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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 808 Documents
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Validity and reliability of “Short-questionnaire of tuberculosis patients’ knowledge about anti-tuberculosis and hepatotoxicity” (SQ-KSH-TB) Dyah Aryani Perwitasari; Muh. Deni Kurniawan; Lalu Muhammad Irham; Imaniar Noor Faridah; Triantoro Safaria; Woro Supadmi; Didik Setiawan; Triantoro Safaria
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (381.673 KB) | DOI: 10.12928/pharmaciana.v13i1.24773

Abstract

Until presently, tuberculosis has been a burden to Indonesia, placing the country third among countries with the heaviest tuberculosis burden in the world. Tuberculosis treatment takes a long period and may cause side effects. Therefore, it requires sufficient tuberculosis knowledge on the patients' part for the patients to know of the side effects of anti-tuberculosis and how to deal with them. This research aimed to obtain a short questionnaire of tuberculosis patients' knowledge about anti-tuberculosis and hepatotoxicity (SQ-KSH-TB) which determines patients' knowledge of anti-tuberculosis side effects and how to handle them. This research employed a cross-sectional design and involved 17 public health services (puskesmas) and three hospitals in Yogyakarta Province. The inclusion criteria were patients diagnosed with pulmonary tuberculosis and being in a tuberculosis treatment period with a public health service or a pulmonary hospital in Yogyakarta Province. The exclusion criteria were the patients passing away, having completed a six months treatment or having been receiving treatment for over six months, and being unwilling to cooperate in the research. The questionnaire used in this research was a questionnaire that was developed based on prior research work, containing eight questions on a Guttman scale. Validity and reliability analyses were carried out with Pearson's product-moment correlation and the Kuder-Richardson-20 test, respectively. As many as 194 subjects enrolled in this research. The eight questions in the questionnaire had r count values greater than the r table, hence meeting the validity criterion. Meanwhile, the KR-20 value obtained was 0.721, indicating a good level of reliability. The SQ-KSH-TB was able to meet the validity and reliability criteria, showing applicability in the Indonesian context.
Evaluation and clinical activity test of various concentrations of peel-off gel mask of robusta coffee seed extract (Coffea canephora) as anti-aging Angga Saputra Yasir; Agesta Yesti Renita; Tutik Tutik
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.035 KB) | DOI: 10.12928/pharmaciana.v13i1.23965

Abstract

 Robusta coffee beans contain antioxidant compounds having anti-aging properties. This study aims to determine the content of secondary metabolites in robusta coffee bean extract, anti-aging effectiveness, and the best peel-off gel mask preparation concentration. The extraction method in this study used maceration with 96% ethanol as solvent. The extraction results were carried out by phytochemical screening and formulation of peel-off gel mask preparations, then tested for anti-aging effectiveness using 12 female volunteers and observed signs of aging, including pores, spots, wrinkles, and moisture for four weeks. Robusta coffee bean extraction results obtained a yield of 9.2%. The results of phytochemical screening showed that robusta coffee bean extract contains flavonoid compounds, alkaloids, tannins, and saponins. The results of the evaluation of the 0.5% formula of robusta coffee bean extract were the most preferred by volunteers. The best effectiveness and concentration test results were found in the peel-off gel mask preparation of 2% robusta coffee bean extract formula (F2) compared to blank and F1 (p-value <0.05). The percentage of improvement in the condition of the volunteers' skin, including pores, spots, wrinkles, and moisture, is 21.88 ± 4.22%, 21.57 ± 3.25%, 17.71 ± 2.44%, and 21.25 ± 3.62%, respectively.
The sulphated polysaccharide compounds from green algae (Ulva lactuca L) as a potential natural anti-inflammatory agent based on molecular docking study targeting cyclooxygenase-2 receptor Dwi Utami; Rezza Wahyudi; Wahyu Widyaningsih
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.25848

Abstract

The rare sulphated polysaccharides of green algae have been explored of several activities such as antioxidant, anti-inflammation, anti-bacterial, and anti-virus. Ulva lactuca L is one of the majoring algae species in Indonesia that promosing to be explored as natural anti-inflammation in the inflammation disorders treatment. The purpose of this study was to conduct an in-silico test of anti- inflammatory potency of sulphated polysaccharide chemical constituent of green algae (Ulva lactuca L) against the cyclooxygenase-2 enzyme. The methods used were the preparation of a protein structure database cyclooxygenase-2 enzyme (4COX), protein preparation using the Biovia Discovery Studio application, molecular docking simulation of sulphated polysaccharide compounds on proteins using the Autodock 4.0 application and visualization using Ligpot+ v2.2. The results of docking sulphated polysaccharide compounds with the cyclooxygenase-2 enzyme, showed a best binding affinity energy of Gluconic acid ulvan -7.62 kcal/mol similar to the control drug sodium diclofenac (-7.81 kcal/mol), followed by Iduronic acid Ulvan -7.57 kcal/mol, Fucoidan (-6.11 kcal/mol), Alpha Carrageenan (-6.93 kcal/mol), and Lambda Carrageenan (-5.38 kcal/mol). In the conclusion based on the molecular docking result, the sulphated polysaccharide compounds in Ulva lactuca L are potential to be developed as natural antiinflammatory agent by in vitro and in vivo investigation
Antibacterial activities of Elaeocarpus ganitrus Roxb. leaves from Kebumen against Escherichia coli and Shigella flexneri Naelaz Zukhruf Wakhidatul Kiromah; Laeli Fitriyati; Sinta Wahyu Septiani
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.19219

Abstract

Ganitri (Elaeocarpus ganitrus Roxb) is a plant known for its antibacterial properties, particularly in its leaves. The leaves of Ganitri contain antibacterial compounds such as flavonoids, alkaloids, and tannins. The objective of this study is to investigate the antibacterial activity and determine the minimum concentration of ethanol, methanol, and distilled water extracts from Ganitri leaves in inhibiting the growth of Escherichia coli and Shigella flexneri bacteria. A preliminary study of phytochemical with Thin Layer Chromatogram (TLC) and antibacterial study was conducted. The study was conducted in vitro by disc diffusion method with positive control of ciprofloxacin 50 µg/mL and negative control of sterile aquadest. The extract concentration series used were 10, 20, 30, 40, 50, and 100%. The extracts of ganitri leaves have antibacterial activities against Escherichia coli and Shigella flexneri bacteria. The TLC results were observed under visible light at 254 and 365 nm. Ethanol, methanol, and aquadest extracts of ganitri leaves produce spots that are almost comparable to the compounds of quercetin and tannic acid. The inhibitory zone range of the extracts in Escherichia coli bacteria is 10.33-19.66 mm with a strong category. In comparison, the inhibitory zone range of Shigella flexneri is 8.88-22.62 mm with a moderate-very strong category. ANOVA test results stated a significance value of p = 0.001 (p <0.05). Therefore, it can be concluded that the ethanol, methanol, and aquadest extracts of ganitri leaves had significant differences. The minimum concentration of each extract in inhibiting the bacteria Escherichia coli and Shigella flexneri is 10%.
Development of transdermal patch preparations binahong leaf extract (Anredera cordifolia (Ten.) Steenis) and antihyperglycemia test in rats Galang Pergiawan Ramadhan; Iis Wahyuningsih; Wahyu Widyaningsih
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i1.24602

Abstract

Binahong leaves are plants that have great potential as antihyperglycemics, and have chemical content including triterpenoids, flavonoids, and saponins. However, the development of binahong leaves in pharmaceutical preparations is still very lacking. Objectives of this study are knowing the transdermal patch formulation of binahong leaf extract (BLE) produces good physical properties and the development of BLE transdermal patches with different extract concentrations may blood glucose lower (BGL) levels in glucose-induced mice. This study uses a single-layer patch because it has the advantage of being able to penetrate faster and is suitable for compounds that have solubility in polar solvents. The research began with the extraction of binahong leaves, then formulated a transdermal BLE patch using a formula that includes HPMC (polymer), glycerol (plasticizer), oleic acid (enhancer) and tween 80 (enhancer). Diabetic rats were divided into 4 groups of 6 rats, negative control group (glucose + placebo), positive control group (glucose + insulin), FI group (glucose+ transdermal patch BLE 30%), and FII group (glucose + transdermal patch BLE 47%). BGL measurements are carried out on the 0th, 3rd, 5th, and 7th days. The physical characterization carried out includes organoleptic, weight uniformity, thickness, pH, folding resistance, and moisture content, obtained FI and FII results that meet the requirements set out by each test standard. BGL (mg/dL) from day 1 to day 7 decreased in each group, positive control (68.8±3.76), negative control (112.5±6.89), FI (81.0±4.04), and FII (72.33±5.12). Based on the statistical results of the T-test on the physical evaluation of BLE transdermal patch preparations of FI and FII there were significant differences in weight and thickness uniformity, but there were no significant differences in pH, folding power, and humidity tests. The administration of a 47% BLE transdermal patch provides a faster but insignificant BGL reduction effect compared to the 30% BLE FI transdermal patch.
Chlorogenic acid in preventing and curing ultraviolet-induced damage in human skin fibroblast as an antiaging cell model Ermi Girsang; I Nyoman Ehrich Lister; Chrismis Novilda Ginting; Wahyu Widowati; Seila Arumwardana; Meganita Marthania; Rizal Rizal
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.24459

Abstract

Continuous ultraviolet (UV) irradiation stimulates the over-production of reactive oxygen species (ROS) to cause degenerative diseases. Chlorogenic acid (CA) is found as plants antioxidant that promises medicinal effects. This study examined CA protection against UV-damage in human skin fibroblast (BJ) cells both for curative and preventive therapy. BJ cells were exposed to UV radiation and the addition of CA (6.26-100 mikro g/mL) by preventive and curative addition methods. The cells viability analysis was conducted employing MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxy-phenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay. CA treatment before UV exposure exhibited an increased percentage of viability cells than the positive control. In detail, the series of CA concentration (6.25, 12.5, and 25 mikro g/mL) significantly enhanced the percentage of viable cells. The addition of CA after UV exposure denoted the same results. Furthermore, the lower CA concentrations used, the higher cell viability resulted. CA at dose 6.25 mikro g/mL showed the highest viability in cells, while CA 100 mikro g/mL resulted in the lowest viability. In short, CA can preserve and treat cells from UV exposure. The outcome suggested prevention and curative on UV-induced BJ cells, and the tested concentration is applicable for further experiments.
Study of adverse effects of extrapyramidal syndrome use of combination of antipsychotics antidepressants in outpatient schizophrenia patients in RSUP Fatmawati for the period 2016-2020 Ema Nillafita Putri Kusuma; Emy Oktaviani; Windi Astutie Harahap
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.23280

Abstract

Schizophrenia disorder is a serious mental disorder and chronic symptoms that have mixed of schizophrenia and mood symptoms. Schizophrenia affects the individual concerned. Schizophrenia has several symptoms that can cause social and occupational dysfunction, such as disruption of work or activities, lack of interpersonal relationships, decreased self-care skills, and mortality. This study was an observational study with a cross-sectional study design using secondary data in the form of medical records. The population of this study is 449 patients, and 126 patients met the inclusion criteria. The number of patients with age 20-35 years is 47.6%, 54% male gender, 96.8% take the drug by oral. The most common diagnosis of the patient with schizophrenia was paranoid schizophrenia 100 (79.4%), and got the most common extrapyramidal adverse effect in acute dystonia is 32.5%. The type of drug that may cause extrapyramidal adverse effects are the Risperidone antipsychotic in 90 (17.9%).  The results of the study showed that there was no significant relationship between the type of drug combination use and the incidence of adverse effects from extrapyramidal syndrome with a sig. 0.966> 0.05. Meanwhile, the number of drugs consumed by the patients did not have a significant relationship with the sig value. 0.119> 0.05. The Gender, patient age, method of administration, and diagnosis of schizophrenia did not affect the adverse effects of extrapyramidal syndrome with sig values of each gender (p=0.881), patient age (p=0.665), method of administration (p=0.920), and diagnosis of schizophrenia (p=0.908).
Effect of Papaya flower ethanolic extract (Carica Papaya) on the time kill of tetracyclin against Escherichia Coli Anugraheni Anugraheni; Chylen Setiyo Rini
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.24711

Abstract

Papaya (Carica papaya) is found throughout Indonesia. Papaya flowers contain saponin, tannin, alkaloid, and flavonoid compounds which functions as antibacterial. Escherichia coli is a Gram-negative rod bacteria that could be found in the human large intestine as a cause of diarrhea. The study aimed to determine the effect of papaya flower extract and a combination of papaya flower extract with tetracycline antibiotics using the smallest concentration capable of inhibiting 50% of bacterial growth against Escherichia coli bacteria ATCC 25922 using the time-kill test method. This study was the method of Minimum Inhibitory Concentration (MIC) and time-kill. The MIC of the ethanol extract of papaya flower was 2 mg/mL. The time-kill test showed that the death phase was occurred at 4 - 24 hours. The bacteriostatic effect of the extract was obtained at 0 hours to 24 hours, while the antibiotic and its combination with the extracts had a bactericidal effect at 8 hours and 24 hours.
Gingerol and shogaol on red ginger rhizome (Zingiber officinale var. Rubrum) using high-performance liquid chromatography Johan Sukweenadhi; Putu Diah Damitasari; Kartini Kartini; Pissa Christanti; Evanie Noor Putri
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.25246

Abstract

Red ginger (Zingiber officinale var. Rubrum) is one of the traditional medicines of the Zingiberaceae family, which contains phenolic ketone compounds, including gingerol and shogaol. At high temperatures, gingerol compounds become unstable and will change into shogaol. This study optimized conditions for the simultaneous separation of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol from the red ginger extract using the High-Performance Liquid Chromatography method. The analytical conditions consisted of five different methods by modifying the composition of the mobile phase, the elution system, the flow rate of the mobile phase and the optimum UV wavelength. The best conditions for the simultaneous separation using a ratio of water: acetonitrile mobile phase in method 4 with a gradient elution system including 0 min (65:35); 1.5 min (40:60); 5-6.5 min (10:90); 7.5–9 min (0:100); 9.5–12 min (65:35); the mobile phase flow rate was 1.1 mL/min at an optimum wavelength of 230 nm with a retention time of 6-gingerol compound, 6-shogaol, 8-gingerol and 10-gingerol respectively were 4.947; 6.168; 6.554; and 7.412 min and its resolution were 2.267; 1.575; 1.315; and 2.215. Then the tailings factor and asymmetry values were obtained with an average value of ± 1.
Comparison effectiveness of use antihypertensive in preeclampsia patient in RSUD Panembahan Senopati Bantul Andriana Sari; Wisi Unggul Pertiwi; Faridah Baroroh
Pharmaciana Vol 13, No 2 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i2.23603

Abstract

Preeclampsia is one of many unsolved obstetric problems. The purpose of this research is to compare effectiveness of antihypertensive in preeclampsia patient in RSUD Panembahan Senopati Bantul in the period January-July 2019. This study needs to analyze about antihypertensive drugs in preeclampsia because Preeclampsia is the 3rd rank of disease in pregnancy that causes maternal death after hemorrhagic and cardiovascular diseases. The study was conducted at Panembahan Senopati Hospital Bantul because hypertension in inpatient was ranked first in 10 distributions of non-communicable diseases. The research was observational analytic using a cross sectional study with retrospective data collection of patient medical record. Samples were selected on inclusion and exclusion criteria in 46 cases. Data analysis using Mann-Whitney to determine differences in drug effectiveness and Fisher's to determine the relationship. The results are found that no relationship between maternal age, obstetrical age, pregnancy status, method of birth, and length of stay, but there was a relationship between the severity of preeclampsia with the achievement of blood pressure targets. The results of comparative analysis of the effectiveness nifedipine monotherapy with combination of nifedipine + methyldopa there was a significant difference (p = 0.006), and there was a significant relationship between nifedipine monotherapy and combination of nifedipine + methyldopa (p = 0.015) OR results = 7.200. The conclusion of this study is more effective to use the combination of nifedipine + methyldopa for patients with preeclampsia.

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