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INDONESIA
Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 808 Documents
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PENGGUNAAN POTENTIALLY INAPPROPRIATE MEDICATIONS (PIMs) PADA PASIEN GERIATRI RAWAT INAP OSTEOARTHRITIS DI RS PKU MUHAMMADIYAH YOGYAKARTA Namirah Muh. Syuaib AS, Andi; Darmawan, Endang; Mustofa, Mustofa
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.48 KB) | DOI: 10.12928/pharmaciana.v5i1.2289

Abstract

Potentially inappropriate medications (PIMs) use among elderly is a serious public health problem because it is intrinsically linked to increased morbidity, mortality, and healthcare costs. This study  aims to determine the association between number of drug prescribed, duration of hospital stay and PIMs use among elderly hospitalized patients at PKU Muhammadiyah Yogyakarta General Hospital. This study was analytic observational with cross-sectional study. Beers criteria 2012 were used to identify PIMs use among elderly hospitalized patients with osteoarthritis. Logistic regression analysis were used to determine association between number drugs of prescribed, duration of hospital stay and PIMs use. The results showed that 7 (38.9%) out of 18 hospitalized elderly patients were identified PIMs use and all of patients received atleast one PIM. The most common agents involved in PIMs were estazolam (11.1%), and metoclopramide (11.1%). Polypharmacy is a major predictor factor of PIMs use in this study.
PENGARUH WAKTU HIDROTERMAL DAN TMAOH DALAM SINTESIS LANGSUNG MCM-41 Ahda, Mustofa; Sutarno, Sutarno; Sri Kunarti, Eko
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (396.473 KB) | DOI: 10.12928/pharmaciana.v5i1.2280

Abstract

The MCM-41processing synthesis with variation time hydrothermal and TMAOH at directsynthesis process has been done. The synthesis of MCM–41 was used templating agents withcetiltrimetilammonium bromide (CTAB). The optimization of synthesis of MCM-41 was carried outto produce good material characteristics. Hydrothermal time variation performed in the synthesis ofMCM-41 for 18 hours, 24 hours, 48 hours and 88 hours has been done. So the study of effect TMAOHwas used CTAB/ TMAOH ratio: 1 and 1.25. The results showed that the 24- hour time hydrothermalwas able to produce the good crystallinity with 100% relative crystallinity. However, the best stabilityof MCM-41 materials synthesized in hydrothermal time during the 48 hours. So the effect ofTMAOH additions in the synthesis MCM-41 can bedecreased crystallinity of MCM-41.
FORMULASI GEL EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) DENGAN VARIASI GELLING AGENT SEBAGAI SEDIAAN LUKA BAKAR Maulina, Lena; Sugihartini, Nining
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (547.163 KB) | DOI: 10.12928/pharmaciana.v5i1.2285

Abstract

Pericarp of mangosteen is waste that has been shown have efficacy as an anti-inflammatory and accelerate the proliferation of fibroblasts. Therefore  it need to be formulated in the form of gel to make easy in the use of preparation. It is needed an appropriate gelling agent to produce the good character of gel. This research aimed to know the type of the gelling agent who has the physical properties gel and the activity of the best treat burns. There are three gel formula designed with various  type of  the gelling agent i.e. FI (the gelling agent carbopol); FII (the gelling agent CMC na); FIII (the gelling agent tragacanth). The obtained gels were tested organoleptic, of homogeneity, pH, spreadibility, adhesivity, consistency and the effect of healing burns in nine groups. The collected data were analyzed statistically using SPSS version 16 with kolmogorov-smirnov and continued one way ANOVA or  Kruskal-Wallis, with level of trust 95 %. The results show that all formula mixed homogeneous gel. Formula I have a pH 3,5 while formula II and III having a ph 5 (p < 0,05). The greater spreadibility given by formula III (p < 0,05) and the longest time of adhesivity given by formula II (p < 0,05). The best activity of wound healing given by formula I (p > 0,05). Based on the result show that type of gelling agent can influence the physical properties and activity in the treating burns. Type of gelling agent that show the best physical properties is CMC Na.
STUDI PENGELOLAAN OBAT SEBELUM DAN SESUDAH JKN DI PUSKESMAS JETIS KOTA YOGYAKARTA Oktaviani, Alfira; Baroroh, Farida
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.341 KB) | DOI: 10.12928/pharmaciana.v5i1.2290

Abstract

The effective and efficient drugs management is very crucial in the whole success of public health center management. The government hold a program called National Health Insurance (JKN) in order to achive quality and cost control which is effective and efficient. The research was aimed to know the drugs management at the public health center in Jetis Yogyakarta which includes drug plan, drug demand, drug acceptance, drug storage, drug distribution and the process of drugs recording and reporting. This study used observasional descriptif desaign. Subjects for this study was the implementation of drugs management work instruktion in public health center .The  technique data collection used triangulation or the combination among stuctured observation result in the form of check list, interview with the human rosources involved of drug management and observation the drug management documentation. The technique analysis used quantative-qualitative descriptive analysis with percentage. The results showed that the drugs management at the public health center Jetis Yogyakarta at the drug plan, was included in both criteria (before JKN 100% and after JKN 100%), the drug demand was included in the criteria quite well (before JKN 63.64% and 63.64% after JKN ), the drug acceptance was included in both criteria (before JKN 100% and after JKN 100%), the drug storage was included in both criteria (before JKN 80.56% and 83.33% after JKN), the drug distribution was included in both criteria (before JKN 76, 92% and after JKN 84.62%), the drug recording and reporting was included in both criteria (prior JKN after JKN 100% and 100%). The general drug management before and after JKN at the public health center Jetis Yogyakarta was applicable standards and good criteria with the percentage of drug management before JKN amounted to 83.91% and after JKN amounted to 86.21%.
PENGARUH UKURAN PARTIKEL BERAS HITAM (Oryza sativa L.) TERHADAP RENDEMEN EKSTRAK DAN KANDUNGAN TOTAL ANTOSIANIN Maulida, Ria; Guntarti, Any
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.845 KB) | DOI: 10.12928/pharmaciana.v5i1.2281

Abstract

Black rice has been tested for its high anthocyanin content. Black rice can be one of the potential sources of anthocyanin. Particle size is one of factors which influences amount of isolated  biocompound  in maceration process. Decreasing particle size can increase the amount of isolated  biocompound and extract yield value. The high value of extract yield shows effectiveness of maceration process. In this research, particle size variation has been done maceration process for investigating its influence on black rice extract yield and total anthocyanin content of maceration  result. This study used black rice ( Oryza sativa L.) from Beringharjo market, Yogyakarta. Maceration  with solvent of ethanol 96% add ed HCl 37% until pH 1,0(1:6) is done for 6 x 24 hours, with particle  size variation: mesh 20/40, 40/60 and whole bran of black rice. Data of extract yield and total  anthocyanin content are analyzed by using one-way ANOVA with confidence level 95%. The results  revealed that extract yield and total anthocyanin content of black rice extract with particle size  variation: mesh 20/40, 40/60 and whole bran of black rice intact 6%; 16%; 11,26%; and  30,76 mg/100  g; 1167,80 mg /100 g; 322,23 mg/100 g, respectively. There is significant difference  between  tested groups (P< 0,05). We concluded that particle size of black rice influences extract yield  and total anthocyanin content of maceration result.
PENINGKATAN STABILITAS KURKUMIN MELALUI PEMBENTUKAN KOMPLEKS KURKUMIN--SIKLODEKSTRIN NANOPARTIKEL DALAM BENTUK GEL Ariani Edityaningrum, Citra; Rachmawati, Heni
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (530.476 KB) | DOI: 10.12928/pharmaciana.v5i1.2286

Abstract

Curcumin is a compound derived from turmeric. This compound is practically insoluble inwater and has poor stability. To improve the benefit of curcumin as a potential active compound in agel preparation, better stability are requested. Encapsulation was performed by freeze drying methodsand all evaluation data confirmed that curcumin included in the -cyclodextrin forming curcumin--cyclodextrin nanoparticle. The formula showed particle size of 156.8 ± 38.3 nm, polydispersity indexof 0.174 ± 0.026, and zeta potential of -17.3  0.2 mV. The gelling agents used for formulation of gelbase were HPMC, CMC-Na, carbopol 940, water-soluble chitosan, and viscolam. Viscolam showedbest stability of pH and viscosity after storage at 25 and 40 oC for 28 days. The inclusion complex andcurcumin were incorporated into gel. Both of the formulas showed good stability in pH and viscosityafter storage at 25 and 40oC for 28 days, and the inclusion complex gel showed improvement in thechemical stability which is approximately 2.12-fold (p<0.01) and 1.41-fold (p<0.05), after storage at25 and 40 oC, respectively.
BENCANA ALAM DAN PENDIDIKAN INTERPROFESI Kusumawati, Wiwik
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (323.302 KB) | DOI: 10.12928/pharmaciana.v5i1.2291

Abstract

Health care provider provide first response to patients in disaster. Medical and health institutions in Indonesia which produce health professional are still in early process to develop IPE for their students. Health professional unaccustomed with team work to serve patients, therefore they are not properly prepared to response natural disasters. The aim of this article is to give understanding for health institutions about interprofessional education (IPE) concept related to natural disaster. Review article conducted by analyzing scientific article from journals and text books. IPE is a necessary step in preparing a collaborative practice ready health work force to respond in disaster and getting better patient outcomes. Patients are the primary focus of any emergency response such as disaster. In disaster team work is the crucial competency that must be think first. Team performance however may not be optimal and it is often the patient who suffers from this dysfunction. Improved inter professional practice in emergency response will lead to better patient outcomes when teams have adequate knowledge and skills. They will manage the patients each other appropriately based on their each role. Health institutions should develop IPE including module focus on disaster/emergency preparedness to optimize role of health provider. Real experience into community exercises also necessary to ensure that student involvement during actual disasters also needed as a part of local disaster management plans.
SINTESIS 4–HIDROKSI–3–KLOROBENZALDEHID DARI p–HIDROKSIBENZALDEHID DAN GAS Cl2 Warsi, Warsi
PHARMACIANA Vol 5, No 1 (2015): Pharmaciana Vol 5 No 1, 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.03 KB)

Abstract

ABSTRAK Kurkumin merupakan senyawa yang potensial untuk dikembangkan. Senyawa analog kurkumin telah banyak disintesis. Senyawa 4–hidroksi–3–klorobenzaldehid merupakan bahan dasar dalam sintesis analog kurkumin dengan substituen –Cl pada inti aromatiknya. Senyawa4–hidroksi–3–klorobenzaldehid telah disintesis melalui reaksi klorinasi antara p–hidroksibenzaldehid dan gas Cl2, kemurnian 4–hidroksi–3–klorobenzaldehid ditentukan berdasarkan jarak lebur, kromatografi lapis tipis dan LC–MS. Identifikasi struktur senyawa hasil sintesis dilakukan dengan teknik spektrometri, meliputi spektramassa (ESI–MS), spektra inframerah (cm-1, KBr), spektra resonansi magnetik inti proton (δ, ppm, DMSO–d6, 1H–NMR, 500 MHz) dan UV–Vis. Reaksi klorinasi p–hidroksibenzaldehid dihasilkan 4–hidroksi–3–klorobenzaldehid yang berbentuk kristal warna kuning, dengan jarak lebur 128,1–130,8ºC. Rendemen rata–rata yang dihasilkan sebesar 51,37 %.Kata kunci: 4–hidroksi–3–klorobenzaldehid, klorinasi, halogenasi
STABILITAS FISIKA DAN KIMIA REKRISTAL DAN DISPERSI PADAT PIROKSIKAM-PEG 6000 Binarjo, Annas
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.36 KB) | DOI: 10.12928/pharmaciana.v5i1.2287

Abstract

It is hoped that solid dispersion and recrystalization can solve the problem of low solubility of piroxicam.  Metastable polymorph or amorph state can be formed in solid dispersion and recrystalization preparation, leading to a better dissolution. During storage, the metastable polymorph or amorph will be changed to stable crystal, so that the dissolution will be decreased (physical instability), beside that the increasing of solubility also trigger the higher rate of decomposition (chemical instability).  This research was purposed to reveal these two instability. The research was began by preparing recrystal of piroxicam (R) and solid dispersion piroxicam-PEG 6000 (DP) by solvent method using aseton.  These preparate were stored in room temperature (25oC). The dissolution was tested after 1, 2, 3, and 4 month of storage, using dissolution efficiency for 60 minutes (DE60) as parameter, and also the drug content in bulk preparate was determined. The result showed that recrystalization and solid dispersion preparation did not decrease  the piroxicam content.  During storage, the DE60 and piroxicam content in R and DP were not changed (p>0.05). It could be concluded that R and DP prepared had a stable dissolution and purity.
ISOLASI DAN PENENTUAN KADAR FLAVONOID EKSTRAK ETANOLIK HERBA SAMBILOTO (Andrographis paniculata (BURM.F.) NESS) Ridwan Rais, Ichwan
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (351.924 KB) | DOI: 10.12928/pharmaciana.v5i1.2292

Abstract

(Andrographis paniculata ( Burm.f. ) Ness ) is containing andrografolid, neoandrografolid,and flavonoids known as apigenin-7,4’-di-O-methyl ether, 5-hydroxy7,8,2’,3’tetrametoxyflavon,dihydroxy-dimetoxyflavon. Flavonoids as antioxidants, have potential as an anti-bacterial activity,anti-inflammatory, anti-allergic and anti-thrombosis. The chemical structure of the drug may explainthe nature of the drug and linkage units and structures of drug molecules with biological activity.Compounds with the same functional groups can provide the same biological response due to work onthe same receptors. This present study is determine the total flavonoid content of the ethanol extract ofA. paniculata use Chang method, identification using spectrophotometric method. The measurementresults showed that total flavonoid content of the ethanol extract of A. paniculata amounted to 46.322g/kg.

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