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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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AKTIVITAS ANTIFUNGI EKSTRAK ETANOL BATANG BINAHONG (Anredera cordifolia (Tenore) Steen.) TERHADAP Candida albicans SERTA SKRINING FITOKIMIA Eka Kumalasari; Nanik Sulistyani
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Anredera cordifolia is a plantused as antifungal empirically. This study aims to find out the antifungal activity of ethanol extract of A. cordifolia stem against C. albicans and to identify the chemical subtance groups of the ethanol extract of A. cordifolia. The A. cordifolia stem was extracted by maceration method using ethanol 70 % as solvent. The antifungal assay was done using liquid dilution method with various concentrations of (85; 86; 87; 88; 89; 90% w /v). The mixtures of extract and suspension of C. albicans in CYG (Casein Yeast Glucose) medium and the media were incubated at 37ºC for 18-24 hours to determine Minimum Inhibitor Conceration (MIC). The culture was streaked on SDA (Sabouraud Dextrose Agar) medium to determine Minimum Fungicidal Conceration (MFC). Chromatographic test and tube test were done to identify the chemical substances of A. cordifolia extract. The result showed that the MIC could not be determined because the extract was brownish and turbid while the MFC of A. cordifolia stem ethanolic extract was 86% w /v. The result of the phytochemical screening with tube test and the thin layer chromatography test showed that the extract of A. cordifolia stem contained flavonoids, polyphenols, and saponin.

Total phenol, flavonoid, and anthocyanin content and antioxidant activity of Etlingera elatior extract and nanoparticle Tresna Lestari; Tita Nofianti; Lilis Tuslinah; Ruswanto Ruswanto; Yulia Salmini; Dewi Dewi; Leli Siti Zaqiah; Anggi Agustira; Putri Pratiwi
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Despite the long and wide application, traditional medicine is known for its minimum efficacy. Nanoparticle technology has reported to optimally address this weakness by enhancing the ability of the medicine to penetrate the biological membrane and, thereby, increasing the absorption. In this research, Etlingera elatior (ginger flower) extract, which has antioxiandt activity, was formulated into nanoparticles with ionotropic gelation method using chitosan (0.08, 0.09, 0.1, 0.2, and 0.3%) and 0.01% NaTPP. The nanoparticles were characterized by their particle size, polydispersity index, zeta potential, and entrapment efficiency against total phenolic compound, flavonoid, and anthocyanin. The ones with the best properties were then analyzed with Scanning Electron Microscopic (SEM) method and tested for its antioxidant activity against DPPH. The results showed that all of the formula variations produced particle size in the range of 147.0-566.2 nm with a polydispersity index of < 0.5 and zeta potential between 0.45-45.90 mV. Also, the absorption efficiencies of phenol, flavonoid, and anthocyanin were 72.62-84.24%, 55.18-92.05%, and 75.67-97.96%, respectively. Overall, the best characteristics were presented by the combination of 0.1% chitosan and 0.01% NaTPP, which produced 246.4-nm nanoparticles with a polydispersity index of 0.418, and zeta potential of 26.60 mV. These nanoparticles also contained phenol, flavonoid, and anthocyanin with good absorption efficiencies, namely 78.5186%, 92.05%, and 97.96%, respectively. SEM analysis showed that these nanoparticles were round and had a soft surface. The radical scavenging activities of the extract and the nanoparticles against DPPH, as presented by the IC50 values, were 19.614 ppm and 160 ppm.

SINTESIS 4–HIDROKSI–5–KLORO–3–METOKSIBENZALDEHID DAN ELUSIDASI STRUKTURNYA Warsi Warsi; Sardjiman Sardjiman; Sugeng Riyanto
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The new compound have been synthesis with the chlorination reaction of vanillinwhich aims to produce vanillin chlorinated as raw material in the synthesis ofanalogues of curcumin with Cl substituents on the aromatic ring. The structure of thiscompound have been elucidated. Chlorination of vanillin performed using Cl2 gas,which produced by reaction of kaporit with concentrated hydrochloric acid. Thisreaction takes at temperature 35ºC for 30 minutes, with the AlCl3 as catalyst and THFas solvent. The purity of compound synthesized are determined by melting point andthin layer chromatography. The structure identification of the compound synthesizedconducted using spectrometry techniques, including UV–Vis spectra, infrared spectra(cm-1, KBr) and Nuclear Magnetic resonance proton spectra (, ppm, DMSO-d6,1H–NMR, 500 MHz). Chlorination reaction of vanillin produced yellow crystal of 5chloro–4–hydroxy–3–methoxybenzaldehyde, its melting point is 163.3 to 164.8ºC. Theaverage yield obtained of the this reseach is 40.54%.

AKTIVITAS EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) PADA RADIAL ARM MAZE DAN PASIVE AVOIDANCE TEST TIKUS MODEL DEMENSIA Didik Yuni Prasetya; Sapto Yuliani
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Curcuma xanthorrhiza Roxb. is a plant containing curcumin. Curcumin has been shown toreduce oxidative damage and memory deficits associated with aging. The aim of the researchwas to know the effect of Curcuma xanthorrhiza Roxb. rhizome ethanol extract to memoryfunction on Wistar rats induced by trimethyltin. The research design was post test onlycontrolled group with 42 rats divided into 6 groups, Each group consist of 7 rats. Group I(healthy controls) were given a solution of 0.5% CMC-Na orally. Group II (negative control)were given a solution of 0.5% CMC-Na orally. Group III, IV, and V were given Curcuma xanthorrhiza Roxb. extract each 120 mg/kgBW, 240 mg/kgBW, and 480 mg/kgBW orally.Group VI (positive control) were given piracetam 500 mg/kgBW intraperitoneally. All groupswere given trimethyltin intraperitoneally except group I. Data indicating memory function wereobtained from radial maze test and passive avoidance test. Radial maze test data were analyzedby ANOVA followed by LSD test, while the passive avoidance test data were analyzed with theKruskal Wallis test followed by Mann-Whitney test. In conclusion, ethanol extract oftemulawak rhizome (Curcuma xanthorrhiza Roxb.) at doses of 120 mg/kgBW, 240 mg/kgBWand 480 mg/kgBW can prevent memory function decline on Wistar rats induced bytrimethyltin.

BENCANA ALAM DAN PENDIDIKAN INTERPROFESI Wiwik Kusumawati
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Health care provider provide first response to patients in disaster. Medical and health institutions in Indonesia which produce health professional are still in early process to develop IPE for their students. Health professional unaccustomed with team work to serve patients, therefore they are not properly prepared to response natural disasters. The aim of this article is to give understanding for health institutions about interprofessional education (IPE) concept related to natural disaster. Review article conducted by analyzing scientific article from journals and text books. IPE is a necessary step in preparing a collaborative practice ready health work force to respond in disaster and getting better patient outcomes. Patients are the primary focus of any emergency response such as disaster. In disaster team work is the crucial competency that must be think first. Team performance however may not be optimal and it is often the patient who suffers from this dysfunction. Improved inter professional practice in emergency response will lead to better patient outcomes when teams have adequate knowledge and skills. They will manage the patients each other appropriately based on their each role. Health institutions should develop IPE including module focus on disaster/emergency preparedness to optimize role of health provider. Real experience into community exercises also necessary to ensure that student involvement during actual disasters also needed as a part of local disaster management plans.

AKTIVITAS ANTIFUNGI EKSTRAK DAUN BELUNTAS, JAWER KOTOK, DAN SIRIH SERTA KOMBINASINYA TERHADAP Candida albicans Umi Yuniarni; Yani Lukmayani
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piper betle, Coleus scutellarioides and Pluchea indica have been used empirically to overcome vaginal discharge and scientifically proven to inhibit the growth of Candida albicans. The goal of this research was to search for a combined extract with effective antimicrobial activity against Candida albicans. Single extract,combination of two and three extracts evaluated antimicrobial activity against Candida albicans using agar diffusion method. Inhibitory effect of Piper betle showed the greatest activity against Candida albicans compared to other single extract. Combination of Piper betle and Pluchea indica (26.57Â±0.56 mm) gave greater inhibition than two otherÂ combination extracts (Piper betle and Coleus scutellarioides (25.17Â±0.96 mm); Coleus scutellarioides and Pluchea indica (22.73Â±0.95 mm).The combination of Piper betle, Pluchea indica and Coleus scutellarioides gave inhibition of 27.53Â±1.10 mm. extracts did not give a better diameter compared to the betle extract.

Anti-inflammatory effects of avocado peels against inflammation induced by carrageenan in mice Eko Aprilianto; Alexander Vito Harmoni Swantika Yuan; Claudia Darantika Pradita; Phebe Hendra
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The aim of this research is to investigate the anti-inflammatory activity of avocado peel against carrageenan-induced inflammation in mice. The group of mice that was used as a negative control group to test the anti-inflammatory activity of infusion and decoction (group I) were given aquadest, while the group for testing the activity of extract (group II) was given CMC-Na. The positive control group (group III) was given potassium diclofenac. Groups IV-VI were given avocado peel infusion with the following doses 667.5; 1335; and 2670 mg/kgBW respectively. Groups VII-IX were given avocado peel decoction with the same doses as the previous groups. Groups X-XII were given 830; 1670; and 3330 mg/kgBW of avocado peel extract respectively. The paw edema were measured using a digital caliper for 6 hours afterwards after carrageenan injection. There were a significant (p<0.05) reduction in paw edema at all doses of infusion, decoction, and extract of avocado peel. Based on the research, it can be concluded that the avocado peels have anti-inflammatory activities.

