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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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Penggunaan Antibiotik yang Paling Hemat Biaya pada Pasien COVID-19: Studi Analisis Minimalisasi Biaya di Rumah Sakit Yusransyah, Yusransyah; Udin, Baha
Jurnal Ilmiah Farmasi Vol. 19 No. 2 (2023): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol19.iss2.art13

Abstract

Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the cause of COVID-19, a respiratory disease. One of the treatments administered to COVID-19 patients is antibiotics to prevent the occurrence of secondary infections. However, the budget allocation for antibiotic use issued by health facilities constitutes a considerable amount due to the significantly high demand, particularly among COVID-19 patients. This situation calls for pharmacoeconomic studies, such as cost-minimization analysis, for a better understanding and management of the financial implications.Objective: This study aimed to assess the economic value of antibiotics in a hospital within Tangerang District in 2021.Method: The method used in this study was non-experimental observation through the retrospective analysis of secondary data, consisting of patient costs and demographic information. The sample was selected based on inclusion and exclusion criteria. Furthermore, the collected data were analyzed using the Kruskal-Wallis test to determine a significant difference between the total cost in each therapy group.Results: In this study, 30 patients’ data met the inclusion and exclusion criteria consisting of 4 groups: ceftriaxone (n = 10), cefixime (n = 10), ceftazidime (n = 7), and cefadroxil (n = 3). Based on the calculation of cost-minimization analysis, the total average cost per patient for the ceftriaxone, cefixime, ceftazidime, and cefadroxil groups was 19,853,503 IDR, 13,330,545 IDR, 38,666,056 IDR, and 21,333,330 IDR, respectively.Conclusion: The results showed that the cefixime group has the most economical value.Keywords: Antibiotics, cost-minimization analysis, COVID-19, hospital
Antidepressant use in pregnancy and the risk of neonatal outcomes: a scoping review Febrianti, Yosi
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art7

Abstract

Background: Depression is a frequently encountered issue during pregnancy and postpartum. Both depression itself and the use of antidepressant medications can have implications for the infant's well-being. Studies have linked maternal depression to adverse outcomes like preterm birth, low birth weight, fetal growth restriction, and potential cognitive and emotional challenges for the child after birth. On the other hand, exposure to antidepressants during pregnancy has been associated with an increased risk of preterm birth, a decrease in birth weight, and congenital malformations. Objectives: In light of these considerations, a scoping review was conducted to examine recent research findings concerning antidepressant use during pregnancy.Methods: This study was a scoping review. Pubmed and Scopus databases were used to search for all relevant studies published from 2019 until 2023. Studies were excluded if they were case reports, narrative reviews, systematic reviews, or meta-analyses. Finally, all eligible articles were assessed for their outcomes. Results: The use of SSRIs and duloxetine antidepressants in perinatal women was linked to preterm birth and smaller gestational sizes compared to controls, according to three cohort studies. Congenital malformation was also associated with duloxetine, mirtazapine, and atomoxetine use during pregnancy (3 cohort studies). Conclusions: Recognizing the potential risks to the infant and the risk of leaving maternal depression untreated is crucial when making the decision to use antidepressants during pregnancy. This underscores the importance of a thoughtful and informed approach to managing depression in pregnant women.Keywords: Antidepressant, drug safety, perinatal depression, pregnancy
UJI STABILITAS FISIK DAN EFEKTIVITAS ANTIBAKTERI PADA PERESEPAN PUYER ERITROMISIN CHEWABLE TERHADAP BAKTERI Escherichia coli DAN Staphylococcus aureus Herawati, Mutiara; Indrati, Oktavia; Romadhonsyah, Fitra; Purbaningtias, Tri Esti; Dini, Sekti Kartika; Rahmadani, Yusi; Mardatillah, Wahidatun
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art6

