Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
Website

Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

39 40 41 42 43

EFEK EKSTRAK ETANOL RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) TERHADAP MEMORI SPASIAL TIKUS MODEL DEMENSIA YANG DIINDUKSI TRIMETHYLTIN Nuroh Aspamufita; Sapto Yuliani
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma xanthorrhiza Roxb is one of the plants containing curcumin. Curcumin has anti-amyloidogenic,antioxidant, and anti-inflammatory activity that can prevent dementia. The aim of the research was to know theeffect of Curcuma xanthorrhiza Roxb rhizome ethanol extract (CREE) to spatial memory on dementia model ratinduced by trimethyltin (TMT). This research use 30 rats, divided into 6 groups, each group consisted of 5 rats. Allgroupswere given trimethyltin intraperitoneal lyexcep tgroup I.Group I (healthy controls) and group II (TMT/illness control) were given a solution of 1% CMC-Na orally. Group III (drug control) were given citicoline 200mg/kgBW orally. Group IV, V, and VI were given CREE orally dose 50 mg/kgBW, 100 mg/kgBW, and 150mg/kgBW respectively. Data of spatial memory were obtained by Morris water maze test consisted of acquisitiontrial, and a probe trial. Data from the test then statistically analyzed by one-way repeated measure ANOVA.Morris water maze test showed that there were significant differences (p<0,05) between TMT group comparedwith CREE dose 50 mg/kgBW, 100 mg/kgBW, and 150 mg/kgBW group. But there was no significant difference(p>0,05) between CREE dose100 mg/kgBW group anddrug control group.Based on the research results can beconcluded that ethanol extract Curcuma xanthorrhiza Roxb rhizome at dose of 100 mg/kgBW can improvespatial memory on dementia model rat induced by trimethyltin.

Effectiveness of banana leaves extract (Musa paradisiaca L.) for wound healing Dimas Ariandi Candra Putra; Heni Lutfiyati; Prasojo Pribadi
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Banana leaves (Musa Paradisiaca, L.) has not been widely used in the treatment purpose of this study was to examine the wound healing activity of the gel of banana leaves (Musa paradiasiaca L.) and determine the most effective concentration for wound healing.Target research is to provide natural wound treatment alternatives. The method used is eksperimental.Prosedur research study began with the identification of a banana leaf, banana leaf extraction, formulation of banana leaf extract gel with a concentration of 1%, 5%, 10% and testing to the test animals were harmed .Animal test are grouped into 5 groups the negative control group (base gel), a positive control (bioplacenton), and 3 groups treatment. Measuring ofÂ diameter wound on day-1 through day 7. The observation was tested by using ANOVA and Post Hoc Tukey HSD. ANOVA test results showed a significant difference between the mean percentage of wound healing all groups Treatment .The result ofÂ Post hoc Tukey HSD at the 95% confidence level showed significant differences in the negative control group when compared to the positive control group and the treatment group gel 5% and 10% .It indicates that the positive control, gel 5% and 10% have a wound healing effect. Positive control group compared with the group treated gel 5% and 10% showed significant differences that the average value of the percentage of wound healing is higher than the positive control treatment group. It means the difference meant that the positive control has better activity. While the group gel 5% when compared with the 10% gel group no significant difference in this case means the group gel 5% with 10% having a comparable effectiveness of wound healing.

ISOLASI DAN IDENTIFIKASI ZAT AKTIF EKSTRAK METANOL RIMPANG KUNYIT PUTIH (Curcuma mangga Val) FRAKSI ETIL ASETAT Kusmiyati kusmiyati; Nurfina Aznam; Sri Handayani
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma mangga contains a lot of variety of active compound which use as traditional medicines. This research aimed to isolated and determinated the active compound of methanol extract Curcuma mangga rhizomes of ethyl acetate fraction and its rendemen. Amount of 1000 g Curcuma mangga rhizomes was macerated with methanol solvent at room temperature for 24 hours. Remaceration was done seventh times. Methanol extract was fractionated with ethyl acetate. About 39,05 g of concentrated ethyl acetate fraction was then separated by Column Chromatography. According to the similarity of UV-Vis spectra and GC-MS, active compound in methanol extract Curcuma mangga rhizomes ethyl acetate fraction is predicted as Labda-8(17),12-dien-15,16-dial with rendemen amount of 0,00149 %.

Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase Sani Ega Priani; Nurrayyan Nurrayyan; Fitrianti Darusman
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this research was to develop SNEDDS formulation of glimepiride to improve oral dissolution and bioavailability. Glimepiride SNEDDSÂ was formulated using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant due to their higher solubilization effect. The formulated SNEDDS were evaluated for % transmittance, dispersibility, thermodynamic stability, dissolution, globule size and morphology analysis. The results showed that the glimepiride SNEDDS was rapidly formed clear emulsion and stabile based on thermodynamic test. Transmission electron microscopy demonstrated the spherical droplets morphology in nanometer range. The globule average diameter size was 45 nm. The SNEDDS formulation significantly increase dissolution of glimepiride compared with pure drug.

VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KLT DENSITOMETRI Nining Sugihartini; Achmad Fudholi; Suwidjiyo Pramono; Sismindari Sismindari
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

TLC Densitometry is one of method which was used to measure amount of activesubstance. Active substance of epigallocathechin gallate is one of in green tea extractcream. Method of analysis must be validated to prove that method will give the dataclose with the real value. Aim of this research is to prove that TLC Densitometry methodhave liniearity, precision and accuration that fulfill the requirement. This study usedconcentration 600, 1800 and 3000 ug/ml with 3 replications to measure precision(based on value of CV) and accuration (based on value of recovery). Liniearity wasknown based on value of r of curve regression between concentration and wide area ofchromatogram. LOD and LOQ was calculated based on curve regression. Researchshowed that method of analyse had liniearity with r= 0,98. Value of CV concentrationof 600, 1800 and 3000 ug/ml were 8,18%; 3,19% and 1,53%, respectively and recoverywere 88,10%; 99,65% dan 111,33%, respectively. Value of LOD was 827,01 Âµg/ml andLOQ was 2756,69 Âµg/ml.

Comparison of carbopol 934 and 941 as thickeners on ketoconazole microemulsions based on physical stability Pramulani Mulya Lestari; Kori Yati; Nanda Savira
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

As a drug delivery system, ketoconazole microemulsion in virgin coconut oil (oil phase) is added with a thickening agent to create transdermal dosage form. This study aimed to compare the physical stabilities of ketoconazole microemulsions formed with different thickeners, namely Carbopol 934 and Carbopol 941. The formula used varying concentrations of Carbopol 934 and Carbopol 941, i.e., 0.15% and 0.25%. The stability was observed during eight-week storage in which the conditions were controlled by different degrees of temperature, i.e., 40C, 25-300C (room temperature), and 400C. The stability tests included organoleptic observation, pH, surface tension, viscosity, particle size, and zeta potential. Based on the Kruskal-Wallis test results, ketoconazole microemulsion with Carbopol 941 that had been stored in different temperature showed a significant difference in particle size (significance value< 0.05), but it did not apply to Carbopol 934. The evaluation revealed that compared to 0.25% of Carbopol 934, microemulsion with 0.15% of Carbopol 934 had a smaller difference between the time intervals. This research concluded that the use of 0.15% of Carbopol 934 as a thickener in ketoconazole microemulsion had better physical stability compared to Carbopol 941 due to the influence of temperature and length of storage.

PERBANDINGAN AKTIVITAS REPELAN ANTARA KRIM MINYAK ATSIRI JAHE (Zingiber offinale, Roxb) DENGAN KRIM MINYAK ATSIRI SERE (Cymbopogon citratus (D.C) Stapf) TERHADAP NYAMUK Aedes aegypti BETINA Azis Ikhsanudin
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The one efforts to prevent dengue fever is to prevent mosquito bites by using mosquitorepellent preparations. The nature of the toxicity of synthetic repellent be the reason for theresearch came from the plant. Sere and ginger into one of mosquito repellent plant because it contains of natural essential oils are many. The aim of this study was to determine the comparativeability repelan effects of essential oils cream sere (Cymbopogon citratus (DC) Stapf) and ginger(Zingiber officinale Roxb). The essential oil of sere (Cymbopogon citratus (DC) Stapf and ginger(Zingiber officinale Roxb), obtained by isolation of leaves and rhizome by steam distillation ofwater which is then tested physical properties including test of adhesion, test of spreadability andtest of mosquito repellent activities. The test of mosquito repellent activities using 20 birds Aedesaegypti mosquito female per cage with the using hand of women as volunteers as much as 4people. In this study were divided into sixth formulas of test. The sixth of cream formula withvariations in the concentration of essential oils sere and ginger wherein the formula I, II and IIIcontain essential oils sere as much as 20% v/w; 30% v/ w and 40% v/w, whereas for formula IV; V;and VI contain the essential oil of ginger as much as 6.25% v/w; 12.5% v/w and 25% v/w. Data ofphysical properties test were analyzed statistically using SPSS. The results showed the cream withthe concentration of essential oils sere 40% v/w (FIII) have better outcomes than others formulascream, where than of adhesion test is 0.46 Â± 0.04 seconds; of the spreadibility test is 56.32 Â± 14.78cm2 and repellent effect of 3014.2 Â± 20.16 seconds.

PENINGKATAN STABILITAS KURKUMIN MELALUI PEMBENTUKAN KOMPLEKS KURKUMIN-ï¢-SIKLODEKSTRIN NANOPARTIKEL DALAM BENTUK GEL Citra Ariani Edityaningrum; Heni Rachmawati
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcumin is a compound derived from turmeric. This compound is practically insoluble inwater and has poor stability. To improve the benefit of curcumin as a potential active compound in agel preparation, better stability are requested. Encapsulation was performed by freeze drying methodsand all evaluation data confirmed that curcumin included in the ï¢-cyclodextrin forming curcumin-ï¢-cyclodextrin nanoparticle. The formula showed particle size of 156.8 Â± 38.3 nm, polydispersity indexof 0.174 Â± 0.026, and zeta potential of -17.3 ï‚± 0.2 mV. The gelling agents used for formulation of gelbase were HPMC, CMC-Na, carbopol 940, water-soluble chitosan, and viscolam. Viscolam showedbest stability of pH and viscosity after storage at 25 and 40 oC for 28 days. The inclusion complex andcurcumin were incorporated into gel. Both of the formulas showed good stability in pH and viscosityafter storage at 25 and 40oC for 28 days, and the inclusion complex gel showed improvement in thechemical stability which is approximately 2.12-fold (p<0.01) and 1.41-fold (p<0.05), after storage at25 and 40 oC, respectively.

PENGARUH KITOSAN DARI CANGKANG UDANG TERHADAP RED BLOOD CELL, HEMOGLOBIN, DAN TROMBOSIT PADA MODEL RHEUMATOID ARTHRITIS YANG DIINDUKSI CFA Suyandra Sah Putra; Endang Darmawan
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The research was conducted the effect of chitosan on rats blood alteration that induced arthtritis. In addition, the research used pre-post test group control design. than used Â was divided into groups (n=6) including normal groups, positive control, negatif control, and Â groups were treated byÂ khitosan at varian 50 mg/200gBB and 100 mg/200gBB doses. Adjuvant-induced was developed using complete Freundâ€™s Adjuvant on 1st day, than 17-47th days after treated given appropriate their groups. To evaluate did blodd counter on 0, 16th,and 47th days after treated with otomatic optic dan electronic resisten method. Than analyzed using ANOVA test and paired t-test (p<0,05). Result of the research is Chitosan 50 mg/200gBW fit to reduce of eritrocid 6,1% (p<0,05), hemoglobin 7,77% (p<0,05) and PLCR 35,29% (p<0,05), meanwhile of Chitosan 100 mg/200gBW fit to reduce of trombocyte 40,49% (p>0,05) and PLCR 35,66% (p<0,05). In additional research, khitosan 50 mg/200gBW fit to complete blood of the rheumatoid arthritic mouse well.

In vitro immunomodulatory activity test of Bengle rhizoma extract (Zingiber cassumunar Roxb.): phagocytic activity of macrophages and lymphocyte proliferation in mice Ghina Adhila; Nurkhasanah Nurkhasanah; Nanik Sulistyani
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Immunomodulators are pharmacological agents that affect the immune system at different levels. Aside from modulating, some immunomodulators stimulate, while some others inhibit immune responses. Zingiber cassumunar Roxb. or Bengle rhizoma has been reported to exhibit immunomodulatory activities. This research was intended to determine the pharmacological effects of its extract on the phagocytic activity Â of Â macrophages and lymphocyte proliferation in vitro. It used the macrophages and lymphocytes of male BALB/c mice, which were divided into normal control and treatment group (receiving 25, 50, and 100 ppm of extract). The immunomodulatory activity test results showed that 100 ppm of Bengle rhizoma extract reduced phagocytosis in macrophages much significantly than the control group and that the treatment groups suppressed the proliferation of lymphocytes more Â substantially than the control group. The extract decreased the phagocytic activity of macrophages and the proliferation capacity of lymphocytes when administered at a concentration of 100 ppm.

Page 41 of 81 | Total Record : 808

39 40 41 42 43

Filter by Year

2011 2025

Filter By Issues

All Issue Vol. 15 No. 3 (2025): Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana Vol 14, No 1 (2024): Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana Vol 13, No 3 (2023): Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana Vol 13, No 2 (2023): Pharmaciana Vol 13, No 1 (2023): Pharmaciana Vol 12, No 3 (2022): Pharmaciana Vol 12, No 2 (2022): Pharmaciana Vol 12, No 1 (2022): Pharmaciana Vol 11, No 3 (2021): Pharmaciana Vol 11, No 2 (2021): Pharmaciana Vol 11, No 1 (2021): Pharmaciana Vol 10, No 3 (2020): Pharmaciana Vol 10, No 2 (2020): Pharmaciana Vol 10, No 1 (2020): Pharmaciana Vol 9, No 2 (2019): Pharmaciana Vol 9, No 1 (2019): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5 No 1, 2015 Vol 5, No 2 (2015): Pharmaciana Vol 5, No 2 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol. 4 No. 2 (2014): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1: Mei 2013 Vol 2, No 2: November 2012 Vol 2, No 2 (2012): Pharmaciana Vol 2, No 2 (2012): Pharmaciana Vol 2, No 1: Mei 2012 Vol 2, No 1 (2012): Pharmaciana Vol 2, No 1 (2012): Pharmaciana Vol 1, No 2 (2011): Pharmaciana Vol 1, No 2: November 2011 Vol 1, No 2 (2011): Pharmaciana Vol 1, No 1: Mei 2011 Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA