocks angiotensin receptor which leads to the decrease of blood pressure, but also activates peroxisome proliferator activated receptor gamma (PPAR-γ) and inhibits transforming growth expression factor of beta-1 (TGFβ-1). Whether telmisartan decreases the kidney collagen volume fraction of excessive NaCl-induced Wistar rats are studied in this experiment. Twenty five male Wistars 2.5-3 months of age and 100-150 g BW rats were used in this research. They were grouped into 5, each consists of 5 rats. Group I (G I) as first negative control did not receive NaCl and telmisartan. G II as second negative control received NaCl but not telmisartan. G III, IV and V received NaCl and telmisartan 3, 6 and 12 mg/kg BW. The treatments were given every day within 8 weeks. At the day of 56 all rats were sacrificed by mean of neck dislocation and operated to take the kidney. The collagen was stained by picrosirius red staining. Data were expressed as mean ± standard deviation. They were analyzed by parametric test (analysis of variance-ANOVA and paired samples t-test) or nonparametric test (Kruskal-Wallis). A value of p0.05 was considered statistically significant. The results showed that intraglomerular and extraglomerular collagen volume fraction were lower in telmisartan-treated Wistar rats group than negative control group (0.05p0.05). In conclusion, intraglomerular and extraglomerular collagen volume fraction were lower in 8% sodium chloride-induced and telmisartan-treated male Wistar rats than the items of negative control group.
Uji Diagnostik Kecacingan antara Pemeriksaan Feses dan Pemeriksaan Kotoran Kuku pada Siswa SDN 1 Krawangsari Kecamatan Natar Lampung Selatan Betta Kurniawan; Muhammad Ricky Ramadhian; Nurul Sahana Rahmadhini
Jurnal Kedokteran Universitas Lampung Vol 2, No 1 (2018): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v2i1.1907

Abstract

Kecacingan terjadi diawali dengan tertelannya telur atau masuknya larva yang infektif ke dalam kulit. Beberapa faktor yang dapat mempengaruhi tertelannya telur cacing berkaitan dengan higinitas yaitu kuku yang panjang dan tidak terawat. Pemeriksaan kotoran kuku akan dibandingkan dengan pemeriksaan gold standard untuk mengetahui nilai sensitivitas pemeriksaan kotoran kuku. Penelitian ini bersifat analitik komparatif dengan pendekatan cross sectional. Subjek penelitian terdiri dari 58 siswa dengan mengambil sampel feses dan kotoran kuku. Pemeriksaan feses dilakukan dengan metode apung dan pemeriksaan kuku dilakukan dengan metode sedimentasi. Angka kejadian kecacingan menggunakan bahan pemeriksaan feses sebesar 56% dan angka kejadian kecacingan menggunakan bahan pemeriksaan kotoran kuku sebesar 24,1%. Berdasarkan uji Mc-nemar didapatkan nilai p sebesar 0,02 yang artinya ada perbedaan yang bermakna antara pemeriksaan kotoran kuku dan pemeriksaan feses. Nilai sensitivitas dan spesifisitas sebesar 18,2% dan 68%. Nilai duga positif sebesar 42,8% dan nilai duga negatif sebesar 43,1%. Hasil pemeriksaan kuku dengan pemeriksan feses secara statistik terdapat perbedaan. Nilai sensitivitas didapatkan rendah, sehingga pemeriksaan kotoran kuku tidak mampu disetarakan dengan pemeriksaan feses.Kata Kunci : Diagnosis, kecacingan, pemeriksaan feses, pemeriksaan kuku
Enterobactericeae Sebagai Bakteri Patogen Infeksi Nosokomial di Rumah Sakit Putri, Abrila Tamara; Soleha, Tri Umiana; Nareswari, Shinta; Ramadhian, M. Ricky
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.942

Abstract

Enterobactericeae are gram-negative rod bacteria which are often pathogenic bacteria that cause nosocomial infections. Enterobactericeae bacteria have several characteristics including small size and rod shape, natural habitat in the digestive tract of humans or animals and some others originate from bodies or inanimate objects, are motile and non-motile, cannot form spores, and are aerobic to facultative anaerobic. Nosocomial infections are infections that are acquired during the health care process at the hospital, but are not present when the patient is admitted to the hospital. The source of transmission of nosocomial infections can result from direct or indirect contamination in the health care process in hospitals. Common nosocomial infections include Central Line Associated Blood Stream Infection (CLABSI), Catheter Associated Urinary Tract Infection (CAUTI), Surgical Site Infection (SSI), and nosocomial pneumonia consisting of Hospital Acquired Pneumoniae (HAP), Ventilator Associated Pneumoniae (VAP), and Health Care Associated Pneumoniae (HCAP). The Enterobactericeae bacteria that often cause nosocomial infections in hospitals include Escherichia coli, Klebsiella sp, Enterobacter sp, Pseudomonas sp, and so on. Nosocomial infections have a negative impact on the health recovery process of inpatients in hospital, so they need to be handled well and preventive efforts are made to avoid this undesirable event through health service efforts that comply with standard operational procedures and pay attention to aseptic principles.
Deteksi Dini dan Tatalaksana Rheumatoid Arthritis Farhry Alvini Rahmania; Sibero, Hendra Tarigan; Ramadhian, Muhammad Ricky
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.967

Abstract

Rheumatoid arthritis (RA) is a long-term progressive inflammatory autoimmune disorder that can caused damage to the joints into disability, if it isn’t handled appropriately. There are 1.4 million people in Indonesia that have been found to suffer from rheumatoid arthritis. In the early stages of rheumatoid arthritis, there are symptoms such as fatigue, flu-like syndromes, swollen joints and pain, and morning stiffness; and also increased levels of C-reactive protein (CRP) and increased sedimentation rate of erythorisite (ESR). In contrast, untreated rheumatoid arthritis displays severe systemic manifestations such as pleural effusion, pulmonary nodules and interstitial lung disease, IMF, vasculitis in small and medium arteries, re-evolution, cartilage damage, rheumatic nodules and others. Diagnosis of rheumatoid arthritis is established after assessing symptoms, physical examination, risk factor, family history, assessment along with ultrasound, and lab marker assessment such as increased levels of CRP and ESR in serum and detection of RA-specific autoantibodies. Rheumatoid arthritis is incurable, but it can be controlled with appropriate medication and prognosis monitoring. The prognosis of rheumatoid arthritis is based on clinical evidence and laboratory examination. Early detection and appropriate management of rheumatoid arthritis are key to better prognosis. This article therefore discusses the importance of early diagnosis and treatment of rheumatoid arthritis.
Enhancing Trauma Care: A Community Service Initiative for Focused Assessment Sonography for Trauma (FAST) Training among Junior Doctors at Dr. H. Abdul Moeloek General Hospital, Bandarlampung, Indonesia Ramadhian, Muhammad Ricky
Indonesian Community Empowerment Journal Vol. 4 No. 1 (2024): Indonesian Community Empowerment Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/icejournal.v4i1.59

Abstract

Focused assessment sonography for trauma (FAST) is a rapid bedside ultrasound examination crucial for the initial assessment of trauma patients. This study reports on a community service initiative aimed at improving FAST competency among young doctors at Dr. H. Abdul Moeloek General Hospital, Bandarlampung, Indonesia. A mixed-methods approach was employed. The program included: 1) A pre-training assessment of FAST knowledge and skills. 2) A structured FAST training curriculum with didactic lectures, hands-on scanning sessions, and case-based discussions. 3) A post-training assessment of FAST competency. 4) Qualitative feedback from participants to assess the program's impact. Thirty-two young doctors participated in the program. There was a significant improvement in FAST knowledge (pre-test mean: 45%; post-test mean: 82%) and scanning skills. Participants reported increased confidence in FAST utilization and its integration into their trauma assessment workflow. This community service initiative demonstrated the effectiveness of a structured FAST training program in enhancing the competency of young doctors in trauma care. Such programs have the potential to improve patient outcomes and contribute to the development of a skilled healthcare workforce.
Laporan Kasus Toksoplasmosis Serebri Pada Pasien HIV Yuniarti, Wulan; Ramadhian, Muhammad Ricky
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 11 (2024): Volume 11 Nomor 11
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i11.17470

Abstract

Infeksi susunan saraf pusat pada pasien HIV sering disebabkan oleh toksoplasmosis serebral, yaitu infeksi intrakranial oportunistik yang disebabkan oleh parasit Toxoplasma gondii. Pasien laki-laki mengeluh pandangan mata kabur, berbayang dan penglihatan terbatas sejak 1 bulan yang lalu. Pasien juga merasakan kedua matanya menjadi juling, nyeri kepala, demam hilang timbul tidak terlalu tinggi, dan pernah kejang. Pasien didiagnosis HIV sejak 2 bulan yang lalu dan sudah mengonsumsi obat ARV. Pada pemeriksaan fisik didapatkan lidah, mukosa rongga mulut, dan palatum ditemukan kandidiasis oral. Pemeriksaan saraf kranial didapatkan lipatan nasolabial tidak simetris, deviasi lidah ke kiri, wajah kesan tertarik ke sisi kiri dan sisi kanan tertinggal, didapatkan strabismus ke arah medial, dan lapang pandang sebelah kiri terganggu. Hasil pemeriksaan anti-Toxoplasma IgG positif. Hasil pemeriksaan CT-scan kepala dengan kontras menunjukkan lesi hipodens di lobus parietalis sinistra, meninges tampak enhanced fokal sugestif meningoencephalitis focal dan oedema cerebri. Pasien didiagnosis toksoplasmosis serebri berdasarkan gejala klinis, pencitraan, dan adanya IgG anti-T. gondii. Pasien diberikan cairan rumatan; obat-obatan simtomatis berupa injeksi phenytoin untuk profilaksis kejang, injeksi ranitidin, parasetamol, dan vitamin B6; dan obat-obatan kausatif seperti clindamycin, nystatin, kotrimoksazol, isoniazid, serta melanjutkan konsumsi ARV.
Literature Review : Antibacterial Activity of Various Mangrove Plant Species Extracts Balqis, Aurelia Corrinna; Kurniawaty, Evi; Maulana, Muhammad; Ramadhian, Muhammad Ricky
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1322

Abstract

The excessive and uncontrolled use of antibiotics has led to antibiotic resistance in pathogenic bacteria, which poses a serious threat to global health. To address this problem, alternative treatments from natural materials, such as mangrove plants, are starting to attract attention. Mangrove plants contain bioactive compounds that have antibacterial potential against various pathogenic bacteria. This study aims to review the antibacterial activity of various mangrove species in Indonesia. The method used was a literature study that included analysis of recent journals on the antibacterial activity of mangrove plants. The results showed that extracts from various mangrove species, such as Bruguiera gymnorrhiza, Rhizophora mucronata, and Heritiera littoralis, had significant antibacterial activity against Gram-positive and Gram-negative bacteria, such as Escherichia coli, Staphylococcus aureus, and Salmonella enterica. The zones of inhibition produced varied between 5 to 20 mm, with the ethanol extract from Bruguiera gymnorrhiza leaves showing the most potent activity. In addition, the assay results showed that the active compounds in the mangrove extracts had the ability to inhibit bacterial growth at low concentrations, indicating great potential for the development of more efficient and economical antibacterial drugs. This study provides evidence that mangrove plant extracts have potential as antibacterial agents that can be further developed for the treatment of infections caused by pathogenic bacteria, thus providing an effective alternative to overcome the problem of antibiotic resistance.
Co-Authors Ade Marantika Adisti, Fransiska Afriyani, Afriyani Akbar, Fareel Wahyu Anggraini, Dian Isti Aprina Adha Widiastini Asep Sukohar Atika Threenesia Balqis, Aurelia Corrinna Benny Bradley Pradana Pangaribuan Betta Kurniawan, Betta Daulay, Suryani Agustina Delvi Rusitaini Putri Diana Mayasari Efrida Warganegara Ekki Pirmansyah Ermin Rachmawati Ety Apriliana Ety Apriliana Falamy, Ryan Farhry Alvini Rahmania Fitria, Aghniya Rizqy George Pestalozi Gultom, Dea Debora Romauli Hanna Mutiara, Hanna Hendra Tarigan Sibero Intanri Kurniati Iswandi Darwis Jhons Fatriyadi Suwandi Khairil Pahmi Khairil Pahmi Khairun Nisa Kurniawaty, Evi Lusina, Septia Eva M Sidratullah Marcellia, Selvi Meta Gapila Muhammad Maulana Muhammad Taupik Nadhifa, Farin Nasution, Salwa Salsabila Nora Ramkita Novita Carolia Nurul Sahana Rahmadhini Nurul Utami Oktadoni Saputra, Oktadoni Putri, Abrila Tamara Ratna, Maya Ganda Reni Zuraida Rifda Khairunnisa Rika Lisiswanti Risti Graharti Septiani, Linda Shinta Nareswari, Shinta Suryadi Islami Sutarto Sutarto Syafira Salsabila Syazili Mustofa Tri Umiana Sholeha Tri Umiana Soleha Tri Umiana Soleha Yuniarti, Wulan Yuningrum, Hesti