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All Journal journal of internal medicine Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kedokteran Indonesian Physical Review Jurnal Ilmiah Farmako Bahari Journal of Classroom Action Research
Ahmad Taufik S
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Medicine & Pharmacology Physics Other

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Tingkat Akurasi Pemeriksaan Sistouretrografi Bipolar berdasarkan Klasifikasi Goldman pada Trauma Uretra dan Kesesuaian Diagnosis Pascaoperasi Novia Andansari; Ahmad Taufik; Bambang Prijanto
Jurnal Kedokteran Vol 8 No 1 (2019)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v8i1.329

Abstract

Latar belakang: Trauma uretra merupakan suatu kegawatan urologi, biasanya disebabkan oleh kecelakaan lalu lintas atau jatuh dari ketinggian yang menyebabkan morbiditas jangka panjang yang signifikan diantaranya adalah inkontinensia dan impotensi, maka dari itu pencitraan uretra yang lengkap sangat penting dibuat untuk evaluasi dan rencana terapi yang akan dilakukan. Sistem klasifikasi menurut Goldman membagi trauma uretra menjadi 6 tipe berdasarkan lokasi ruptur, dan dengan klasifikasi diharapkan dapat membantu untuk memprediksikan integritas dari mekanisme berkemih. Penelitian ini bertujuan untuk mengetahui nilai diagnostik pemeriksaan sistouretrografi bipolar menurut klasifikasi Goldman dalam menentukan lokasi dan jenis kelainan pada trauma uretra di RSUD Provinsi NTB periode Maret 2018-September 2018. Metode: Data pemeriksaan sistouretrografi bipolar pasien trauma uretra sebanyak 20 pasien yang didapat dari expertise yang tercantum di rekam medis periode Maret 2018-September 2018. Lalu oleh peneliti seluruh data tersebut diklasifikasikan menurut Goldman dan dilakukan uji diagnostik terhadap hasil diagnosis yang juga telah diklasifikasikan menurut Goldman oleh peneliti. Hasil: Berdasar kelompok menurut umur maka terbanyak pada rentang 26-45 tahun. Pada uji diagnostik didapatkan sensitivitas 100%, spesifisitas 93%, akurasi 75%, nilai prediksi positif 50%, nilai prediksi negatif 100% dengan jumlah n sebesar 20. Sedangkan berdasarkan tipe trauma, sensitivitas tertinggi adalah pada tipe I (n:14), spesifisitas tertinggi pada II (n:2), serta akurasi tertinggi pada II (n:2) Kesimpulan: Pemeriksaan sistouretrografi bipolar dengan klasifikasi Goldman memiliki sensitivitas, spesifisitas dan akurasi yang tinggi untuk mendeteksi trauma uretra.
PERANAN KADAR HEMATOKRIT, JUMLAH TROMBOSIT DAN SEROLOGI IgG - IgM ANTIDHF DALAM MEMPREDIKSI TERJADINYA SYOK PADA PASIEN DEMAM BERDARAH DENGUE (DBD) DI RUMAH SAKIT ISLAM SITI HAJAR MATARAM Taufik S, Ahmad; Yudhanto, Didit; Wajdi, Farid; -, Rohad
journal of internal medicine Vol. 8, No. 2 Mei 2007
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.86 KB)

Abstract

The mortality rate of Dengue Haemorrhagic Fever is still high. It is still very difficult to predict shock. The commonlaboratory feature to predict shock are low platelet count, high hematocrit level and the positive result of serologic test (IgG andIgM antiDHF), but the validity remains controversial. This researh was determine many factor to predict shock in denguehemoragik fever patient . This research was case-control study. Data was collected from secondary data based on hematologic andserologic findings of patients with DHF who were hospitalized in Siti Hajar Islamic Hospital Mataram in the period of June 1,2005 until June 1, 2006. The samples of this study were patients that diagnosed as DHF based on WHO criteria and performedwith rapid serologic test Pan Blow? made in America, for Ig G and Ig M anti DHF. DHF patients that suffering shock werecatogorized as case group (n=47), and DHF patients without shock were control group (n=94). The total number of control groupwas two times of case group. Risk factor of shock were analyzed using chi-square test and multiple logistic regressions with levelof significance of < 0.05. The number of samples used in this study were 141 patients diagnosed as DHF, there were 47 patienstsDHF with shok and 94 DHF patients without shock. There was 70% patient with thrombositopenia and 44% patient had high rateof hematokrit more than 41.5 %. Shock was more frequent among pasients age more than 25 years, male, hematokrit level lessthan 40% and platelet count 50,000-100,000/ml. Based on univariate analysis, age, gender, high hematocrit value andtrombositopenia were not significantly different to predict shock. On multiple logistic regression methode, primery infection(IgM+ and IgG-) and secondary infection (IgG positif and IgM+/-) were not significantly different to predict shock. The conclusionof this study is high hematocrit value, platelet count and serology IgM or and IgG antiDHF there were no factor that couldpredict shock in DHF patients.
Karakteristik Ganguan Penghidu pada Pasien COVID-19 yang Dirawat di Rumah Sakit Universitas Mataram Didit Yudhanto; Triana Dyah Cahyawati; Ahmad Taufik S; Eka Ari Yuliyani; Wahyu Sukistiya Affarah
Journal of Classroom Action Research Vol. 5 No. 2 (2023): Mei
Publisher : Program Studi Magister Pendidikan IPA, Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jcar.v5i2.4491

Abstract

COVID-19 ini dengan penyebaraan pandemi dan merupakan penyakit baru sehingga gejala klinis dan patofisiologinya juga masih baru. Gangguan penghidu yang muncul sebagai hiposmia atau anosmia tidak jarang terjadi sebagai gejala COVID-19. Data mengenai gangguan penghidu pada pasien COVID-19 di luar negeri sudah banyak dilaporkan, namun di Indonesia masih sedikit dan di NTB belum ada yang melaporkan. Data karakteristik gejala gangguan penghidu diambil dari rekam medis pasien yang dirawat inap di Rumah Sakit Universitas Mataram (RS Unram) dan terkonfirmasi positif COVID-19 dengan rt-PCR. Data gangguan penghidu disajikan secara deskriptif mengenai karakteristik gangguan penghidu berdasarkan jenis kelamin, usia, pendidikan dan gejala yang dikeluhkan pada pasien COVID-19. Pada penelitian ini didapatkan pasien COVID-19 dengan gangguan penghidu sebanyak 32 (7,5%) pasien COVID-19 yang dirawat inap di RS Unram periode Januari sampai dengan Agustus 2021. Seluruh pasien dengan keluhan gangguan penghidu mengeluhkan tidak bisa mencium bau (anosmia). Berdasar jenis kelamin 20 (62,5%) adalah laki-laki dan 12 (37,5%) perempuan, kelompok usia paling banyak adalah 20-30 tahun dengan rata-rata usia 34 tahun. Gejala lain yang dikeluhkan pasien COVID-19 dengan gangguan penghidu adalah batuk 8 (25%) pasien, pilek 5 (15,6%), demam 3 (9,4%). Pasien Covid-19 dengan keluhan gangguan penghidu yang dirawat di RS Univeritas Mataram adalah 7,5% dengan karakteristik gejala yang dilaporkan pasien keseluruhannya adalah tidak dapat mencium atau anosmia
Isolation of Chitosan Biopolymer from Nacre (Pinctada maxima) as Bone Scaffold Candidate Taufik S, Ahmad; Alawiyah, Geby; Rahayu, Susi; Kurniawidi, Dian W; Handayana, I Gusti Ngurah Yudi; Cahyawati, Triyana Dyah; Purnaning, Dyah; Amin, Muhamad
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.44794

Abstract

The rising incidence of bone injuries necessitates researching and developing safe bone replacement materials. Chitosan biopolymer is one of the available materials. Because it is non-toxic, biocompatible, and biodegradable, chitosan can be employed as a bone scaffold material. According to the European Pharmacopeia 6.0 (Eur: Ph 6.0), chitosan, with a deacetylation level of more than 70%, is safe for medicinal usage. The purpose of this research was to analyze the  characteristics of chitosan isolated from nacre and the influence of nacre powder mass  on the degree of deacetylation of  chitosan. Chitosan was extracted by the processes of deproteination, demineralization, and deacetylation. Organoleptic tests, yield calculations for each stage, examination of the degree of deacetylation, creation of functional groups, and vibrational modes based on Fourier Transform Infrared (FTIR) data were performed on the isolated chitosan. The produced chitosan exhibited the properties of being beige color, odorless, and in powder form. The yield of insulation results obtained by the mass of chitosan. 3.7 % of the mass of nacre powder. The resultant chitosan has the formation of hydroxyl (OH) and amine (NH2) groups and vibrational stretching and bending modes. The variation in nacre powder mass throughout the isolation procedure altered the degree of deacetylation of the resultant chitosan and the wave number spectra of the hydroxyl (OH) and amine (NH2) groups. Chitosan, with a mass of 80 grams of nacre powder and a value of 76.94%, exhibited the highest degree of deacetylation. Considering that the functional groups generated in chitosan are comparable to those in bone, chitosan is a potential material for bone scaffolds.
INFLUENCE OF COMPOSITION AND LYOPHILIZATION TIME ON PHYSICAL PROPERTIES OF HA/Cs/Coll/ HYDROXYPROPYL METHYLCELLULOSE BIOCOMPOSITES FOR BONE SCAFFOLDS Purnaning, Dyah; Hurnah, Hurnah; Taufik S, Ahmad; Rahayu, Susi; Kurniawidi, Dian W.; Hadi, Kasnawi Al
Indonesian Physical Review Vol. 8 No. 2 (2025)
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/ipr.v8i2.474

Abstract

Biomaterial implants are one of the alternatives to replace damaged organs in the body system temporarily (scaffolding) or permanently. Bone biomaterial implants can be obtained through the manufacture of HA/Cs/Coll (HA/Cs/Coll) biocompositeses with the addition of Hydroxypropyl Methylcellulose (HPMC) matrix. The objective is to evaluate how variations in material composition and lyophilization time affect the physical properties of the biocomposites, including density, compressive strength, Young’s modulus, and surface morphology. The manufacture of  biocomposites uses the mechanical thermal method for mixing materials and the freeze drying method for the biocomposites drying process. Composition ratios of HA:Cs/Coll were varied at 3:7, 5:5, and 7:3, while lyophilization durations were set at 24, 48, and 72 hours. Characterizations were performed through density measurements, mechanical testing using a Tensilon machine, and surface morphology analysis using a digital microscope. The results showed that the comparison of biocomposites with a ratio of 7:3 had the highest density of 0.150 gr/cm³, compressive strength of 0.046 MPa, and young modulus of 0.3 MPa. Meanwhile, the biocomposites that was lyophilized for 48 hours showed the best balance between a density of 0.145 gr/cm³, a compressive strength of 0.08 MPa, and a young modulus of 0.17 MPa. Morphological analysis revealed improved porosity and surface uniformity with longer freeze-drying times. Based on this, the resulting HA/Cs/Coll biocompositese has potential as an implant material but further research is needed to improve its mechanical properties by increasing the concentration of the binder, namely HPMC.
Effect of Injectable Bone Substitute Preparation Formulation on Microscopic and Macroscopic Characteristics for Bone Graft Alaydrus, M. Mukaddam; Rahayu, Susi; Purnaning, Dyah; Isa A.A, Maz; Oktri P, Awanda; Taufik S, Ahmad
Jurnal Ilmiah Farmako Bahari Vol 16 No 2 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i2.42506

Abstract

Biocompatible, mechanically stable, and easy-to-use injectable biomaterials are often needed for bone defects caused by trauma, disease, or surgery. This study aims to investigate the effect of polyvinyl alcohol (PVA) concentration on the microscopic and macroscopic characteristics of injectable bone substitute (IBS) formulations composed of Hydroxyapatite (HAp), chitosan, and PVA. The biopolymer chitosan was extracted from pearl oyster shell waste (Pinctada maxima), and HAp was synthesized via precipitation. The formulations were prepared with varied PVA concentrations (5%, 10%, and 15%) and evaluated for their structural, physicochemical, and functional properties. Fourier-transform infrared (FTIR) spectroscopy was employed to determine the presence of functional groups and molecular interactions. Results showed that increasing PVA content enhanced the intensity and sharpness of phosphate () bands, with Sample C (15% PVA) exhibiting the strongest interaction, indicated by a peak shift to 1047.32 cm⁻¹. Organoleptic observations revealed stable color across all samples, with increasing viscosity and paste-like consistency observed in higher PVA concentrations. Sample C had the highest viscosity (82.2 dPa·s) and the lowest injectability (92.43%), while Sample A exhibited the highest injectability (98.33%) and the lowest viscosity (2.79 dPa·s). Sample B (10% PVA) showed balanced characteristics with a viscosity of 38.93 dPa·s and injectability of 97.26%, aligning closely with ideal ranges for injectable biomaterials. Density measurements indicated that all samples approximated or exceeded the minimum density of healthy bone, with Sample C reaching 1.18 g/cm³. pH monitoring over 21 days revealed a consistent value of ~6, suggesting good chemical stability. These results demonstrate that the 15% PVA formulation achieves an optimal compromise between physicochemical properties and clinical applicability. This composite's injectability enables precise defect filling and promotes new bone formation, making it a superior and promising alternative as an injectable bone graft material in patients.
Co-Authors A.A. Ketut Agung Cahyawan W Alawiyah, Geby Alaydrus, M. Mukaddam Bambang Prijanto Cahyawati, Triyana Dyah Didit Yudhanto Eka Ari Yuliyani Hadi, Kasnawi Al Handayana, I Gusti Ngurah Yudi Hurnah, Hurnah Isa A.A, Maz Kurniawidi, Dian W Kurniawidi, Dian W. Muhamad Amin Novia Andansari Oktri P, Awanda Purnaning, Dyah Rohad - Susi Rahayu Triana Dyah Cahyawati Wahyu Sukistiya Affarah