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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Antibacterial Activity of Parijoto (Medinilla speciosa Blume) Fruit Against Serratia marcescens and Staphylococcus aureus Tiana Milanda; Keri Lestari; Nimas T. I. Tarina
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.32166

Abstract

Parijoto (Medinilla speciosa Blume) is a plant found in Mount Muria, Kudus, Central Java. The local community often uses its fruit to treat various diseases, as well as antibacterial, anti-inflammatory, antioxidant, and anti-cancer. This study aimed to determine the antibacterial activity of n-hexane, ethyl acetate and methanol extract from parijoto fruit against Staphyococcus aureus ATCC 29213 and Serratia marcescens clinical isolates. Gradual maceration of simplicial and antibacterial activity testing of the extracts was performed, followed by determining the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and comparative antibacterial activity most active extract against ampicillin and cefadroxil. The results showed that all extracts exhibited activity against S. aureus ATCC 29213, but only ethyl acetate and methanol extracts had activity against S. marcescens clinical isolates. The highest antibacterial activity was shown by the methanol extract, which was more effective against S. aureus ATCC 29213, having the largest inhibition diameter and lowest MIC and MBC values (6.25 and 12.5 mg/mL). The comparative analysis indicated that the methanol extract demonstrated lower antibacterial activity against S. aureus ATCC 29213 than cefadroxil (72,511: 1). This antibacterial activity is presumed to be generated from alkaloids, polyphenols, tannins, flavonoids, quinones and saponina in the extract.Keywords: Amoxicillin, Cefadroxil, MIC, MBC 
Isolation and Characterization Chemical Compounds From N-Hexane Extract of Zodia Leaves (Evodia suaveolens Scheff.) Mutakin Mutakin; Wina Yunita; Titi Wirahardja Nikodemus
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.32401

Abstract

Zodia (Evodia suaveolens Scheff.) (Rutaceae) is one of Indonesia's native plants, which comes from Papua which is widely used as traditional medicine. Empirically, zodia leaves are used as anti-mosquitoes, dysentery drugs, boiled bark is useful as a reliever for malaria fever, leaf decoction is used as a tonic, and increases stamina. Until now, no investigation has been carried out for the main compounds of the zodia leaf n-hexane extract which have proven activity. Therefore, it was done the isolation and characterization of the main compound in the zodia leaf n-hexane extract (Evodia suaveolens Scheff.). Zodia leaves were extracted with n-hexane using the Soxhlet tool. The n-hexane extract was fractionated using column chromatography with a gradient of n-hexane-chloroform mixture. Isolates were isolated in the form of white needle crystals which were purified by washing with n-hexane. Isolates were characterized by analyzing various UV, IM, 1D and 2D RMI spectrometry data which were confirmed by analyzing the mass spectrum. Based on the results of spectrometric analysis, it is known that the isolate is thought to be a triterpenoid compound, namely neohop-13 (18) -ene-3α-ol.Keywords: Evodia suaveolens, neohop-13(18)-ene-3α-ol, triterpenoide, 
Acute Oral Toxicity of Cincalok Oil in Wistar Rats Siti Nani Nurbaeti; Inarah Fajriaty; Fajar Nugraha; Hadi Kurniawan; Winda Rahmalia; Thamrin Usman; Dwi I. Prayitno
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.26343

Abstract

Cincalok is a West Kalimantan traditional fermented food that has an opportunity to be developed into supplement products as a source of omega 3 and astaxanthin. This study was designed to observe the acute toxicity of Cincalok oil in female rats for its safety profile using AOT 425 program. Cincalok oil for the acute (2000 and 5000 mg/kg) toxicity studies was administered orally according to the OECD guidelines 425. The rat’s body and organs weight were observed then signs of toxicity were assessed. LD50 was being determined at the end of the study. The result showed that a single dose of Cincalok oil at 2000 or 5000 mg/kg had no lethal effect, behavioral change, a significant change in rat’s bodyweights, or any lesion on the rat’s organs. The LD50 of Cincalok oil for oral administration was higher than 5000 mg/kg and categorized as practically non-toxic.Keywords: Acute Toxicity, Cincalok Oil, LD50.
Tyrosinase Inhibition from Green Tea (Camellia sinensis (L.) Kuntze) gel Hanifah Rahmi; Supandi Supandi; Naniek Setiadi Radjab; Tiara Julianti
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.27145

Abstract

Green tea (Camellia sinensis (L.) Kuntze) leaf has polyphenol substance that able to inhibit tyrosinase enzyme. Tyrosinase enzyme is one of the essential components that can be initiated melanin formation on the skin (melanogenesis). The natural inhibitory enzyme can be utilized in cosmetics and medicinal industries as depigmentation agent. Green tea leaf was formulated in the dosage form of a gel with carbomer 934 as a gelling agent. This study aimed to determine the optimum concentration of carbomer 934 on green tea leaf extract gel that has an inhibitory tyrosinase activity. This research used three carbomer 934 concentration, there was 0.5%, 0.75%, and 1% respectively. Which every formula was evaluated during six weeks involve organoleptic, homogeneity, viscosity, pH, centrifuge, and freeze-thaw test (during six cycles). The optimum formula was evaluated tyrosinase activity used a spectrophotometer-vis. The results showed that the great concentration of carbomer 934 was contained on the first formula, which has not phase separation and 49.62 ppm of IC50 value. This research showed that green tea leaf extract gel with 0,5% carbomer 934 prevented tyrosinase activity. Keywords: Carbomer 934, gel, green tea leaf extract, inhibitory of tyrosinase
Piroxicam Percutaneous Permeation from Gels Through Membrane Models of Shed Snakeskin and Cellulose Anis Yohana Chaerunisaa; Marline Abdassah; Jutti Levita; Ellin Febrina; Ulfinana Hafni
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 2 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i2.29017

Abstract

Skin has a very important role in determining percutaneous absorption of active substance in topical administration. Study on percutaneous permeation of piroxicam from gel had been conducted using Franz Diffusion Cell with membrane model of shed snakeskin and cellulose. Piroxicam gels were made using Aqupec HV-505 base with 0; 2.5; 5; and 7.5% of DMSO as an enhancer. The results showed that the most stable gel preparation was the one with 5% DMSO (F2), so it was used for further investigation to which percutaneous permeation test. The permeation test was conducted in preparation without and with 5% DMSO (F2) in vitro through shed snakeskin and cellulose membranes. The results showed that F2 increased the permeation rate by as much as 0.0281% per minute. In comparison, the permeation rate of formulation without DMSO (F0) was 0.012% per minute. It can be concluded that DMSO can increase piroxicam penetration through shed snakeskin. Permeation study using cellulose membrane on formula F2 revealed permeation rate as much as 0.006% per minute whereas that without DMSO (F0) was 0.0112% per minute.Keywords: DMSO, cellulose membrane, percutaneous permeation, piroxicam, shed snakeskin.
Antioxidant Activity and Cytotoxicity Against WiDR Cell and Vero Cell of The Karamunting (Rhonomyrtus tomentosa L.) Leaves Ethanol Extract Marwati Marwati; Andi Anggriani; Asril Burhan; Akbar Awaluddin; Syamsu Nur; Rizky Dharmayanti; Ega Lilingan; Melkisedek D. Tiboyong
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.26769

Abstract

Karamunting (Rhodomyrtus tomentosa L.), a plant used as a traditional medicine, is widely distributed throughout Indonesia. Karamuting has the potential as an antioxidant and anticancer agents because of its phenolic and flavonoid components. This study aimed to determine total phenolic level, antioxidant activity and cytotoxic of karamunting leaves extract. The simplisia of karamunting leaves were extracted by maceration method using 96% ethanol, tested for its antioxidant activity using DPPH and its citotoxic by MTT method (3- (4,5-dimethyltiazol-2-il) -2,5-diphenyl tetrazolium bromide) on WiDr cells and Vero cells. The results of this study showed that the yield of karamunting extract were 15.635% with a total phenolic level of 0.76%, antioxidant activity (IC50 values) of 15,330 μg / mL and cytotoxicity (IC50 values) of 205.7069 μg / mL for WiDr cells and 44.87703 μg / mL for Vero cells. Ethanol extract of karamunting leaves possessed a very strong antioxidant activity while it showed a weak cytotoxic effect on WiDr cells and toxic effect on Vero cells.Keywords: Antioxidant, Anticancer, Karamunting
Preventive Activity of Muntingia calabura Fruits Extract in Aspirin-induced Gastric Ulcer Rat Cynthia Astiti Putri; Arba P. Ramadani; Maulidha Amanati
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.28935

Abstract

Gastric ulcer can be affected people at any age. One cause of this disease is NSAID usage. The aim of this study is to determine Muntingia calabura L. fruit activity for prevent ulcer using aspirin-induced gastric ulcer in rat model. Thirty male Wistar rats were divided become six groups: normal (CMC 0.5%), negative control (CMC 0.5%), positive control (omeprazole 20 mg/kg), treatment group (ethanol M. calabura L. fruit extract): I (100 mg/kg), II (200 mg/kg), and III (300 mg/kg) and given orally once a day for 9 days. On the 10th day, aspirin at a dose of 500 mg/kg was given to all groups except the normal group. Four hours after induction, all animals were sacrificed. Preventive effect against stomach ulcer were determined by calculating the index of ulcer and histopathological examination. Index ulcer of M. calabura fruit extract at all dose were different than negative group, although not significant (p<0.05). Histopathological examination of M. calabura extract at a dose of 300 mg/kg showed few inflammatory cells and congestion compared with the other treatment group. Therefore, ethanol M. calabura L. fruit extract at a dose 300mg/kg gave best activity in preventive of gastric ulcer.Keywords: aspirin, gastric ulcer, Muntingia calabura fruit
Gastroprotective Effect of Ethanol Stem Bark Extract of Pepolo (Bischofia javanica Blume) Against Aspirin-Induced in Wistar Rat Yuliet Susanto; Rini Saputri; Khildah Khaerati
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.35452