Abstract

Background: Pediatric patients frequently receive prescriptions for erythromycin due to its availability in chewable tablet form. Some conditions lead to the powdering of chewable tablets to enhance patient acceptability. Modifying the dosage form of chewable tablets into powder can change the drug's surface, affecting its physical stability and effectiveness against bacteria.Objective: This study aims to determine the physical stability of divided powder and the effectiveness of erythromycin pulveres against E. coli and S. aureus on the 1st to 14th days.Method: For this study, we prepared up to 200 mg of erythromycin powder, typically administering it to pneumonia patients at a dose of 50 mg/kgBW/day. We will evaluate pulveres physical stability through organoleptic and humidity tests. Next, the powder's effectiveness was evaluated using the disk diffusion method (Kirby Bauer) with an erythromycin powder inhibition zone diameter of 25.65 μg containing 15 μg of erythromycin against E. coli and S. aureus bacteria.Results: After day 9, the organoleptic test results showed a slight hardening; however, the moisture balance test results showed the change in humidity percentage was still in the stable range (1.24-2.12%). The inhibition zone (DIZ) of erythromycin powder against S. aureus was 91.7–97.40% bigger than the positive control. The DIZ against E. coli was 44.6–88.70% bigger than the positive control.Conclusion: Erthyromycin powder was stable for 14 days and is effective against S. aureus bacteria.Keywords: Erythromycin, divided powder, S. aureus, E. coli Intisari Latar belakang: Eritromisin sering diresepkan untuk pasien pediatrik karena tersedia dalam bentuk tablet kunyah. Pada beberapa kondisi, tablet kunyah dibuat puyer untuk meningkatkan kenyamanan pasien dalam mengonsumsi obat. Perubahan bentuk sediaan tablet kunyah menjadi puyer dapat memperluas permukaan obat sehingga berisiko mempengaruhi stabilitas fisik sediaan dan efektivitasnya terhadap suatu bakteri. Tujuan: Penelitian ini bertujuan untuk mengetahui stabilitas fisik puyer dan efektivitas puyer eritromisin terhadap E. coli dan S. aureus pada hari ke-1 sampai ke-14.Metode: pengujian ini dilakukan dengan membuat puyer eritromisin dalam dosis 200 mg yang biasa diberikan untuk pasien pneumonia dengan dosis 50 mg/kgBB/hari. Puyer akan diuji stabilitas fisiknya melalui uji organoleptis dan kelembaban. Selanjutnya puyer diuji efektivitasnya menggunakan metode difusi cakram (Kirby Bauer) dengan mengukur diameter zona hambat puyer eritromisin 25,65 μg yang mengandung eritromisin 15 μg terhadap bakteri E. coli dan S. aureus.Hasil: Hasil uji organoleptis menunjukkan adanya sedikit pengerasan setelah hari ke 9 namun hasil uji moisture balance menunjukkan perubahan persentase kelembaban masih pada rentang stabil (1,24-2,12%). Daya hambat puyer eritromisin terhadap S. aureus sebesar 91,7-97,40% dibandingkan kontrol positif, sementara itu, daya hambat terhadap E. Coli berada pada rentang 44,6-88,70. Kesimpulan: Puyer ertiromisin stabil selama 14 hari dan efektif terhadap bakteri S. aureus. Kata kunci: Eritromisin, puyer, S. aureus, E. coli
Optimasi Formula Gel Hand Sanitizer Minyak Atsiri Daun Jeruk Nipis (Citrus aurantifolia) dengan Variasi CMC-Na dan Gliserin Secara Desain Faktorial Lestari, Agatha Budi Susiana; Winarti, Elisabet
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art8

Abstract

Background: Lime leaves (Citrus aurantifolia) contain essential oils that are proven to inhibit the growth of bacteria. Objective: This study aims to formulate the essential oil from lime leaves in an emulgel dosage form that meets the quality requirements, using CMC-Na as a gelling agent and glycerin as a humectant using factorial design. Methods: Antibacterial activity tests are carried out using the diffusion method. The positive control used is ceftazidime, while the negative control is DMSO. The quality parameters used are physical properties (organoleptic, homogeneity, pH, viscosity, and spreadability), and physical stability of the preparation (pH shift, viscosity shift, and spreadability shift) using the freeze and thaw method. Results: Antibacterial test results show that lime leaf essential oil at concentrations of 10, 15, 20, 25, and 50% can inhibit the growth of bacteria that show strong antibacterial activity. Overall, the average test of physical properties and physical stability of the essential oil preparation of lime leaves meets the range of reception, pH 4.5–6.5, viscosity 112.77-180.66 dPa.s., and spreading power 5.55-7.97 cm. Conclusion: The optimum area specified indicates that all four formulas fulfill the criteria of pH, viscosity, spreadability, and pH shift.Keywords: CMC-Na, emulgel, essential oil of lime leaves, factorial design, glycerin Intisari Latar belakang: Daun jeruk nipis (Citrus aurantifolia) memiliki kandungan minyak atsiri yang terbukti dapat menghambat pertumbuhan bakteri. Tujuan: Penelitian ini bertujuan untuk memformulasikan minyak atsiri daun jeruk nipis dalam sediaan emulgel yang memenuhi persyaratan kualitas, dengan CMC-Na sebagai gelling agent dan gliserin sebagai humektan dengan metode desain faktorial. Metode: Uji aktivitas antibakteri dilakukan menggunakan metode difusi sumuran, dengan kontrol positif ceftazidime, sedangkan untuk kontrol negatif digunakan yakni DMSO. Parameter yang digunakan untuk kontrol kualitas sediaan emulgel meliputi uji sifat fisik (organoleptis, homogenitas, pH, viskositas dan daya sebar) dan uji stabilitas fisik (pergeseran terhadap respon pH, respon viskositas, respon daya sebar) dengan metode freeze and thaw. Hasil: Berdasarkan pengujian aktivitas antibakteri minyak atsiri daun jeruk nipis pada konsentrasi 10, 15, 20, 25 dan 50%, semuanya dapat menghambat pertumbuhan bakteri Escherichia coli dan termasuk dalam kategori kuat. Sediaan emulgel yang dihasilkan memenuhi syarat secara organoleptis maupun sifat fisik sediaan, dengan hasil pH 5-7, viskositas 112,77–180,66 dPa.s., dan daya sebar 5,55–7,97 cm. Untuk stabilitas fisik, sediaan emulgel memenuhi persyaratan pergeseran pH. Kesimpulan: Berdasarkan hasil analisis, diperoleh area optimum dari keempat formula memenuhi kriteria pH, viskositas dan daya sebar dan pergeseran pH.Kata kunci: Minyak atsiri daun jeruk nipis, CMC-Na, gliserin, emulgel, desain faktorial
Anticancer chemotherapies targeting Wnt/β-catenin signaling pathway: a review on molecular insights Nguyen, Thi Quynh Huong; Tran, Thi-Kieu-Trinh; Nguyen, Vu-Quynh-Nhu; Pham, Thuy-Loc; Nguyen, Thi-Thuy; Ngo, Thi-Kieu-Diem; Vu, Thi-Tram; Pham, Thi-Phuong-Thao; Ha, Hai-Anh
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art4

Abstract

Background: The Wnt/β-catenin signaling pathway, a highly conserved signaling axis involved in diverse physiological processes such as proliferation, differentiation, apoptosis, migration, invasion, and homeostasis balance, has been implicated in human cancer development and progression. Notably, various cancer types, such as colorectal cancer, hepatocellular carcinoma, melanoma, thyroid cancer, desmoid tumors, ovarian tumors, and multiple myeloma, have demonstrated associations with specific Wnt-activating mutations, emphasizing the widespread influence of the Wnt pathway in diverse malignancies. Objective: This review highlights the inhibitors targeting the Wnt ligand-receptor interface, focusing on their preclinical and clinical evaluations in various cancer types. Additionally, we explore small-molecule design strategies, focusing on inhibitors of β-catenin, GSK-3, and Porcupine. Method: Conducted as a narrative review, we collected and analyzed relevant papers from PubMed/Google Scholar and clinical trials associated with Wnt pathway inhibitors from clinicaltrial.gov. A total of 61 papers and 24 clinical trials were reviewed, providing an overview of the molecular insights within the research landscape of this field. Result: Dysregulated Wnt/β-catenin signaling is implicated in the progression of several solid tumors and hematological malignancies, highlighting the urgent need for targeted anticancer interventions. Our discussion on the inhibitors targeting the Wnt ligand-receptor interface highlights promising outcomes in both preclinical and clinical settings. This paper also presents the chemical structures of these compounds, detailing their interactions with key Wnt signaling components and their potential to disrupt aberrant signaling. The strategies for small-molecule design targeting the Wnt signal are discussed, highlighting inhibitors targeting β-catenin, GSK-3, and Porcupine. The complex chemical structures of these compounds are elucidated, showcasing their specific interactions with key components of the Wnt signaling pathway and their potential to disrupt aberrant Wnt signaling in diverse cancer types. The emerging directions and future prospects in Wnt pathway research demonstrate the importance of utilizing big data and artificial intelligence for drug development. Conclusion: The review delves into the potential inhibition of the disheveled protein as a promising target for cancer therapy, proposing novel molecular design strategies based on recent discoveries. Keywords: Wnt signaling pathway, β-catenin inhibitors, GSK-3 inhibitors, porcupine inhibitors, Disheveled protein inhibitors
Begonia medicinalis: a review of Phytochemistry and Pharmacology Velincia Tanriono, Levana; Hayati, Farida; Zubair, Muhammad Sulaiman
Jurnal Ilmiah Farmasi Vol. 20 No. 1 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss1.art3

Abstract

Background: Begonia medicinalis, often referred to as benalu batu, is a plant belonging to the Begoniaceae family. It is renowned for its wide range of pharmacological activities and its extensive application in the treatment of many diseases. Saponins, tannins, flavonoids, phenolics, steroids, alkaloids, and triterpenoids are some of the chemical compounds in this plant responsible for its pharmacological activity.Objective: The aim of this review is to provide information about the phytochemical and pharmacological properties of B. medicinalis.Method: This narrative review was performed by conducting literature searches on various relevant reputable online databases, and there were 17 articles that discussed the phytochemistry and pharmacology activity of B. medicinalis. Results: People have long used B. medicinalis as a test treatment for a variety of diseases. Flavanols, 2-O-β-glucopyranosyl cucurbitan D, β-sitosterol-3-O-β-D-glucopyranoside, and 9(11)α,16(17)α-dioxirane-20,25-dihydroxy-β-sitosterol-3-O-β-glucopyranoside are among the compounds found in the plant. Studies have demonstrated the immunomodulatory, anticancer, antiviral, and antioxidant activity of this plant. In vitro toxicity tests revealed that this plant is toxic and has anticancer potential. The in vivo toxicity test revealed that this plant has mild toxicity.Conclusion: This study suggests that B. medicinalis has strong potential for future development into herbal medicine.Keywords: Begonia medicinalis; Begonia sp.; pharmacological; phytochemical
DESAIN PRIMER IN SILICO UNTUK AMPLIFIKASI GEN gyrA PADA Escherichia coli DENGAN POLYMERASE CHAIN REACTION (PCR) Munakarim, Arbela Hafsah; Qurrohman, Muhammad Taufiq Qurrohman; Dewangga, Vector Stephen
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art5

Abstract

Background: The gyrA gene is an important genetic marker associated with fluoroquinolone resistance in Escherichia coli. Accurate primer design is crucial for enabling the successful amplification of this gene using the polymerase chain reaction (PCR).Objective: This study aims to evaluate the effectiveness of the designed primer pair in amplifying the gyrA gene in ciprofloxacin-resistant E. coli isolates.Method: DNA from E. coli isolates was extracted using the Presto™ Mini Bacteria Kit, followed by qualitative and quantitative analysis using UV-Vis spectrophotometry. Primer design was performed using databases and tools from NCBI, OligoEvaluator, and NetPrimer. PCR amplification was optimized at an annealing temperature of 59 °C, and results were visualized by agarose gel electrophoresis using a GelDoc system.Results: The qualitative test showed a clear DNA band, while the DNA purity ratio was 1.5, showing mild protein contamination. PCR amplification successfully produced a distinct DNA band at 221 bp, confirming that the primer pair was specific and effective.Conclusion: The primer pair (Forward: 5′-ACTGTGAAGAAAACCGTCCT-3′; Reverse: 5′-CCTAAACGAATACCGCGAAC-3′) is effective for amplifying the gyrA gene in E. coli and is suitable for further molecular detection applications.
The analysis of hydroquinone levels in the product of whitening hand and body lotion in online shops, using the UV-Vis spectrophotometry method Mellynia, Sri Agfa; Lestari, Yulianita Pratiwi Indah; Mi'rajunnisa
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art6

Abstract

Background: Hydroquinone serves as a skin-lightening agent by suppressing melanin production. However, its usage in cosmetic formulations has been prohibited under the Indonesian Food and Drug Authority regulations, as stated in Regulation Number 18 of 2015. Despite this restriction, numerous studies show that various whitening hand and body lotion products commonly contain hydroquinone.Objective: This study aimed to conduct a qualitative and quantitative analysis of hydroquinone in body-whitening hand and body lotion products available through online retail platforms.Method: The methodology employed in this study involved the use of Thin Layer Chromatography (TLC) for qualitative analysis, complemented by UV-Vis spectrophotometry, which had undergone prior validation to serve as a quantitative analytical tool.Results: The qualitative analysis conducted via Thin Layer Chromatography (TLC) identified six positive samples containing hydroquinone, characterized by an Rf value of 0.75. According to the validation results, the method demonstrated a linearity value with a correlation coefficient (r) of 0.9976, a limit of detection (LOD) of 0.3862 g/mL, and a limit of quantification (LOQ) of 1.2872 g/mL. An RSD value of 1.912% showed precision, while accuracy was confirmed through a recovery rate of 96.77%. The validation outcomes suggested that this approach is robust for analyzing hydroquinone in body-whitening hand and body lotion products. The UV-Vis spectrophotometry result showed that samples 1 through 6 had hydroquinone in them at levels of 0.0418, 0.0448, 0.0361, 0.0283, 0.0365, and 0.3193%, respectively.Conclusion: The research conducted revealed that the qualitative analysis using Thin-Layer Chromatography (TLC) yielded six positive samples, indicating the presence of hydroquinone. Furthermore, the quantitative analysis indicated that whitening hand and body lotion products available in online shops contained hydroquinone at concentrations ranging from 0.0283 to 0.3193 g/mL. This finding underscores the continued prevalence of prohibited chemicals in certain cosmetic products.
Formulasi Krim Bibir dengan Ekstrak Antosianin dari Bunga Telang (Clitoria ternatea) sebagai Pewarna Alami Aprilia, Jelita; Rahmalia, Winda; Budi, Firman Shantya
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art4

Abstract

Background: Butterfly pea (Clitoria ternatea) is a tropical plant rich in anthocyanins, particularly from the flavonoid group, which has potential as a natural dye and antioxidant in cosmetic formulations.Objective: This study aims to investigate the phytochemical characteristics of anthocyanin extract from butterfly pea flowers and the physical and chemical stability of lip cream formulated with the extract.Method: Anthocyanin extract from butterfly pea flowers was formulated into a lip cream base at concentrations of 0, 2, 4, and 6%, followed by a physical stability test conducted over a period of one month on days 0, 7, 14, 21, and 28. The results were then compared with established standards.Results: The anthocyanin extract of butterfly pea flower contains flavonoids, saponins, tannins, and terpenoids. Four lip cream formulations prepared with varying concentrations of the extract exhibited a thick texture, a grape-like aroma, and colors ranging from ivory to purple. The formulations had viscosities between 5,500 and 13,000 cP, adhesion times ranging from 7.10 to 26.8 seconds, and spreadability values between 5 and 7.5 cm.Conclusion: All stability tests of the butterfly pea flower extract lip cream formulations met the required criteria, except for the homogeneity test. Formulation 1 (2%) was identified as the most optimal. All stability tests for the butterfly pea flower extract lip cream formulations met the required criteria, except for the homogeneity test. Formulation 1 was identified as the most optimal, containing 2% extract concentration.

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