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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
Arjuna Subject : -
Articles 494 Documents
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In Silico Analysis of Physical-Chemical Properties, Target Potential, and Toxicology of Pure Compounds from Natural Products Purnawan Pontana Putra; Annisa Fauzana; Henny Lucida
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 3 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i3.26403

Abstract

Several studies have shown that pure compounds from west sumatera medicinal plants have beneficial therapeutic effects so that they are potential candidates for active pharmaceutical ingredients (API). Andalas Sitawa Fitolab has been able to produce 10 pure isolates. The development of a new drug candidate requires an in silico study to predict physicochemical properties, potential target, and toxic properties. The purpose of this study was to initially screen the structure of candidates to predict the potential the compound as an API by using big data and machine learning. The chemical structure were analyzed using software and servers. The Software used was Marvin Sketch, QSAR Toolbox, Swiss Potential Target and ChemBioDraw. Results showed that log P of compounds revealed in a range of -0.54 to 4.64, Polar Surface Area (PSA) in range of 20.23 to 315.21. Asiaticoside did not meet Lipinski's rules. Compounds with high potential hazard were catechin, curcumin, andrographolide, asiaticoside deoxyelephantopin, ethylmethoxycinnamate, alpha-mangostin and piperine. The compounds such as curcumin, alpha mangostin, plumbagin, and piperine were predicted to have spesific target proteins. This study concluded that asiaticoside compounds have a high potential hazard, if it was developed as an API.Keywords: analysis of physical-chemical properties, in silico, pure isolate, toxicology
Molecular Docking Study of Anthocyanidin Compounds Against Epidermal Growth Factor Receptor (EGFR) as Anti-Lung Cancer Riska Prasetiawati; Meilia Suherman; Benny Permana; Rahmawati Rahmawati
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29872

Abstract

It is presumed that antiproliferative activity of anthocyanidin has interaction with Epidermal Growth Factor Receptor (EGFR) which has effect on lung cancer cell growth. This study aimed to observe the interaction between anthocyanidin and EGFR and to find out prediction, absorption, distribution activities as well as anthocyanidin toxicity compared to Gefitinib, an EGFR inhibitor. All test compounds were optimized with Autodock Tools®, then molecular docking simulations and predictions of absorption, distribution and toxicity were carried out. Malvidin was stated to meet the Lipinski's Rule of Five, indicating good bioavailability. Result of molecular docking simulation showed that malvidin had better affinity against EGFR than Gefitinib. Molecular docking visualization result showed that malvidin had interaction with amino acid residue such as Met793, Gln791, Leu718, Thr854, Asp855 and Lys745. Absorption and distribution predictions included percentage scores of Human Intestinal Absorption (HIA), human colon adenocarcinoma (Caco-2), and Plasma Protein Binding. Toxicity test revealed that malvidin was mutagenic compound but not carcinogenic one. The findings indicated that malvidin was potential to be an anti lung cancer candidate through EGFR inhibition.Keywords: Antiproliferative, Anthocyanidin, Epidermal Growth Factor Receptor, Molecular Docking
Antiproliferation Assay of Essential Oil of Curcuma Rhizoma (Curcuma xanthorrhiza Roxb.) Against P388 Leukemia Cell Ida Musfiroh; Angga Geganaputra; Ajeng Diantini; Yasmiwar Susilawati; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 3 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i3.27210

Abstract

Leukemia or blood cancer is a disease which marked by abnormal increasing of blood producer`s cells. Chemotherapies which used as anticancer have a many adverse effect and toxicity. The volatile oil of turmeric rhizome (Curcuma xanthorriza) contains sesquiterpene which has an pharmacological activity. The aimed of this research to assay the antiproliferation activity of volatile oil from curcuma rhizome to leukemia P388 cells using MTT (3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyl tetrazolium bromide) method. The methods were contain of identification of volatile oil (produced from distillation water-steam) using organoleptic test and TLC, and activity test was using seven various concentrations, which were 0.1; 0.3; 1; 3; 10; 30; 100 µg/mL. The result showed that the sample can inhibit leukemia P388 cells with the value of IC50 was 15.5 µg/mL. The volatile oil of Curcuma rhizome has an antiproliferative activity to leukemia P388 cell.Keywords: Curcuma rhizome, MTT assay, leukemia cell P388, volatile oil
Antiviral Activity and Toxicity Prediction of Compounds Contained in Figs (Ficus carica L.) by In Silico Method Sophi Damayanti; Khonsa Khonsa; Tasia Amelia
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29868

Abstract

Viral infection is a global health problem that can cause endemic to pandemic. Compounds delivered from plants has been developed as an alternative antiviral agent. One of the plants that can be used as antiviral therapy is Ficus carica L. (figs). The aim of this research is to predict the inhibitory activity and toxicity of compounds contained in figs as an antiviral for HIV-1 using in silico method. Compounds were docked to the HIV-1 Reverse Transcriptase protein (PDB ID: 3LAL). Threedimentional structures were modeled using GaussView and optimized using Gaussian 09W. Optimized compounds were docked to the target protein using AutoDock Tools and the interaction to protein binding side were analyzed in comparison with the standard compounds. The standard compound used for the analysis nevirapine, efavirenz, and doravirine. The compound toxicity was analyzed using ECOSAR and Toxtree. Based on the results, the compounds that has similar interaction to the standard compounds were campesterol which has 4 similar hydrophobic interactions. Based on the classification of Cramer Rules for toxicity test, campesterol are classified in class 3 (high toxicity) and according to the Benigni/Bossa Rulebase classification, campesterol are negative for genotoxic and nongenotoxic carcinogenicity.Keywords: Antivirus, HIV, figs, molecular docking, toxicity
Effect of Administration of Combination of Captopril and Celery Extract on Blood Pressure and Electrolyte Levels of Hypertensive Rats Siska Siska; Franciscus D. Suyatna; Abdul Mun'im; Anton Bahtiar
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 3 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i3.26732

Abstract

Based on previous reports, the combination of captopril and celery could reduce blood pressure in hypertensive patients. This study aimed to investigate the changes of blood pressure, urine volume, sodium, and potassium level, due to concomitant administration of captopril with celery extract orally in male rats induced by 4% NaCl. The blood pressure was measured using a non-invasive tail method. The urine and blood were collected, and the sodium, potassium concentration, and cumulative urine volume were measured. The combination of 5 mg/kgBW of captopril and 40 mg/kgBW of celery extract decreased the blood pressure in hypertensive rats better than 5 mg/kgBW of captopril alone. The fell in blood pressure was followed by an increase in urine volume. Urinary and serum sodium, serum potassium levels tended to increase in all treatment groups, but not significantly different from the healthy group. Urinary potassium levels tended to decrease except in the combined 5 mg/kgBW of captopril and 40 mg/kgBW of celery extract. In conclusion, oral administration of a combination of 5 mg/kgBW captopril and 40 mg/kgBW celery extract decreased the blood pressure to the standard value in NaCl-induced hypertension rats.Keywords: Apium graveolens, captopril, celery, hypertension, pharmacodynamic
In Silico Study of Compounds Contained in Hemigraphis alternata Leaves against 5-LOX for Anti-Inflammatory Yeni Yeni; Rizky Rachmania; Mochamad D. Yanuar
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29869

Abstract

Inflammation is a self-protection response to begin the healing process. One of the anti-inflammatory targets worth developing is lipoxygenase inhibitors, which have been studied for several diseases, including severe airways disease. The aim of this study was to predict the affinity of 23 compounds that contained in Hemigraphis alternata leaves against 5-lipoxygenase (5-LOX). The compounds of Hemigraphis alternata leaves were screened for its affinity againts 5-LOX using docking software, DOCK 6.9, with zileuton as the comparator. Based on the grid score, most of the 23 of Hemigraphis alternata leaves compounds showed a higher affinity towards 5-LOX compare to zileuton. The highest affinity was shown by n-hexadecanoid acid. The study showed that Hemigraphis alternata leaves contains potential active components that could be developed as 5-LOX-inhibitor.Keywords: In silico, Hemigraphis alternata, lipoxygenase, anti-inflammatory
The Effectiveness of Aloe vera Hydrogel Against Fusobacterium nucleatum Chandra Susanto; Ermi Girsang
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 3 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i3.26618

Abstract

Bacteria can cause infectious diseases on oral health such as gingivitis and periodontitis. Scaling and rootplaning are effective against this disease, nevertheless several types of antimicrobial material can be added to increase the effectiveness of the initial treatment. Aloe vera is one of the natural antimicroba materials that is usually used. Hydrogel is a polymetric material that is stable in wet conditions, especially in the gingival sulcus. Sodium alginate is a natural polymer that is often used to produce hydrogels due to its biocompability. The aim of this study was to know the the effectiveness of Aloe vera hydrogel against Fusobacterium nucleatum by in vitro method. This research is experimental research with a total of 20 samples. The samples used were 5% and 10% sodium alginate based Aloe vera hydrogel which were placed in pure culture of F. nucleatum in MHA media for 24 hours. The inhibition zone diameter were measured using calipers. The results of the study using Shapiro-Wilk normality test showed that the data were not normally distributed. Then Kruskal Wallis test was performed which showed significant differences in each treatment group followed by Post Hoc Mann Whitney test to see a significant difference in the 5% group and 10%. Aloe vera hydrogel showed a significant inhibition against F. nucleatum bacteria at both 5% and 10% concentrations.Keywords: Alginate, Aloe vera, Antimicrobial material, Fusobacterium nucleatum, Hydrogel, Inhibitory zone
Formulation and Physical Evaluation of Edible Film Dosage from Ethanol Extract of Betel Leaves (Piper betle L) for Canker Sore Drugs Yenni Puspita Tanjung; Andi Ika Julianti; Aghnia Wulan Rizkiyani
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29225

Abstract

Canker sore which in medical terms is called aphthous stomatitis is a wound in the mouth that can cause pain and discomfort. Piper betel leaf can be used for strengthening the teeth, cure canker sores, treat the bad breath and stop the gum from bleeding. The research aimed to determine the edible film formula of betel leaf ethanol extract that met the physical evaluation requirements and to determine the effect of variation concentration of sorbitol and HPMC (Hydroxypropyl methylcellulose) on the physical evaluation. Edible film preparation from betel leaf extract is a thin layer made from the basic ingredients of corn starch, sorbitol, and HPMC. In this research, 3 edible film formulas were made with variations in the concentration of sorbitol and HPMC, namely: F1 (5%;5%), F2 (4%;4%), F3 (3%;3%). Data of evaluation results were analyzed statistics by Kruskal wallis method. The results showed that F1, F2 and F3 meet the physical evaluation requirements for edible film dosage. Variations in the concentration of sorbitol and HPMC gave different results significantly influence (p<0.05) on weight uniformity, film thickness, solubility and dissolution time, and did not significantly influence (p>0.05) on the organoleptic test, fragility of edible film, water resistance (swelling) and moisture content.Keywords: Betel leaf extract, edible film, HPMC, canker sore, sorbitol 
Activity Screening and Structure Modification of Trigonelline as New Anticancer Drug for Non Small Cell Lung Cancer Through In Silico Kelvin F. Pratama; Muhammad Fauzi; Aliya Nur Hasanah
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 3 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i3.26765

Abstract

The biggest case of death in 2018 is caused by lung cancer. Non-small cell lung cancer (NSCLC) is most common. One of the cause lung cancer is the over expression of EGFR. Erlotinib is the first line of anticancer for NSCLC with EGFR mutations. However, erlotinib can cause side effects such as liver damage therefore new safe anticancer is needed. Trigonelline is an alkaloid compound from coffee beans that had anticancer activity in pancreatic cancer cells by inhibiting Nrf2 in vitro and in vivo at concentrations of 0.1-1 µM. Development of cancer cells by Nrf2 is regulated by EGFR. In this study screening and modification of trigonelline structure was carried out to obtain compounds that have anticancer activity on NSCLC against EGFR computationally. The research procedures carried out are modification of ten trigonelline derived structures, the molecular docking and prediction of physicochemical profiles from trigonelline and its modification also their ADMET. Based on results, KF9 has the lowest free energy of binding which was -8,88 kcal/mol and binds to Met769 which has biological activity with receptor. KF9 has good physiochemical profile and absorption, distribution, also toxicity parameters. KF9 has potential to become a new anticancer drug for NSCLC.Keywords: Coffee, Drug discovery and Drug development, Molecular structure modification, Nonsmall cell lung cancer, Trigonelline
The Effect of Chilli Extract on Gastroprotective Function in Male Tahyatul Bariroh; Siska Siska
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.26988

Abstract

Chilli is one of plant from genus Capsicum and as vegetable commodities most consumed by the Indonesian people. Chilli contains a unique compound called capsaicin which gives a burning sensation like burning when consumed. This research aims to determine the effect of chilli extract on gastroprotection in the stomach of mice. The study used 35 white male rats were divided into seven groups, one group as the control group, and six groups were given extracts from three varieties of chilli (red chilli, green chilli, and chilli) with high doses (1 g / kg bb) and low doses (0.5 g / kg bb) for 14 days. On the 15th day, gastric decapitation and isolation were carried out to make histological preparations of the rat's stomach. The results showed mucosal tissue in the stomach of rats given a dose of 0.5 g/kg BW remained in normal condition compared to the group of rats given high doses of chilli. In this group, a lot of damage to the gastric mucosal tissue of rats (ulcers). This study concludes that consuming 0.5 g/kg BW chilli does not cause damage to the gastric mucosal tissue of rats.Keywords: Chilli, Gastric mucose, Gastroprotective

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