Abstract

Prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) can trigger ulcers and bleed in the gastric mucosa. Pepolo stem bark (Bischofia javanica Blume) was a traditional plant that has been empirically used to treat gastric ulcers. This plant contains secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and triterpenoids with gastroprotective potential. This study aims to determine the gastroprotective effect of pepolo stem bark extract (PSBE) against gastric ulcers of Wistar rat induced by Aspirin. The study used 24 rats grouped into six groups. Aspirin (150 mg/kg BW) was administered orally to all the groups except normal control. After 4 h of induction, normal and negative control received Na CMC 0.5%, while the positive group received Omeprazole (3.6 mg/kg BW). The remaining low, middle, and high dose groups received PSBE (100, 200, and 300 mg/kg BW). The treatment was given orally for eight days. On the 9th day, the rats were dissected and tested on the stomach organs. The parameters measured were scores based on the severity of rat peptic ulcers, ulceration index, and percentage protection ratio. The scoring data were analyzed using the Kruskal-Wallis non-parametric test and post hoc the Mann-Whitney test. The administration of PSBE showed the ability to reduce the ulcer index and increase the percentage of ulcer inhibition significantly compared to the negative control (p<0.05). This study showed that PSBE could be a promising gastroprotective herbal medicine.Key words: Aspirin, pepolo stem bark, gastric ulcer
Determination and Purification of Ricin Protein from Ricinus communis L. Seeds using CLC (Column Liquid Chramotagoraphy) and FPLC (Fast Protein Liquid Chramatography) Irma Erika Herawati; Ronny Lesmana; Jutti Levita; Anas Subarnas
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.35454

Abstract

Proteins found in all biological systems, from prokaryotes to eukaryotes. Ricin, one of the most toxic substances known isolated from Ricinus communis L. seeds, is a heterodimeric two-domain polypeptide protein that includes chain A (30 kDa) and chain B (35 kDa) linked by a disulfide bond. Ricin binds to cells by the B chain and is then internalized. Ricin has been reported as a potential chemical for cancer treatment. The measurement of protein concentration in an aqueous sample is an important assay in biochemistry research. However, so far, the quantification of ricin protein is not much reported. In this study, the quantification ricin protein extracted from R. communis L. seeds originated from Nganjuk, East Java, Indonesia. The techniques used column liquid chromatography (CLC) and fast protein liquid chromatography (FPLC), followed by quantification protein content used Bradford method. Results showed that all techniques positively confirm the presence of ricin protein. Ricin protein content were 0.171±0.021 mg/mL and 0.382±0.023 mg/mL using CLC and FPLC respectively. This study might contribute to understanding the biological and chemical properties of the ricin protein of R. communis L. seeds. Ricin protein content measured with FPLC were higher than CLC. Keywords: Ricin, Ricinus communis,CLC, FPLC.
Analytical Method Development of Content and Dissolution Assay of Ursodeoxycholic Acid Capsule Wanti Megawati; Sophi Damayanti
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 3 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i3.31420

Abstract

Ursodeoxycholic acid is an active compound to treat cholesterol gallstones which is included in Biopharmaceutical Classification System class II. Ursodeoxycholic acid capsule formulations have been developed by the pharmaceutical industries. Due to requirement, active ingredient testing and dissolution tests need to be routinely carried out to control quality of the drug. Therefore, aim of this study was to develop a simultaneously analytical method for assay and dissolution test. Optimum condition of analysis were using HPLC-RID, C18 column (5 µm; 3.9 x 300 mm), flow rate 1 mL/min, 50 µL volume injection, acetonitrile:buffer phosphate pH 3.0 (55:45 v/v) as mobile phase, column, detector, and sample temperature were 40 oC. This method provides good linearity in a range of 50-130 % concentration for assay and dissolution test with correlation coefficient values of 1 and 0.9995, respectively. LOD and LOQ for assay were in value of 4.892 µg/mL and 14.824 µg/mL whereas for dissolution tests in a value of 6,501 µg/mL and 19,701 µg/mL. The average percent recovery for assay and dissolution test were in a range of 100.018±0.888% and 98.936±2.124 %. Repeatability and intermediate precision of assay were obtained by determining RSD values of 0.466% and 0.279-0.483 %, while the dissolution test were 1.137% and 0.032-0.289 %. The validation show this method are linear, selective, accurate, and precise.Keywords: Assay, dissolution test, Ursodeoxycholic acid, validation

Page 24 of 50 | Total Record : 494

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