Uji sitotoksisitas dan antiproliferatif ekstrak etanol daun leunca (Solanum Nigrum,L) terhadap sel raji Rahma Dona; Nanik Sulistyani; Laela Hayu Nurani
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Leunca (Solanum nigrum,L.) is one of the medicinal plant which used society for traditional medication as antipyretic, hypotensive and anticancer. The aim ofÂ this research was to know an anticancer activity of ethanol extract of leunca leaves, emphasized on an ability to inhibit the growth Raji cell. Ethanol extract took from leunca leaf powder that epitomized using ethanol solvent by Soxhlet instrument. Citotoxicity test was done by incubating Raji cell at a density of 2x104 with treatment using ethanol extract from leunca (Solanum nigrum L.) leaf in several concentration 500; 250; 125; 62,5; 31,25; 15,62; 7,81 and 3,90 Âµg/ml. A test was done by MTT method and the percent of cell mortality was calculated. The LC50 values were calculated using probit analysis. The research continued with antiproliferation test on treatment sample concentration 50; 25 Âµg/ml with cell control for 24, 48, and 72 hours.The result of research indicate that ethanol extract of leunca leaves had cytotoxic effect towards Raji cell with LC50 values 59,22 Âµg/ml. The result ofÂ antiproliferation test showed that there were the growth of inhibitation on treatment sample with doubling time values 69,56 hour at concentration 50 Âµg/ml; 60,00 hour at concentration 25 Âµg/ml, and doubling time cell control is 44,98 hour.

STANDARISASI PARAMETER NON SPESIFIK DAN PERBANDINGAN KADAR KURKUMIN EKSTRAK ETANOL DAN EKSTRAK TERPURIFIKASI RIMPANG KUNYIT Barokati Azizah; Nina Salamah
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Turmeric (Curcuma domestica Val.) is one of the plants that contain curcumincompounds with various activity. Use of curcumin from turmeric is widely used in theform of ethanolic extract, but there are ballast substances that cause low levels ofcurcumin. This can be pursued with the manufacture of a purified of ethanolic extract.Ethanolic extract of turmeric was made by maceration using ethanolic 96%. Ethanolicextract soaked with hexane until the hexane phase is clear and purified extract obtainedis insoluble hexane phase. Curcumin levels determined using Thin LayerChromatography (TLC) method with the stationary phase silica gel 60 F and mobilephase of chloroform: ethanolic: glacial acetic acid (94: 5:1) and be analyzedquantitatively using densitometry with a maximum wavelength of 426 nm . The watercontent of the extract determined using toluene distillation method, ash and acidinsoluble ash content determined using gravimetric method. The statistic analysis withLSD showed significant differences of curcumin content and analysis of non-specificparameter values on ethanolic extract and purified extract.

Hubungan kualitas hidup dan persepsi pasien tentang penyakit diabetes mellitus tipe 2 dengan komplikasi Setiyo Budi Santoso; Dyah Aryani Perwitasari; Imaniar Noor Faridah; A.A Kaptein
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kualitas hidup merupakan acuan penilaian outcome pasien diabetes mellitus tipe 2 (DMT2). Kualitas hidup pasien DMT2 dapat semakin menurun akibat komplikasi yang menyertainya. Aspek penting dalam pertimbangan intervensi peningkatan kualitas hidup adalah persepsi tentang penyakit. Tujuan penelitian ini untuk pengaruh persepsi tentang penyakit terhadap kualitas hidup pasien DMT2 dengan komplikasi.Studi potong lintang terhadap populasi terjangkau berlangsung selama Juli-September 2015 di Poliklinik Penyakit Dalam Rumah Sakit PKU Muhammadiyah Bantul. Kuesioner Short Form-36Â digunakan untuk mengukur kualitas hidup dan Brief-Illness Perceptions Questionnaire untuk persepsi tentang penyakit. Analisis uji T dan Anova satu jalan dilakukan untuk mengetahui perbedaan kualitas hidup dan persepsi tentang penyakit berdasarkan karakteristik dasar pasien (jenis kelamin, umur, pendidikan, pekerjaan, kadar gula darah sewaktu, tekanan darah, dan durasi diabetes), dan pengaruh persepsi tentang penyakit terhadap kualitas hidup.Penelitian melibatkan 51 pasien DMT2 dengan komplikasi. Subyek dengan tingkat pendidikan rendah memiliki peran fisik yang lebih buruk daripada subyek dengan pendidikan menengah dan tinggi (p=0,049). Persepsi subyek yang positif dapat meningkatkan kualitas hidup pada aspek; peran fisik (p=0,032), vitalitas (p=0,032), kesehatan mental (p=0,001), dan fungsi sosial (p=0,037).Â Â Â Â Â Â Â Â Â Â Â Kualitas hidup pasien DMT2 dengan komplikasi dipengaruhi oleh tingkat pendidikan dan persepsi tentang penyakit.

Page 40 of 81 | Total Record : 808

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA