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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 796 Documents

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POTENSI PERAN FARMASIS DALAM MENINGKATKAN KUALITAS HIDUP PASIEN LANJUT USIA: PERSPEKTIF RAWAT RUMAH Perwitasari, Dyah Aryani; Muttaqien, Arief
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The Home Health Care program is getting popular as well. One of the outcomemeasured in this program is patientâs quality of life. Home Health Care program is amultidisciplin program, which need the pharmacist role. The aim of this study was tofind out the potencial pharmacist role in increasing elderly patientsâquality of lifeparticipated in Home Health Care program. This study used descriptive design withprospective data sampling. (World Health Organization Quality of Life) We usedWHOQoL as the instrument. The study period was conducted for 13 week in 2009 byvisiting the patients at their homes. The patients were participated in Home HealthCare program of Dr Sardjito hospital, Yogyakarta. Data was descriptively analized.Were recruited seven subjects in this study. In average, their quality of life was low(46,1Â±4,4). All of the patients received polypharmacy and were found the patientsincompliance in taking the medicines. The role of pharmacist were important in HomeHealth Care program for elderly patients to increase their quality of life. Thepharmacists are supposed to do the drug used monitoring, especially to the elderlypatients with polypharmacy. The advance technique for communication, information,and education is suggested to the pharmacist in this program.

UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEME (1)-N-(2-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA DAN (1)-N-(4-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA SECARA IN VITRO Nurani, Laela Hayu; Utami, Dwi; Widyaningsih, Wahyu; Narwanti, Iin; Nurwening, Eti; Jumina, Jumina
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The inhibitory activity of heme polymerization of (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide have been done. This study aims to analyse the (1)-N-(2-nitrobenzyl)-1,10-phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide as inhibitory of polimerization heme. Analysis of heme inhibtory polimerization activity used the experimental in vitro method. The activity showed by IC50 (the capable concentration of extract to inhibiting polymerization heme by 50% ). The IC50 value acquired by probit analysis. Assess IC50 of (1)-N-(2-nitrobenzyl)- 1,10-phenantrolinium iodide not to be identified, (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide and chloroquine by successively are 0,571Â±0,071; 25,498Â±1,876 mg/mL. The result showed the (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide had the highest value of the heme polymerization inhibitory activity than chloroquin, (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide hadnât the heme polymerization inhibitory activity.

PENETAPAN KADAR Ã-KAROTEN PADA BEBERAPA JENIS CABE (Genus Capsicum) DENGAN METODE SPEKTROFOTOMETRI TAMPAK Octaviani, Tri; Guntarti, Any; Susanti, Hari
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Beta carotene is provitamin essential role for vitamin A formation. Most of vitamin Asources are Ã-carotene. In the body, Ã-carotene will be converted into vitamin A. Chilies areconsidered as one of the essential food. Chillies are known as very good sources of Ã-carotene.Therefore, it is important to conduct a research in order to observe the content of Ã-carotene inthe chillies using visible spectrophotometry. Fresh chillies were extracted with a mixture ofhexane:acetone:ethanol (2:1:1) v/v using a maceration method. After the extraction process wascomplete, aquabidest was added. The extraction result was non-polar phase. It was separatedand evaporated. The residue was further subjected to qualitative and quantitative analysis102 PharmaÒ«iana, Vol. 4, No. 2, 2014: 101-109obtained. Qualitative analysis by using Carr-Price method. Determination of Ã-carotene wasconducted using visible spectrophotometry method at 452,4 nm. The qualitative test resultsshowed that the Capsicum annuum L. Var. abreviatum Fingerhuth, Capsicum annuum L. Var.Longum sendt) and Capsicum frutescens L. contain Ã-carotene. From the research, it wasobtained that the average levels of Ã-carotene on the Capsicum annuum L. Var. abreviatumFingerhuth was (10,54Â±0,07) mg/100g, Capsicum annuum L. Var. Longum sendt was(5,57Â±0,13) mg/100g and Capsicum frutescens L. was about (0,36Â±0,01) mg/100g. Statisticalanalysis using LSD test of Ã-carotene levels in the Capsicum annuum L. Var. abreviatumFingerhuth, Capsicum annuum L. Var. Longum sendt) and Capsicum frutescens L. weresignificantly different at P of 0.05.

SINTESIS 4âHIDROKSIâ5âKLOROâ3âMETOKSIBENZALDEHID DAN ELUSIDASI STRUKTURNYA Warsi, Warsi; Sardjiman, Sardjiman; Riyanto, Sugeng
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The new compound have been synthesis with the chlorination reaction of vanillinwhich aims to produce vanillin chlorinated as raw material in the synthesis ofanalogues of curcumin with Cl substituents on the aromatic ring. The structure of thiscompound have been elucidated. Chlorination of vanillin performed using Cl2 gas,which produced by reaction of kaporit with concentrated hydrochloric acid. Thisreaction takes at temperature 35ÂºC for 30 minutes, with the AlCl3 as catalyst and THFas solvent. The purity of compound synthesized are determined by melting point andthin layer chromatography. The structure identification of the compound synthesizedconducted using spectrometry techniques, including UVâVis spectra, infrared spectra(cm-1, KBr) and Nuclear Magnetic resonance proton spectra (, ppm, DMSO-d6,1HâNMR, 500 MHz). Chlorination reaction of vanillin produced yellow crystal of 5chloroâ4âhydroxyâ3âmethoxybenzaldehyde, its melting point is 163.3 to 164.8ÂºC. Theaverage yield obtained of the this reseach is 40.54%.

FORMULASI TABLET SERBUK PISANG RAJA (Musa xparadisiaca AAB) SEBAGAI PENUTUP TUKAK LAMBUNG PADA TIKUS Wahyuningsih, Iis
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Mucoadhesive is a topic of current interest in the design of drug delivery systemand treatment of peptic ulcers. This concept is based on the strength of adhesion of aprotective material to the mucosa. King Banana (Musa xparadisiaca AAB) is oftenused in the treatment of abdominal pain. It has been suspected having muchoadhesivestrength to cover peptic ulcer. The study was armed to formulate king banana tabletwhich has muchoadhesive ability to protect gastric mucosa become ulcer. The aim ofpeptic ulcer cover test was to see the ability of king banana tablet to covered ulcer at thegroups test that received different treatment of the negative control group (solvent), thebanana tablet suspension group, and sucralfate group. The ulcer severity wasdetermined by scoring method. All experimental data were tested by SPSS analyticalstatistics. The result showed that king banana tablet has similar strength to peptic ulcercover of sucralfat and not significantly different.

PENGARUH PEMBERIAN INFORMASI OBAT TERHADAP TINGKAT KEPATUHAN PENGGUNAAN ANTIBIOTIKA PADA PASIEN ISPA DI PUSKESMAS KOTAGEDE I YOGYAKARTA Muljabar, Stefy Muliyani; Supadmi, Woro
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ARI is an acute respiratory infection requiring antibiotics. The use of antibiotics shouldbe routinely to prevent resistance. The design of this research was experimental by treatment ofthe cases. How to collect the data used prospective method. The subjects of research who fulfilthe inclusion criteria were 44 patients with acute respiratory infection were divided into twogroups: 22 patients who were given information as the treatment group and 22 patients whowere not given information as the control group. Data was collected through interview to knowthe rest of the drug and questionnaires filling compliance with Modification Morisky AdherenceScale (MMAS). The pattern for antibiotic used in patients of acute respiratory infection atcommunity health centre Kotagede I Yogyakarta were Amoxicillin (65.9%), Cotrimoksazol (25%), Erithromycin (6.8%), and Ciprofloxacin (2.3%). The level of patients compliance byquestionnaire MMAS was 59.09% high compliance, and 40.91 % low compliance. The level ofpatients compliance by the rest of drug was 86.36% and patients uncompliance was 11.36%.The results of questionnaire MMAS with the Chi-Square test p=0.220 (p>0.05), this shows thatgiving drug informations had no influence to level compliance for antibiotic used in patiens ofacute respiratory infection at Community Health Centre Kotagede I Yogyakarta.

PENGARUH UMUR DAN PENYAKIT PENYERTA TERHADAP RESIKO INFEKSI LUKA OPERASI PADA PASIEN BEDAH GASTROINTESTINAL Faridah, Imaniar Noor; Andayani, Tri Murti; Inayati, Inayati
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Surgical Site Infection/SSI is the result of the contamination of bacteria whichenter the body during surgery. High risk of SSI is occured in gastrointestinal surgeryand influenced by the characteristics of the patients such as age and comorbidity sincethey deal with immunity system of the body. The research was aimed to identity theinfluence of age and comorbidity to the high risk of SSI in gastrointestinal surgerypatients. The research was a cross sectional research conducted prospectively at PKUMuhammadiyah Hospital Yogyakarta from January to March 2012. The researchsubjects were all inpatients undergoing gastrointestinal surgery, having visiblesurgical site and using antibiotic to prevent surgical site infection. There are 68patients in the research. Data that were analyzed comprised the characteristics ofpatients such as age and congenital disease to the risk of surgical site infection. Theresult of this research indicated that 2 patients (2,94%) suffering SSI. Based on the age,SSI happened to 2 patients in the age range of 41-60 years old. However, based on thestatistical result, there was no correlation between age and the existence of SSI(p>0.05). SSI also occured in 2 patients with comorbidity. However, there wascorrelation between the existence of comorbidity and SSI (p<0.05).

KAJIAN INTERAKSI OBAT ANTIHIPERTENSI PADA PASIEN HEMODIALISIS DI BANGSAL RAWAT INAP RSU PKU MUHAMMADIYAH YOGYAKARTA PERIODE TAHUN 2010 Rahmiati, Siti; Supadmi, Woro
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Drug interactions are one of the Drug Related Problems (DRPs) that may affectpatient treatment outcomes. Hypertension occurs in approximately 10% to 81.5% ofhemodialysis patients. The purpose of this study was to determine the incidence ofantihypertensive drug interactions in hemodialysis patients in the inpatient wards PKUMuhammadiyah Hospital of Yogyakarta period in 2010. This study descriptive design.Data retrieved retrospectively. Data retrieval were done by taking all the data thatmeet the criteria of existing research on the medical records of hemodialysis patients inPKU Muhammadiyah Hospital of Yogyakarta who received antihypertensive withabove normal blood pressure (= 130/80 mmHg). Data were analyzed based on thedescriptive level of significance, onset, and severity. The results showed that there were54.79% (40 patients) of 73 hemodialysis patients potentially experienced druginteractions. Antihypertensive drugs most widely used in hemodialysis patients wereACEI, CCB, and diuretics. Incidence of antihypertensive drug interactions 27 cases(45.76% were most common at a significance level 3, 48 cases (81.36%) were onsetdelayed, and the severity minor of 44 cases (74.58%). The mechanism of interactionspharmacodynamic were 37 cases (62.71%) of the total 59 events that have druginteractions. Drugs often interactions were furosemide and captopril.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETIL ASETAT DAUN BINAHONG (Anredera scandens (L.) Moq.) TERHADAP Shigella flexneri BESERTA PROFIL KROMATOGRAFI LAPIS TIPIS Wardhani, Lilies Kusuma; Sulistyani, Nanik
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antibacterial compounds that can be used for the treatment of infections causedby bacteria. Traditionally, Anredera scandens is one of plant used as traditionalmedicine. The aims of this research are to find out the antibacterial activity of ethylacetate extract of Anredera scandens leaf and Minimum Bactericidal Concentration(MBC) against Shigella flexneri and to identify the chemical subtances of the ethylacetate extract found in Anredera scandens. The Anredera scandens leaf was extractedby use of maseration method using ethyl acetate as solvent. The antibacterial assay wasdone using liquid dilution method with varied concentration of Anredera scandens(8,5%, 8%, 7,5%, 7%, 6,5%, 6%, 5,5%, dan 5% w/v) to determine MBC.Chromatography test was done to identify the chemical substances of Anrederascandens extract. The result of this research showed that the MBC of Anrederascandens leaf extract was 8% w/v. The result of the phytochemical screening with tubetest and thin layer chromatogram showed that the extract of Anredera scandens leafcontained, polyphenols, and saponin.

PEMANFAATAN PERASAN BUAH KEPEL (Stelechocarpus burahol (Blume) Hook & Thomson) SEBAGAI ANTISEPTIK LUKA Pribadi, Prasojo; Latifah, Elmiawati; Rohmayanti, Rohmayanti
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Fruit of kepel known contain of saponin and flavonoid, fruit of kepel is a plant that hasantibacterial and antiinflamation activity. This research purposed for made juice of fruit kepeland test of open wound healing process activity. Juice of fruit kepel is made with variety ofconcentration, which 20%, 40%, 60%, and 80%. Negative control used aquadest and positivecontrol used BetadineÂ® (Povidon Iodine). This type of research is experimental research,procedure start from the preparation of test materials, first identifying plants, then make fruitjuice of kepel and divide into several concentration, followed by grouping into six group of testanimals. All quantitative data were statistically analyzed using Anaylsis of Variance (Anova)and continued with Tukey Test, The lowest activity on the negative control and increase on thegroup of juice with concentration 20%, 40%, 80%, and 60%, higher activity on the positivecontrol. With wound healing broad parameters result that the group fruit juice of kepelconcentration 60% and 80% showed the statistically analyzed was more significant (p<0.05) 178 PharmaÒ«iana, Vol. 4, No. 2, 2014: 177-183than the negative control. So it can be taken conclusion that fruit juice of kepel concentration60% and 80% having wound healing activity.

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
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Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA