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All Journal Abdimas Universal Plexus Medical Journal
Jarot Subandono
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Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Pembentukan dan Pelatihan Kader Kesehatan Anak Berkebutuhan Khusus tentang Protokol Kesehatan Masa Pandemi COVID-19 Risya Cilmiaty A. R.; Ida Nurwati; Selfi Handayani; Muthmainah Muthmainah; Dyah Ratna Budiani; Betty Saptiwi; Sarsono Sarsono; Martini Martini; Danus Hermawan; Jarot Subandono
Abdimas Universal Vol. 4 No. 1 (2022): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Balikpapan (LPPM UNIBA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/abdimasuniversal.v4i1.141

Abstract

The incidence of COVID-19 in Indonesia is significantly increasing. In Indonesia, there were 965.283 confirmed cases and 27.453 people died of covid as of January 22, 2021. Meanwhile, the 7.505 confirmed cases and 352 death were from Surakarta. In this pandemic situation, the community must protect itself from being infected by the virus. Prevention is done by implementating the 5M health protocol, which are wearing mask, social distancing, and hand washing. Those health protocols are also part of clean and healthy lifestyle (PHBS). Special needs children (ABK) are those who have different characteristics than any other common children. Special health consideration should be given for those special needs child, including PHBS because of the special needs they are having and probable difficulties into implementing PHBS. The consideration can be given by their teacher, caretaker, parents, or trained social health workers in the hope of special needs children become independent into implementing the PHBS. The aim of this program is implementating social service program and helping special needs children to become independent in implementating PHBS and health protocol. The program was held by lecturing, demonstration, simulation, and supervised practice. This program hopefully will prevent either health issues or prevent the spreading of infective disease, specifically in this pandemic situation.
Pengaruh Ekstrak Etanolik Daun Kelor (Moringa oleifera, Lam.) Terhadap Ekspresi Reseptor ACE2 Pankreas Tikus Wistar (Rattus Norvegicus) Model Sindrom Metabolik Julian, Lydia; Budiani , Dyah Ratna; Jarot Subandono
Plexus Medical Journal Vol. 2 No. 3 (2023): Juni
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v2i3.695

Abstract

Pendahuluan: Angiotensin Converting Enzyme 2 merupakan enzim yang berada pada membran sel beberapa organ, salah satunya pankreas. ACE2 memiliki fungsi untuk mengkatalis perubahan angiotensin II menjadi angiotensin 1-7. Pada penderita sindrom metabolik terjadi hiperglikemia, hiperinsulinemia, obesitas, serta resistensi insulin yang meningkatkan produksi angiotensin II dan aktivitas sistem RAS. Ekspresi ACE2 meningkat sebagai kompensasi dari peningkatan sistem RAS. Daun kelor memiliki mampu mengatasi sindrom metabolik. Penelitian bertujuan untuk melihat pengaruh ekstrak etanolik daun kelor terhadap ekspresi reseptor ACE2 pankreas tikus wistar terinduksi sindrom metabolik. Metode: Penelitian bersifat eksperimental laboratorik dengan post-test only control group design. Sampel berupa 30 tikus dibagi kedalam 5 kelompok, KI sebagai kelompok kontrol; KII sebagai kelompok model SM diinduksi STZ-NA serta pakan tinggi lemak; KIII, KIV, dan KV sebagai kelompok model SM diinduksi STZ-NA, pakan tinggi lemak, dengan perlakuan asupan  ekstrak etanolik daun kelor selama 28 hari dengan dosis 150 mg/kgBB, 250 mg/kgBB, dan 350 mg/kgBB. Ekspresi reseptor ACE2 dihitung menggunakan rumus Intensity Distribution Score. Analisis menggunakan uji one-way ANOVA dan uji post-hoc Tukey HSD. Hasil: Ekspresi reseptor ACE2 tertinggi pada KII (222.56) dan terendah pada KV (188.38). Uji statistik didapatkan ekspresi reseptor ACE2 signifikan (p<0.05) pada KI terhadap KIV dan KV; KII terhadap KIV dan KV. Selain kelompok tersebut didapatkan perbedaan ekspresi reseptor ACE2 yang tidak signifikan (p>0.05). Kesimpulan: Ekstrak etanolik daun kelor dengan dosis 250 mg/kgBB dan 350 mg/kgBB mampu menurunkan ekspresi reseptor ACE2 pankreas tikus wistar model sindrom metabolik secara signifikan.  
Co-Authors . Kustiwinarni . Widiastuti Aiman Hilmi Asaduddin Azhar Citra Lukito Benedictus . Betty Saptiwi Bhisma Murti Bima Wahyu Wijaya Budiani , Dyah Ratna Danus Hermawan Devi Purnamasari Sasongko Dyah Ratna Budiani Endang Listyaningsih Faisal Hafidh Fernando Feliz Christyan Ginong Pratidina Wijnaputri Ida Nurwati Ita Kusumawati Julian, Lydia Martini . Martini Martini Muthmainah Muthmainah Risnu Ardian Witjaksana Risya Cilmiaty A. R. Sarsono Sarsono Selfi Handayani Shafira Yasmine Anshari Siska Dewi Agustina Sri Hartati Hadinoto Supardi . Yohana Trissya Anggraeni