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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL DAUN KELENGKENG (Euphoria longan (L) Steud.) DENGAN METODE PENANGKAPAN RADIKAL 2,2â-DIFENIL-1-PIKRILHIDRAZIL Widyasari, Erlinda; Salamah, Nina
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The degenerative diseases is caused by endogenous antioxidant cannot neutraliced from increased concentration of free radicals, therefore it is necessary to consume antioxidant from the outside ofbody for neutralizing and destroying free radicals. The aim of this research is to evaluate the antioxidant activity of methanolic extract of longan leaves. The experiment of antioxidant activity from extract longan leaves uses the scavenging assay using 2,2â-diphenyl-1-pycrylhydrazyl (DPPH) method and quersetin as positive control. The analytical result is processed using linear regression methode in order to get ES50 value. The results of research showed that theincreasing concentration ofÂ methanolic extract, and quercetin causes the higher percentage of DPPH radical scavenging. The ES50 values of methanolic extract and quercetin obtained are 40.32 Âµg/ml and 2.48 Âµg/ml respectively.

EKSTRAK HEKSAN BIJI JINTAN HITAM (Nigella sativa L) MENINGKATKAN AKTIVITAS FAGOSITOSIS MAKROFAG TIKUS BETINA GALUR SD (Sprague Dawley) YANG DIINDUKSI DMBA (7,12Dimetilbenz(Î±)antrasen) SECARA IN VITRO Akrom, Akrom; Fatimah, Fatimah
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Previous research has shown that black cumin seed oil is as an immunomodulator, but the mechanism MBJH as an immunomodulator in DMBA-induced macrophage unknown. A study to determine the effects of EHBJH on the activities of SD rat peritoneal macrophage phagocytosis induced DMBA has been conducted. This study was conducted on 10 female Sprague Dawley rats were divided into two groups, namely 5 mice without any treatment group and 5 mice DMBA DMBA treatment groups. Once a week administration of 15 mg DMBA of mice,rats dissected and taken peritonealnya fluid for isolation of macrophages to be cultured for 24 hours. The peritoneal macrophages were given hexane BJH (Nigella sativa Lour) as much as 1 mg/mL, 5 mg/mL, 25 mg/mL, and were given a standard timokuinon for each group without induction DMBA and DMBA treatment groups. Macrophages were incubated for 2 hours back. Phagocytosis test is done by adding the latex particles on cultured macrophages and Giemsa staining. Data percentage of macrophages that eat latex and phagocytosis index were analyzed using the Kolmogorov-Smirnov test followed by ANOVA and LSD test with a 95% confidence level. The results showed that the activity and phagocytosis index DMBA -induced macrophages that is not greater than the index of activity and macrophage phagocytosis induced macrophages (p<0.05). A group of 25 mg/mL EHBJH have activity and phagocytosis index is highest when compared with the other treatment group (p<0.05). Â Conclusion: The study showed that the hexane BJH (Nigella sativa Lour) can improve macrophage phagocytic activity of female rats Sprague Dawley strain.

PENINGKATAN SISTEM IMUN OLEH KOMBINASI EKSTRAK ETANOL DAUN AWAR â AWAR (Ficus septica burm. F) DAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera) SEBAGAI KO-KEMOTERAPI KANKER PADA TIKUS PUTIH BETINA GALUR SPRAGUE DAWLEY YANG DIINDUKSI DOKSORUBISIN Anovia, Rizka Angerti; Sari, Dewi Indah; Yazin, Annisa Hardikasari; Ismayani, Ulfa; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Use of the drug doxorubicin for cancer therapy causes decreasing of immune system reported. Leaves of Ficus septica Burm. F and leaves of Moringa oleifera as immunostimulatory agents. The purpose of this study, among others, determine the combined effects of ethanol extract of Ficus septica Burm. F leaves and ethanol extract of Moringa oleifera leaves as co-chemotherapy for in female rats Sprague Dawley strain induced doxorubicin. Eighteen Sprague Dawley rats were divided into six treatment groups, normal group was given 0.9% NaCl 10ml / kgBB, positive control group were given by doxorubicin with dose of 4.67 mg / kgBB, single-dose treatment group were each given ethanol extract of Ficus septica Burm F leaves dose of 750 mg / kgBB and ethanol extract of Moringa oleifera leaves 500 mg / kgBB, treatment groups were given by combination of ethanol extract Ficus septica Burm. F leaves and Moringa oleifera leaves with a dose of 1.25 g / kgBB and a dose of 1 , 75 g / kgBB. treatment carried out for 7 days. On days 1 and 4 of each treatment groups except the normal group induced by doxorubicin 4.67 mg / kgBB intramuscularly. Blood sampling performed on day 0 and 7 th for lymphocytes CD3+ and lymphocytes CD8+ test. The results showed that the combination of ethanol extract Ficus septica burm. F leaves and Moringa oleifera leaves dose of 1.25 g / kgBB and the dose of 1.75 g / kgBB can enhanched immune system relative small which was not statistically significantly different (p> 0.05). However, a single dose of ethanol extract Moringa oleifera leaves dose of 500 mg/kg have immunostimulatory activity as lymphocytes CD3+ and lymphocytes CD8+ were more effective than a single dose of ethanol extract of Ficus septica Burm. F leaves dose of 750 mg/kgBB.

EFEK HEPATOPROTEKTIF EKSTRAK METANOL JAHE MERAH (Zingiber officinale Roscoe) PADA MENCIT JANTAN YANG DIINDUKSI CCl4 Bachri, Moch Saiful
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

MeOH extract of Zingiber officinale Roscoe (ZO) were investigated forhepatoprotective effect at the doses (p.o) of 100 and 200 mg/kg body weight using CCl4induction method. Male Swiss mouse (25Â±1,5 g) were treated with ZO doses 100 and200 mg/kg bw and Sillymarin (100 mg/kg bw) for two week before treatment with asingle dose of CCl4, 0.5 ml/kg bw, intraperitoneally. The mouse were sacrifactivity ofSGPT-SGOT. The study showed the activity of SGPT of MeOH extract of ZO doses 100mg/kg bw and 200 mg/kg bw, Sillymarin, control and normal groups are (34,51Â±5,34)(27,38Â±4,28) (27,26Â±1,06) (36,61Â±1,87) dan (25,37Â±2,01I) U/L. respectively. Whilethe activity of SGOT of MeOH extract of ZO doses 100 mg/kg bw and 200 mg/kg bw,Sillymarin, control and normal groups are (88,88Â±0,94) (83,88Â±3,91) (83,99Â±7,24)(92,97Â±8,16) (82,99Â±3,97) U/L.respectively. MeOH extract of ZO dose 200 mg/kg BWand Sillymarinsignificantly (p < 0,05) decrease the activities two enzymes (SGPT andSGOT). The results showed MeOH extract Zingiber officinale Roscoe hashepatoprotective effect.

EFEK ANTI INFLAMASI KITOSAN DARI CANGKANG UDANG PANTAI TRISIK PADA TIKUS MODEL RHEUMATOID ARTHRITIS Hanifah, Nurul; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This research was conducted to investigate the effect of chitosan as anti-inflammatory in rheumatoid arthritic in reduction of paw edema using plethysmometer. Chitosan was isolated from the shrimp shell on the Trisik Coastal were administered orally on 17-32th day with CMC 0,5%. This research using repeated measure design. To evaluate anti-inflammatory effect of the suspension, an arthritic rats model was developed using Complete Freund`s Adjuvant (CFA) on 1-16th day. In addition, the research was divided into 5 groups (n=6) including normal control groups, positive control groups, negative control groups, 1 group were treated by chitosan suspension at 50 mg/200 gram BW doses and the other group were treated by chitosan suspension at 100 mg/200 gram BW doses. The reduction of paw edema were determined every 3 day after 17th days then analyzed using general linear repeated measure test (p<0,05). The results showed that paw edema of arthritic rats were evidently decreased by chitosan suspension at 100 mg/200 gram BW doses (142,66%) better than chitosan suspensionÂ at 50 mg/200 gram BW doses (117,23%). In conclusion, the chitosan from shrimp shell of Trisik coastal is found to be effective as anti-inflammatory in rheumatoid arthritic rats model.

