The Journal of Pure and Applied Chemistry Research
The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.
Articles
306 Documents
<![CDATA[Synthesis and Modification of Macroporous Titania using Silver Nanoparticles ]]>
<![CDATA[Natalita Maulani Nursam]]>;
<![CDATA[Jeannie Ziang Yie Tan]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2018.007.03.406
<![CDATA[A synthesis method for preparing macroporous nitrogen and silver-modified titania via sol-gel route is presented. The addition of nitrogen and silver nanoparticles was carried out simultaneously with a hard templating technique using silica spheres packed into a three dimensional opal structure. The influence of such modifications on the optical and chemical properties of titania was evaluated using photocatalytic degradation under visible light. The macroporous opal templated samples in this work performed better than the commercial titania, Degussa P25. The highest photocatalytic enhancement, showing more than eight times higher activity than the non-modified titania, was achieved by the opal templated sample prepared with 1.0 mol % of silver. Although silver addition and macroporous templating enhanced the visible light activity, the most significant improvement was afforded by the utilization of the silica opal template that gave rise to high surface area (>100 m2 g-1) and promoted the surface charge interaction.]]>
<![CDATA[Antinutritional Content, Flour Characteristics, and Protein Profiles of Taro Tubers (Colocasia esculenta) by Fermentation with Lactobacillus plantarum ]]>
<![CDATA[Maria Natalia Wewo]]>;
<![CDATA[Sasangka Prasetyawan]]>;
<![CDATA[Arie Srihardyastutie]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2018.007.03.425
<![CDATA[The purpose of this research was studying the optimum condition, the change of oxalate content, the characteristic of flour, and protein profile of taro tuber that fermented with Lactobacillus plantarum. The optimum condition of fermentation was determined based on the lowest oxalate content in flour. The optimum conditions of fermentation studied were variation of pH (4-6), temperature (30⁰–50 ⁰C) and incubation time (6–48 hours). The result showed that the optimum condition of fermentation was achieved at pH 5, 35 °C in 48 h incubation time. The fermented taro flour characteristics were the increasing level of starch (4.76%), amylose (0.43%). amylopectin (4.36%) and protein (0.99%). The fermented taro protein profiles showed that the allergenic proteins were not present, suggesting those proteins were missing due to fermentation process. ]]>
<![CDATA[A Validated Ultra Performance Liquid Chromatography Method for Quantification of Metformin in Human Plasma ]]>
<![CDATA[Vycke Yunivita Kusumah Dewi]]>;
<![CDATA[Atu Purnama Dewi]]>;
<![CDATA[Budi Setiabudiawan]]>;
<![CDATA[Edhyana Sahiratmadja]]>;
<![CDATA[Triana Nurul Meirina]]>;
<![CDATA[Harold Eka Atmaja]]>;
<![CDATA[Rovina Ruslami]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2018.007.003.414
<![CDATA[Metformin is oral hypoglycemic or blood sugar-lowering drug which is used for the first- line drug in the treatment of diabetes mellitus type 2. This study presented the validated Ultra Performance Liquid Chromatography UltraViolet (UPLC-UV) method for the determination of metformin in human plasma. Metformin levels were measured using UPLC with a UV detector and liquid-liquid extraction method. Separation was carried out on an Acquity UPLC HSS T3 100mm × 2.1mm i.d. column (1.8μm particle size) using gradient elution of acetonitrile and phosphate buffer 0.02 M (0.6 mL/min) as mobile phase at 30°C. The analyte was monitored at 236 nm. No endogenous substances were found to interfere with the peaks of drug and internal standard. The value of percent deviation and the coefficient variation obtained respectively less than the percentage set in the FDA guidelines. The linearity factor values were more than 0.997 and LOD was 0.01µg/mL. UPLC with UV detector is able to analyze metformin in a short time with good precision and accuracy which is useful for bioequivalence and bioavailability studies.]]>
<![CDATA[The Effect of Rice Bran Cereals on Total Cholesterol, Malondialdehyde (MDA) Levels and Histopathology Description of Aortic Organ on Mice Model of Hypercholesterolemia ]]>
<![CDATA[Dolly Irnawati Neno]]>;
<![CDATA[Chanif Mahdi]]>;
<![CDATA[Sasangka Prasetyawan]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2018.007.003.429
<![CDATA[Rice bran cereals could be used as the alternative treatment on hypercholesterolemia condition. Tocopherol as an antioxidant and dietary fiber as cellulose, hemicellulose, and lignin which contained in rice bran cereals have the potential to decrease total cholesteroland malondialdehyde levels. The aims of this study are to determine the role of rice bran cereals to decrease total cholesterol, malondialdehyde levels and improve the histopathologyof the aortic organ due to hypercholesterolemia. This study used rats (Rattus Norvegicus) as animals model which were divided into 5 groups: control group (healthy rats), hypercholesterolemia group (sick rat) and 3 therapy groups with variation dose respectively 270, 540 and 810 mg/kg body weight. Data analysis for total cholesterol and malondialdehyde levels used one-way ANOVA with α = 0.05 with Tukey test as a follow-up test. The results of statistical analysis proved that rice bran cereals with a dose of 810 mg/kg body weight effect for the changes of total cholesterol and malondialdehyde levels which are 21.72% and 50.88%, respectively. In addition, results showed that rice bran cereals therapy could significantly influence (p = 0.05) decrease of total cholesterol, malondialdehyde levels and improve the histopathology of an aortic organ in hypercholesterolemic rats.]]>
