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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 18 Documents
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Search results for , issue "Vol 12, No 1 (2025)" : 18 Documents clear
Assessment of Total Phenolic and Flavonoid Content from Nine Different Families of Herbal Medicines Originated from West Java, Indonesia Hasanah, Aliya Nur
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.53533

Abstract

Indonesia is known as a country with abundant natural resources, one of which is herbal plants. These herbal plants contain secondary metabolites such as polyphenol and flavonoid that have some health advantages. The amounts of these two chemicals can be measured using the UV-visible spectrophotometric method, with gallic acid for polyphenols and quercetin for flavonoids as reference standards. In this study, 18 herbal plants from 9 different families were used to calculate the total phenolic content calculated as gallic acid and the total flavonoid content calculated as quercetin. Quantitative analysis was calculated using a UV-Visible spectrophotometry instrument. Meanwhile, qualitative analysis was observed using thin layer chromatography (TLC). The result shown that five plant extracts from Lauraceae, Fabaceae, Myrtaceae, and Melastomataceae family were obtained which had the highest total phenolic content, namely cinnamon cortex (Cinnamomum burmannii), angsana leaves (Pterocarpus indicus Willd.), bay leaves (Syzygium polyanthum (Wight.) Walp.), harendong bulu leaves (Clidemia hirta (L.) D. Don), and clove leaves (Syzygium aromaticum L.) with respective levels of 2120.00; 2056.19 ; 2049.52 ; 1989.52 and 1837.14 mgGAE/g. Meanwhile, the five plant extracts from Zingiberaceae, Fabaceae, and Lamiaceae family that had the highest total flavonoid levels were red ginger (Zingiber officinale cv rubra), temu ireng (Curcuma aeruginosa), temu giring (Curcuma heyneana), gayam leaves (Inocarpus fagiferus Fosb.), and nilam leaves (Pogostemon cablin Benth.) with respective levels of 130.47; 125.74; 107.91 ; 82.89 and 79.25 mgQE/g
Isolation of Chitosan Biopolymer from Nacre (Pinctada maxima) as Bone Scaffold Candidate Taufik S, Ahmad; Alawiyah, Geby; Rahayu, Susi; Kurniawidi, Dian W; Handayana, I Gusti Ngurah Yudi; Cahyawati, Triyana Dyah; Purnaning, Dyah; Amin, Muhamad
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.44794

Abstract

The rising incidence of bone injuries necessitates researching and developing safe bone replacement materials. Chitosan biopolymer is one of the available materials. Because it is non-toxic, biocompatible, and biodegradable, chitosan can be employed as a bone scaffold material. According to the European Pharmacopeia 6.0 (Eur: Ph 6.0), chitosan, with a deacetylation level of more than 70%, is safe for medicinal usage. The purpose of this research was to analyze the  characteristics of chitosan isolated from nacre and the influence of nacre powder mass  on the degree of deacetylation of  chitosan. Chitosan was extracted by the processes of deproteination, demineralization, and deacetylation. Organoleptic tests, yield calculations for each stage, examination of the degree of deacetylation, creation of functional groups, and vibrational modes based on Fourier Transform Infrared (FTIR) data were performed on the isolated chitosan. The produced chitosan exhibited the properties of being beige color, odorless, and in powder form. The yield of insulation results obtained by the mass of chitosan. 3.7 % of the mass of nacre powder. The resultant chitosan has the formation of hydroxyl (OH) and amine (NH2) groups and vibrational stretching and bending modes. The variation in nacre powder mass throughout the isolation procedure altered the degree of deacetylation of the resultant chitosan and the wave number spectra of the hydroxyl (OH) and amine (NH2) groups. Chitosan, with a mass of 80 grams of nacre powder and a value of 76.94%, exhibited the highest degree of deacetylation. Considering that the functional groups generated in chitosan are comparable to those in bone, chitosan is a potential material for bone scaffolds.
Functional beverage formulation of faloak (Sterculia quadrifida R.Br) stem bark kombucha with the addition of lontar palm sugar Lalong, Paulus Risan F; Naben, Maria Novalina; Laynurak, Yoseph M
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.52821

Abstract

Local potential and alternative substrates have been widely utilized to make kombucha with the aim of increasing its compound content and potential functional properties. In general, kombucha is made of black or green tea fermented using white cane sugar. On the other hand, the making of kombucha using faloak (Sterculia quadrifida R.Br) stem bark fermented using lontar palm sugar is relatively new. Therefore, the development of the optimum formula needs to be explored to confirm its functional properties. This study aims to determine the optimum formulation of lontar palm sugar concentration and fermentation time in terms of the chemical characteristics and antioxidant activity of faloak stem bark kombucha. The Response Surface Methodology (RSM) was employed in this study with two research factors, i.e., lontar palm sugar concentration and fermentation time. The results reveal the optimum formulation of palm sugar concentration of 15% and fermentation time of 15.18 days which can cause significant changes in properties, showing pH value of 2.72, total acid of 1.264%, total sugar of 6.451%, total phenol of 452.783 mg GAE/L, and antioxidant activity (IC50 value) of 70.877 ppm. In conclusion, the use of 15% lontar palm sugar fermented for 15.18 days can produce faloak stem bark kombucha with potential as a functional beverage.
The Optimization of Porang starch-lactose as a co-processed excipient of Bajakah (Spatholobus littoralis Hassk) root dried extract's effervescent tablet Ermawati, Dian Eka; Andini, Bimar Putri; Damayanti, Avina Kusuma
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.46521

Abstract

Bajakah root has stronger antioxidant activity than vitamin C. The Dayak people use it to maintain health. Bajakah root infusion has an unpleasant taste and aroma, also unstable, so effervescent tablets are developed to resolve that problem. Effervescent tablets are prepared by direct compression method. The starch of porang tuber is a food that can act as fillers and tablet binders. The co-processed excipient can produce tablet fillers for the directly compressed method. Co-processed excipients of lactose-porang starch have excellent flow properties, improve tablet hardness, have good compatibility, and are cheaper. In this study, the proportions of porang starch and lactose as co-processed excipients were determined using the Simplex Lattice Design method, and then tested the flow properties and granule repose angle. The physical properties of the tablets include weight uniformity, hardness, brittleness, dissolution time, and antioxidant activity test. Test data were analyzed using the One Sample T-test. The results showed that effervescent tablets with co-processed excipient porang starch-lactose 64: 36% provide good physical stability, granule flow time of 10.45 ± 0.29 gram/second, granule repose angle of 27.52 ± 0.95°; tablet weight uniformity with a CV value of 1.021%; tablet hardness 5.74 ± 0.07 Kg, tablet friability of 0.549 ± 0.03%; tablet disintegration time 86 ± 4 seconds. The bajakah root has antioxidant activity of 0.155 mg/mL.
A Preliminary Study of Formulations of Transfersomes for Improved Transdermal Peptide Delivery Surini, Silvia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.55269

Abstract

Peptide-containing dosage forms are often administered through invasive injection. However, due to their great ultra-mobility, transfersomes offer a promising alternative for non-invasive and non-allergenic transdermal peptide delivery. Therefore, this study aimed to conduct preliminary investigations into the formulations of transfersomes for transdermal peptide delivery. Transfersomes were prepared using the thin-layer hydration method with Tweenâ 80 as an edge activator and Phospholiponâ 90G as vesicle formers. Four formulations: F1, F2, F3, and F4 were optimized with various ratios of the two components, including 90:10, 85:15, 80:20, and 75:25. Particle size, zeta potential, deformability index, polydispersity index (PDI), and vesicle morphology were used to assess transfersomes. As a result, the zeta potential was -37.2 ± 2.19, the deformability index was 1.78 ± 0.03 and the smallest vesicle size (147 ± 1.93), PDI value of 0.105 ± 0.01 and spherical were all found in the optimal formula, F3, with an 80:20 ratio. These results suggest significant potential for the further development of transfersomes using Tweenâ 80 and Phospholiponâ 90G as effective transdermal peptide delivery systems.
Acute Toxicity of Petai Cina (Leucaena leucocephala (Lam.) de Wit) Leaf Extract to the Hepar of Balb/c Mice Wulandari, Ririn Lispita
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.49645

Abstract

Daun petai cina memiliki banyak efek farmakologi namun belum diketahui profil keamanannya sebagai obat tradisional. Penelitian ini bertujuan untuk menguji efek toksik akut ekstrak daun petai cina (EEDPC) terhadap hepar mencit Balb/C dan menentukan nilai LD50. Pemeriksaan yang dilakukan meliputi gejala toksik, jumlah  hewan mati, berat badan, makroskopis hepar, dan kadar SGPT SGOT. Penelitian ini merupakan penelitian eksperimental. Ekstrak daun petai cina diperoleh dengan cara maserasi. Uji toksisitas akut dilakukan menggunakan metode fixed dose melalui uji pendahuluan dan utama. Berdasarkan uji pendahuluan ditetapkan dosis 2000 mg/kg BB sebagai dosis awal uji utama. Hewan uji dibagi menjadi 2 kelompok, masing-masing diberi CMC Na 1% (kontrol) dan EEDPC 2000 mg/kg BB. Gejala toksik dan kematian diamati selama 14 hari untuk menentukan kisaran nilai LD50. Pada hari ke-15 dilakukan pemeriksaan makroskopis dan SGPT SGOT hepar. Gejala toksik dan makroskopis hepar dianalisis deskriptif, sedangkan berat badan dan kadar SGOT SGPT dianalisis statistik. Hasil penelitian menunjukkan bahwa EEDPC memiliki kisaran nilai LD50>2000 mg/kg BB dan menurunkan berat badan tidak signifikan. Kondisi hepar secara makroskopis dan rata-rata kadar SGPT SGOT tergolong normal, meskipun kadar SGPT berbeda signifikan dengan kontrol, dan kadar SGOT berbeda tidak signifikan dengan kontrol.
Development and Validation of Analytical Method for Piperine in Phytopharmaceutical Product Containing Cabe Jawa Fructus by HPLC Galih, Wening; Permana, Benny; Damayanti, Sophi
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.46348

Abstract

Cabe Jawa fruit (Retrofractii fructus) has empirically known to have effects such as anti-inflammatory and analgesic due to the presence of piperine. The maximum daily dose for piperine is 0.300–0.540 mg/kg/person/day. A reliable analytical method is required to ensure that phytopharmaceutical preparation is safe. This study developed and validated a piperine analysis method using phytopharmaceutical samples containing Cabe Jawa. A Shimadzu prominence HPLC SIL-20A Prominence autosampler and an X-Bridge C18 column (5 m x 250 mm x 4.6 mm) were used in the research devices. The OFAT method optimised the mobile phase, instrument systems, and sample preparation. The instrument system was optimized for acetonitrile:1% glacial acetic acid (48:52), 40°C, and a 1 mL/min flow rate. Each solid and liquid sample was prepared using the multilevel methanol dilution and water-dichloromethane liquid-liquid extraction (LLE) method. The results of validating the analytical procedures for solid and liquid samples were LOD and LOQ of 1.290 g/mL and 4.300 g/mL, 1.310 g/mL and 4 g/mL, respectively. Precision: 0.157% and 1.174%. Accuracy for three different concentrations were 94.232±1.050%, 95.387%±0.176%, and 96.272±1.043%; 88.801±0.428%, 89.473 ±0.252%, and 89.338 ±0.052% respectively. The analysis of the sample's piperine revealed that this method met the criteria for the validation parameters.
Formulation and Characterization Sunscreen Emulgel Containing Cinnamon Bark Oil (Cinnamomum Burmannii Nees Ex Blume) Priani, Sani Ega
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.46573

Abstract

Cinnamon bark oil is known to contain high levels of cinnamaldehyde (>50%). Cinnamaldehyde is an aromatic compound that is conjugated with a carbonyl group and potential to have photoprotective activity. The purpose of this study was to develop an emulgel preparation containing cinnamon bark oil and to evaluate the  emulgel in terms of its physical properties, stability, and sunscreen activity. Cinnamon bark oil was characterized based on SNI 06-3734-2006. Cinnamon bark oil at concentrations of 0.5 and 1 % was formulated into an emulgel using a combination of stearic acid and triethanolamine as an emulsifier and viscolam mac 10 as a gelling agent. The preparation was evaluated for its physical characteristics and stability. The sunscreen activity test was carried out in vitro by determining the Sun Protection Factor's values (SPF), % erythema, and % pigmentation.  The results showed that cinnamon oil met the SNI standards of cinnamaldehyde concentration (53.33 %). Cinnamon oil emulgel preparation has good physical properties in terms of organoleptic, pH, viscosity, rheology, spreadability, and stability based on centrifugation and freeze-thaw tests. The addition of 0.5 and 1% of cinnamon oil significantly increased the sunscreen activity of the emulgel based on the SPF, % erythema, and % pigmentation values with the extra protection category. An emulgel containing cinnamon bark oil has been successfully developed which has good physical properties and stability and has sunscreen activity based on the value of FPS, % erythema, and % pigmentation. 
Nanoparticle Technology for Development of Immunostimulant Drugs Using Natural Product : Narrative Review Seran, Yuvina
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.53217

Abstract

The field of nanotechnology focuses on systems at the nanometer scale. Nanotechnology is used in the medical field for drug development, medical imaging, and gene therapy. One application of nanotechnology is nanoparticles. Nanoparticles have sizes in the nanometer range, with a scale of 1 to 100 nm. Nanoparticles can be designed to stimulate the immune system and improve the immune response. Literature study using research articles from national and international journals the application Publish or Perish 8 based on the keywords "Immunostimulants, Nanotechnology, nanoparticle, gold nanoparticle, and silver nanoparticle." Based on searching various literature studies, it is proven that nanoparticle preparations can increase immunostimulants with various testing instruments that are often found, namely FTIR (Fourier Transform Infrared), WHICH (Scanning Electron Microscopy), XRD (X-ray Diffraction), HE HAS (Transmission Electron Microscopy), particle size, zeta potential, and spectroscopy UV-visible. Nanoparticles can be an effective drug delivery system and can help maintain the immune system in the body.
Matoa Leaf Serum (Pometia pinnata Forst) : Physical Characteristics and Antioxidant Activity Khairunnisa, Amalia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.49154

Abstract

Matoa Leaf (Pometia pinnata Forst) has antioxidant activity that inhibits free radicals. This research aims to determine the physical characteristic and antioxidant activity of facial serum Matoa leaves (P. pinnata Forst.) with concentrations of the ethanol extract F1 (1%), F2 (3%), and F3 (5%). The physical characteristics tested included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesivity. Antioxidant activity was determined by the DPPH method. The organoleptic results showed that the serum had a yellowish-brown to greenish-brown color, a distinctive aroma of extract, a slightly viscous liquid, and homogeneity. pH test results in F1, F2, and F3 were 6.93±0.02, 5.66±0.02, and 5.05±0.01. Viscosity test results in F1, F2, and F3 were 2983.3±76.3 cP, 3200±50 cP, and 3950.0±50.0 cP. Spreadability test results in F1, F2, and F3 were 5.33±0.05 cm, 5.06±0.05 cm, and 5.03±0.05 cm. Adhesivity test results in F1, F2, and F3 were 1.3±0.04 seconds, 1.89±0.07 seconds, and 2.43±0.09 seconds. Antioxidant activity values in F1, F2, and F3 were 206,445±2,900 ppm (very weak), 149,464±4,025 ppm (moderate), and 49,204±0.383 ppm (very strong). This research concludes that increasing the concentration of the extract increases color and aroma intensity, viscosity, and adhesivity, and decreases the pH value, spreadability, and IC50 value of facial serum.

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