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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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ANALISIS ADVERSE DRUG REACTIONS OBAT ANTI RETROVIRAL PADA PENGOBATAN PASIEN HIV/AIDS DI RSUD GUNUNG JATI CIREBON TAHUN 2013 Nur Rahmi Hidayati; Syamsudin Abdillah; Sesilia A. Keban
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Acquired Immunodeficiency Syndrome (AIDS) is a disease caused by infection with Human Immunodeficiency Virus (HIV). The pharmacology treatment for the infection was antiretroviral therapy. The problem from the use of antiretroviral drugs (ARV) is the emergence of unwanted drug reactions (adverse drug reaction). The purpose of this study was to identify and analyze the incidence of adverse drug reactions from the use of antiretroviral drugs in the treatment of patients with HIV / AIDS that occurred in RSUD Gunung Jati Cirebon. This study involves 122 patients. Data were obtained from medical records and patient interview form. The data were evaluated with a descriptive analysis of demographic profile of patients and the percentage of adverse drug reaction (ADR) The results showed an adverse drug reaction (ADR) on the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon. ARV regimens are the most widely used is the combination of Zidovudine + Lamivudine + Nevirapine / Efavirenz (AZT + 3TC + EFV) as much as 31.2% (38 people). Duration of therapy ARV in Seroja Clinic RSUD Gunung Jati Cirebon most is> 2 years - 4 years 28.7% (35 people). Types of adverse drug reaction (ADR), which occurs in the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon include: headache (22.1%), fatigue (6.8%), anemia (9.3%), itching (14.4%), nausea / vomiting (20.1%), diarrhea (7.2%), lipodystrophy (2.0%), rash (11.3%), skin discoloration (1.6%), neuropathy (1.6%) and sleep disorders (3.6%).

EFEK HIPOGLIKEMIK EKSTRAK ETANOL UMBI KETELA RAMBAT (Ipomoea batatas P) (EEUKR) PADA MENCIT SWISS YANG DIINDUKSI ALOKSAN Akrom Akrom; Harjanti P D; Armansyah T
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Sweet potatos rood contain lots of beta-carotene, polyphenols and flavonoids. Alloxan provenpancreatic cell damage through oxidative stress mechanisms. The compound beta-carotene,polyphenols and flavonoids are thought to antioxidative and cytoprotective, inhibit cell damage causedby alloxan exposure. This study aimed to determine the effect of ethanolic extract of sweet potatos(Ipomoea batatas P) (EEUKR) on blood glucose levels and pancreatic histopathology on alloxaninducedSwiss mice. Used 15 test animals, Swiss mice, with an average weight of 20-30 grams. Testanimals were divided into 5 groups, with each group consisting of 3 mice. Group I was the negativecontrol group who were given distilled water (akua group), and group II, III, IV and V are thetreatment group were given ethanolic extract of sweet potatos rood (EEUKR) at a dose of 2.5, 7.5,22.5 and 67.5 mg/KgBW/day orally for 10 days, 7 days before and 3 days after the alloxan induced.Alloxan induction performed on the 7th day intraperitoneally at a dose of 120 mg/kgBW. Examinationof blood glucose levels conducted on 4th and day 10th day of treatment. On the 10th day of the testanimals were sacrificed for isolated pancreas and histopathologic examination. Analysis of varianceconducted to determine the significance difference in average blood glucose levels between groupsduring the test and ANOVA followed by LSD test at 95% confidence level. Pancreatic histopathologydata were analyzed qualitatively. The results showed that the EEUKR dose of 22.5 and 67.5mg/kgBW/day had the effect of hypoglycemia in Swiss mice. Blood glucose levels of Swiss micebefore alloxan induced in treatment group with EEUKR dose of 67,5 mg/Kg BW were lower thanblood glucose levels of akua groups, statistically significant (p <0,05). Blood glucose levels of alloxaninduced swiss mice of treatment groups with EEUKR dose of 22.5 and 67.5 mg/KgBW were lowerthan blood glucose level of akua group and statistically significant (p <0.05). The percentage ofpancreatic necrosis of alloxan-induced Swiss mice of treatment groups with EEUKR dose of 22.5 and67.5 mg/kg BW were lower than the percentage of necrosis of akua group. Based on these results itcan be concluded that the EEUKR doses of 22.5 and 67.5 mg/KgBW are found to be hypoglycemic inSwiss mice both before and after alloxan induced. The EEUR also shown to decrease the incidence ofpancreatic necrosis in alloxan-induced Swiss mice.

Pengaruh ekstrak kulit umbi bawang putih (Allium sativum L.) Terhadap kadar kolesterol total darah tikus jantan galur wistar diabetes mellitus Rina Wijayanti; Abdur Rosyid; Iffa Kholishotul Izza
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Diabetes mellitus (DM) adalah gangguan metabolisme dikarakterisasi oleh hiperglikemia. Penderita dengan kadar gula darah tinggi akan mengalami gangguan metabolisme lemak, salah satunya peningkatan kadar kolesterol. Kulit umbi bawang putih mengandung senyawa yang dapat menurunkan kadar kolesterol total darah pada diabetes mellitus. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol kulit umbi bawang putih (Allium sativum L.) terhadap kadar kolesterol total darah pada tikus putih jantan galur wistar diabetes mellitus.Penelitian ini adalah penelitian eksperimen dengan menggunakan rancangan penelitian posttest only randomized control group design. Penelitian ini menggunakan tikus putih jantan galur wistar 25 ekor terdiri dari lima kelompok yaitu kelompok I adalah normal, kelompok II adalah induksi aloksan 160 mg/kg BB, kelompok III adalah induksi aloksan dan ekstrak dosis 1000 mg/kg BB, Kelompok IV adalah induksi aloksan dan ekstrak dosis 2000 mg/kg BB, Kelompok V adalah induksi aloksan dan ekstrak dosis 4000 mg/kg BB, pemberian ekstrak dilakukan selama 14 hari. Analisis yang digunakan dalam penelitian ini adalah kruskal-wallis dengan Mann-Whitney.Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan antara kelompok induksi aloksan dengan kelompok normal, ekstrak etanol 70% kulit umbi bawang putih dosis 1000 mg/kg BB, 2000 mg/kg BB, dan 4000 mg/kg BB menunjukkan perbedaan signifikan dengan kelompok induksi aloksan dan kelompok normal.Kesimpulan yang diambil bahwa ekstrak etanol kulit umbi bawang putih untuk semua dosis menurunkan kadar kolesterol total darah.Â Kata Kunci : Kolesterol, diabetes mellitus, kulit umbi bawang putih

RESIDU PESTISIDA ALDRIN DAN DIELDRIN PADA SAMPEL TANAH DAN AIR DI DESA SRIGADING KECAMATAN SANDEN KABUPATEN BANTUL Iin Narwanti; Eko Sugiharto; Chairil Anwar
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Aldrin and dieldrin pesticide residue in soil and water samples from Srigading Village, Sanden District,Bantul Regency has been investigated. The purpose of this study were to analyze, identificate and evaluatepyrethroid pesticide residues in soil and water samples. Soil sample was extracted using shaker with acetonesolvent. Water samples was extracted using separator funnel with 15% (v/v) dichloromethane/n-hexanesolvent.Clean-up was couducted using chromatography column using florisil and determination of pesticideresidue in the samples was carried out by gas chromatography apparatus equipped with electron capture detector(GC-ECD). The result showed that pesticide residues in soil sample in the range level: aldrin (4,8-64,8 ppb) anddieldrin (not detected-6,0 ppb). In water sample pesticide residues in the range level: aldrin (not detected-1,0 ppb)dan dieldrin (-not detected1,2 ppb). The quality or water sample taken from onion field is laid under the standardof water that has been settled.

KAJIAN PERESEPAN ANTIBIOTIKA PADA PASIEN DEWASA DI SALAH SATU PUSKESMAS KOTA YOGYAKARTA PERIODE JANUARI - APRIL 2010 Muhammad Muhlis
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

To achieve optimal therapy of antibiotics isonefactor supporting the accuracy inprescribing antibiotics errors in prescribing can cause lack of rationality in the use ofantibiotics . Antibiotic was commonly used in the clinicor in private practice doctorsbut also in the centers of other health services such as polyclinics and hospitals theaim of this study is to assess antibiotic prescribing patterns and the level ofrationality the use of antibiotics in adult patients at one center of Yogyakarta on thebasis of data prescriptions. This Study used descriptive design with retrospective datacollection The data was collected from January to April 2010 Data source is aprescription of antibiotics in adult patients We analyzed the antibiotics prescription inthe study based on the selection appropriate dos age frequency and duration. Werecruited 320 patients receive ing antibiotics. The of antibiotics used were amoxicillin64.5 % ampicillin 11.3 % kontrimoksazol 15.9% chloramphenicol 0.6 % metronidazole2.8 % and etracycline 49 % Most of the Patients received a single antibiotic 97.9 %),while the remaining patients received a combination of antibiotics 2.1 % Allprescribing meet appropriate dosage, and frequency except cotrimoxazole (98%) andampicillin 49%). All prescriptions (100%) improper duration. In general antibioticsprescription for adult patients at one health center in Yogyakarta City is comply withthe standard use of antibiotics in Public Health Centers. However, the duration ofantibiotic utilization still became the perspective of the health providers in PublicHealth Centers.

Formulation and antibacterial activity test toothpaste combination of triclosan-extract ethanol of suji leaves (Pleomele angustifolia N.E Brown) Elya Zulfa; Rima Andriani
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The suji leaf are generally used by the community as a gargle to remove plaque. Toothpaste is one form of dosage suitable for oral health with triclosan active ingredients, but triklosan is corrosive, resistant to bacteria, and decrease the hormonal system, especially the thyroid hormone. The aim of this research is to know the effect of the addition of variation of the concentration of combination of triclosan-ethanol extracts of suji leaf (T-EESL) on toothpaste preparation to the chemical characteristics, antibacterial activity of Streptococcus mutans. The ethanol extract of 70% of suji leaf was obtained by maceration method, then made toothpaste preparation with variation of T-EESL combination of FI (1:0), FII (0,5:0,5), FIII (0:1). Toothpaste was tested chemical physics characteristics (organoleptic, viscosity, pH, and foam power), antibacterial activity test. The test results are analyzed descriptively. Based on the results of the research obtained it can be concluded that the results of testing the physical physics of chemistry showed the results that all toothpaste formulas meet the physical characteristics of chemical toothpaste. T-EESL toothpaste (0.5:0,5) (FII) has strong antibacterial activity against Streptococcus mutans so it can be used as an alternative to the existing dosage preparation in the market with triclosan active substance.Â Â

EFEK PROTEKTIF EKSTRAK ETANOL HERBA PEGAGAN (Centella asiatica (L.) Urban) TERHADAP PEMBENTUKAN KATARAK TIKUS WISTAR YANG DIINDUKSI SODIUM SELENIT Sapto Yuliani
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cataract is one of the eye pathology that can cause blindness. Oxidative stresshas been identified as an initiating factor of cataract. The objective research was tostudy the protective effect of ethanol extract Centela asiatica toward cataract formationon Wistar rat induced by sodium selenite. Cataract was induced in 9 days old Wistarrat, which 5 groups of 7 each. Group I got injection aquadest and the test groups gotinjection CMC-na (group II), vitamin E dose 378 IU/kg bw (group III), ethanol extractGotu cola herb dose 100 mg/kg bw (group IV), and 200 mg/kg bw (group V), 400mg/kgbw, subcutaneously, respectively, for 3 days. After 4 hours, all rats got injection asingle dose 50 ug/kg of BW sodium selenite intraperitoneally. Then eyes were observedin all groups on postnatal day 16, when the eyes of the rat first opened. Then percentageof cataract incidence were calculated. Finally, rats were executed and eyes were takenfor lens histophatological analyses with hematoxiline eosin staining. Based onmacroscopic and microscopic analyses it can be concluded that ethano extract ofCentella asiatica had protective effect toward cataract formation on Wistar rat inducedby sodium selenite. The least cataract incidence was showed at dose 200 mg/kg bw.

The gel formulation of the aqueous phase of snakehead fish (Channa striata) extract with various combinations of HPMC K4M and Carbopol 934 Wintari Taurina; Mohamad Andrie; Lea Anjeli
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Gel is a clear and semi-solid material, translucent and contains active material. The liquid phase of Ekstrak Ikan Gabus contains reactive Albumin benefits to advance the wound-healing process. HPMC and carbopol is the gelling agent uses to form gel material. This research aims to acknowledge the effect of basic combination variety (gelling agent) towards physical and chemical stability of gel material during liquid phase of Ekstrak Ikan Gabus in length of period 28 days.Â Variety of HPMC: Carbopol used, 25:75%, 50:50%, and 75:25%. Physical and chemical test conducted they are, organoleptic test, dispersion test, bonding strength test and pH test. The result is analyzed through one-way ANOVA and continued by LSD test with validity 95%. The whole formula is resulted a stable physical and chemical during 28 days. The higher the consentration of HPMC the the better its physic and chemistry stability. The best and optimum formula was shown by F3 (75:25%), with a stable organoleptic result during 28 days, homogen, the result of the dispere power weight 50 g (Â±14,517 cm2) weight 100 g (Â±16,169 cm2) weight 150 g (Â±16,957 cm2 ) and the average weight is (Â±15,881 cm2), the sticky power (Â±2301,78 second) and pH (Â±6,42) in which can be considered safe for skin.

IDENTIFIKASI POTENSI INTERAKSI OBAT PADA PASIEN RAWAT INAP PENYAKIT DALAM DI RSUD Prof. Dr. MARGONO SOEKARJO PURWOKERTO DENGAN METODE OBSERVASIONAL RETROSPEKTIF PERIODE NOVEMBER 2009-JANUARI 2010 Andriana Sari; Djoko Wahyono; Budi Raharjo
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The potensial drug interaction is potential action of a drug that changed orinfluced by other drugs concurrenly. Drug interactions are defined as a phenomenonthat occurs when the pharmacokinetic effect of a drug changes due to other drugdelivery. Drug interactions could cause advers drug reactions when the potential for apreviously unknown interaction. The purpose of this study is to identify potential druginteractions in patient hospitalized in the Prof. Dr. Margono Soekarjo PurwokertoHospital. The research method was an observasional retrospective study (November2009-January 2010) by using descriptive methods for the data analysis.The resultshowed that the potential drug interactions in the hospitalized patients in Prof. Dr.Margono Soekarjo Hospital is 56,76% (n= 259). Based on the significance categorieswhich proposed by Tatro (2006): a potential drug interaction with significancecategory 1 in ward patients in prof. Dr. Margono Soekarjo Hospital is 16,67%. Thedrug used thet known potential interaction, especially in the category of significance 1should be tailored to the patientâ€™s need, risk and benefit, and have made efforts tooptimize it.

PENGARUH WAKTU HIDROTERMAL DAN TMAOH DALAM SINTESIS LANGSUNG MCM-41 Mustofa Ahda; Sutarno Sutarno; Eko Sri Kunarti
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The MCM-41processing synthesis with variation time hydrothermal and TMAOH at directsynthesis process has been done. The synthesis of MCMâ€“41 was used templating agents withcetiltrimetilammonium bromide (CTAB). The optimization of synthesis of MCM-41 was carried outto produce good material characteristics. Hydrothermal time variation performed in the synthesis ofMCM-41 for 18 hours, 24 hours, 48 hours and 88 hours has been done. So the study of effect TMAOHwas used CTAB/ TMAOH ratio: 1 and 1.25. The results showed that the 24- hour time hydrothermalwas able to produce the good crystallinity with 100% relative crystallinity. However, the best stabilityof MCM-41 materials synthesized in hydrothermal time during the 48 hours. So the effect ofTMAOH additions in the synthesis MCM-41 can bedecreased crystallinity of MCM-41.

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA