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Indonesian Journal of Pharmaceutical Science and Technology

ijpst
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Published by Universitas Padjadjaran

ISSN : 23561971 EISSN : 2406856X DOI : -

Core Subject : Health, Science,

Computer Science & IT Medicine & Pharmacology

Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.

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Articles 511 Documents

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Effect of Carrageenan as Gelling Agent on Tocopherol Acetate Emulgels Meiti Rosmiati; Marline Abdassah; Anis Yohana Chaerunisaa
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Vitamin E (Tocopherol acetate) is used in both oral and topical dosage. The aim of the research was to study different concentration of Carrageenan, as gelling agent in Tocopherol acetate Emulgels. This experimental study was initiated by emulgel formulation using different concentration of carrageenan as gelling agent, as much as 0,5% (F1), 0,75% (F2), 0,85% (F3), 0,95 % (F4), 1% (F5), 1,125% (F6), 1,25% (F7), 1,5% (F8) and 2% (F9). Tween 20 and Span 20 were used as emulsifiers (1 and 1,5 %), Liquid paraffin as oily phase (7,5%), Propylen glycol as humectant (10%), propyl and methyl paraben as antimicrobial preservative (0,01% and 0,03%). The physical investigation of emulgel were included pH, spreading test, viscosity and freeze thawtest. The results for promising formula F5 showed that physical parameters of emulgels were in the range of requirement for topical dosage form. Keywords: Tocopherol acetate (Vitamin E), emulgels, carrageenan

Effect of Ethanol Concentration on Antibacterial Activity of Bligo Fruit Extract (Benincasa hispida Thunb) to Salmonella typhi Fhahri Mubarak; Sartini Sartini; Dia Purnawanti
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 3 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Bligo fruit (Benincasa hispida Thunb) is one of medicinal plants that used to cure typhoid fever which caused by Salmonella typhi bacteria. The aim of this research is to find ont the effect of ethanol concentration as a solvent from Bligo fruit (Benincasa hispida Thunb) extracts as an antibacterial, especially to Salmonella typhi. This simplicia was being extracted with 96% ethanol, 70% ethanol, and 50% ethanol by using maceration method for 3x24 hours. The antibacterial activity test was done by diffusion of agar method to the MHA medium by obserring the resistor zone which formed from 96% ethanol, 70% ethanol and 50% ethanol. The diametres that have been obtained are 6,815 mm for 96% ethanol, 25,223 mm for 70% ethanol while for 50% ethanol there is no resisten zone can be seen. From the result canbe conclude that the best concentration of ethanol that has a great potencial as resistor to Salmonella typhi bacteria is the Bligo fruit (Benincasa hispida Thunb) extracts of 70% ethanol.Key words: Bligo fruit (Benincasa hispida Thunb), Antibacterial, Salmonella typhi.

Optimasi Konsentrasi Etil Selulosa dan Lama Pengadukan dalam Preparasi Microspheres Metformin Hidroklorida Ninda Sukmaningrum; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 3 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Metformin hidroklorida (MH) merupakan obat pilihan pertama yang digunakan dalam terapi diabetes mellitus tipe 2, namun dapat menimbulkan efek samping pada saluran pencernaan sehingga MH tepat dipreparasi menjadi sediaan microspheres. Banyak faktor yang mempengaruhi hasil preparasi microspheres di antaranya adalah konsentrasi etil selulosa (EC) dan lama pengadukan yang digunakan. Penelitian ini bertujuan untuk mengetahui komposisi terbaik konsentrasi EC dan lama pengadukan yang dapat menghasilkan microspheres MH-EC dengan entrapment efficiency (EE) tertinggi menggunakan optimasi desain faktorial. MH digunakan sebagai bahan aktif, EC digunakan sebagai polimer serta non-aqueous solvent evaporation method sebagai teknik yang dipilih dalam preparasi microspheres. Hasilnya microspheres yang menggunakan konsentrasi EC sebanyak 4.500 mg dan lama pengadukan selama 2 jam menghasilkan EE sebesar 84,6 ± 0,557% dengan nilai verifikasi EE sebesar 98,1%, drug loading sebesar 12,7 ± 0,173% dan yield sebesar 95,1 ± 0,612%. Microspheres memiliki bentuk sferis dan morfologi permukaan yang relatif halus dan cerah serta ukuran partikel sebesar 173,8 ± 4,41µm. Hasil analisis FTIR menunjukkan bahwa tidak ada perubahan gugus fungsi spesifik pada MH sebagai bahan aktif. Kata kunci: microspheres, metformin hidroklorida, etil selulosa

Cytotoxic Activity and Phytochemical Analysis of Breynia cernua from Papua Septriyanto Dirgantara; Rosye H.R. Tanjung; Hendra K. Maury; Edy Meiyanto
Indonesian Journal of Pharmaceutical Science and Technology Suppl 1, No. 1 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Breynia cernua (local name Katuk Hutan) is an Indonesian medicinal plant (family: Euphorbiace- ae) originated from Papua which have been used traditionally as alternative treatment for breast and cervical cancer. The objectives of this research were to investigate potential cytotoxic activity and phytochemical aspect test of B. cernua extract and its fractions. Extraction was performed by macera- tion using ethanol 96%, followed by successive fractionations. Phytochemical screening and in vitro cytotoxic activity test were obtained for extract and active fraction with Brine Shrimp Lethality Test (BSLT) method and MCF-7 tumor cell lines were assessed by 3-(4-5-dimethylthiazol-2yl)-2,5-diphe- nyl tetrazolium bromide (MTT) assay. The results from cytotoxic activity test of breast cancer MCF-7 cell line from ethanolic 96% extract and three fractions: n-hexane, ethylacetate and water fractions showed 246.841 ppm, 165.65 ppm, 562.57 ppm dan 713.78 ppm respectively meanwhile the IC50 value of doxorubicin as the positive control was 6 μM. TLC and phytochemical screening showed the pres- ence of alkaloids, terpenoid, avonoids and tannins compounds in this active plant. Keywords: Antitumor, Breynia cernua, BSLT, MCF-7

Aktivitas Antibakteri Ekstrak Etanol Dari Lima Tanaman Terhadap Bakteri Staphylococcus Epidermidis Dengan Metode Mikrodilusi M7 – A6CLSI Shendi Suryana; Yen Yen Ade Nuraeni; Tina Rostinawati
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 1 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Telah dilakukan penelitian uji aktivitas antibakteri dari ekstrak etanol daun Leucaena leucocephala, Camellia sinensis, Psidium guajava L, Anredera cordifolia (Ten.) Steenis dan Solanum nigrum L. terhadap Staphylococcus epidermidis menggunakan metode mikrodilusi. Sebagai pembanding digunakan antibiotik tetrasiklin HCl, kloramfenikol dan amoksisilin. Ekstrak etanol Leucaena leucocephala, Camellia sinensis dan Psidium guajava L memiliki aktivitas sebagai antibakteri, sedangkan ekstrak etanol uji lainnya memiliki aktivitas antibakteri yang tidak signifikan. Nilai Konsentrasi Hambat Minimum (KHM) ekstrak etanol Leucaena leucocephala terhadap Staphylococcus epidermidis adalah 62,5 μg/ml. Nilai Konsentrasi Bakterisidal Minimum (KBM) ekstrak etanol Camellia sinensis dan Psidium guajava L adalah 125 μg/ml.

Antioxidant Activity of Combination Ethanol Extract of Turmeric Rhizome (Curcuma Domestica Val) and Ethanol Extract of Trengguli Bark (Cassia Fistula L) with DPPH Method Triyono Triyono; Anis Yohana Chaerunisaa; Anas Subarnas
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 2 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Turmeric rhizome (Curcuma domestica Val) and Trengguli bark (Cassia fistula L) contain antioxidant compounds which can be determined by 1,1-Diphenyl-2- Pycrylhydrazyl (DPPH) free radical inhibition method. This research was conducted to determine DPPH free radical inhibition by ethanol extract of turmeric rhizome, the ethanol extract of trengguli bark, and a combination of turmeric rhizome extract - trengguli bark extract (1:1,5) with ascorbic acid as a comparison. Identification of secondary metabolite classes is performed by phytochemical screening. Antioxidant activity was performed by inhibition of free radical color of DPPH using UV-Vis spectrophotometry. The study showed IC50 value of ascorbic acid, as a comparasion, is 3,14 μg/mL. While ethanol extract of trengguli bark has the best antioxidant activity with IC50 value 10,98 μg/mL compare to combination ethanol extract of turmeric rhizome - trengguli bark (1 :1,5) and ethanol extract of turmeric rhizome with IC50 value is 13,70 μg/mL and 41,95 μg/mL, respectively.Keywords: Antioxidant, Curcuma domestica, Cassia fistula, DPPH Method

Uji Aktivitas Antibakteri Ekstrak Etilasetat Daun Sirih Hijau (Piper betle L.) terhadap Bakteri Staphylococcus epidermidis Sukriani Kursia; Julianri Sari Lebang; Nursamsiar Nursamsiar
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 2 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.512 KB)

Daun sirih hijau (Piper betle L.) merupakan salah satu tanaman yang digunakan oleh masyarakat Indonesia sebagai obat tradisional. Ekstrak etil asetat daun sirih hijau mengandung senyawa antibakteri yang terdiri dari senyawa fenol dan turunannya. Penelitian ini bertujuan untuk menentukan aktivitas antibakteri ekstrak etil asetat daun sirih hijau terhadap bakteri Staphylococcus epidermidis. Sirih hijau diekstraksi menggunakan pelarut etil asetat dan diuji aktivitas penghambatannya terhadap bakteri Staphylococcus epidermidis dengan metode difusi agar. Hasil penelitian menunjukkan daya hambat ekstrak pada konsentrasi 3% dan 5%, yaitu 9,8 dan 15 mm. Hasil penelitian menunjukkan bahwa ekstrak etil asetat memiliki aktivitas antibakteri dalam kategori sedang-kuat.Kata kunci : Daun sirih hijau, Piper betle L difusi agar, Staphylococcus epidermidis, etil asetat

Formulasi Granul Effervescent Sari Kering Lidah Buaya sebagai Makanan Tambahan Muthmaina Wijayati; Nyi Mekar Saptarini; Irma Erika Herawati
Indonesian Journal of Pharmaceutical Science and Technology Vol 1, No 1 (2014)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Aloe vera has high nutrition content, but bitter taste so direct consumption infrequently. The bitter tastes overcome with preparation. The aim of this study is to make effervescent granule of dried aloe gel as food supplement. The steps in this study consist of making of dried aloe gel, phytochemistry screening and formulation of effervescent granule, quality tests, and hedonic test of effervescent granule. Freeze drying produced 7.57% dried aloe gel. Phytochemistry screening showed quinones, flavonoids, and saponins content. Effervescent granule formulated with concentration of dried gel 20% (F1), 25% (F2), and 30% (F3). The result of granule quality tests showed that effervescent granule meet good requirements with moisture content 0.20-0.21%, bulk density 0.5341-0.5384 g/mL, tapped density 0.6154-0.6178 g/mL with Carr index 13.29±0.025%, flow rate 9.61-9.71 g/s, rest angel 27.15-27.79o, pH 5.82-5.8, and F1 as the most favorable formula. Keywords: Aloe vera, dried gel, effervescent granule, food supplement

Activity Assay of Etanol Ectract of Lansau As Antihyperlipidemic Ruslin Ruslin; Henny Kasmawati; Suriani Suriani; Sundar Ihsan; Desi Sartina
Indonesian Journal of Pharmaceutical Science and Technology Vol 6, No 3 (2019)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.21611

Hyperlipidemia is a condition due to increased levels of total cholesterol such as triglycerides, Low Density Lipoprotein (LDL) and decreased levels of High Density Lipoprotein (HDL). Hyperlipidemia can trigger wall thickening and narrowing of arteries, this condition can cause abnormality of fat metabolism in the blood and creates chronic disease. Lansau herb of the Muna tribe of Southeast Sulawesi consists of 44 ingredients of medicinal plants empirically used to treat various diseases such as koleseterol. The aim of this study was to determine the effect of ethanolic extract to the hispatology of the liver that had hyperlipidemia. The parameters are fatty cell and necrosis forming. Mice were induced by cholesterol and high-fat feed. 24 wistar rats were divided into 6 groups consisting of normal control (1% Na CMC), cholesterol and high fat diet food induction control, positive control (simvastatin 0.4 mg / kgbw), group 1 (dose 6.907 mg / kgbw) group II (dose 13.814 mg /kgbw), group III (dose 27.628 mg/kgbw). After 14 days of treatment, hispatological datas of liver were observed. The results showed that the ethanol extract of lansau had the potential activity as antihyperlipidemia, and cell repairing, especially in administering doses of 27.628 mg/kgbw and had effectiveness that was not much different from the administration of simvastatin in reducing fat degeneration and cell death.Key word : Aterosclerosis, hyperlipidemic, Lansau, simvastatin.

Sintesis dan Karakterisasi Senyawa Antibakteri Kompleks Schiff Base dengan Tembaga (Cu) Lasmaryna Sirumapea; Desi Anggraini
Indonesian Journal of Pharmaceutical Science and Technology Vol 3, No 1 (2016)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Senyawa Schiff base adalah senyawa dengan gugus fungsional azometin (-CH=N-), yang terbentuk dari kondensasi amin primer dengan senyawa karbonil. Beberapa senyawa Schiff base yang berhasil disintesis terbukti bersifat sebagai antimikroba. Telah disintesis senyawa Schiff base dari 4,4 diamino difenil eter, ortohidroksi benzaldehid serta kompleksnya dengan ion logam Cu (II). Senyawa Schiff base yang terbentuk dan kompleks dikarakterisasi gugus fungsinya dengan spektrometer FT-IR. Senyawa yang terbentuk kemudian diuji aktivitas antibakterinya terhadap bakteri Escherichia coli menggunakan metode difusi agar. Spektrum senyawa Schiff base mempunyai puncak pada bilangan gelombang 1620,21 cm-1 dan spektrum senyawa kompleks mempunyai puncak pada bilangan gelombang 1612,49 cm-1. Puncak pada senyawa Schiff base mengindikasikan adanya ikatan CH=N, pergeseran puncak pada kompleks Schiff base menunjukkan adanya ikatan antara nitrogen dengan ion logam. Hasil pengujian senyawa Schiff base dan kompleks terhadap bakteri Escherichia coli menunjukkan snyawa ini positif sebagai antibakteri Escherichia coli. Aktivitas sebagai antibakteri, baik Schiff base maupun kompleksnya lebih kecil dibandingkan aktivitas yang diberikan oleh kontrol, yaitu kloramfenikol. Kata kunci: Antibakteri, ortohidroksi benzaldehid, Schiff-base, 4,4 diaminodifenil eter

Page 21 of 52 | Total Record : 511

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