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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 15 Documents
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Search results for , issue "Vol 11, No 2 (2024)" : 15 Documents clear
Film Polielektrolit Berbasis Karagenan untuk Luka Bakar Menggunakan Getah Jatropha Curcas Thomas, Nur A.; Zakaria, Mohamad Rahmatullah; Mustapa, Muhammad A.; Maulana, Irvan
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.39801

Abstract

Luka bakar derajat dua merupakan luka yang sering terjadi akibat kecelakaan dan memiliki nilai mortalitas yang tinggi. Pengembangan pembalut luka bakar primer seperti “film polielektrolit” dapat dilakukan untuk mengontrol pelepasan zat aktif dan menjaga kelembaban luka. Efektivitas film ini dapat ditingkatkan dengan penambahan getah dari tanaman Jarak Pagar (Jatropha curcas) yang secara ilmiah memiliki aktivitas dalam penyembuhan luka seperti Flavonoid, Saponin dan Tanin. Matriks dari Film Polielektrolit memiliki kemampuan yang baik apabila dibentuk dari biopolimer yang biodegredibel dan biokompatibel serta nontoksik seperti Karagenan dan Kitosan. Karagenan diekstrak dari Alga Merah (Eucheuma spinossum) dengan metode maserasi. Karagenan dikombinasikan dengan Kitosan sebagai polimer penyusun film polielektrolit dievaluasi meliputi Uji Organoleptik, Uji Ratio Swelling, dan Uji Fraksi Gel. Formula terbaik di uji iritasi selama 3 x 24 jam dan kemudian diuji efektivitas terhadap 5 kelompok hewan uji mencit dengan perlakuan berbeda yakni PE/JS0 (film polielektrolit); JS5 (getah 5%); JS10 (getah 10%); PE/JS5 (film polielektrolit dengan getah 5%); dan PE/JS10 (film polielektrolit dengan getah 10%). Dimana pengukuran penurunan dievaluasi secara statistik menggunakan metode One Way – Anova (α=0,05). Hasil menunjukan formula PE/JS10 memiliki aktivitas penyembuhan luka sebesar 100% selama 14 hari.
Senyawa Non-aromatik Herba Centella asiatica menggunakan Metode Baru melalui Karbon Aktif, dan Analisis Farmakologi Jejaring pada Luka Bakar Awaluddin, Rizki; Mustaqim, Rafli Mulkan; Arbain, Dayar; Hayati, Farida; Khaerunnisa, Siti
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.50623

Abstract

Prevalensi luka bakar masih menjadi perhatian kaitannya dengan perubahan fisik pasca luka bakar yakni contractures, hypertrophic scar dan keloid yang menurunkan fungsi, kualitas hidup dan estetika kulit. Herba pegagan (Centella asiatica) melalui senyawa triterpen telah dikenal untuk mempercepat luka bakar. Namun, sifat senyawa triterpen yang polar identik dengan keberadaan klorofil dan senyawa lainnya yang sulit dipisahkan. Masih adanya kontroversi terkait protein yang berperan dalam kesembuhan luka bakar membutuhkan kajian untuk menentukan protein potensial. Penelitian ini bertujuan untuk mengeksplorasi metode baru pada ekstraksi herba pegagan menggunakan karbon aktif serja kajian farmakologi jejaring untuk menentukan protein potensial. Herba pegagan diekstraksi menggunakan metode maserasi pada pelarut metanol dan dilanjutkan dengan penambahan karbon aktif. Hasil purifikasi diidentifikasi menggunakan KLT dengan fase gerak kloroform: asam asetat glasial: metanol: akuades (60:32:12:8 v/v) dan pereaksi semprot anisaldehid-asam sulfat. Kajian farmakologi jejaring dilakukan secara in silico untuk mengkaji interaksi protein-protein dan senyawa-protein berkaitan dengan luka bakar. Hasil skrining fitokimia menunjukkan keberadaan asaticoside pada ekstrak terpurifikasi dan maserat dengan nilai Rf yang relatif identik. Senyawa non aromatik berperan dalam mempercepat kesembuhan luka bakar dengan mempengaruhi protein IL1β, IL6, MAPK8, PTGS2, NOX4, IFN-γ, NFKB1, TGFβ1, MMP13, dan TNF.
The Impact of Variations in The Concentration of Wungu Leaf Extract (Graptophyllum Pictum (L.) Griff) Upon The Physical Properties of Sunscreen Spray Preparations Aktifa, Ana Fadilia; Rahmayanti, Mayu; Amalina, Faidatul
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.43542

Abstract

Sunscreen is applied to the skin to protect it from UV rays. Wungu leaves (Graptophyllum pictum (L.) Griff), which are rich in flavonoids and exhibit antioxidant activity, are one of the substances that can be used to create sunscreen formulations. The purpose of this research is to determine how varying concentrations of wungu leaf extract affect the physical qualities of sunscreen spray formulations. This research method involves extraction, extract assessment (organoleptic, yield, and water content), formulation with different extract concentrations (500 ppm, 1,000 ppm, and 1,500 ppm), and physical evaluation (organoleptic, homogeneity, pH, viscosity, and spraying pattern). Data analysis use linear regression equations in the software Microsoft Excel. All formulations with different extract quantities yielded green, transparent, liquid, homogenous solutions with a pronounced smell of wungu leaf extract. The results of pH and viscosity tests on formulations including diverse extracts satisfied the requirements for topical spray preparations, with pH and viscosity values sequentially dropping (Formulas 1, 2, and 3) with slope values of -0.43 and -4.835, respectively. The results of the spray pattern test indicate an oval to circular spread with increased diameter values in the extract variation and slope values of 0.55, 0.568, 0.6685, and 0.4865 at spraying distances of 3, 5, 10, and 15 cm, respectively. On the basis of the study's findings, it can be inferred that differences in the content of wungu leaf extract have an effect on the physical properties of spray sunscreen formulations, as measured by pH, viscosity, and spray pattern diameter.
Drug Solubility Enhancement Strategies Using Amorphous Solid Dispersion: Examination on Type and The Amount of the Polymer Seftian, Muhammad; Laksitorini, Marlyn Dian; Sulaiman, Teuku Nanda Saifullah
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.46908

Abstract

Solubility is one of the critical factors affecting the biopharmaceutical process of drugs. Low solubility limits the dissolution rate and the oral bioavailability. As a result, a higher drug load is required to compensate for the low bioavailability. Amorphous solid dispersion (ASD) is a recent approach to increase drug solubility by dispersing the drug in a carrier-commonly a hydrophilic polymer. It improves the solubility and dissolution rate by affecting the thermodynamic equilibrium of the drug in solution. The amorphous system has a random molecular arrangement leading to higher thermodynamic activity. The amorphous system in ASD has a higher free energy which facilitates a higher solubility and dissolution rate. Polymer is the main component after the active substance in the ASD system. Therefore, the success of ASD formulation will be determined by the selection of polymers and additives as well as their proportions in the system. In addition to the polymer, surfactants are used as a ternary system to give a synergistic effect on the dissolution rate. The system maintains drug supersaturation in the solution state through two main mechanisms: reducing molecular mobility and plasticizing effect.
Determination of Vitamin C Red Guava (Psidium Guajava Linn) Fruit Juice, with Variation of Beverage Packaging Lubis, Novriyanti; Septiani, Wulan; Abdillah, Muhammad Nur; Prasetiawati, Riska; Junaedi, Effan Cahyati
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 2 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i2.42420

Abstract

The quantitative analysis of vitamin C content from variations beverage  packaging  containing red guava (Psidium Guajava Linn) fruit juice had been done. In this study, 4 samples were obtained from the shopping center in Garut and Bandung City. Samples were tested quantitatively by 2,6-dichlorophenol indophenol titration method. The results showed different concentration of 4 samples consist of  tetra pack packaging, tin, glass, and plastic bottles, such as; 17.99 mg/100 gr, 31.46 mg/100 gr, 13.00 mg/100 gr, and 12.01 mg/100 gr, respectively. These result indicated that the packaging variations affected to the level of vitamin C content which was characterized by decreased levels of vitamin C. It means the levels of vitamin C from this research were not in accordance to nutritional value information on the packaging. Tetra pack packaging was the most stable compared to other packaging even though it had a shorter expired date than with other. 

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