<![CDATA[The Development of Diazinon Sensors using Polyvinyl Alcohol (PVA) Membrane CuO on Surface Screen-Printed Carbon Electrode (SPCE) as a Receptor ]]>
<![CDATA[Anisa Resti]]>;
<![CDATA[Ani Mulyasuryani]]>;
<![CDATA[Diah Mardiana]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 8, No 2 (2019): Edition May-August 2019 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2019.008.02.468
<![CDATA[The development of Diazinon sensor has been studied using polyvinyl alcohol (PVA-CuO membrane on the surface of the screen-printed carbon electrode (SPCE) as a receptor. The membrane used consisted of polyvinyl alcohol (PVA) 5% (w/v), citric acid 5% (w/v), glutaraldehyde 4% (v/v), Diazinon solution 40 ppm (v/v), and CuO 5% (w/v). This study established the effect of Diazinon at 0.01,0.02 and 0.03 (w/w). besides, the concentration of CuO was 0.5 and 1 (w/w). Signal measurements were carried out in the concentration range of the Diazinon 10-12 - 10-5 M solution in Britton-Robinson buffer at pH 2 - 5. Besides, the influence of the electrolyte type was studied using HCl pH 4, 10-5 M KCl, pH 3 phosphate, and phosphate-KCl pH 3 buffers. The results of the Diazinon sensor characterization showed that the highest sensitivity was obtained at 42 mV/decade with a response time of 180 seconds.]]>
<![CDATA[Flow Injection–Indirect Spectrophotometry for Hydroquinone Analysis Based on the Formation of Iron(II)-Phenanthroline Complex ]]>
<![CDATA[Mariam Mohamed Omar Alshibani]]>;
<![CDATA[Hermin Sulistyarti]]>;
<![CDATA[Akhmad Sabarudin]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 8, No 3 (2019): Edition September-December 2019 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2019.008.03.478
<![CDATA[Hydroquinone is an organic antioxidant widely used for skin lightening products which can cause negative impact in excessive use. This study is focused on the development of fast method for the determination of hydroquinone using flow injection-indirect spectrophotometry based on the formation of red complex Iron(II)-phenanthroline. In this method, hydroquinone reduced iron(III) to iron(II) which in the presence of phenanthroline formed Iron(II)-phenanthroline complex detected at maximum wavelength of 510 nm. The common operational and chemical conditions were optimized and the effect of several interfering compounds was also studied to achieve the highest sensitivity with acceptable analysis time. The optimum method performance was obtained under the conditions of 100 µL sample volume, 50 cm mixing coil-1and 75 cm mixing coil-2, 5 ml/min flow rate, 100 mgL-1 Iron(III) concentration, and 0.15 % phenanthroline. Under these conditions the proposed FI-spectrophotometry gave results to linear calibration over the concentration range from 2-100 mgL-1 (y = 0.028x and R2 of 0.999). The method was not interfered in the presence of vitamin C 1 mgL-1 and resorcinol up to 10 mgL-1. However, the higher concentration of vitamin C ³10 ppm and resorcinol ³ 20 ppm gave significant error of measurements. Method validation using standard additions gave results to average recovery value of 97.02 %, which indicates that the FI-spectrophotometry method can be used as an alternative method for determining hydroquinone in cosmetic. Key words: Hydroquinone, flow injection, spectrophotometry, iron, phenanthroline. ]]>
<![CDATA[Physical Properties Investigation on Sunscreens with Colloidal Gold and Moringa oleifera Extract ]]>
<![CDATA[Ruth Febriana Kesuma]]>;
<![CDATA[Eva Monica]]>;
<![CDATA[Rokiy Alfanaar]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 9, No 1 (2020): Edition January-April 2020 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/jpacr.ub.2020.009.01.464
<![CDATA[Botanicals were known as active ingredients in sunscreens due to their dermal protecting. Gold in colloidal form has a completely unique property for the reason that it may be used as photoaging material. The exposure of UV radiation to skin can cause erythema and skin cancer. The aim of this study was to determine the physical properties of the sunscreens made from Au/ZnO and antioxidant from Moringa oleifera extract such as the sun protection factor (SPF), pH, spreadability, and adhesion. The Moringa oleifera were extracted by maceration. Maceration with 70% ethanol of dried leaves exhibited DPPH scavenging activity (EC50 235.01 μg/mL). Diffuse reflectance UV-Vis spectra of ZnO and Au/ZnO revealed absorption at λex of 385 nm which were equivalent to a bandgap energy of 3.22 eV. Au/ZnO posed a localized state at λex of 385 (3.65 eV). The sunscreens with formulations F1, F2, F3, and F4 showed high SPF number of 20.1479, 21.0008, 22.3872, and18.4631. Kruskal-Wallis test showed significant differences between sunscreen formulations.]]>
<![CDATA[Analysis of Mercury Concentration on The Water and Sediment at Tiabo River, Roko, West Galela District, North Halmahera ]]>
<![CDATA[Margaretha Tabita Tuny]]>;
<![CDATA[Kurnia Kurnia]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 9, No 1 (2020): Edition January-April 2020 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2020.009.01.511
<![CDATA[Gold mining activity at Tiabo river in the North Halmahera causes the water on the river is contaminated by mercury. The contamination mercury on the water can damage food chain and adverse consequences toward health of people, fish, and so on. The purpose of this study is to obtain the concentration of mercury contamination that was caused by gold mining activity. The water and sediment sample was obtained by purposive sampling. The characterization of concentration mercury in the water and sediment using mercury analyzer HG-300 in the wave length 253.72 nm. The result shows that mercury concentration of the water in the six and five sample point in the rainy session and the dry session respectively is <0.66 µg/L, and the mercury concentration in the sediment shows that the lower value in the upstream river was 1.2 mg/kg and the higher concentration in the middle of river was 8.94 mg/kg respectively in the rainy session. The result indicates that the contamination mercury in the moderate danger level according to the IADC/CEDA data standard.]]>
<![CDATA[Extraction of Sodium Alginate from Sargassum sp. using Microwave-Assisted Extraction (MAE) ]]>
<![CDATA[Ruslan Ruslan]]>;
<![CDATA[Amran Amir]]>;
<![CDATA[Agrippina Wiraningtyas]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 8, No 1 (2019): Edition January-April 2019 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2019.008.01.420
<![CDATA[The method used in alginate extraction has been using conventional heating. Lately, Microwave-Assisted Extraction (MAE) has been widely used to extract active compounds from natural ingredients. This study aims to extract sodium alginate from Sargassum sp. using MAE method. This research was conducted by determining the optimum power level and extraction time using a commercial microwave. Power level optimization is carried out at level 70; 80; 90 and 100, while extraction time is carried out for 15; 16; 17 and 18 minutes. The results showed that sodium alginate products were obtained at levels 70, 80, 90 and 100, respectively 0.5%; 37.13%; 23.36% and 1.2%. While sodium alginate products are obtained at variations in extraction time for 15; 16; 17 and 18 minutes were obtained respectively 27.4%; 37.13%; 26.1% and 25.76%. The characterization of sodium alginate products was carried out by analysis of water content, ash content, brightness, and viscosity in the sequence obtained by 14.43%; 14.63%; 78.62 and 95.00 cps. The results of the analysis of heavy metal content obtained that the product of sodium alginate extracted did not contain metal Pb and Hg. FTIR spectra results showed the presence of hydroxyl (-OH) functional groups at wave numbers 3448.7 cm-1 and 1620.21 cm-1; C-H bond at 2931.8 cm-1; alkene group at 2337.7 cm-1; sodium (Na) bond at 1419.61 cm-1; carbonyl group at 1095.57 cm-1 and carboxylic and ketone groups at 1033.85 cm-1. Based on the results of the characterization proving that the product obtained is a sodium alginate compound.]]>
<![CDATA[The Potential Role of Rosmarinic Acid and Sinensetin as α-Amylase Inhibitor: In Silico Study ]]>
<![CDATA[Hazna Noor Meidinna]]>;
<![CDATA[Fatchiyah Fatchiyah]]>
<![CDATA[ The Journal of Pure and Applied Chemistry Research Vol 8, No 1 (2019): Edition January-April 2019 ]]>
Publisher : <![CDATA[Chemistry Department, The University of Brawijaya ]]>
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DOI: 10.21776/ub.jpacr.2019.008.01.460
<![CDATA[The study of natural compound as α-amylase inhibitor has been a concern since the synthetic drugs for the management of type 2 diabetes mellitus have several side effects. The present study was carried out to predict the ability of rosmarinic acid and sinensetin as human α-amylase inhibitor by in silico study. All of the prepared 3D structures were used in the molecular docking by using Hex 8.0.0. The visualization of the molecular interactions of those compounds with human salivary α-amylase or human pancreatic α-amylase was established in the Discovery Studio Client 4.1 software. The result of this study determined that rosmarinic acid and sinensetin bound to the A domain of human pancreatic α-amylase and human salivary α-amylase. Rosmarinic acid-human salivary α-amylase complex was observed to possess high number of hydrogen bonds compared to sinensetin-human salivary α-amylase complex. The similar result was observed in the comparison of rosmarinic acid-human pancreatic α-amylase complex and sinensetin-human pancreatic α-amylase complex. The rosmarinic acid was able to bind the Glu233 of human pancreatic α-amylase. These data suggest rosmarinic acid as a potential inhibitor of human salivary α-amylase and human pancreatic α-amylase. Further experimental evidence is needed to confirm this observation.]]>