EFEK TOKSISITAS FRAKSI ETIL ASETAT AKAR SENGGANI (Melastoma affine D.Don ) PADA ORGAN HEPAR, GINJAL DAN TESTIS Bachri, Moch Saiful
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Melastoma affine (MA) is a medicinal plant commonly found in south East Asiaand China. The aim of the study is to investigate the toxicity effect of MA toward vitalorgans. Thirty two Wistar adult male rats were divided into five groups consisting of sixanimals each the rats in group except control group, eight animals. The rats in group I(control) were administered 0.5% CMC Na orally, while CMC Na suspension of ethylacetate fraction of MA root (62.5, 125, 250,and 500 mg/kg body weight) were given tothe II, III, IV and V groups, respectively. The CMC Na suspensions of ethyl acetatefraction of MA root were administered for 22 days. Rats were sacrificed at the 23th day.Liver, kidney, testis were collected for histopathological observation. The observationresult on liver and kidney showed no difference compare to control groups, meanwhileon testis, the administration of ethyl acetate fraction of MA root at dose (250, 500 mg/kgbody weight) caused necrosis on seminiferus tubules and decreasing sperm counting.The conclusion, administration of ethyl acetate fraction of MA root caused toxicityeffect on testis with necrosis on seminiferus tubules.

ANALISIS COST-EFFECTIVENESS PENGGUNAAN SEFTRIAKSON DAN SEFOTAKSIM PADA TERAPI PROFILAKSIS APENDEKTOMI DI RS PKU MUHAMMADIYAH YOGYAKARTA TAHUN 2006-2007 Muhartati, Sri Aisyah; Muhlis, Muh; Supadmi, Woro
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cost-effectiveness analysis of ceftriaxone and cefotaxim prophylactic antibioticsof appendectomy in PKU Muhammadiyah Hospital Yogyakarta from January 2006 toDecember 2007 has been studied. This study was aimed to explore the direct medicalcost, cost-effectiveness ratio, and determine whether drugs of ceftriaxone or cefotaximwhose had more effective cost. This study was carried out by descriptive retrospectivedesign. The population was all inpatients of appendectomy getting prophylaxisantibiotics with either ceftriaxon or cefotaxim therapy in PKU MuhammadiyahHospital Yogyakarta. The population target were the appendectomy patients in thethird class of PKU Muhammadiyah Hospital Yogyakarta from January 2006 toDecember 2007. The result indicated that direct medical cost of the patients gettingceftriaxone therapy was Rp 422.257, whereas the cost of the patients getting cefotaximtherapy was Rp 487.680. Cost-effectiveness ratio of whom getting ceftriaxone therapywas Rp 105.564/day, whereas the ratio of whom getting cefotaxim therapy was Rp162.560. Finally, it have not been able to determine which drug is more cost-effective.

EFEK EKSTRAK ETANOL GANGGANG HIJAU (Ulva Lactuca L) TERHADAP BERAT BADAN DAN KADAR TRIGLISERIDA TIKUS JANTAN YANG DIBERI DIET LEMAK TINGGI Widyaningsih, Wahyu; Salamah, Nina
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Previous studies showed the potential of melatonin of green algae ( Ulva lactuca L ) to reduce the risk of coronary heart disease with the activity of antihiperlipidemia. Obesity and hiperlipidemia were the risk factor of degenerative diseases such as heart disease. This research aims was explore the effect of ethanol extract of green algae against weight, consumption of rat feed test white male rat were given high fat diet . Research was started with extraction green algae with ethanol 96 % to obtained concentrated extract. The extract was tested to wistar rats age of 2 months. Animals test divided into 6 group. Group I was control group, treated with high fat diet of lard 2 ml / 200g BW, of group II given high fat diet and simvastatin, group III, IV and V given high fat diet and green algae extract doses 50 mg/ Kg BW, 100 mg/Kg BW and 200 mg/ Kg BW. Group VI is the control group without diet fat high. Treatment was conducted over 28 days. Measuring normal of his weight every five day for 28 days and in measuring consumption feed with measure weight feed the rest of feed early 20 g. The difference of data weight rats per 5 days and consumption fodder for 28 days counted area under curve ( AUC ) from curves time versus weight. The measurement of triglycerides levels. The result showed the high fat diet with lard 2 ml / 200g BW for 28 days reduce weight and consumption feed mice in a significantly than control without high fat diet. The treatment with extract ethanol dose of 50 , 100 and 200 mg / Kg BW did not reduce weight, feed consumption, triglyceride levelsofÂ mice were given high fat diet.

FORMULASI VANISHING CREAM MINYAK ATSIRI SERE (Cymbopogon citratus (DC) Stapf) DAN UJI SIFAT FISIKNYA SERTA UJI AKTIVITAS REPELAN TERHADAP NYAMUK Aedes aegypti BETINA Ikhsanudin, Azis
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Essential oil of sere leaf has been proven as repellant against mosquitoes. Thisresearch aims to know about the influence of concentration sere essential oil(Cymbopogon citratus (DC) Stapf) in a vanishing cream bases to physical propertiesand repellant testing against female Aedes aegypti mosquitoes. Essential oil of sere(Cymbopogon citratus (DC) Stapf) was isolated with steam water distillation and wasevaluated the organoleptic appearance and refraction index. Furthermore, theessential oils were formulated in a vanishing cream base with the different formulas,contain formula I: 20% v/w; formula II: 30% v/ w and formula III: 40% v / w. Then thisthree formulas were evaluated for physical properties including adhesive, dispersiveand the repellent activity testing against female Aedes aegypti mosquitoes amount oftwenty mosquitoes per cage while seven female volunteers as the probandus. The datahave been analyzed using Kolmogorov-Smirnov test and t-test (Main-Whitney), with95% signifancy level. The results were obtained that the adhesion of formula I: 0.90 Â±0.029 seconds, formula II: 0.60 Â± 0.017 seconds, formula III: 0.46 Â± 0.040 seconds,while the dispersion of formula I is 64.89 Â± 4.559 cm2, the formula II is 64.71 Â± 4.600 cm2 and the formula III is 54.96 Â± 14.783 cm 2. The longest time repellent was formula IIIshowed 3014.2 Â± 20.163 seconds or 50.23 minutes. It was concluded that the increase ofconcentration essential oils of sere leaf followed by the increase of repellant activity.

KUALITAS PELAYANAN FARMASI BERDASARKAN WAKTU PENYELESAIAN RESEP DI RUMAH SAKIT Rusdiana, Nita; Wijayanti, Rahayu; Wahyuni, Sri
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Based on Standard of Pharmaceutical Quality in Hospitals, there are methods are applied to distribute pharmaceuticals. One outpatient care efforts is to obtain medication prescribed by a doctor in a short time. The quality of outpatient pharmacy services as measured by the time of complete prescription at the pharmacy installation hospitals are based on reliability, responsiveness, assurance, empathy and tangibles. The study use cross-sectionalâs method, which is done by January-February in 2015, to analyze pharmacy quality standard and time of complete prescription. The data used in this study are primary data. This study was used sample of 157 respondents for quetioners and 787 outpatients prescriptions. The results showed that the highest satisfaction turn around time is 13 minutes. For the five variables tested showed that the responsiveness had the highest scores of 3.18 and tangibles has the lowest score of 2,53. Conclusion, time of complete prescription less than 13 minutes and supported by quetioners shows the highest variables of responsiveness at 3,29 are agreed that time to wait is not too long.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Kota yogyakarta,

Daerah istimewa yogyakarta

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