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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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Peran Short Chain Fatty Acids (SCFAs) Terhadap Kejadian Hipertensi Agus Sulaeman; Puput Novriana; Marita Kaniawati
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art11

Abstract

Background: Hypertension is a persistently elevated arterial blood pressure called the silent killer because sufferers often do not show signs and symptoms. Low Short Chain Fatty Acids (SCFA) is a risk factor for hypertension. Therefore, many efforts have been made in overcoming hypertension through the role of SCFA. Objective: This review article was conducted to see the SCFA mechanism against the incidence of hypertension so that it is hoped that we can find medicinal plants that can prevent and treat hypertension.Method: This article is compiled based on a review of several works of literature related to the role of SCFA in hypertension from articles published in the electronic database.Results: The SCFA mechanism is involved in lowering blood pressure through G-protein coupled receptors (GPCRs). Acetate binding to GPR43 causes hyperpolarization of the colonic epithelium, propionate activates GPR41 signals located in the vascular endothelium and butyrate binds to GPR109a and exerts anti-inflammatory effects. It was also found that giving baicalin and olive oil was shown to increase SCFA-producing bacteria.Conclusion: The role of SCFA in the development of hypertension occurs through the mechanism of diffusion and transport of solutes from SCFA which then activates GPCRs including GPR43, GPR41, and GPR109a so that they have a vasodilating effect by reducing inflammation, improving intestinal permeability, decreasing sympathetic nerve activity, and increasing Treg cells. Keywords: gut microbiota; SCFA; hypertension Intisari Latar belakang: Hipertensi adalah tekanan darah arteri yang meningkat secara persisten disebut juga silent killer karena penderita sering tidak menampakkan tanda dan gejala. Rendahnya Short Chain Fatty Acids (SCFA) menjadi faktor risiko dari hipertensi. Oleh karena itu, telah banyak upaya yang dilakukan dalam mengatasi hipertensi melalui peran SCFA.Tujuan: Review artikel ini dilakukan untuk melihat mekanisme SCFA terhadap kejadian hipertensi sehingga diharapkan dapat mencari tanaman obat yang dapat mencegah dan mengobati hipertensi.Metode: Artikel ini disusun berdasarkan review beberapa literatur yang terkait peran SCFA dalam hipertensi dari artikel yang diterbitkan di electronic database.Hasil: Mekanisme SCFA yang terlibat dalam penurunan tekanan darah melalui G-protein coupled receptors (GPCRs). Asetat mengikat GPR43 menyebabkan hiperpolarisasi epitel kolon, propionat mengaktifkan sinyal GPR41 yang terletak di endotel vaskuler dan butirat mengikat GPR109a memberikan efek anti-inflamasi. Kesimpulan: Peran SCFA dalam perkembangan hipertensi terjadi melalui mekanisme adanya difusi dan transport zat terlarut dari SCFA yang kemudian mengaktivasi GPCR termasuk GPR43, GPR41 dan GPR109a sehingga memberikan efek vasodilatasi dengan menurunkan inflamasi, memperbaiki permeabilitas usus, menurunkan aktivitas saraf simpatis dan meningkatkan sel Treg.Kata kunci: mikrobiota usus; SCFA; hipertensi
Efek Pemberian N-Asetilsistein sebagai Terapi Pencegahan Contrast Induced Nephropathy Pasca Intervensi Koroner Perkutan pada Lansia Putu Rika Veryanti; Gamaliel Agripa
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art7

Abstract

Background: Contrast-induced nephropathy (CIN) is a common complication in patients undergoing percutaneous coronary intervention (PCI). The Elderly is one of the risk factors for CIN and increase mortality. N-acetylcysteine is recommended as preventive therapy for CIN post PCI due to its antioxidant activity. However, previous studies have shown that the effectiveness of n-acetylcysteine as preventive therapy for CIN is still inconsistent. Objective: The aim of this study was to determine the effect of N-acetylcysteine as preventive therapy for CIN post PCI in the elderly. Method: This study used a retrospective study design. Data collection was carried out at one General Hospital in Jakarta from January until March 2020. The medical records in the 2019 period were used for the population. We included an elderly patient who underwent PCI by purposive sampling technique and obtained 78 samples. Data were analyzed by paired t-test to determine the effect of N-acetylcysteine as preventive therapy for CIN post PCI in the elderly. Results: The characteristic of elderly patients who underwent PCI were dominated by males (66.67%) with a GFR <60 mL/min/1.73m2 (74.36%). About 92.31% of patients did not have CIN and only 7.69% of patients showed a significant acute renal impairment (LFG decreased > 20%). Overall, there was an increase in average GFR value (2.33±7.90) in elderly who underwent PCI after n-acetylcysteine administration (p=0.011).Conclusion: N-acetylcysteine was effective in preventing the incidence of CIN post PCI in the elderly.Keywords: N-acetylcysteine, preventive therapy, contrast-induced nephropathy (CIN), percutaneous coronary intervention (PCI), elderly IntisariLatar belakang: Contrast Induced Nephropathy (CIN) diketahui sebagai komplikasi yang banyak terjadi pada pasien yang menjalani intervensi koroner perkutan (IKP). Usia lanjut merupakan salah satu faktor resiko terjadinya CIN dan dapat meningkatkan mortalitas. N-asetilsistein direkomendasikan sebagai terapi pencegahan CIN pasca IKP karena dihubungkan dengan aktivitas antioksidannya. Namun dari berbagai penelitian terkait efektivitas N-asetilsistein untuk mencegah CIN masih beragam dan tidak konsisten.Tujuan: Tujuan penelitian ini untuk mengetahui efek N-asetilsistein sebagai terapi pencegahan CIN paska IKP pada lansia.Metode: Penelitian menggunakan rancangan studi retrospektif. Pengambilan data dilakukan di salah satu rumah sakit umum di Jakarta pada bulan Januari – Maret 2020. Sampel yang digunakan adalah data rekam medik pasien periode tahun 2019 yang menjalani IKP dan berusia lanjut. Pengambilan sampel menggunakan teknik purposive sampling, diperoleh 78 sampel yang memenuhi kriteria inklusi dan eksklusi. Data diolah dan dianalisis dengan uji-t berpasangan untuk mengetahui efek N-asestilsistein sebagai terapi pencegahan CIN paska IKP pada lansia.Hasil: Karakteristik pasien lansia yang menjalani IKP didominasi oleh laki-laki (66,67%) dengan nilai LFG <60 mL/min/1,73m2 sebanyak 74,36%. Dari 78 pasien yang diberi terapi N-Asetilsistein, 92,31% diantaranya tidak mengalami CIN dan hanya 7,69% yang mengalami penurunan nilai LFG >20%. Secara keseluruhan, terjadi peningkatan rata-rata nilai LFG pada lansia yang menjalani IKP setelah pemberian N-asetilsistein sebesar 2,33±7,90 (p=0,011).Kesimpulan: N-asetilsistein efektif dalam mencegah kejadian CIN paska IKP pada lansia.Kata kunci: N-asetilsistein, contrast induced nephropathy (CIN), intervensi koroner perkutan (IKP), lansia
Antioxidant Potential of Telang Flower (Clitoria ternatea L.) As an Inhibitor of Hyperpigmentation Ultraviolet Exposure. Potensi Antioksidan Bunga Telang (Clitoria ternatea L.) Sebagai Penghambat Hiperpigmentasi Akibat Paparan Sinar Ultraviolet Ni Putu Anggun Cipta Rosalita Jelantik; Erna Cahyaningsih
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art5

Abstract

Background: Hyperpigmentation is a condition in which increased melanin production causes the formation of dark spots and lesions on the face. Antioxidants are used to reduce melanin production. Telang flowers have an antioxidant potential because it contains anthocyanins and other flavonoids. The potential of telang flowers is important to be recognized as a source of natural antioxidants that inhibit hyper-pigmentation on the skin due to UV exposure. Objective: To learn about the potential of telang flowers (Clitoria ternatea L.) as an inhibitor of skin hyperpigmentation due to UV exposureMethods: Data was collected using a systematic review method. The data was obtained from Google Scholar, ScienceDirect, and PubMed databases with the keywords “Clitoria ternatea L. antioxidant activity”; “phytochemical analysis of Clitoria ternatea”; “traditional use of Clitoria ternatea L”; “protective UV effect of Clitoria ternatea L.Results: Flavonol glycosides are the most common flavonoids found in telang flowers. Flavonoids exhibit antioxidant properties by counteracting the formation of free radicals caused by UV radiation in the melanin biosynthetic pathway. In addition, flavonoids act as metal chelators on tyrosinase, thereby inactivating tyrosinase during melanogenesis. Telang flowers also have the ability to absorb UV-B and UV-C, playing a role in modulating the protective effect against UVR exposure on the skin.Conclusion: Telang flowers have the potential as an inhibitor of skin hyper-pigmentation due to UV exposure.Keywords: Antioxidant, telang flower, hyper-pigmentation, ultraviolet IntisariLatar belakang: Hiperpigmentasi merupakan keadaan bertambahnya produksi melanin yang menyebabkan terbentuknya lesi dan noda hitam pada wajah. Antioksidan diketahui dapat digunakan untuk mengurangi produksi melanin. Bunga telang memiliki potensi antioksidan, karena terdapat antosianin dan flavonoid lainnya. Potensi bunga telang penting diketahui sebagai sumber antioksidan alami penghambat hiperpigmentasi pada kulit akibat paparan sinar UV.Tujuan: Untuk mempelajari mengenai potensi bunga telang (Clitoria ternatea L.) sebagai penghambat hiperpigmentasi kulit akibat paparan sinar UVMetode: Pengumpulan data dilakukan menggunakan basis data Google Scholar, Science Direct dan PubMed dengan kata kunci “Clitoria ternatea L. antioxidant activity”; “phytochemical analysis of Clitoria ternatea”; “traditional use of Clitoria ternatea L”; “protective UV effect of Clitoria ternatea L.Hasil: Flavonol glikosida merupakan flavonoid yang paling banyak dijumpai pada bunga telang. Flavonoid menunjukkan sifat antioksidan dengan menangkal pembentukan radikal bebas yang disebabkan oleh radiasi UV pada jalur biosintesis melanin. Selain itu, flavonoid bertindak sebagai pengkelat logam pada tirosinase, sehingga menonaktifkan aktivitas tirosinase selama melanogenesis. Bunga telang juga memiliki kemampuan dalam menyerap UV-B dan UV-C yang berperan dalam memodulasi efek perlindungan terhadap paparan UVR pada kulit.Kesimpulan: Bunga telang memiliki potensi sebagai penghambat hiperpigmentasi kulit akibat paparan sinar UV.Kata kunci: Antioksidan, bunga telang, hiperpigmentasi, sinar ultraviolet
Combination of ethanolic extract on total flavonoid Centella asiatica L. leaves and Imperata cylindrica L. roots with UV-VIS spectrophotometric method Anita Puspa Widiyana; Sri Herlina; Didi Nurhadi Illian
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art6

Abstract

Background: Flavonoids are widely employed as phytomedicines and as secondary metabolites generated by plants, where they serve key roles in plant physiology. Antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal, and antiviral activities are only a few of the potential biological effects of flavonoids. The discovery of medicinal plants containing flavonoid chemicals is potential as a supportive and preventative treatment, notably for COVID-19 which has caused a pandemic in several countries, including Indonesia.Objective: This study aimed to determine the total flavonoid content in the ethanolic extracts of C. asiatica leaves and Imperata cylindrica roots to find the potential of flavonoid-rich plants as an alternative source of COVID-19 treatment.Methods: The ethanolic extracts from the combination of C. asiatica leaves and I. cylindrica roots (with five combination ratios) were tested for total flavonoid content using the UV-Vis Spectrophotometry method. The total flavonoid content of the extract combination was analyzed using a one-way ANOVA test.Results: The total flavonoid contents of the combination of C. asiatica leaf and I. cylindrica root extracts at a ratio of 1:1, 2:3, 3:2, 4:1, and 1:4 were 45.88 ± 0.08, 42.14 ± 0.08, 40.52 ± 0.08, 66.28 ± 0.08, and 40.88 ± 0.13 mg/g EQ, respectively. The homogeneity with Levene's test obtained a p-value of 0.303. The one-way ANOVA exhibited the p-value of F-test statistics < 0.001. Conclusion: The total flavonoid contents of ethanolic extracts from C. asiatica leaves and I. cylindrica roots are at a ratio of 4:1 > 1:1 > 2:3 > 1:4 > 3:2. The high total flavonoid content plays a role in increasing anti-inflammatory and immunomodulatory activities in COVID-19 patients.Keywords: Total flavonoid content, C. asiatica, I. cylindrica, UV-Vis Spectrophotometry, COVID-19
Skrining Pigmen, Uji Fitokimia, dan Sitotoksik Ekstrak Etanol Teripang Holothuria atra dari Perairan Pulau Lemukutan Wenti Yuliana; Nora Idiawati; Dwi Imam Prayitno
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art4

Abstract

Background: Holothuria atra is a type of sea cucumber found in the waters of Lemukutan Island, West Kalimantan, which has economic and ecological benefits. Personal experience found the presence of a water-soluble pigment when isolating sea cucumbers, which was bright red, thus drawing attention. Research on the water-soluble pigment of the ethanol extract of H. atra from Lemukutan Island waters has not been carried out yet. Natural pigments in sea cucumbers have a specific role as part of secondary metabolite compounds with the potential of having antimicrobial, antifungal, anticancer, antitumor, antiviral, anticoagulant, and antioxidant activities.Objective: This study aimed to determine the natural pigments, secondary metabolites, and cytotoxic compounds in the ethanolic extract of H. atra.Methods: Samples of H. atra were extracted with 96% ethanol. The pigment analysis used UV-Vis spectrophotometry while the secondary metabolites were tested by the phytochemical screening method, and the cytotoxicity testing involved the Brine Shrimp Lethal Toxicity (BSLT) method.Results: The obtained optimum absorption was 230 nm, which indicated a melanin pigment. The phytochemical test on the ethanolic extract of H. atra found flavonoid, phenolic, alkaloid, saponin, and triterpenoid compounds. The cytotoxicity test based on LC50 was 6.985 ppm, indicating the extract was categorized as extremely toxic because it was <30 ppm.Conclusion: The pigment in H. atra is melanin, the secondary metabolites consist of flavonoids, phenolics, alkaloids, saponins, and triterpenoids, and it has a highly toxic activity.Keywords: Holothuria atra, melanin, phytochemical test, BSLT, cytotoxic IntisariLatar belakang: Holothuria atra adalah salah satu jenis teripang yang ditemukan di Perairan Pulau Lemukutan Kalimantan Barat, memiliki manfaat ekonomi maupun ekologi. Pengalaman saat pengambilan sampel dijumpai adanya pigmen larut air dari tempat sampel, berwarna merah cerah dan menarik perhatian. Penelitian tentang pigmen larut air pada ekstrak etanol H. atra dari perairan Pulau Lemukutan belum pernah dilakukan. Pigmen alami pada teripang memiliki peranan tertentu, sebagai bagian dari senyawa metabolit sekunder berpotensi sebagai antimikroba, antijamur, antikanker, antitumor, antivirus, antikoagulan dan antioksidan.Tujuan: Penelitian ini bertujuan mengetahui pigmen alami, senyawa metabolit sekunder dan potensi sitotoksik pada ekstrak etanol H. atra.Metode: Sampel H. atra diekstraksi dengan etanol 96%. Analisis pigmen menggunakan spektrofotometri UV-Vis, pengujian senyawa metabolit sekunder dengan metode skrining fitokimia dan uji sitotoksik menggunakan metode Brine Shrimp Lethal Toxicity (BSLT).Hasil: Serapan optimum yang dihasilkan oleh ekstrak etanol adalah 230 nm yang merupakan pigmen melanin. Hasil uji fitokimia pada ekstrak etanol H. atra ditemukan senyawa flavonoid, fenolik, alkaloid, saponin dan triterpenoid. Uji sitotoksik berdasarkan LC50 adalah 6,985 ppm menunjukkan ekstrak dengan kategori sangat toksik karena nilainya <30 ppm.Kesimpulan: Pigmen pada H.atra yaitu melanin. Kadungan ekstrak etanol metabolit sekunder teridiri dari flavonoid, fenolik, alkaloid, saponin dan triterpenoid serta memiliki aktivitas toksistas yang sangat toksik.Kata kunci: Holothuria atra, melanin, uji fitokmia, BSLT, sitotoksik
Antibacterial activity of the combination of Mentha spicata and Allium sativum extracts on the growth of Mycobacterium tuberculosis clinical isolates Yunan Jiwintarum; Maruni Wiwin Diarti; I Gede Angga Adnyana; Hady Anshory
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art10

Abstract

Background: Tuberculosis (TB) is a disease with a high mortality rate in the world, including in Indonesia. In addition, the problem of Mycobacterium tuberculosis resistance to antibiotics is getting higher. Mint leaves and garlic have been shown its the ability to kill M. tuberculosis. However, it has never been studied how the combined effect the M. tuberculosis growth.Objective: The major objective of this study was to investigate the anti-mycobacterial activity of mint leaves-garlic combination to growth inhibition of clinical culture M. tuberculosis.Method: Extraction of mint leaves and garlic was carried out by maceration using ethanol as a solvent. M. tuberculosis cultures were obtained from clinical samples of patients diagnosed with new tuberculosis (TBB) and MDR- tuberculosis (TBB). The growth inhibition activity test was carried out using the agar dilution method on Lowenstein Jensen (LJ) media.Results: Mint and garlic extracts, and their combination can inhibit the growth of M. tuberculosis clinical culture from TBB and TBM patients with minimal inhibitory concentration (MIC) of 3 mg/mL.Conclusion: Mint and garlic extracts, and their combination are effective in inhibiting the growth of M. tuberculosis clinical culture and can be used as an alternative treatment for tuberculosis disease.Keywords: mint leaves (Mentha spicata), garlic (Allium sativum), Mycobacterium tuberculosis, multidrug-resistant (MDR)-Tuberculosis Intisari Latar belakang: Tuberkulosis (TBC) merupakan penyakit dengan tingkat kematian yang tinggi di dunia, termasuk Indonesia. Selain itu, masalah resistensi bakteri terhadap antibiotik semakin tinggi. Daun mint (Mentha spicata) dan bawang putih (Allium sativum) telah terbukti dapat membunuh bakteri M. tuberculosis. Namun belum pernah diteliti bagaimana efek kombinasi keduanya dalam membunuh atau menghambat pertumbuhan bakteri M. tuberculosis. Tujuan: Mengetahui aktivitas kombinasi ekstrak daun mint dan bawang putih dalam menghambat pertumbuhan bakteri M. tuberculosis isolat klinik.Metode: Ekstraksi daun mint dan bawang putih dilakukan secara maserasi menggunakan pelarut ethanol. Bakteri uji M. tuberculosis diperoleh dari sampel klinik pasien terdiagnosis tuberkulosis baru (TBB) dan tuberkulosis multidrug resistant (TBB). Uji aktivitas penghambatan pertumbuhan dilakukan menggunakan metode dilusi padat pada media Lowenstein Jensen (LJ).Hasil: Ekstrak daun mint dan bawang putih serta kombinasi keduanya dapat menghambat pertumbuhan bakteri M. tuberculosis isolat klinik dari pasien TBB maupun TBM dengan konsentrasi terkecil 3 mg/mL.Kesimpulan: Ekstrak daun mint dan bawang putih serta kombinasi keduanya efektif menghambat pertumbuhan bakteri M. tuberculosis isolat klinik dan berpotensi untuk digunakan sebagai alternatif pengobatan tuberkulosis.Kata kunci: daun mint (Mentha spicata), bawang putih (Allium sativum), Mycobacterium tuberculosis, multidrug-resistant (MDR)-TB
Relationship Between Appropriateness of Empirical Antibiotics Based on ATS/IDSA with Clinical Outcome and Length of Stay in ICU (Intensive Care Unit) Patient with Sepsis Pneumonia Muhammad Luthfi Aziz; Ika Puspita Sari; Rizka Humardewayanti Asdie
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art9

Abstract

Background: In ICU (Intensive Care Unit), sepsis is the most common cause of death, with pneumonia being the most common source of infection. The management of sepsis pneumonia is determined by the therapy used. One of the supporting aspects in the successful treatment of sepsis pneumonia is appropriate empiric antibiotic therapy.Objective: Determine the relationship between the appropriateness of empirical antibiotics based on ATS/IDSA (American Thoracic Society/ The Infectious Disease Society of America) with clinical outcome and LOS (Length Of Stay) in ICU patients with sepsis pneumonia.Method: An observational study with a retrospective cohort design in ICU patients with sepsis pneumonia from January 2019-December 2020 at RS X Jakarta. The study involved 99 patients who were divided into two groups based on appropriate and inappropriate with ATS/IDSA. Data were analyzed using bivariate and multivariate for reducing the confounding factor.Results: The appropriateness of empirical antibiotics was found to be appropriate in 48.48% (48 patients), while 51.52% (51 patients) were inappropriate with ATS/IDSA. There was a relationship between empirical antibiotic appropriateness and clinical outcome (p=0.042; RR=1.430; 95%CI=1.039-1.969) based on the chi-square test, but no relationship with LOS (p=0.629) based on the Mann Whitney test. The multivariate analysis showed that there were no confounding factors affecting the clinical outcome (p>0.05).Conclusion: There is a relationship between empirical antibiotic appropriateness based on ATS/IDSA with clinical outcomes but not related to the length of stay in sepsis pneumonia patients in the ICU.Keywords: sepsis pneumonia, antibiotic empiric, clinical outcome, LOS IntisariLatar belakang: Sepsis merupakan penyebab kematian terbanyak di ICU (Intensive Care Unit), dengan sumber infeksi tertinggi adalah pneumonia. Keberhasilan pengobatan sepsis pneumonia bergantung pada terapi yang diberikan. Pemberian terapi antibiotik empirik yang sesuai merupakan salah satu faktor penunjang keberhasilan pengobatan sepsis pneumonia.Tujuan: Mengetahui hubungan kesesuaian antibiotik empirik berdasarkan ATS/IDSA (American Thoracic Society/ The Infectious Disease Society of America) dengan outcome klinik dan lama waktu rawat pasien sepsis pneumonia di ICU.Metode: Penelitian observasional dengan rancangan kohort retrospektif pada pasien ICU dengan diagnosis sepsis pneumonia periode 1 Januari 2019-31 Desember 2020 di RS X Jakarta. Penelitian melibatkan 99 pasien yang terbagi dalam kelompok sesuai dan tidak sesuai ATS/IDSA. Data dianalisis dengan uji bivariat serta multivariat untuk mereduksi variabel pengganggu.Hasil: Kesesuaian antibiotik empirik diperoleh sebesar 48,48% (48 pasien) telah sesuai dan 51,52% (51 pasien) tidak sesuai ATS/IDSA. Berdasarkan hasil uji chi-square terdapat hubungan kesesuaian antibiotik empirik dengan outcome klinik (p=0,042; RR=1,430; 95%CI=1,039-1,969) dan berdasarkan uji mann whitney tidak terdapat hubungan antara kesesuaian antibiotik empirik dengan lama waktu rawat (p=0,629). Hasil analisis multivariat menunjukkan tidak ada faktor pengganggu yang mempengaruhi outcome klinik (p>0,05).Kesimpulan: Kesesuaian antibiotik empirik berdasarkan ATS/IDSA pada pasien sepsis pneumonia di ICU memiliki hubungan dengan outcome klinik namun tidak berhubungan dengan lama waktu rawat.Kata kunci: sepsis pneumonia, antibiotik empirik, outcome klinik, lama waktu rawat
¬¬Faktor-faktor yang Memengaruhi Tingkat Pengetahuan DAGUSIBU pada Masyarakat Desa Yulianto; Mega Alfiana; Vitarani D.A Ningrum
Jurnal Ilmiah Farmasi Vol. 18 No. 1 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss1.art8

Abstract

Background: As RISKESDAS findings indicate that most families obtain drugs from prescription or self-medication. A good understanding of drug management is needed to minimize the risks of inappropriate drug use, counterfeit drugs, and other negative impacts. GKSO (The Family Drug Awareness) with the DAGUSIBU slogan (Obtain, Use, Store, Dispose) is an Indonesian Pharmacist Association’s program to raise awareness of exemplary behavior toward family drug management. Objective: This study analyzed the factors influencing DAGUSIBU knowledge among the people in Sekarbagus Village of Lamongan Regency. Methods: A cross-sectional survey study was conducted from March-May 2021 with the levels of DAGUSIBU knowledge assessed using a validated questionnaire. Data analysis used the chi-square in SPSS 21. Results: The results from 113 respondents indicated that the majority of the community had poor knowledge of using and disposing of medications with 57.52% and 87.61%, respectively. Compared to other knowledge, storing medications had the largest proportion (14,16%). There were no respondents with good knowledge of obtaining medications. This study also found that educational level and types of occupations correlated with levels of knowledge (p < 0.05). Conclusion: With more than a third of the population having poor knowledge, pharmacists are expected to educate the community to improve their knowledge and good practice of DAGUSIBU.Keywords: DAGUSIBU, knowledge, village community, influencing factors IntisariLatar belakang: Seiring dengan hasil RISKESDAS terkait mayoritas keluarga memiliki persediaan obat yang diperoleh melalui peresepan maupun layanan swamedikasi. Pemahaman yang baik tentang pengelolaan obat diperlukan untuk meminimalkan risiko ketidaktepatan penggunaan, pemalsuan obat, dan dampak negatif lainnya. Gerakan Keluarga Sadar Obat (GKSO) dengan slogan DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang obat) merupakan program Ikatan Apoteker Indonesia untuk meningkatkan kesadaran berprilaku benar tentang pengelolaan obat keluarga. Tujuan: Penelitian ini menganalisis faktor-faktor yang memengaruhi tingkat pengetahuan masyarakat desa Sekarbagus Kecamatan Sugio Kabupaten Lamongan tentang DAGUSIBU. Metode: Penelitian berdesain cross-sectional survey dilakukan selama bulan Maret-Mei 2021 dengan penilaian tingkat pengetahuan DAGUSIBU menggunakan kuesioner yang telah divalidasi. Analisis data menggunakan uji chi-square dengan SPSS versi 21. Hasil: Hasil penelitian pada 113 responden menunjukkan masyarakat berpengetahuan rendah mayoritas pada aspek dapatkan dan buang obat yakni masing-masing sebanyak 57,52% dan 87,61%, berturutan. Dibandingkan lainnya, pengetahuan simpan obat menunjukkan proporsi tertinggi berpengetahuan baik (14,16%). Tidak ditemukan responden dengan pengetahuan kategori baik pada aspek dapatkan. Studi ini juga menemukan tingkat pendidikan dan jenis pekerjaan berkorelasi dengan tingkat pengetahuan masyarakat (p <0,05). Kesimpulan: Temuan masyarakat berpengetahuan kurang pada semua aspek DAGUSIBU sebanyak lebih dari sepertiga populasi menghendaki edukasi apoteker untuk meningkatkan pengetahuan dan kesadaran praktek pengelolaan obat di masyarakat pedesaan. Kata Kunci: DAGUSIBU, pengetahuan, masyarakat desa, faktor yang memengaruhi
REVIEW: RANDOMIZED CLINICAL TRIAL STUDY OF INFLUENZA VACCINE IN CHILDREN AGE 6-35 MONTHS Cecep Suhandi; Cheryl Alodya; Abednego Kristande; Rano Kurnia Sinuraya
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art13

Abstract

Background: Influenza is a contagious viral infection disease that causes acute disorders of the respiratory tract. The prevalence of infection due to influenza virus is higher in children than adults. Thus, it is very important to vaccinate children using the most effective type of vaccine.Objectives: The purpose of this review was to investigate type of influenza vaccine with the highest effectiveness in children 6 to 35 months of age based on RCT study.Methods: The review is carried out by collecting articles from Elsevier and Medline database using “.Influenza Vaccine”, “Randomized Control Trial”, and “Children” as the keywords.Results: Based on the initial searching, it was found 6.261 articles and 9 articles that fulfill the review criteria. The results showed that the best vaccine efficacy has gotten by trivalent vaccines against the strains of viruses A (H1N1), A (H3N2), and B (Yamagata) with vaccine efficacy values of 94.1%; 100%; and 97.1%, respectively. While the use of quadrivalent vaccines against strain B (Victoria) virus with a vaccine efficacy value of 87.2%.Conclusions: Trivalent vaccine more effective for strain A and B (Yamagata) virus, moreover quadrivalent vaccine more effective for strain B (Victoria)Keywords: Influenza, vaccine, children, trivalent, quadrivalent Intisari Latar Belakang: Influenza merupakan suatu penyakit infeksi virus menular yang mengakibatkan gangguan akut pada saluran pernapasan. Insidensi infeksi akibat virus influenza lebih tinggi terjadi pada anak-anak dibanding dewasa. Dengan demikian, sangat penting untuk memberikan vaksinasi pada anak-anak menggunakan jenis vaksin yang paling efektif. Tujuan: Tujuan dari review ini adalah untuk menentukan jenis vaksin influenza dengan efektivitas tertinggi terhadap anak usia 6-35 bulan berdasarkan hasil studi (RCT).Metode: Review dilakukan dengan penelusuran pustaka pada database ELSEVIER dan MEDLINE dengan kata kunci “Influenza Vaccine”, “Randomized Control Trial”, dan “Children”.Hasil: Berdasarkan hasil penelusuran, diperoleh 6.261 artikel dan 9 artikel yang memenuhi kriteria review. Hasil telaah dapat menunjukkan bahwa efektivitas vaksin terbaik pada vaksin trivalent terhadap virus strain A (H1N1), A (H3N2), dan B (Yamagata) dengan nilai efikasi vaksin secara berurutan sebesar 94,1%; 100%; dan 97,1% untuk usia anak 12-35 bulan. Sedangkan penggunaan vaksin quadrivalent terhadap virus strain B (Victoria) dapat mencapai nilai efikasi vaksin 87,2% pada anak usia 6-35 bulan. Kesimpulan: Vaksin trivalent lebih efektif pada virus strain A dan B (Yamagata), sedangkan vaksin quadrivalent lebih efektif pada strain B (Victoria)Kata kunci: Influenza, vaksin, anak-anak, trivalent, quadrivalent
Analisis biaya pasien Severe Cutaneous Adverse Reactions (SCARs) Qarriy 'Aina Urfiyya; Musa Fitri Fatkhiya; Dyah Aryani Perwitasari; Sri Awalia Febriana; Woro Supadmi
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art12

Abstract

Background: Severe Cutaneous Adverse Reactions (SCARs), including Stevens-Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and Drug Reaction with Eosinophilia and Systemic Symptom (DRESS), were the idiosyncratic reactions most commonly caused by drugs which have an impact on increasing the patient's financial burden. Objectives: This study aims to determine the highest cost component and the illness cost in patients suffering from Severe Cutaneous Adverse Reactions (SCARs). Methods: This study was an analytic observational study with a cross-sectional design. We collected direct medical costs, direct non-medical costs, and indirect costs for inpatients with SJS, TEN, and DRESS at Dr. Sardjito Yogyakarta Hospital from 2014-2018, retrospectively. Based on the societal perspective, we defined the highest cost component and the illness cost in patients with SCARs. Results: The highest cost component for SJS, and TEN patients were obtained in the health professional services (24,1% and 25,2%, respectively). Meanwhile, the highest cost component for DRESS patients was the cost of drugs (20,2%). The total illness cost of 47 SCARs patients (22 SJS patients, 6 TEN patients, and 19 DRESS patients) was IDR 666.615.321, with the highest average cost for TEN patients, followed by SJS and DRESS (IDR 16.510.595, IDR 14.205.545, and IDR 13.445.555, respectively). Conclusions: The highest cost component was the health professional services in SJS and TEN patients and the cost of medicine for DRESS patients. The management of SCARs requires considerable cost, and it is still being a financial burden on the patients.

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