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Jurnal Ilmiah Farmasi
Published by Universitas Islam Indonesia
ISSN : 16938666     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JIF merupakan jurnal yang dikelola oleh Prodi Farmasi Universitas Islam Indonesia, dan diterbitkan dua kali dalam setahun. Jurnal ini dirancang sebagai sarana publikasi penelitian yang mencakup secara rinci sejumlah topik dalam bidang farmasi yang berkaitan dengan farmasi sains dan teknologi serta klinik dan komunitas. Jurnal ini menyediakan sebuah forum sebagai sarana pertukaran gagasan dan dan informasi antar peneliti, akademisi dan praktisi sehingga diharapkan mampu mendukung dan menginisiasi berbagai penelitian terkini yang terkait dengan ilmu kefarmasian. Hasil penelitian yang disajikan dalam jurnal ini diharapkan dapat memberikan kontribusi bagi perkembangan ilmu di bidang farmasi dan kesehatan.
Arjuna Subject : -
Articles 269 Documents
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CONCENTRATION OF DIAFILTRATE IN LOCAL GREEN TEA (Camellia sinensis) WITH Arraca yabukita GRADE THROUGH NANOFILTRATION MEMBRANE ANTI AS STRESS COMPOUND Agustine Susilowati; Aspiyanto Aspiyanto
Jurnal Ilmiah Farmasi Vol. 8 No. 2 (2011)
Publisher : Universitas Islam Indonesia

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Abstract

Proses pemekatan diafiltrat ieh hijau lokal (Camellia sinensis) grade Arraca yabukita merupakan rangkaian multifiltrasi untuk memisahkan dan memekatkan L-theanine dari komponen teh hijau lainnya yang didominasi oleh polyfeno!. L-theanine merupakan komponen yang berperan sebagai senyawa untuk relaksasi dan berpotensi untuk anti stres. Pemekatan dilakukan dengan menggunakan modul nanofiltrasi (NF) pad a tekanan proses 25 bar, kecepatan motor pompa 25 Hz, selama 0, 30, 60, 90, 120 dan 150 menit, dan pada suhu ruang (- 23 - 25°C). Hasil penelitian Menunjukkan bahwa sistem NF memisahkan L-theanine dengan sempurna dimana L-theanine lebih banyak tertahan pad a retentatlkonsentrat dari pada Lolos dalam permeat. Selektifitas membran nanofiltrasi terhadap L-theanine, protein terlarut,total polytenol dan total padatan tercapai masing-masing sebesar 97,92 %, 99,75 %, 10,38 % dan 99,78 %. Semakin lama proses NF akan meningkatkan L-theanine, total polytenol, protein terlarut dan total padatan dalam retentat,namun menurunkan nilai fluks permeat. Konsentrasi L-theanine tertinggi dicapai pada waktu pemekatan optimal 150 menit. Pad a kondisi ini menghasilkan nilai fluks sebesar 12,22 Liter/m2 .jam dengan kandungan L-theanine sebesar 7,2117 %, total polytenol 9,84 %, protein terlarut 2 mg/mL dan total padatan 1,2102 %. Permeat berpotensi sebagai minuman fungsional untuk relaksasi. Kata kunci: diafiltrat, L-theanine, teh hijau (Camellia sinensis), konsentrat, Nanofiltrasi (NF) 
The phenolic compounds of ethanolic extract of date seed (Phoenix dactylifera L.) exert hepatoprotective activity on rat induced carragenan Warsinah Warsinah; Esti Dyah Utami; Hanif Nasiatul Baroroh
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art10

Abstract

Background: Hepatotoxic effects can occur with the use of toxic drugs or standard doses, but in the long term or chronic therapy. In addition to the drugs, carrageenan also causes hepatotoxic after 12 hours of induction intraperitoneally. The effect of liver cell repair is highly related to the antioxidant activity of phenolic compounds in date seeds.Objective: The present study determined the total phenolic levels and hepatoprotective activity of ethanol extracts of date palm seeds (EEBK) in carrageenan-induced rats.Method: Determination of total phenolics in palm ethanol extract samples was carried out with the Folin- Ciocalteu reagent. This study was the pre and post-test control group design. Examination of SGOT and SGPT levels was performed by the kinetic method based on IFCC. Data was analyzed using paired t-test and ANOVA test. Results: The total phenolic content of the ethanol extract of date seeds of Deglet Noor variety was 8.521% GAE. The ethanol extract of date seed (EEBK) with the dose of 150 mg/kg BW showed the highest reduction in SGOT levels (34.80 U / L). The highest average decrease in SGPT levels occurred at a therapeutic dose of 300 mg/kg BW was 16.20 U / L compared to doses of 150 and 600 mg/kg bb (11.60 and 15.60 U / L respectively).Conclusion: The ethanol extract of date seed (EEBK) with the doses of 150, 300, and 600 mg/kg BW   had hepatoprotective activity in carrageenan-induced rats as observed from a significant decreased in SGOT and SGPT levels (p <0.05). Key word: Date seed, phenolic total, extract, SGPT, SGOT 
Total phenolic and flavonoid contents of n-hexane fraction in binjai leaves (Mangifera caesia Jack. ex. Wall) Cahaya Rahayu Yuliani; Hafiz Ramadhan; Putri Indah Sayakti; Cast Torizellia
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art2

Abstract

AbstractBackground: Binjai leaves (Mangifera caesia Jack. ex. Wall) or M. caesia contain phenolic and flavonoid compounds important in medicinal plants development. The solvent difference and fractionation will give various active substance concentrations.Objective: To evaluate the phenolic and flavonoid content qualitatively and quantitatively from the n-hexane fraction of binjai leaves methanol extract.Methods: The soxhletation method with methanol was used to extract binjai leaves followed by fractionation. Thin Layer Chromatography (TLC) followed by spraying reagents were used to test phenols and flavonoids compounds. Folin-Ciocalteu reagents were used to analyzed total phenolics, while AlCl3 reagents were used to quantify the total flavonoid content.Result: This study gave positive results on the qualitative test of phenolics and flavonoids. Meanwhile, the fraction assay results showed total phenolic levels of 45.19 µgGAE/mg and total flavonoid levels of 165.06 µgQE/mg.Conclusion: The n-hexane fraction of M. caesia leaves methanol extracts contains phenols and flavonoid content so that it has the potential as a medicinal plant.Keywords: Binjai leaves, methanol extracts, n-hexane fraction, phenol, flavonoid. IntisariLatar belakang: Daun binjai (Mangifera caesia Jack. ex. Wall) memiliki senyawa fenolik dan flavonoid yang penting dalam pengembangan tanaman obat. Perbedaan pelarut dan fraksinasi akan memberikan kadar senyawa aktif yang berbeda.Tujuan: Penelitian ini bertujuan untuk mengetahui secara kualitatif dan kuantitatif senyawa fenolik dan flavonoid dari fraksi n-heksan ekstrak metanol daun binjai.Metode: Metode soxhletasi dengan pelarut metanol digunakan untuk mengekstraksi daun binjai yang dilanjutikan dengan fraksinasi. Kromatografi Lapis Tipis (KLT) yang dilanjutkan dengan reagen semprot digunakan untuk menguji senyawa fenolik dan flavonoid. Reagen Folin-Ciocalteu digunakan untuk menetapkan kadar total fenolik, sedangkan pereaksi AlCl3untuk menetapkan kadar total flavonoid.Hasil: Penelitian ini memberikan hasil positif pada uji kualitatif fenolik dan flavonoid, sedangkan hasil penetapan kadar fraksi memberikan hasil total fenolik sebesar 45,19 µgGAE/mg dan kadar total flavonoid 165,06 µgQE/mg.Kesimpulan: Fraksi n-heksana ekstrak metanol daun M. caesia memiliki kandungan fenolik dan flavonoid sehingga berpotensi untuk dikembangkan sebagai tanaman obat,Kata Kunci: Daun binjai, ekstrak metanol, fraksi n-heksan, fenolik, flavonoid.
Kaolin in pharmaceutical preparations: a review Rezkia Azka Kamila
Jurnal Ilmiah Farmasi Vol. 17 No. 2 (2021): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol17.iss2.art5

Abstract

Background: Kaolin is a clay mineral with Al2Si2O5(OH)4 structure which can be found in sedimentary rocks also known as clay stones. Kaolin consists of clay materials such as quartz, illite, smectite, and hematite, with the largest constituent component being kaolinite. Kaolin is one of the most common minerals with an abundant presence in the earth's crust compared to other minerals, especially in Indonesia. In the pharmaceutical sector, this clay mineral is widely used in Indonesia. Kaolin is known to be a good adsorbent and has good physical, chemical, and surface physicochemical properties. Objective: This review article aims to provide information about the uses of kaolin in the pharmaceutical industry.Methods: This review article was written by conducting a literature search study method in the PubMed, ScienceDirect, and Google Scholar databases.Results: In the pharmaceutical field, kaolin is used as an excipient in various types of medicinal preparations, one of which is as a suspension agent because of its ability to stabilize suspensions in a deflocculated state as an emulsifying agent, crushing agent, filling agent, and drug carrier. As an active substance, kaolin is widely used because it has a therapeutic activity. In the cosmetic industry, kaolin can be administered in a variety of topical dosage forms which act as skin protective agents or sunscreens.Conclusion: Based on the results of the review, it was found that kaolin, with its abundant presence on earth and its great potential in the pharmaceutical field, is used as an active medicinal substance, excipient ingredient, and in the cosmetic field as a sunscreen.Keywords: Kaolin, excipient, active pharmaceutical ingredient, cosmeticsIntisariLatar belakang: Kaolin merupakan mineral dengan struktur Al2Si2O5(OH)4 yang dapat ditemukan pada bebatuan sedimen yang juga dikenal sebagai batu lempung. Kaolin terdiri dari berbagai macam mineral lain sebagai penyusunnya seperti kuarsa, illit, smektit, hematit, dan komponen mineral penyusun yang paling besar adalah kaolinit. Kaolin adalah salah satu mineral paling umum dengan keberadaannya yang melimpah di kerak bumi dibandingkan dengan mineral lain khususnya di Indonesia dapat dimanfaatkan dalam bidang farmasi. Kaolin dikenal sebagai bahan adsorben yang baik dan juga memiliki sifat fisika, kimia, dan sifat fisikokimia permukaan yang baik.Tujuan: Ulasan artikel ini bertujuan untuk memberikan informasi mengenai kaolin di bidang kefarmasian. Metode: Ulasan artikel ini ditulis dengan melakukan metode studi penelusuran literatur dalam database Pubmed, Science Direct, dan Google Scholar.Hasil: Dalam bidang kefarmasian, kaolin digunakan sebagai bahan eksipien berbagai macam jenis sediaan obat salah satunya adalah digunakan sebagai bahan pensuspensi karena kemampuannya untuk menstabilkan suspensi dalam keadaan deflokulasi, sebagai agen pengemulsi, penghancur, pengisi, dan pembawa obat. Sebagai zat aktif kaolin banyak digunakan karena memilki aktivitas terapeutik. Dalam industri kosmetik kaolin dapat diberikan dalam berbagai macam bentuk sediaan topikal yang berfungsi sebagai agen pelindung kulit atau tabir surya.Kesimpulan: Berdasarkan hasil ulasan, didapatkan bahwa kaolin dengan keberadaan yang melimpah di bumi dan potensinya yang besar dalam bidang farmasi, diyakini memiliki peran besar dalam pengembangan di industri farmasi dan kosmetik.Kata kunci : Kaolin, Eksipien, Zat Aktif, Kosmetik
The pattern of vancomycin, gentamycin, and meropenem prescriptions for the inpatients of a regional public hospital in Yogyakarta, Indonesia Mutiara Herawati; Mir-a Kemila; Putri Anggriani; Nur Mardhiyah; Siti Maulida
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art16

Abstract

Background: The mechanism of action of gentamycin is inhibiting protein synthesis inside bacteria. Meropenem and vancomycin have the same mode of action that inhibit bacterial cell wall activity. Antibiotic resistance occurs when antibiotic use does not follow the guidelines. Therefore, this study aims to determine how vancomycin, gentamycin, and meropenem are prescribed in a regional public hospital. Objective: This study aimed to evaluate the prescription of vancomycin, gentamycin, and meropenem in Yogyakarta Regional Public Hospital in 2017. Methods: This research employed a descriptive analysis with a cross-sectional design. The study was conducted to describe the profiles of vancomycin, gentamycin, and meropenem utilization. Data collection was performed retrospectively using patients’ medical record data including the diagnosis, dosage, and duration of administration.Results: The study showed that the total number of patients who received aminoglycoside: meropenem: vancomycin antibiotics in 2017 and met the research criteria was 6:8:24. According to the diagnosis, gentamycin was used for post-operation (75%), then sepsis and encephalitis. Meropenem was used for sepsis with a percentage of 67% while vancomycin was for endocarditis, intraabdominal, MRSA, cellulitis, pneumonia, and sepsis. Based on the appropriate dosage in the guidelines, the prescribing of gentamycin and meropenem resulted in 100% properness and 69.23% for vancomycin. For the duration of appropriate utilization, it was found that the most prolonged use was in patients given meropenem for 29 days, and the fastest use was a day for patients using vancomycin. Conclusion:Vancomycin, gentamycin, and meropenem had the appropriate dosage. However, discrepancies were still found in the indication and duration of the treatment using these antibiotics.Keywords: Vancomycin, gentamycin, meropenem, antibiotics
Identification of waste: DOWNTIME in the outpatient prescription services at the pharmacy installation of Rumah Sakit Islam Siti Hajar Mataram Nur Atikah; Sari Nanchi Parhatiwi; Ajeng Dian Pertiwi; Evi Fatmi Utami; Firman Firman
Jurnal Ilmiah Farmasi Vol. 17 No. 2 (2021): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol17.iss2.art1

Abstract

Background: The hospital pharmacy installation is a health service unit that is required to provide professional services and improve quality which is oriented towards achieving patient satisfaction. Waste identification in pharmaceutical services is important because it has an impact on stakeholder satisfaction. Objective: Identifying waste using the DOWNTIME method for the outpatient prescription services at the pharmacy installation of Rumah Sakit Islam Siti Hajar Mataram. Methods: The study used the cross-sectional design, with the population being all outpatients who were provided with pharmaceutical services during February – April 2019 as well as all staff. Data were tabulated and analyzed descriptively. Critical waste was obtained through questionnaires and the root causes of critical waste were obtained through in-depth interviews with 5-why methods.Results: Waste waiting had the highest rate compared to other wastes, reaching 44% or 53 out of 121 respondents, followed by inventory (26%), extra processing (19%), transportation (14%), defects (14%), motion (13%), over production (8%), and non-utilized skills (7%). Meanwhile, from the staff respondents, waiting was also the highest waste (18%), followed by inventory (16%), motion (13%), over production (12%), transportation (12%), non-utilized skills (10%), extra processing (10%), and defects (9%). The root cause of waste waiting was the frequent drug unavailability due to delays in payment of services from the cooperating party to the hospital as well as the narrow service areas.Conclusion:Waste waiting became the critical waste with the highest percentage of dissatisfaction in the patient respondents (44%) and staff respondents (18%).Keywords: Waste, DOWNTIME, outpatient prescription services, pharmacy installation of RSI Siti Hajar MataramIntisari Latar belakang: Instalasi farmasi rumah sakit (IFRS) merupakan unit pelayanan kesehatan yang diharuskan untuk melayani secara profesional dan meningkatkan mutu yang berorientasi pada tercapainya kepuasan pasien. Identifikasi waste dalam pelayanan kefarmasian penting, karena berdampak kepada kepuasan stakeholder. Tujuan: Melakukan identifikasi waste dengan metode DOWNTIME di IFRS Rawat Jalan RSI Siti Hajar Mataram. Metode: Desain penelitian adalah cross sectional, dengan populasi seluruh pasien rawat jalan yang diberikan pelayanan kefarmasian pada bulan Februari–April tahun 2019, dan seluruh staf IFRS. Data ditabulasi dan dianalisis secara deskriptif. Waste kritis diperoleh melalui penyebaran kuisioner dan akar penyebab waste kritis diperoleh melalui wawancara mendalam dengan metode 5 why. Hasil: Waste waiting mendapat angka paling tinggi dibandingkan waste yang lainnya, dimana 44% atau 53 responden dari 121 responden. Kemudian disusul oleh inventory (26%), extra preccesing (19%), transportation (14%), defect (14%), motion (13%), over production (8%) dan non-utilized skill (7%). Bagi responden staf IFRS, waiting juga menjadi waste tertinggi (18%), diikuti oleh inventory (16%), motion (13%), over production (12%), transportation (12%), non-utilized skill (10%), extra processing (10%), dan defect (9%). Akar penyebab waste waiting adalah sering terjadi kekosongan obat akibat keterlambatan pembayaran jasa pelayanan dari pihak kerjasama kepada rumah sakit serta area pelayanan yang sempit. Kesimpulan:Waste waiting menjadi waste kritis dengan persentase ketidakpuasan tertinggi pada responden pasien (44%) dan pada responden staf (18%).Kata kunci :Waste, DOWNTIME, pelayanan resep, pasien rawat jalan, IFRS RSI Siti Hajar Mataram
Isolation of endophytic fungi from benalu batu (Begonia medicinalis) and their toxicity on Artemia Salina Syariful Anam; Armini Syamsidi; Musyahidah Musyahidah; Nurul Ambianti; Agustinus Widodo; Muhammad Sulaiman Zubair
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art3

Abstract

Abstract   Background: Endophytic fungi are microorganisms found in plant tissues that are mutually beneficial to the host plant. They are known as sources of bioactive metabolites which possess various biological activities such as antimicrobial, anticancer, antiviral, antifungal, and antioxidant.  Benalu batu (Begonia medicinalis) has been used empirically as a medicinal plant and has shown anticancer activity in breast cancer cells (T47D cells) and cervical cancer cells (HeLa cells).Objective: This study aimed to isolate the endophytic fungi from benalu batu and determine the toxicity activity and Lethal Concentration 50% (LC50) value of isolated endophytic fungi using shrimp larvae (Artemia salina). Method: Endophytic fungi were isolated from fresh parts; leaves, stems, roots of Benalu Batu. The selected parts were sterilized with ethanol 70% and sodium hypochlorite 1% subsequently placed into Potato Dextrose Agar Chloramphenicol (PDAC) then incubated at 28°C for 7 days. Isolated endophytic fungi were extracted by sonication method using ethyl acetate. The toxicity activity of isolated endophytic fungi was determined using the Brine Shrimp Lethality Test (BSLT).Results: Isolation of the endophytic fungi from benalu batu obtained 10 isolates, which the leaves part obtained 6 isolates, the stem obtained 3 isolates and the root obtained 1 isolate. The results of screening for toxicity test of 10 isolates at concentrations of 500 µg/mL shown that isolate D3, D5, and D6 gave 100% mortality. The LC50 values of isolate D3, D5, and D6 were obtained respectively in 448.03, 8.784, and 9.13 µg/mL.Conclusion: These results indicated that isolate D5 exhibits the greatest toxicity and needs to be investigated the activity for testing on cancer cells.Keywords: endophytic fungi, Begonia medicinalis, toxicity, Artemia salina Intisari  Latar belakang: Jamur endofit merupakan mikroorganisme yang terdapat dalam jaringan tumbuhan yang bersifat mutualisme terhadap tumbuhan inang. Jamur endofit telah diketahui sebagai sumber metabolit yang memiliki beberapa aktivitas biologi seperti antimikroba, antikanker, antivirus, antijamur, dan antioksidan. Tumbuhan benalu batu (B. medicinalis) telah digunakan secara empiris dan terbukti memiliki aktivitas antikanker pada sel kanker payudara (Sel T47D) dan sel kanker leher rahim (Sel HeLa). Tujuan: Studi ini bertujuan untuk melakukan isolasi jamur endofit dari benalu batu dan mengetahui toksisitas isolat jamur endofit serta menentukan nilai Lethal Concentration 50% (LC50) terhadap larva udang (Artemia salina)Metode: Jamur endofit diisolasi dari bagian segar; daun, batang, akar benalu batu. Bagian-bagian tersebut disterilisasi dengan etanol 70% dan natrium hipoklorit 1% selanjutnya diletakkan pada media Potato Dextrose Agar Chloramphenicol (PDAC) kemudian diinkubasi pada suhu 28°C selama 7 hari. Isolat jamur endofit diekstraksi dengan metode sonikasi menggunakan etil asetat. Aktivitas toksisitas isolat jamur endofit ditentukan menggunakan metode Brine Shrimp Lethality Test (BSLT).Hasil: Isolasi jamur endofit dari benalu batu diperoleh 10 isolat, bagian daun diperoleh 6 isolat, bagian batang diperoleh 3 isolat dan bagian akar diperoleh 1 isolat. Hasil penapisan uji toksisitas 10 isolat pada konsentrasi 500 µg/mL menunjukkan bahwa isolat D3, D5, dan D6 memberikan persentase mortalitas sebesar 100%. Nilai LC50 isolat D3, D5, dan D6 diperoleh masing-masing sebesar 448,03, 8,784, dan 9,13 µg/mL.Kesimpulan: Hasil ini menunjukkan isolat D5 memiliki toksisitas paling besar dan perlu dilanjutkan untuk pengujian pada sel kanker.Kata kunci : jamur endofit, Begonia medicinalis, toksisitas, Artemia salina
MIKROENKAPSULASi KAPTOPRIL DENGAN PENYALUT ETIL SELULOSA MENGGUNAKAN METODA PENGUAPAN PELARUT Ade Arinia Rasyad; Deni Noviza Muslim
Jurnal Ilmiah Farmasi Vol. 8 No. 2 (2011)
Publisher : Universitas Islam Indonesia

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Abstract

Telah dilakukan penelitian untuk membuat suatu sediaan Ie pas lambat dengan cara mikroenkapsulasi menggunakan metoda penguapan pelarut. Bahan polimer yang digunakan untuk membentuk dinding mikrokapsul adalah etil selulosa dengan berbagai perbandingan (1:1; 1:1,25; 1: 1,5). Sediaan mikrokapsul yang terbentuk dievaluasi dengan distribusiukuran partikel, foto mikroskopis dan uji disolusi. Formula 3 mikrokapsul kaptopril dengan perbandingan 1: 1,5 memberikan hasil yang baik. Uji disolusi mikrokapsul menggunakan metode II (metode dayung) dengan medium dapar posfat pH 6,8 memenuhi persyaratan untuk sediaan lepas lambat, yaitu dalam waktu 6 jam persentase obat terdisolusi sebesar 55,76 %. Kata kunci: kaptopril, etilselullosa, mikroenkapsulasi, penguapan pelarut 
Antioxidant activity of methanol extract of cassava leaves (Manihot esculenta Crantz) using CUPRAC method Putri Indah Sayakti; Norma Anisa; Hafiz Ramadhan
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art12

Abstract

Background: Antioxidants are a group of organic molecules and enzymes that work synergistically to enhance cellular defenses and combat oxidative stress. Antioxidants can come from plants because they contain many groups of phytochemical compounds and vitamins. One of the plants that has compounds with antioxidant activity is cassava.Objective: To measure the antioxidant activity of methanol extract of cassava leaves using the CUPRAC method.Methods: Cassava leaves were extracted by maceration using methanol as a solvent with the addition of 5% H2SO4. Phytochemical screening of flavonoids with Mg and HCl, while phenol with the addition of FeCl3. The antioxidant activity based on the reaction of the test solution with CUPRAC reagent. Antioxidant activity can be determined by IC50 value by using x value as concentration and y value as absorbance.Results: The results of phytochemical screening showed that the methanol extract of cassava leaves contained flavonoids and phenolic groups. The antioxidant capacity of the methanol extract of cassava leaves obtained an IC50 value of 156.03 ppm, while quercetin has a very strong capacity as an antioxidant with an IC50 of 9.83 ppm.Conclusion: The methanol extract of cassava leaves has a weak antioxidant capacity in reducing metal ions. Keywords: Cassava leaves, Manihot esculenta Crantz, methanol extract, antioxidants, CUPRAC.IntisariPendahuluan: Antioksidan adalah kelompok molekul organik dan enzim yang bekerja secara sinergis untuk meningkatkan pertahanan seluler dan memerangi stres oksidatif. Antioksidan dapat berasal dari tanaman karena banyak mengandung golongan senyawa fitokimia dan vitamin. Salah satu tanaman yang memiliki kandungan metabolit sekunder berupa flavonoid dan fenol yang berfungsi sebagai antioksidan adalah Singkong (Manihot esculenta Crantz).Tujuan: Penelitian ini bertujuan untuk mengukur kapasitas antioksidan dari ekstrak metanol daun Singkong menggunakan metode CUPRAC (Cupric Ion Reducing Antioxidant Capacity).Metode: Daun Singkong diekstraksi secara maserasi menggunakan pelarut metanol dengan penambahan H2SO4 5%. Skrining fitokimia flavonoid dengan Mg dan HCl, sedangkan fenol dengan penambahan FeCl3. Kapasitas antioksidan berdasarkan reaksi larutan uji dengan reagen CUPRAC yang diukur menggunakan spektrofotometer UV-Vis.Hasil: Hasil skrining fitokimia menunjukkan ekstrak metanol daun Singkong mengandung golongan flavonoid dan fenolik. Kapasitas antioksidan dari ekstrak metanol daun Singkong didapatkan nilai IC50 sebesar 156,03 ppm, sedangkan quersetin memiliki kapasitas yang sangat kuat sebagai antioksidan dengan IC50 sebesar 9,83 ppm.Kesimpulan: Berdasarkan hasil tersebut, dapat disimpulkan bahwa ekstrak metanol daun Singkong memiliki kapasitas antioksidan yang lemah dalam mereduksi ion logam.Kata kunci: Daun Singkong (Manihot esculenta Crantz), Ekstrak Metanol, Antioksidan, CUPRAC.
The study of drug interaction on pneumonia patients at RSUP Dr. M. Djamil Padang Lola Azyenela; Mimi Aria; Lana Aristya
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art15

Abstract

AbstractBackground: Pneumonia is one of the diseases that cause high rates of toddler deaths in the world. In Indonesia, pneumonia is the second cause of death of infants and toddlers after diarrheal diseases. Most pneumonia patients are treated with other diseases so many pneumonia patients receive more than two types of drugs in one prescription, this has the potential for drug interactions with drugs.Objective: The aim of this study was to look at potential occurrences of drug interactions in toddler patients at Dr.M. Djamil Padang Hospital hospitalized in 2019.Methods: This research was nonexperimental research design with cross-sectional descriptive methods of analysis and the data retrieved retrospectively. The patient's medical records were analyzed using the Drugs.com software and Medscape.Results: There were 62 patients who met the inclusion criteria. Among them, there were 5 pneumonia patients (8.1%) who experienced drug interactions with drugs, with the pharmacokinetic category as many as 3 cases (42.9%) affecting metabolism and drug interactions in the pharmacodynamic category by 4 cases (57.1%). Based on the severity of drug interactions, this study found 1 minor case (14.3%), 5 moderate cases (71.4%), and 1 major case (14.3%).Conclusion: From the results of the study it can be concluded that there was a potential for drug interactions in pneumonia toddler patients at Dr.M. Djamil Padang Hospital in the period 2019.Keywords: Bronchopneumonia, drug Interactions, toddlerIntisariLatar belakang: Pneumonia merupakan penyakit infeksi saluran pernapasan penyebab kematian utama pada balita di seluruh dunia. Di Indonesia, pneumonia menduduki peringkat kedua penyebab kematian bayi dan balita setelah diare. Pneumonia dapat disebabkan karena bakteri yang menyerang saluran pernapasan. Tatalaksana terapi pada pneumonia umumnya kombinasi beberapa obat. Hal ini berpotensi menimbulkan masalah pengobatan khususnya interaksi obat. Tujuan: Penelitian ini bertujuan untuk melihat kejadian interaksi obat pada pasien balita di instalasi rawat inap anak RSUP Dr. M. Djamil tahun 2019. Metode: Desain penelitian yang digunakan adalah cross-sectional deskriptif dengan pengambilan data secara retrospektif melalui rekam medis pasien. Setiap jenis obat yang tertulis rekam medis dianalisis dengan menggunakan bank data dari software Drug.com dan Medscape. Hasil: Data diambil dari 62 pasien, berdasarkan jumlah tersebut dapat diidentifikasi 5 pasien mengalami interaksi obat (8,1%), terdiri dari 71,4% moderat, 14,3% minor dan 14,3% mayor. Kesimpulan: Interaksi obat yang sering terjadi pada pasien balita dengan pneumonia adalah penggunaan kaptopril dengan furosemid. Kata kunci: Balita, interaksi obat, pneumonia

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