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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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Interferons and its use in children with COVID-19: A narrative review Chairunnisa Chairunnisa; Suharjono Suharjono
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art18

Abstract

Background: All ages, including children, are susceptible to the disease COVID-19. The severity of COVID-19 in children is mild than in adults. One of the recommended antiviral drugs for COVID-19 in children is interferon. Objective: To describe the efficacy and safety of using interferon in children with COVID-19 Method: The article is a narrative study. The main databases in the article search process in this literature review are PubMed and Google Scholar. Results: The articles could potentially be involved in this study were 28 articles. A total of 13 articles included the criteria, 9 articles discussed the use of interferon against respiratory syndrome, 4 articles on interferon in children, and one reference from a literature search. Conclusion: Interferon therapy in COVID-19 in children has a high cure rate but needs to be evaluated in a larger sample of pediatric patients.
Skrining senyawa Eurycoma longifolia terhadap siklus sel dengan metode docking melalui interaksi cylcin Samsul Hadi; Khoerul Anwar; Noer Komari; Desiya Ramayanti Azhara; Diah Aulia Rosanti
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art15

Abstract

Background: The community has known pasak bumi for generations to increase sexual desire in men (aphrodisiac). Besides, it can improve the performance of sports athletes and as an antistress, reduce tension, anger, and confusion. Objective: This relatively large number of uses encourages researchers to want to do in silico screening of active compounds against antitumors by going through 2 stages, namely through online PASS and docking. Method: Docking method to see the stability interaction of compounds with cyclin. In this test, Pyrx was used as a docking tool with various cell cycle-related targets, namely cyclin D3 (PDB ID: 3G33), cyclin A (PDB ID: IJSU), cyclin A (PDB ID, cyclin C (1ZP2), cyclin D (ID PDB: 2W9F), cyclin H (PDB ID: 1KXU), and cyclin T (PDB ID: 3BLR). Results: The docking result showed that each cyclin showed the best interaction with these compounds: Cyclin A and 9-Methoxycanthin-6-one 3-N-oxide (-8.6 Kcal/mol), cyclin H and Niloticin (-8.0 Kcal/mol), cyclin D3 is 9-Methoxycanthin-6-one 3-N-oxide (-7.2 Kcal/mol), cyclin D is Eurycolactone F (-8.4 Kcal/mol), cyclin C is and Niloticin (-7.5 Kcal/mol), and cyclin T and Niloticin (-8.2 Kcal/mol). Conclusion: Based on the docking score obtained, the stability of the interaction is predicted to occur in cyclin A and 9-Methoxycanthin-6-one 3-N-oxide (ΔG: -8.6 Kcal/mol). Intisari Latar belakang: Pasak bumi telah dikenal oleh masyarakat secara turun-temurun untuk meningkatkan gairah seksual pada pria (afrodisiaka). Disamping itu dapat meningkatkan performa atlet olahraga dan sebagai antistress, menurunkan tegangan, kemarahan, dan kebingungan. Tujuan: Penggunaan yang relatif banyak ini mendorong peneliti berkeinginan melakukan skrining senyawa aktif terhadap antitumor secara in silico dengan melalui 2 tahap yaitu melalaui PASS online dan docking. Metode: Metode docking dipakai untuk melihat interaksi stabilitas senyawa dengan cylin. Dalam pengujian ini, Pyrx digunakan sebagai alat docking dengan berbagai target yang berhubungan dengan siklus sel, yaitu cyclin D3 (PDB ID: 3G33), cyclin A (PDB ID: IJSU), cyclin C (PDB ID: 1ZP2), cyclin D (ID PDB: 2W9F), cyclin H (ID PDB: 1KXU), dan cyclin T (ID PDB: 3BLR). Hasil: Hasil docking pada masing-masing cyclin menunjukkan interaksi terbaik dengan senyawa berikut ini: cyclin A dan 9-Methoxycanthin-6-one 3-N-oxide (-8,6 Kkal/mol), cyclin H dan Niloticin (-8,0 Kkal/mol), cyclin D3 dan 9-Methoxycanthin-6-one 3-N-oxide (-7,2 Kkal/mol), cyclin D dan Eurycolactone F (-8,4 Kkal/mol), cyclin C dan Niloticin (-7,5 Kkal/mol), serta cyclin T dan Niloticin (-8,2 Kkal/mol). Kesimpulan: Berdasarkan skor docking yang diperoleh, kestabilan interaksi diprediksi akan terjadi pada cyclin A dengan 9-Methoxycanthin-6-one 3-N-oxide (ΔG: -8.6 Kkal/mol).
Karakterisasi dan Penetapan Kadar Flavonoid Total Ekstrak dan Fraksi Bunga Pepaya Jantan (Carica papaya L.) dengan Spektrofotometri UV-Vis Dilla Nur Pratiwi; Nastiti Utami; Diah Pratimasari
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art20

Abstract

Background: The potential of pepaya jantan flowers (Carica papaya L.) as functional herbal ingredients, such as antioxidants, is influenced by the activity of secondary metabolites, one of which is flavonoids. Objective: This study aims to determine the total flavonoid content and characterization of flavonoids in the ethanol extract and flower fraction of papaya jantan (Carica papaya L.). Method: Pepaya jantan flower was extracted by maceration using ethanol 70% then fractionated using multilevel fractionation. The identification of flavonoids was tested using Taubeck, Wilstater, and TLC. Extract and fractions were determined of flavonoid content using the colorimetric method and identification of flavonoids based on the wavelength of cinnamoyl and benzoyl in the spectrum UV-Vis. Results: The results of the determination of flavonoid content showed that ethanol extract was the highest at 0.6805 ± 0.0045 %QE and n-hexane fractions were the lowest at 0.4178 ± 0.0058 %QE. Identification of flavonoids using the UV-Vis spectroscopy method showed the absorption of substituted 3-OH flavonol and free 3-OH flavonol.  Conclusion: The highest flavonoid content was found in the ethanol extract of papaya jantan flower. The types of flavonoids in the extract and fractions of male papaya flower indicated the type of flavonol based on the wavelength of cinnamoyl and benzoyl.
Potensi Enzim Superoksida Dismutase dari Biji Jagung (Zea Mays L.) untuk Perbaikan Sel Fibroblas 3t3 Yang Dipaparkan Sinar Ultraviolet A Mustika Endah Pratiwi; Jason Merari Peranginangin; Isna Jati Asiya; Ana Indrayati
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art16

Abstract

Background: UV-A radiation induct disorder to the skin called photoaging. It requires treatment with antioxidant agent. Superoxide dismutase (SOD) is the first line antioxidant in the treatment of free radicals.  Objective: This study aimed to find out anti-photoaging activities of SOD extract of corn (Zea mays L.) kernels on radiated UV-A rays 3T3 fibroblast cells. Method: SOD extraction of corn kernels was done by centrifugation, precipitation and dialysis method. The activity of SOD extract in corn kernels was measured by WST-1 method. Anti-photoaging activity test of SOD extract in corn kernels was done on radiated UV-A rays 3T3 fibroblast cells with parameters of cell viability. Anti-photoaging activity test using cell control, negative, sample and positive control.   Results: SOD activity showed that the highest percent inhibition value was SOD extract of corn kernels in precipitation of ammonium sulphate concentration was 60-90% with inhibition percentage was 65.50%. The result of anti-photoaging activity SOD extract of corn kernels showed significant difference in the value of percent cell viability in fibroblast cells between the extract group and the negative control group with the highest percent cell viability in SOD extract corn kernels with the concentration was 100 mg/mL, namely 142.31%. Conclusion: SOD extract from corn kernels has proven had antioxidant activity that could be used as anti-photoaging through fibroblast cell reparation mechanism.
Evaluation of single and combination chemotherapy agents in patients with metastatic breast cancer Martanty Aditya; Godeliva Adriani Hendra; Suhul Raos Kumawula Ing Gustyas
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art14

Abstract

Background: There are several ways to treat breast cancer, one of which is administering chemotherapy agents. Chemotherapy agents have activity in inhibiting the cell cycle. That will affect the effectiveness of therapy and the side effects of chemotherapy agents. Objective: This study aimed to evaluate single and combination chemotherapy agent therapeutic efficacy and side effects Method: The design of this study used an observational cohort study with retrospective data collection from January to December 2019. Patients obtained from medical records were diagnosed with metastatic stage of breast cancer at Panti Nirmala Hospital, Malang. The effectiveness of the chemotherapy agent was seen from the carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3), which were carried out in the first and third cycles, then analyzed using the Wilcoxon and U-Mann Whitney tests. Side effects of chemotherapy agents were analyzed descriptively. Results: Analysis of the Wilcoxon test showed differences between the two groups of chemotherapeutic agents in CEA and CA15-3 (p<0.05). U-Mann Whitney test analysis showed no difference after administration of the two groups of chemotherapy agents at CEA (p>0.05). However, there was a difference in CA15-3 (p<0.05). Both chemotherapy agents showed most common side effects such as pain, nausea,  vomiting, and alopecia. Conclusion: Patients who received a combination of chemotherapy agents had lower CA15-3 levels than single chemotherapy agents.
Phyllanthus niruri (Meniran) Sebagai Imunomodulator: Mekanisme aksi dan senyawa bioaktif Uzulul Hikmah; Asih Triastuti
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art19

Abstract

Background: Phyllanthus niruri (meniran) is a medicinal plant with antimicrobial, antioxidant, anticancer, anti-inflammatory, antiplasmodial, antiviral, hepatoprotective diuretic, and immunomodulator properties. Objective: This review examined the activity, mode of action, and active compounds of P. niruri as an immunomodulator in various preclinical and clinical studies, along with the bioactive compounds and their mechanism. Results: Flavonoids, lignans, terpenoids, and alkaloids, among other phytochemicals found in P. niruri, play an essential part in the pharmacological activity of the plant. The immunomodulation activity of P. niruri has been extensively researched in preclinical (in silico, in vitro, and in vivo) and clinical trials. A study in silico revealed the potential of P. niruri as an immunomodulator in Covid-19 infection by inhibiting the COVID-19 target receptors spike glycoprotein (6LZG) and major protease (5R7Y and Mpro). In addition, P. niruri boosted macrophage phagocytic activity, increased antibody total, and reduced inflammation in vitro and in vivo experiments. P. niruri also showed immunomodulatory effects in both healthy subjects and patients.  Conclusion: P. niruri exhibits pharmacological potential as an immunomodulator in preclinical and clinical trials, according to the findings of various investigations. Keywords: Phyllanthus niruri, immunomodulator, immunostimulant Intisari  Latar belakang: Phyllanthus niruri merupakan tanaman obat yang memiliki beberapa aktivitas farmakologi seperti antimikroba, antioksidan, antikanker, antiinflamasi, antiplasmodium, antivirus, diuretik, hepatoprotektif, dan sebagai imunomodulator.  Tujuan: Melakukan tinjauan analisis mengenai aktivitas, mekanisme, dan senyawa aktif P. niruri sebagai imunomodulator pada uji preklinis maupun uji klinis. Hasil: Kandungan kimia P. niruri seperti flavonoid, lignan, terpenoid, dan alkaloid berperan penting pada aktivitas farmakologi P. niruri sebagai imunomodulator.  Uji in silico menunjukkan potensi P. niruri sebagai imunomodulator pada infeksi Covid-19 dengan berikatan pada protein spike dan protease yang bertanggungjawab pada replikasi dan pematangan virus. Uji in vitro dan in vivo menunjukkan bahwa P. niruri mampu meningkatkan aktivitas fagositosis dari makrofag, meningkatkan antibodi serum total, dan mengurangi inflamasi. Pengujian klinis membuktikan bahwa P. niruri memiliki aktivitas imunomodulator baik pada subjek uji sehat maupun pada pasien.  Kesimpulan: P. niruri memiliki aktivitas sebagai imunomodulator baik pada pengujian preklinis maupun klinis.  Kata kunci : P. niruri, imunomodulator, imunostimulan
In vivo nephroprotective effect of herbal plants towards gentamicin-induced nephrotoxicity: A literature review Erlyn Dwi Cahyani; Rahmad Aji Prasetya; Izzatul Ma'rifah; Deby Nanda Tri Widia; Tiara Sri Dewi; Sulfa Putri
Jurnal Ilmiah Farmasi Vol. 18 No. 2 (2022): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol18.iss2.art17

Abstract

Background: Gentamicin can cause nephrotoxicity due to accumulation in proximal tubules then triggering free radicals generation that damage the nephrons. In response, our body produces endogenous antioxidants. However, extensive formation of free radicals requires exogenous antioxidants which can be obtained from herbal plants to compensate. Thus, rigorous preclinical and clinical studies are needed to prove the efficacy of medicinal plants that protect the kidneys from gentamicin nephrotoxicity. Objective: This review article provides a scientific overview of the herbal plants’ nephroprotective activity towards gentamicin induction in vivo. Method: A literature search through ScienceDirect database in July 2022 using the keywords “kidney damage”, “herbal plants”, and “gentamicin” resulted in 12 articles to be reviewed. Results: We found 12 herbal plants proven to reverse the declining kidney function. We observed significant attenuation in elevated Blood Urea Nitrogen (BUN) and/or creatinine levels in subject animals receiving herbal plants compared to the gentamicin-induced group. This nephroprotective effect is due to the content of several compounds such as flavonoids, polyphenols, and tannins. Although each plant contains different compounds, all of them have antioxidant activity that inhibits oxidation in nephrons due to gentamicin induction. Conclusion: The antioxidant compounds contained in herbal plants have the potential to prevent or treat nephrotoxicity due to gentamicin usage.
In Silico Study of Monascus sp. Pigment Derivatives as Anticardiovascular Candidate Dichy Nuryadin Zain; Anna Yuliana
Jurnal Ilmiah Farmasi Vol. 19 No. 1 (2023): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol19.iss1.art1

Abstract

Abstract Background: Cardiovascular disease is the leading cause of death in the world. The therapeutic activity of Monascus sp. pigment can act as an anticardiovascular agent. Research on Monascus sp. pigment is rapidly developing, including the discovery of new pigments, the methods used, and their identification. Currently, there are 57 dyestuff compounds that have been successfully isolated from Monascus molds. So, researchers conducted an in-silico study of Monascus sp.Objective: To determine whether it can have better interactions and activities as an anticardiovascular medicine candidate.Method: PAK1 is used as a receptor for anticardiovascular drugs. 57 test compounds were carried out for ligand preparation and application of Lipinski's rule of five by using MarvinSketch software, ADME prediction and toxicity testing using PreADMET, the docking process using Autodock tools, and visualization using Discovery Studio.Results: The results of the docking analysis are seen from the values of binding affinity consecutively. compound R3 (-8.74 kcal/mol), red shandong (-8.16 kcal/mol), and monaphilol (-8.14 kcal/mol) are lower than the comparison compound bisoprolol (-6.44 kcal/mol), which shows that the three compounds have better interactions than the comparison compounds. Conclusion: Derivative compounds from Monascus sp. Pigment are predicted to have better interactions and can be used as anticardiovascular medicine candidates.Keywords: Monascus sp., pigment, anticardiovascular, in silico, PAK1, ADME, and toxicity
Aktivitas antikanker ekstrak etanol, fraksi n-heksan, dan etil asetat daun tin (Ficus carica l.) pada sel kanker payudara MCF-7 Aji Winanta; Widhi Yana Sari
Jurnal Ilmiah Farmasi Vol. 19 No. 1 (2023): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol19.iss1.art4

Abstract

Abstract Background: Breast cancer is ranked as the second-highest cause of death in Indonesia. Many of the available cancer treatments result in severe adverse effects for patients. Tin (Ficus carica L.) leaves contain ingredients that can function as anticancer agents. Objective: The study aims to identify phytochemical secondary metabolites in tin leaves and the cytotoxic activity of the extract and tin leaf fraction on MCF-7 cells.Method: Tin leaf powder was macerated with 70% ethanol for 7 days. The extracts were fractionated using n-hexane and ethyl acetate. An identification test with ethanol extract was then carried out using spray reagents. The cytotoxic activity of ethanolic extract, n-hexane and ethyl acetate fraction of tin leaf was determined using the MTT method.Result: The results of the identification with TLC found that the ethanol extract of tin leaves contains flavonoids and steroids. The ethyl acetate fraction of tin leaf was thought to have weak cytotoxic properties with an IC50 value of 274.5877 ug/mL while the ethanol extract and n-heksan fraction of tin leaf do not have cytotoxic properties because they have an IC50 value of 562.827 and 576.3552 ug/mL. Conclusion: Based on the results, tin leaves have the potency to be developed as a chemopreventive agent for MCF-7 breast cancer cells.Keywords: Breast Cancer, MCF-7 cells, tin leaf (Ficus carica), cytotoxic activity
Drug utilization pattern and cost estimates of antihypertensive drugs in pharmacies BPJS Kesehatan back-referral program in Kudus Regency Wildayanti; Tri Wijayanti; Tri Murti Andayani
Jurnal Ilmiah Farmasi Vol. 19 No. 1 (2023): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol19.iss1.art3

Abstract

AbstractBackground: Hypertension is one of the main causes of mortality and morbidity in Indonesia. Drug usage, utilization patterns, and cost estimates are important elements in calculating drug needs in the forecasting of drug needs plans for pharmacies.Objective: to determine the pattern of drug use with the Anatomical Therapeuetik Chemical (ATC)/Defined Daily Dose (DDD) and Drug Use 90% (DU90%) methods and the estimated cost of antihypertensives with the use of antihypertensive drugs based on the national formulary.Methods: This research uses observational methods using a cross-sectional design. Retrospective data collection includes prescription from BPJS Kesehatan back-referral program (PRB) which goes into pharmacy A, B, and C for the period 2020.Results: The most widely used drugs at pharmacy A, B and C based on ATC/DDD classification were amlodipine, candesartan, ramipril, hydrochlorothiazide, and lisinopril. Amlodipine was the most frequent drug in the DU segment 90%. The highest cost of using the drug was candesartan 16 mg (Rp 4,381,531). The percentages of adherence to the use of antihypertensive drugs with the national formulary in pharmacy A, B, and C were 73.91%, 80%, and 68.42%, respectively.Conclusion: In general, the highest consumption of antihypertensive drugs in Back-Referral Program (PRB) pharmacies in the area of Kudus Regency, which is included in the DU segment 90%, was amlodipine, and the suitability of drugs with the National Formulary has not reached 100%. Referring to the results of the pattern of use of PRB drugs in this study, it is hoped that there will be better coordination between BPJS Kesehatan and pharmacies regarding the distribution and availability of PRB drugs.Keywords: ATC/DDD, DU 90%, hypertension, national formulary, PRB IntisariLatar belakang: Hipertensi merupakan salah satu penyebab utama mortalitas dan morbiditas di Indonesia. Pola pemakaian obat dan perkiraan biaya merupakan elemen penting dalam menghitung rencana kebutuhan obat di apotek. Tujuan: Penelitian ini bertujuan untuk mengetahui pola penggunaan obat dengan metode Anatomical Therapeuetik Chemical (ATC)/ Defined Daily Dose (DDD), DU 90%, perkiraan biaya antihipertensi dan kesesuaian penggunaan obat antihipertensi dengan Formularium Nasional (Fornas).Metode: Penelitian menggunakan metode observasional dengan desain cross sectional. Pengumpulan data dilakukan secara retrospektif meliputi resep Program Rujuk Balik (PRB) yang masuk ke apotek A, B dan C pada periode 2020.Hasil: Penggunaan obat di apotek A, B dan C berdasarkan ATC/DDD yang banyak digunakan yaitu amlodipin, candesartan, ramipril, hidroklorotiazid dan lisinopril. Segmen DU 90% penggunaan obat tertinggi adalah amlodipin dan biaya penggunaan obat tertinggi yaitu candesartan 16mg sebesar Rp4.381.531,00. Persentase kesesuaian penggunaan obat antihipertensi dengan Fornas pada apotek A, B, dan C yaitu 73,91%, 80%, dan 68,42%. Kesimpulan: Secara umum konsumsi obat antihipertensi terbanyak di apotek PRB Kabupaten Kudus yang masuk dalam segmen DU 90% adalah amlodipin serta kesesuaian obat dengan Fornas belum mencapai 100%. Merujuk pada hasil pola penggunaan obat PRB pada penelitian ini, diharapkan adanya koordinasi yang lebih baik antara BPJS Kesehatan dengan pihak apotek mengenai distribusi dan ketersediaan obat PRB.Kata kunci: ATC/DDD, DU 90%, hipertensi, formularium nasional, PRB

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