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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 796 Documents

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PENETAPAN KADAR FENOLIK TOTAL EKSTRAK METANOL KELOPAK BUNGA ROSELLA MERAH (Hibiscus sabdariffa Linn) DENGAN VARIASI TEMPAT TUMBUH SECARA SPEKTROFOTOMETRI Alfian, Riza; Susanti, Hari
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The purpose of this research is to determine the total phenolic content of Hibiscussabdariffa calyx in variations of growing area. Red Rosell calyxs were collected fromGlagah, Kediri, and Samigaluh. Phenolic compounds of Hibiscus sabdariffa calyx wereextracted using maceration method with methanol. Total phenolics content weredetermined using visible spectrophotometry method with Folin Ciocalteau reagent. Theprinciple of this method is the formation of blue complex compound fromphospomolybdate-phosphotungstate reduced by phenolic compound in the basiccondition, which can be measured by spectrophotometry. Galic acid was used ascomperator in this research. Total phenolic content in red calyx Glagah, Kediri andSamigaluh were respectively 1.40 g GAE/100 g extract, SD 0.06 (n=12), 1.41 gGAE/100 g extract, SD 0.07 (n=12) dan 2.12 g GAE/100 g extract, SD 0.05 (n=15).Based on this results it could be concluded that growing area affected total phenoliccontent in the methanol extract of red calyx Rosell.

AKTIVITAS EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) PADA RADIAL ARM MAZE DAN PASIVE AVOIDANCE TEST TIKUS MODEL DEMENSIA Prasetya, Didik Yuni; Yuliani, Sapto
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma xanthorrhiza Roxb. is a plant containing curcumin. Curcumin has been shown toreduce oxidative damage and memory deficits associated with aging. The aim of the researchwas to know the effect of Curcuma xanthorrhiza Roxb. rhizome ethanol extract to memoryfunction on Wistar rats induced by trimethyltin. The research design was post test onlycontrolled group with 42 rats divided into 6 groups, Each group consist of 7 rats. Group I(healthy controls) were given a solution of 0.5% CMC-Na orally. Group II (negative control)were given a solution of 0.5% CMC-Na orally. Group III, IV, and V were given Curcuma xanthorrhiza Roxb. extract each 120 mg/kgBW, 240 mg/kgBW, and 480 mg/kgBW orally.Group VI (positive control) were given piracetam 500 mg/kgBW intraperitoneally. All groupswere given trimethyltin intraperitoneally except group I. Data indicating memory function wereobtained from radial maze test and passive avoidance test. Radial maze test data were analyzedby ANOVA followed by LSD test, while the passive avoidance test data were analyzed with theKruskal Wallis test followed by Mann-Whitney test. In conclusion, ethanol extract oftemulawak rhizome (Curcuma xanthorrhiza Roxb.) at doses of 120 mg/kgBW, 240 mg/kgBWand 480 mg/kgBW can prevent memory function decline on Wistar rats induced bytrimethyltin.

EVALUASI ADVERSE DRUG REACTION ANTIDIABETES BERDASARKAN ALGORITMA NARANJO DI BANGSAL RAWAT INAP RS PKU MUHAMMADIYAH YOGYAKARTA PERIODE DESEMBER 2011-JANUARI 2012 Fitriyani, Fitriyani; Supadmi, Woro
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This study is aimed to evaluated the antidiabetic adverse reaction using theNaranjo algorithm for diabetes mellitus patients in PKU Muhammadiyah HospitalYogyakarta for period December 2011-January 2012. This study used descriptivemethod. The data was collected from the medical record and interviews from patientswith diabetes mellitus who had used antidiabetic drugs after 3 days. The data wereanalyzed using the Naranjo algorithm. The results showed that during the periodDecember 2011-January 2012 there were 17 male patients and 14 female patients withdiabetes mellitus. The antidiabetic drugs that used to patients were metformin,metformin combined with glibenclamide, metformin combined with insulin, thecombination with insulin and insulin glimepirid. Then, the study showed that Naranjoalgorithm method was not suitable for evaluation the antidiabetic adverse reaction fordiabetes mellitus patients in PKU Muhammadiyah Hospital in Yogyakarta for periodDecember 2011-January 2012, because from 10 questions on the Naranjo algorithmthere were only 4 questions that could be answered. Its because there was not data toanswer questions. Research on the side effects cohort method should be done with theinterview and patient monitoring.

PENETAPAN KADAR ASAM BENZOAT DALAM BEBERAPA MERK DAGANG MINUMAN RINGAN SECARA SPEKTROFOTOMETRI ULTRAVIOLET Wati, Wahyu Irna; Guntarti, Any
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Benzoic acid is one of the synthetic preservatives, work effectively at pH 2.5 to4.0, therefore it is widely used in acidic food or drink. This study aims to determinebenzoic acid content in some soft drink products, their conformity with Permenkes RINo.722/Menkes/Per/IX/88 on food additives, and to find out if there were any varianceof benzoid acid content in a different kinds of soft drink products.Determination of benzoid acid levels was performed by ultravioletspectrophotometry following solvent extraction of the benzoid acid with chloroform.Qualitatively, it was found that all of the sample contained benzoid acid. Quantitatively,the amount of benzoid acid in sample A was 227,73 mg/kg of materials; sample B was182,38 mg/kg of materials; sampel C was 259,52 mg/kg of materials; sample D was325,01 mg/kg of materials; sample E was 357,33 mg/kg of material. The resultindicated that there were variance of benzoid acid content in different soft drinkproducts. The use of benzoic acid in soft drinks was lower compaired to that ofPermenkes RI No.722/Menkes/Per/IX/88 (600 mg/kg of materials).

EFEK PROTEKTIF EKSTRAK ETANOL HERBA PEGAGAN (Centella asiatica (L.) Urban) TERHADAP PEMBENTUKAN KATARAK TIKUS WISTAR YANG DIINDUKSI SODIUM SELENIT Yuliani, Sapto
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cataract is one of the eye pathology that can cause blindness. Oxidative stresshas been identified as an initiating factor of cataract. The objective research was tostudy the protective effect of ethanol extract Centela asiatica toward cataract formationon Wistar rat induced by sodium selenite. Cataract was induced in 9 days old Wistarrat, which 5 groups of 7 each. Group I got injection aquadest and the test groups gotinjection CMC-na (group II), vitamin E dose 378 IU/kg bw (group III), ethanol extractGotu cola herb dose 100 mg/kg bw (group IV), and 200 mg/kg bw (group V), 400mg/kgbw, subcutaneously, respectively, for 3 days. After 4 hours, all rats got injection asingle dose 50 ug/kg of BW sodium selenite intraperitoneally. Then eyes were observedin all groups on postnatal day 16, when the eyes of the rat first opened. Then percentageof cataract incidence were calculated. Finally, rats were executed and eyes were takenfor lens histophatological analyses with hematoxiline eosin staining. Based onmacroscopic and microscopic analyses it can be concluded that ethano extract ofCentella asiatica had protective effect toward cataract formation on Wistar rat inducedby sodium selenite. The least cataract incidence was showed at dose 200 mg/kg bw.

PEMURNIAN ETANOL HASIL FERMENTASI KULIT UMBI SINGKONG (Manihot Utilissima Pohl) DARI LIMBAH INDUSTRI KERUPUK SANJAI DI KOTA BUKITTINGGI BERDASARKAN SUHU DAN WAKTU DESTILASI Marjoni, Mhd. Riza
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Bukittinggi city with approximately 132 industry crackers Sanjai spend 300-500 kg ofcassava per day for each industry. Solid waste production process results Sanjai crackers thisone is skin cassava. Cassavaâs peel produces 15-20% carbohydrate content of 68-85% of theweight of the bulb, so it has great potential to be converted into bioethanol.Carbohydrates in the tuber peel can be processed into ethanol by fermentation and for separatingethanol from itâs mixture used method of distillation. Distillation temperature and time used affects the quality and quantity of bioethanol produced. This study aims to determine the besttime and temperature distillation to produce bioethanol at the highest levels. Ethanol contentanalysis was conducted using the specific gravity using line arregression equation and Tablegravity of Indonesian Pharmacopoeia. The results showed that the highest levels of ethanoldistillate obtained in the distillation temperature of 71o C for 5 hours is 16.60% using regressionmethods and 14.1% according to Table Pharmacopoeia with yield ranging between 2.30%-5.80% and the efficiency of distillation 28, 94% -57.50%. Time and temperature distillationhave a real impact on the levels of ethanol produced atthe level of 5%.

STUDI KELARUTAN PROPAGERMANIUM DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI Putranti, Widyasari; Martodihardjo, Suwaldi; Lukitaningsih, Endang
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Propagermanium, a synthetic organic compound of germanium is known as Î²- or biscarboxyethylgermaniumsesquioxide or Ge-132. It is found in some plants such as shelf fungus,ginseng, garlic, and Aloe vera. Ge-132 plays an important role for the pharmacological effectsof the plants. The solubility of propagermanium at a certain pH is not exactly known yet. Untilnow, the analytical methods for the analysis of Ge-132 so far have the shortcoming and thepropagermanium as germanium metal in the sample, so that improvement for propagermaniumanalysis was necessary to be conducted, primarily to be used for solubility assay. This studyaims to determine the effects of pH on the propagermanium solubility using HPLC method foranalysis. The results showed that validation parameters for analysis by using HPLC method e.iaccuracy, precision, and linearity, have met to the quantitative analysis requirements. Increasingthe pH causes increasing the solubility of propagermanium in the pH range of 3.0-3.6. Thesolubility result was 9.8514; 10.4204; 12.5446 mg/mL on pH 3.0; 3.3; 3.6.

ISOLASI DAN AKTIVITAS LARVACIDA MINYAK ATSIRI AKAR (Curcuma mangga, Val.) TERHADAP LARVA Aedes Aegypti DAN PROFIL GC-MS NYA Lolita, Lolita
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma mangga, Val. has been recognized as a traditional drug since a longtime ago. The active ingrediences of this plant especially the volatile oil containsmonoterpenes and sesquiterpenes. This research was aimed to study about thelarvacideâs activity of the volatile oil Curcuma mangga, Val. rhizome and also toanalyze its chemical compounds using the GC-MS. The volatile oil was isolated fromCurcuma mangga, Val. with steam and water distillation. The test method for larvicidewas done by dissolving the substances into water and added by Tween 20 10% v/v to thethe volatile oil. The concentration of the volatile oil of Curcuma mangga, Val. rhizomewere 100 ppm, 150 ppm, 200 ppm, 250 ppm, 300 ppm, and 350 ppm. The concentrationof positive control âabateâ were 0,01 ppm; 0,025 ppm; 0,05 ppm; 0,1 ppm; 0,5 ppmwhile as the negative control was Tween 20 solution. The perception time of larvaeâsmortality was 24 hours. The chemical compound of Curcuma mangga, Val. can beanalysed by the GC-MS. Data of larvaeâs mortality were used to estimate the values ofLC50 with the probit analyzis method. This study showed that the volatile oil of Curcumamangga, Val. have clear-brass colour, bitter taste, typically aromatic like mango,rendement equal to (1,23 Â± 0,029)% v/b and refractive index 1,4881. The value of LC50for the volatile oil of Curcuma mangga, Val. rhizome is (216,17 Â±12,51) ppm whileabate equal to (0,072 Â± 0,024) ppm. This finding indicates that abate were more potentto larvae of Aedes aegypti. The GC-MS showes 30 peaks chromatogram and six peakswhich indicates the possibility of alpha-pinene, camphene, beta-pinene, beta-myrcene,eukalyptole, ar-turmerone presence.

VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KLT DENSITOMETRI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, Sismindari
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

TLC Densitometry is one of method which was used to measure amount of activesubstance. Active substance of epigallocathechin gallate is one of in green tea extractcream. Method of analysis must be validated to prove that method will give the dataclose with the real value. Aim of this research is to prove that TLC Densitometry methodhave liniearity, precision and accuration that fulfill the requirement. This study usedconcentration 600, 1800 and 3000 ug/ml with 3 replications to measure precision(based on value of CV) and accuration (based on value of recovery). Liniearity wasknown based on value of r of curve regression between concentration and wide area ofchromatogram. LOD and LOQ was calculated based on curve regression. Researchshowed that method of analyse had liniearity with r= 0,98. Value of CV concentrationof 600, 1800 and 3000 ug/ml were 8,18%; 3,19% and 1,53%, respectively and recoverywere 88,10%; 99,65% dan 111,33%, respectively. Value of LOD was 827,01 Âµg/ml andLOQ was 2756,69 Âµg/ml.

ANALISIS KUALITATIF KANDUNGAN SAKARIDA DALAM TEPUNG DAN PATI UMBI GANYONG (Canna edulis Ker.) Kusbandari, Aprilia
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Canna Tubers (Canna edulis Ker.) is one of the plants producing carbohydrates. ItsÂ also contains of protein, fat, vitamins, minerals,Â phosphorus, iron and more calciums. The purpose ofÂ this study is to identify ofÂ sugarÂ in the powder and starch from canna tuber is a hydrolysis and didnât hydrolysis. The method of qualitative analysis with tube testÂ andÂ Thin Layer Chromatography (TLC). The result indicated that before hydrolysisÂ canna powderÂ gaveÂ sucrose (Rf = 0.45) and mannose (Rf=0.51), while after hydrolysis it gaveÂ glucose (Rf=0.44), fructose (Rf=0.61) and mannose (Rf=0.51). In addition, canna starch gaveÂ Â glucose (Rf=0.44) and maltose (Rf=0.35).

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Muhammad Syahrir

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m.syahrir7406@unm.ac.id

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nurkhasanah@pharm.uad.ac.id

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Kota yogyakarta,

Daerah istimewa yogyakarta

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