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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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PENGARUH PEMAKAIAN KOMBINASI MINYAK JINTEN HITAM (Nigella sativa) dan MADU (Apis mellifera) SEBAGAI ANTI-ACNE SECARA TOPIKAL PADA SUKARELAWAN WANITA Baiq Lenysia Puspita Anjani; Ari Sabar Hati; Halimah Az-Zahra; Fitri Rahmawanti; Endang Darmawan
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Acne mostly affects teenagers with prevalence of 85%. Changing habits of cosmetics may affect the incidence of acne vulgaris. Healing acne can use herbal ingredients such as black cumin oil and honey. Black cumin oil effective for treating mild acne vulgaris and moderate acne vulgaris. Honey has property that can kill the bacteria Propionibacterium acnes. Â The purpose of this study is to determine the anti-acne activity in use of black cumin oil and honey combination in 1:1 ratio for 14 days in women. This study included experimental study with pre-post treatment study design. There are 2 groups, control group (six women volunteer) and treatment group (six women volunteer). For 14 days, control group use chemical drugs anti-acne, while treatment group use black cumin oil and honey combination in 1:1 ratio. Analysis of data used independent sample t-test with confidence interval 95%. The results show that treatment group of women who use black cumin oil and honey combination in 1:1 ratio for 14 days compared with the control group of women there is no difference in reducing the number of parameters black blackheads, white blackheads, papules, pustules, hyperpigmentation, erythema, pruritis, xerosis, desquamation, and sunburn with a value of p> 0.05. The conclusion of this study is the use black cumin oil and honey combination in 1:1 ratio for 14 days has effect as Â anti-acne in women, but statistically not significant.Â

UJI AKTIVITAS PENYUBUR RAMBUT KOMBINASI EKSTRAK AIR TEH HIJAU DAN HERBA PEGAGAN Lela Sulastri; Teti Indrawati; Shelly Taurhesia
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hair fertilizer was used to stimulate hair growth that is used topically on the scalp. Natural materials are expected to be used as fertilizer hair is green tea leaves and herb gotukola. Because the green tea leaves contain a chemical polyphenol compounds that are flavonoids and their derivatives and herb gotukola contain lead compound triterfenoid saponin that are asiatikoside, flavonoids, phytosterols, madecassid acid, madecassoside, asiatic acid and amino acids are thought to have properties as fertilizer hair. This study was conduced to determine whether the combination of the water extract of green tea leaves and herb gotukola has activity as a hair fertilizer and combination which has the most optimum activity. Test hair fertilizer activities include the rate of hair growth, hair growth acceleration and the weight of the hair. In this study used three combinations are combination 1 ( the water extract of green tea leaves and 5% water gotukola herb extract 2.5%), combination 2 (the water extract of green tea leaf extract 7.5% and 2.5% water gotukola herb) and combination 3 (the water extract of green tea leaves and 5% water gotukola herb extract 7.5%). The results showed the combination of the water extract of green tea leaves and water extract herb gotukola has activity as fertilizer hair and extract the most optimum combination is a combination of 1 with a concentration of water extract of green tea leaves (5%) and water extract of the herb gotukola (2.5%) the rate of hair growth 2.689 cm in 28 days, accelerated hair growth 0.128 cm / day and the hair weighs 0.1938 grams in 28 days.

PENGEMBANGAN SENYAWA TURUNAN BENZALASETON SEBAGAI SENYAWA TABIR SURYA Susy Yunita Prabawati; A Wijayanto; Aria Wirahadi
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The goal of this research was to synthesize benzalaceton derivative i.e. 4-dimethyl-aminodibenzalacetonto increase the potency as sunscreen agent. The synthesis was carried out through aldolcondensation reaction with 4- dimetilamino-benzaldehida as a starting material and NaOH as catalystat various reaction times i.e. 3 , 4 and 6 hours. The characterizations of the product was observed bymelting point, FTIR and 1H NMR spectrometers. The product was obtained as a yellowish orangesolid with a melting point between 62-640C. The activity assay as sunscreen agent showed that the 4 â€“dimethylamino-dibenzalaseton have a maximum wavelength at 340 nm, so its can be active as asunscreen in the UV - A rays. The SPF value at 15 ppm was 17.409 with ultra protection type.

Potensi ekstrak etanol 70% akar saluang balum (Lavanga sarmentosa blume kurz) terhadap kualitas dan viabilitas sperma mencit Yaumi Musfirah Syarif; Moch Saiful Bachri; Laela Hayu Nurani
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The present study tried to investigate potency of L. sarmentosa root extract on quality and viability of mice sperm.This study used 25 Swiss male mice were randomly divided into five experimental groups of 5. The ethanolic extract of L. Sarmentosa (100, 200, 400 mg/kg b.w/days), control and X-gra were administered orally for 14 days. The animals were evaluated for sperma quality (sperm count and sperm motility) and viability at 14 days treatment. The results showed that administration of L.sarmentosa roots extract significantly increasing the sperm count (970x106cell/mL) at 400 mg/kg b.w/days (P 0.0040). The extract dose of 200 mg/Kg b.w and 400 mg/Kg b.w had the highest motility values (95%). Viability of sperm are 83.8%; 96.0%; 87.8% respectively at a dose of 100 mg/kg b.w, 200 mg/kg b.w and 400 mg/kg b.w. Present finding oral administration ofÂ L. sarmentosa roots extract has a potency of the quality and viability of mice sperm.

ISOLASI DAN UJI PENANGKAPAN RADIKAL BEBAS DPPH OLEH ISOLAT-1, FRAKSI ETIL ASETAT, DAN EKSTRAK ETANOL AKAR PASAK BUMI (Eurycoma longifolia Jack) Laela Hayu Nurani
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The free radical was produced when undertaking processes metabolit or opposedinfection and when the body dissolved food. The unstable free radical could beneutralised with antioxidant. The root of the pasak bumi (Eurycoma longifolia Jack)was known contained the compound flavonoid, that it was known had the activity asantioxidant. This research aimed at knowing the activity capacity of the capture of thefree radical the water fraction and the faction ethyl acetate fraction the extract ethanolof the root of the pasak bumi by using the DPPH method.The root of the pasak bumi was extracted with ethanol 70% used maceration. Theethanolic extract was dissolved in ethyl acetate, fractination with ethyl acetate so as tobe received by the fraction ethyl acetate. The concentration of the ethanolic extract andthe fraction of ethyl acetate that was used were 2; 4; 8; 16 ug/mL and isolat-1 that is:0.8; 1.6; 3.2; and 6.4 ug/mL.Results of the research showed that all the treatments had the activity asscavenging the free radical. Results of the analysis statistika with the Kruskal Wallismethod in the level of the confident 95% that was followed by the test Mann Whitneyshowed the existence of the difference of the activity of the capture of the free radicalwho was significant between respectively the treatment group. The conclusion from thisresearch was the value ES50 ethanalic extract (15.64 ug/mL) bigger than the factionethyl acetate fraction and higher (13.948 ug/mL) value of ethanalic extract was thanisolat 1 (3.961 g/mL).

Uji sifat fisik repelan minyak atsiri kombinasi rimpang temulawak dan rimpang jahe basis cold cream fatma fatima; Wahyu Widyaningsih; Azis Ikhsanudin
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Rimpang jahe (Zingiber officinale Roxb. Rhizome) dan rimpang temulawak (Curcuma xanthorrhiza roxb. Rhizome) memiliki kandungan minyak atsiri yang dapat berfungsi sebagai repelan. Guna mengatasi mahalnya rimpang jahe dan sifat iritatif minyak atsiri rimpang jahe, maka dikombinasikan dengan minyak atsiri rimpang temulawak. Basis cold cream memiliki fase minyak yang lebih banyak yang dapat meningkatkan kemampuan pengikatan minyak atsiri. Adanya basis tersebut diharapkan dapat meningkatkan efek repelan. Oleh karenanya, terkait efek repelan perlu dilakukan uji sifat fisik minyak atsiri untuk memastikan kemurnian dan mutunya, kemudian sebelum dilakukan uji efek repelan, perlu dilakukan uji sifat fisik sediaan repelan untuk memperoleh formula terbaik, yaitu formula yang dapat dioleskan dengan mudah dan nyaman jika digunakan.Â Â Â Â Â Â Â Â Â Â Â Minyak atsiri rimpang temulawak dan rimpang jahe diisolasi dengan metode destilasi uap dan air dan diuji sifat fisiknya, yang terdiri dari uji organolepstis, indeks bias dan berat jenis. Repelan dibuat dalam berbagai konsentrasi 2% v/b, 5% v/b, 10% v/b, 15% v/b, 20% v/b, dan 25% v/b, kemudian dilakukan uji daya sebar, daya lekat, dan viskositasÂ Â Â Â Â Â Â Â Â Â Â Berdasar hasil uji sifat fisik, minyak atsiri rimpang temulawak dan minyak atisri rimpang jahe telah terbukti kemurniannya. Semakin besar konsentrasi miyak atsiri kombinasi rimpang temulawak dan rimpang jahe pada sediaan repelan dengan basis cold cream, semakin kecil viskositasnya, sehingga daya lekat semakin kecil namun daya sebar semakin besar. Berdasar hasil tersebut, konsentrasi 25% Â b/v s(konsentrasi terbesar) adalah sediaan repelan yang paling baik karena paling lunak sehingga mudah diambil, dioleskan karena konsistensinya tidak keras dan paling mudah untuk dibersihkan dengan air

The determination of metal content, microbial contamination and dissolution assessment of the ethanol extract of pasak bumi root Laela Hayu Nurani; Eka Kumalasari; Zainab Zainab; Achmad Mursyidi; Sitarina Widyarini; Abdul Rohman
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Â The Eurycoma longifoliais bitter therefore, to address this problem, it is prepared in a capsule form. The capsule dosage form Â must has Â the parameters of good quality, thus expected to increase the potential use of biodiversity and the interest of the community in consuming the medicine from the natural materials. The purpose of this research is to get the capsule product of ethanol extract of the Eurycoma longifolia root of quality through the test of total plate value and yeast yeast contamination, the determination of the metal content of Pb, Hg, Cd and the level of flavonoids released in the capsule dissolution test of ethanol extract Eurycoma longifolia root. The result of this research shows that the dissolution efficiency (DE120) capability of ethanol extract of Eurycoma longifolia root is 81,04Â±2,38%. Test of heavy metal content in capsule of Â of ethanol extract of Eurycoma longifolia root found level of Pb equal to 4,132 ppm and not detected content of Cd and Hg in capsule. This indicates that the capsule meets the requirements set by BPOM RI. Tests for total plate numbers (ALT) and yeast capsule ethanol extract of the E. longifolia root were each obtained data of 70 x 102 colonies / g and 4 x 102 colonies / g. It also shows that the capsules meet the requirements by BPOM RI.

OPTIMASI KOMPOSISI TEPUNG BERAS DAN FRAKSI ETANOL DAUN SENDOK (Plantago major, L) DALAM FORMULASI TABIR SURYA DENGAN METODE SIMPLEX LATTICE DESIGN Nining Sugihartini
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Octyl methoxycinnamate is an active ingredient in sunscreen that will bedegradated after exposure by sunlight. On the other hand, antioxidants have potentialcapability as photoprotector which in this study is used the ethanol fraction of leaf ofPlantago major, L to support activity of OMS. In addition, rice flour is added toobecause it has the ability to reflect sunlight. The aim of this study is to obtain theoptimum composition of them, based on the effectivity of OMS. This study used threeformulas based on the simplex lattice design method with a comparison of octylmethoxycinnamate and rice flour as follows: FI (100%: 0%), the formula II (50%:50%), formula III (0%: 100%). All formulas were exposured by sunlight for 5 hours (at09:00 to 14:00 GMT) and in interval one hour samples were taken to measure the valueof % erythema transmission (% Te) and pigmentation (% Tp). Data were analysed toget the optimum composition which has the highest of response. The results showed that100% rice flour was the optimum addition to support activity of OMS as sunscreen withdecreasing of % erythema transmission and pigmentation was 200%, 75%,respectively.

The effects of croscarmellose sodium concentration on the physicochemical characteristics of orodispersible tablets of atenolol Nani Parfati; Karina Citra Rani
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hypertension is the most common cardiovascular diseases suffered by geriatric patients. Their physiological changes make the administration of conventional tablets less effective, especially regarding compliance. One approach to overcome this problem is the development of orodispersible tablets, which soften easily and disintegrate quickly in the oral cavity. Atenolol is a class of Î²-blocker functioning as an anti-hypertensive drug that has been extensively used in hypertension therapy, and it has the potential to being developed as orodispersible tablets. A faster disintegration of orodispersible tablets will facilitate an earlier onset of dissolution. The addition of superdisintegrants can reduce the disintegration time of these tablets. Croscarmellose sodium is a superdisintegrant that can decrease the disintegration time to less than three minutes. This study aimed to optimize the formula of orodispersible tablets of atenolol using different concentrations of croscarmellose sodium, namely 10% (formula 1) and 20% (formula 2). The physicochemical characteristics of the tablets were evaluated to determine the best formula. The evaluation included a comparison to the control formula (0% of croscarmellose sodium). The results showed that formula 1 (10% of croscarmellose sodium) produced orodispersible tablets with the best physicochemical characteristics regarding tablet hardness, friability, in vitro dispersion time, and disintegration time. Formula 1 (%Q30 minutes= 98.31%) also met the standard of the dissolution of atenolol tablets set by the Farmakope Indonesia, i.e., the percent of dissolved drug in 30 minutes has to be higher than 85%. The drug dissolution efficiency of formula 1 was twice higher than that of the control formula.

STUDI KAPASITAS ADSORPSI-REDUKSI ION Au(III) PADA ASAM HUMAT HASIL ISOLASI DARI TANAH GAMBUT RAWA PENING Dian Prasasti; Sri Juari; Sri Sudiono
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Isolation of peat soil humic acid and its application for adsorption-reduction ofAu(III) have been conducted. Humic acid was isolated from peat soil that was collectedfrom Rawa Pening, Central Java. Isolation of humic acid from peat soil was based onconventional alkaline extraction. Humic acid was extracted from peat soil with NaOH0.1 M, then precipitated with 0.1 M HCl, and purified with 0.1 M HCl/0.3 M HF 1/1.The isolated humic acid was characterized by FTIR spectroscopy, then applied foradsorption reduction of Au(III). Isothermic adsorption capacity on adsorptionreduction process of Au (III) also were studied. The gold metal formed was confirmedby XRD diffractogram, and photo optical microscope. The adsorption capacity withLangmuir isothermic model for humic acid was 192 mg/g. Peaks of gold particles in thedifractogram are 2 = 38, 44, and 64.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA