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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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ANALISIS SGPT-SGOT EKSTRAK ETANOL DAGING BUAH PARE (Momordica charantia L.) PADA TIKUS JANTAN PUTIH GALUR WISTAR Nugrahani, Dwi Ari; Sofia, Vivi
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The traditional medicine in Indonesia which is the cultural heritage and hasbecome an integral part of the life of the nation Indonesia, want to be employed in theformal health care system. As the circulation of drugs in general terms, traditionalmedicine should fulfill the requirements of quality, safe, and efficacious. This studyaims to analyze the levels of SGPT, SGOT of suspension of the ethanol extract of bittermelon fruit (Momordica charantia L.) by orally. The study was conducted using a whitemale Wistar rats amounted to 36 animals, divided into 6 groups. Each group consistedof 6 male white rats. Group I (control) were given 0.5% CMC solution of 2.5 ml/200 gBW. Group II was given a suspension dosage doses of bitter melon fruit extract ethanol0.5 g/kg, then consecutive group III with the test preparation doses of 1 g/kg, the testpreparation group IV were given a dose of 2 g/kg, group V was given dosage test doseof 4 g/kg, and group VI were given the highest dose of the test preparation 8 g/kg. Theresults of acute toxicity tests on white male Wistar rats showed that administration ofethanol extract of peroral dosage suspension pare (Momordica charantia L.) singledose on white male Wistar rats from the dose of 0.5 g/kg until a dose of 8 g/kg did notsignificantly influence the value of SGPT, SGOT.

HUBUNGAN JUMLAH OBAT YANG DIRESEPKAN DENGAN POTENSIAL PENGGUNAAN OBAT YANG TIDAK TEPAT PADA PASIEN PENYAKIT GINJAL KRONIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Mulyani, Evi; Darmawan, Endang; Mustofa, Mustofa
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Age-related decrease of physiological function caused some healt problem in elderly, so the problem of treatment in the elderly is also not uncommon found as polypharmacy and Potentially Inappropriate medication (PIMs). The purpose of this study to determine the relationship of the number of drug prescribed with PIMs in elderly patients with CKD in PKU Muhammadiyah Yogyakarta Hospital. PIMs identification by STOPP criteria, while the number of drugs prescribed seen by drugs control books. To assess the patients medical history by interviews and search records. Patient characteristics were analyzed descriptively, correlations between variables were analyzed with chi square test. From 53 samples, PIMs identified 17% and average one sample got one PIMs, while of the 410 drugs that prescribed average patient receivingÂ 8 drugs (> 6). Bivariate test results showed that no significant relationship between the number of drug prescribed with PIMs.

KAJIAN PERESEPAN ANTIBIOTIKA PADA PASIEN DEWASA DI SALAH SATU PUSKESMAS KOTA YOGYAKARTA PERIODE JANUARI â APRIL 2010 Muhlis, Muhammad
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

To achieve optimal therapy of antibiotics isonefactor supporting the accuracy inprescribing antibiotics errors in prescribing can cause lack of rationality in the use ofantibiotics . Antibiotic was commonly used in the clinicor in private practice doctorsbut also in the centers of other health services such as polyclinics and hospitals theaim of this study is to assess antibiotic prescribing patterns and the level ofrationality the use of antibiotics in adult patients at one center of Yogyakarta on thebasis of data prescriptions. This Study used descriptive design with retrospective datacollection The data was collected from January to April 2010 Data source is aprescription of antibiotics in adult patients We analyzed the antibiotics prescription inthe study based on the selection appropriate dos age frequency and duration. Werecruited 320 patients receive ing antibiotics. The of antibiotics used were amoxicillin64.5 % ampicillin 11.3 % kontrimoksazol 15.9% chloramphenicol 0.6 % metronidazole2.8 % and etracycline 49 % Most of the Patients received a single antibiotic 97.9 %),while the remaining patients received a combination of antibiotics 2.1 % Allprescribing meet appropriate dosage, and frequency except cotrimoxazole (98%) andampicillin 49%). All prescriptions (100%) improper duration. In general antibioticsprescription for adult patients at one health center in Yogyakarta City is comply withthe standard use of antibiotics in Public Health Centers. However, the duration ofantibiotic utilization still became the perspective of the health providers in PublicHealth Centers.

VALIDASI ST EUROPEAN QUALITY OF LIFE-5 DIMENSIONS (EQ-5D) VERSI INDONESIA PADA PASIEN HIPERTENSI DI PUSKESMAS KOTAGEDE II YOGYAKARTA Sari, Andriana; Yuni Lestari, Nidia; Aryani Perwitasari, Dyah
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hypertension is a major risk factor for the occurrence of deaths from non-communicable diseases in the world. In the World Health Statistics 2012, WHO reported that approximately 51% of deaths from stroke and 45% of coronary heart disease due to hypertension. Patients with obsesitas, hypertension, and diabetes can worsen patientâs quality of life both physically and mental status. This study aims to assess the quality of life by the European Quality of Life-5 Dimensions (EQ-5D) questionnaire. This study aims to determine the validity and reliability of the EQ-5D in Indonesian version as an instrument for measuring the quality of life of patients with hypertension in the Health Center Kotagede II Yogyakarta. The method of this study was descriptive observational. Data were collected using a questionnaire conducted at a particular time. The instrument used in this study is the EQ-5D which has been translated into Indonesian. Affordable population in this study were all patients with hypertension in Health Center Kotagede II Yogyakarta at May to June 2014. The sample in this study are in accordance with the criteria for inclusion and exclusion criteria. Analysis of the validity was constructs validity with Pearson method. Test reliability was Cronbachs alpha coefficient. From the data analysis for 51 patients Hypertension Pearson correlation coefficient obtained results are above 0.30, so it can be concluded instrument EQ-5D questionnaire Indonesian version is valid. Results CornbachsÎ± is 0718 so it can be concluded instrument EQ-5D questionnaire Indonesian version is reliable.

ISOLASI DAN IDENTIFIKASI ZAT AKTIF EKSTRAK METANOL RIMPANG KUNYIT PUTIH (Curcuma mangga Val) FRAKSI ETIL ASETAT kusmiyati, Kusmiyati; Aznam, Nurfina; Handayani, Sri
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma mangga contains a lot of variety of active compound which use as traditional medicines. This research aimed to isolated and determinated the active compound of methanol extract Curcuma mangga rhizomes of ethyl acetate fraction and its rendemen. Amount of 1000 g Curcuma mangga rhizomes was macerated with methanol solvent at room temperature for 24 hours. Remaceration was done seventh times. Methanol extract was fractionated with ethyl acetate. About 39,05 g of concentrated ethyl acetate fraction was then separated by Column Chromatography. According to the similarity of UV-Vis spectra and GC-MS, active compound in methanol extract Curcuma mangga rhizomes ethyl acetate fraction is predicted as Labda-8(17),12-dien-15,16-dial with rendemen amount of 0,00149 %.

REAKSI PENATAAN ULANG FRIES PADA EUGENIL ASETAT kusmiyati, kusmiyati; Matsjeh, Sabirin; Jumina, Jumina
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Fries Rearrangement of eugenyl acetate in order to study allilic substituentgroup influence has been done. Fries rearrangement of eugenyl acetate was done byheating at 120Â°C for 3 hours under AlCl3, dichloromethane as the catalyst and solvent,respectively. The structure of the compound was identified using Infra Redspectrometry (IR) and GC-MS. The result of te research showed that rearrangementfries of eugenyl acetate are not formed, but yielded lightly brown oil of dimmer.

AKTIVITAS ANTIFUNGI EKSTRAK ETANOL BATANG BINAHONG (Anredera cordifolia (Tenore) Steen.) TERHADAP Candida albicans SERTA SKRINING FITOKIMIA Kumalasari, Eka; Sulistyani, Nanik
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Anredera cordifolia is a plantused as antifungal empirically. This study aims tofind out the antifungal activity of ethanol extract of A. cordifolia stem against C.albicans and to identify the chemical subtance groups of the ethanol extract of A.cordifolia. The A. cordifolia stem was extracted by maceration method using ethanol 70% as solvent. The antifungal assay was done using liquid dilution method with variousconcentrations of (85; 86; 87; 88; 89; 90% w/v). The mixtures of extract and suspensionof C. albicans in CYG (Casein Yeast Glucose) medium and the media were incubated at37ÂºC for 18-24 hours to determine Minimum Inhibitor Conceration (MIC).Theculturewas streaked on SDA (Sabouraud Dextrose Agar) medium to determineMinimum Fungicidal Conceration (MFC). Chromatographic test and tube test weredone to identify the chemical substances of A. cordifolia extract. The result showed thatthe MIC could not be determined because the extract was brownish and turbid while theMFC of A. cordifolia stem ethanolic extract was 86% w/v. The result of thephytochemical screening with tube test and the thin layer chromatography test showedthat the extract of A. cordifolia stem contained flavonoids, polyphenols, and saponin.

EVALUASI UJI IRITASI DAN UJI SIFAT FISIK SEDIAAN EMULGEL MINYAK ATSIRI BUNGA CENGKEH (Syzigium aromaticum) Sari, Delia Komala; Sugihartini, Nining; Yuwono, Tedjo
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Inflammation is the human bodys response to a tissue damage as indicated by an increase of vascular permeability. One of the natural substances that can be used to treat inflammation is clove oil (MABC). This study aimed to evaluate the physical properties and MABC emulgel irritation test (Syzygium aromaticum). This experimental study was initiated by the emulgel formulation with three kinds of formula, with each formula contains MABC levels of 10% (F1), 12.5% (F2), and 15% (F3). The physical tests for emulgel was done including pH, spreading test and adhesive test and irritation test in guinea pigs using Draize test method. Statistical analysis by t test with a level of confidence 95% was conducted to detect a significant differences between the treatment groups. The emulgel formula with a concentration of 10%, 12.5% and 15% were physically stable, moreover the dispersive power test for each formula showed normal distribution data (p>0.05) and homogeneous (p>0.05), ANOVA test results obtained significantly different results in each formula (p<0.05), whereas the stickiness test results for each formula more than 30 minutes with pH 6. The results of irritation test by using Draize test Â method, indicated that each formula did not show any irritant effect.

PENGARUH PEMAKAIAN KOMBINASI MINYAK JINTEN HITAM (Nigella sativa) dan MADU (Apis mellifera) SEBAGAI ANTI-ACNE SECARA TOPIKAL PADA SUKARELAWAN WANITA Anjani, Baiq Lenysia Puspita; Hati, Ari Sabar; Az-Zahra, Halimah; Rahmawanti, Fitri; Darmawan, Endang
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Acne mostly affects teenagers with prevalence of 85%. Changing habits of cosmetics may affect the incidence of acne vulgaris. Healing acne can use herbal ingredients such as black cumin oil and honey. Black cumin oil effective for treating mild acne vulgaris and moderate acne vulgaris. Honey has property that can kill the bacteria Propionibacterium acnes. Â The purpose of this study is to determine the anti-acne activity in use of black cumin oil and honey combination in 1:1 ratio for 14 days in women. This study included experimental study with pre-post treatment study design. There are 2 groups, control group (six women volunteer) and treatment group (six women volunteer). For 14 days, control group use chemical drugs anti-acne, while treatment group use black cumin oil and honey combination in 1:1 ratio. Analysis of data used independent sample t-test with confidence interval 95%. The results show that treatment group of women who use black cumin oil and honey combination in 1:1 ratio for 14 days compared with the control group of women there is no difference in reducing the number of parameters black blackheads, white blackheads, papules, pustules, hyperpigmentation, erythema, pruritis, xerosis, desquamation, and sunburn with a value of p> 0.05. The conclusion of this study is the use black cumin oil and honey combination in 1:1 ratio for 14 days has effect as Â anti-acne in women, but statistically not significant.Â

UJI EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KACAPIRING (Gardenia augusta, Merr) PADA TIKUS PUTIH JANTAN GALUR WISTAR Baroroh, Farida; Aznam, Nurfina; Susanti, Hari
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kacapiring leaf (Gardenia augustaÂ Merr.) was often used in traditional drugs fortreatment diabetes mellitus. This research aim to know the antihiperglycemic effectethanolic extract of kacapiring leaf on white rats male strain of Wistar and how muchantihiperglycemic effect compared with glibenklamid. This study used oral glucosetolerance test method with loading glucose 4,5 g/kgW. Tested animal where 24 whitemale rats strain of Wistar age 2-3 months with weight 180-250 gram, devided into 4groups, each groups consist of 6 rats. Group I was as negative control group givenCMC-Na 1%, group II was as positive control group given glibenklamid dose 1,35mg/kgBB, group III and IV where given ethanolic extract of kacapiring leaf dose 500mg/kgBB and 250 mg/kgBB. Glibenklamid and exstract are given orally 60 minutesbefore glucose. Blood was taken from orbitalis sinus at minute (-90), (-60), 0, 30, 60,120, 180, 240, and 300. Blood glucose level was determined with GOD PAP enzymaticmethod, absorbance was observed using spectrophotometer at 500 nm. The result of thestudy was performed by giving ethanolic extract of kacapiring leaf dose 500 mg/kgWand 250 mg/kgW had antihiperglycemic effect. Ethanolic extract of kacapiring leaf dose500 mg/kgW and 250 mg/kgW could reduce blood glucoce level 58,97% and 80,60%compared with glibenklamid dose 1,35 mg/kgW could reduce blood glucoce level73,93%.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA