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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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POTENSI LIMBAH KULIT JERUK NIPIS (Citrus auronfolia) SEBAGAI INHIBITOR TIROSINASE Siti Hindun; Taofik Rusdiana; Marline Abdasah; Reti Hindritiani
Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 2 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.989 KB) | DOI: 10.15416/ijpst.v4i2.12642

Abstract

Hiperpigmentasi merupakan kelainan kulit wajah yang umum terjadi, terutama karena adanya peningkatan melanogenesis, dengan gambaran berupa warna kulit menjadi hitam atau coklat kehitaman. Kelainan ini terdapat pada beberapa macam penyakit kulit diantaranya melasma, melanoderma paska inflamasi, lentigo solaris dan freckles. Salah satu prinsip penanganan hiperpigmentasi yaitu menghambat sintesis melanin yang dapat dilakukan dengan menggunakan agen depigmentasi yang mekanisme kerjanya menghambat aktivitas enzim tirosinase. Penelitian ini bertujuan untuk menguji potensi kulit jeruk nipis sebagai inhibitor tirosinase. Kulit jeruk nipis diektraksi dengan etanol 96 %, identifikasi flavonoid, menghitung flavonoid total, kemudian diuji inhibisi tirosinase menggunakan instrumen microplate reader (ELISA). Hasil penelitian ekstrak kulit jeruk mengandung flavonid, dengan total flavonid totalnya 0,667 % b/b dan inhibition concentration (IC) 50 42,11 mg/mL, Kulit jeruk berpotensi sebagai inhibisi tirosinase.Kata kunci:    Citrus auronfolia, Hiperpigmentasi, IC50, Tirosinase
Molecular Docking Studies of Compounds from Brucea javanica (L.) Merr. Towards The Discovery of Potential H5N1 Neuraminidase Inhibitors Rina Fajri Nuwarda; Zelika Mega Ramadhania; Imam Adi Wicaksono; Muhammad Yusuf; Ade Rizqi Ridwan Firdaus; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.25643

Abstract

The occurrences of a highly pathogenic avian influenza virus (HPAI) type A H5N1 has caused infections in millions of poultry as well as hundreds of human cases and even mortalities. Indonesia has become one of the world’s highest casualty rates of H5N1 human infections, with the number of deaths was 167 from a total of 199 cases. The development of viral resistance towards the available anti-influenza drugs neuraminidase (NA) inhibitors required the discovery of new inhibitors. In the recent advance of drug discovery, natural products have been considered as one of the essential sources of medicinal agents, and Brucea javanica has been found to possess antiviral activity against H5N1 NA. Thus, this research aimed to investigate the in silico activities of compounds from B. javanica using molecular docking methods against H5N1 NA. In this study, docking-based virtual screening of compounds from B. javanica to quickly select in silico hits to be potential NA inhibitors was performed. Subsequently, the intermolecular interactions of the inhibitor compounds with the H5N1 NA were analysed to examine the most preferred interactions. The results showed that brucein G and bruceoside C were found having the lowest binding energy and most preferred interactions with H5N1 NA and therefore, can be proposed for further study as potential NA inhibitors.Keyword: antiviral, Brucea javanica, H5N1, molecular docking, neuraminidase
Inhibition of Heme Polymerization Invitro Assay Of Extract of Sirih Leaf (Piper betle Linn.) and Sun Flower Leaves (Helianthus annuus L.) Ami Tjitraresmi; Moelyono Moektiwardoyo; Yasmiwar Susilawati
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.25319

Abstract

Malaria is a disease that occurs in tropical countries like Indonesia. The incidence of malaria in the world is still quite high and the occurrence of cases of Plasmodium resistance to antimalarial drugs and the widespread of resistance have prompted researchers to look for new antimalarial drugs, especially from natural materials. Betel leaf (Piper betle Linn.) And sunflower leaf (Helianthus annuus L.) have long been used by the people of Indonesia as an antimalarial drug. The purpose of this study was to determine antimalarial activity through inhibition of heme polymerization and determine secondary metabolite compounds by phytochemical screening from betel leaves and sunflower leaves. The heme polymerization inhibition activity assay was carried out by the in-vitro method using a microplate reader at 415 nm and 630 nm wavelengths. IC50 values of betel leaf extract and sunflower leaf were 178.67 μg/ml and 160.10 μg/ml, respectively. Phytochemical screening results from betel leaf showed the presence of flavonoids, polyphenols, tannins, quinones, saponins, and monoterpenoids-sesquiterpenoids, while sunflower leaves contain alkaloids, polyphenols, flavonoids, steroids and monoterpenoids-sesquiterpenoids.Keywords: Piper betle Linn., Helianthus annuus L., Malaria, Heme Polymerization
In Silico Study of Aglycon Curculigoside A and Its Derivatives as α-Amilase Inhibitors Nursamsiar Nursamsiar; Maya M. Mangande; Akbar Awaluddin; Syamsu Nur; Aiyi Asnawi
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.23062

Abstract

α-amilase is an enzyme that catalyzes the hydrolysis of starch polysaccharides into oligosaccharides to then produce glucose. Inhibitions of the α-amylase enzyme is an effective strategy in modulating blood sugar levels in diabetics. The aglycon curculigoside A has similar structure to chalcon which is able to inhibit the α-amilase enzyme for the treatment of type 2 diabetes. The aim of this study was to determine the interaction of the curculigoside A aglycone compound and its derivatives with the α-amylase enzyme by using the docking simulation method. Docking simulations were carried out by using AutoDock 4.2 and α-amilase protein (PDB ID: 1B2Y) as macro molecule. The docking results showed that the aglycone curculigoside A and its derivatives able to interacted into the active site of the α-amylase enzyme. Three best ligands according to the simulation and prediction tests were compound 10, compound 23, and compound 41 has formed hydrogen bonding to Asp197, Glu233 and Asp300 residues with free bonding energy of -7.29, -7.22, dan -7.84 kcal/mol, respectively. In conclusion, Three best ligands has the same pattern of hydrogen bonds to the native ligand AC1 (6-methyl-5-(4,5,6-trihydroxy-3-hydroxymethyl-cyclohex-2-enylamino)-tetrahydro-pyran-2,3,4-triol) via amino acids redisues of α-amylase that play a role in the substrate by hydrolysis process.Keywords: aglycon curculigoside A, α-amylase, diabetes, docking 
Comparison Ability of Polymers Acrycoat S100 And HPMC K4M to Entrapment Efficiency Domperidone in Microspheres Pratiwi Apridamayanti; Nora Nurlina Sinaga; Rise Desnita
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 1 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i1.18461

Abstract

Domperidone is a prokinetic and antiemetic agent which has low bioavaibility. To increase the bioavaibility of drug, it can be modified into microsphere that can hold drug more longer in gastric to improve the bioavaibility. The microsphere preparation requires a polymer that can make matrix system to protect and deliver the drugs. Acrycoat S100 and HPMC K4M are the usual polymers that used for encapsulation and  have biodegradable characteristic. The aim of this research is to know the comparison ability of two different polymers to entrapment the drug in microsphere. Microsphere domperidone made by solvent evaporation method in 6 formula. F1, F2 and F3 using 50 mg, 100 mg and 150 mg Acrycoat S100 polymer, while F4, F5 and F6 using 50 mg, 100 mg and 150 mg HPMC K4m polymer. The tests were conducted by the determination of the percentage of entrapment efficiency using UV spectrophotometer and evaluation of organoleptic, particle measurement and surface microsphere morphology. The results showed that F3 with Acrycoat S100 polymer has a greater entrapment efficiency of 78,712% ± 4,260% compared to the highest percentage efficiency of HPMC K4M polymer of 4,734±0,390.Key words: Acrycoat S100, domperidone, entrapment efficiency, HPMC K4M, microsphere
Molecular Docking of Active Compounds Piper crocatum on the A-Glucosidase Enzyme as Antidiabetic Mustika Weni; Mega Safithri; Djarot Sasongko Hami Seno
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.21120

Abstract

Ethanol extract of Piper crocatum leaves has inhibitory activity of α-glucosidase enzyme. Ethyl acetate fraction from Piper crocatum leaves has the highest antioxidant activity. Previous research has provided information that the ethyl acetate fraction of Piper crocatum leaves has an inhibition of α-glucosidase containing 6XO32ZSP1D, Ethyl L-serinate hydrochloride compound, Schisandrin B compound, Columbin compound, 4- (4-methoxy-phenylamino) -2 compound, 3-dihydro-1H-4a, 9-diazacyclopenta (b) fluorine-10-carbonitrile, compound 6-Amino-4- [3- (benzyloxy) phenyl] -3-tert-butyl-2,4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile, compound 4 - {{4.6-Bis [(3R, 5S) -3,5-diamino-1-piperydinyl] -1,3,5-triazine-2-yl} amino) benzenesulfonamide and compound 1.1 '- (1,4-butanediyl) bis {2,6-dimethyl-4 - [(3-methyl-1,3-benzothiazol-2 (3H) ylidene) methyl] pyridinium. This study aims to study the interaction between bioactive compounds contained in ethyl acetate fraction of Piper crocatum leaves with α-glucosidase enzyme in In Silico using AutoDock Vina, Columbin shows the lowest binding energy with binding sites with amino acids Ser240, Asp242, His280, Arg315, Glu411, Phe159, Arg442, Tyr158 and Phe303. Columbin has the stability and inhibits the α-glucosidase enzyme from S. cerevisiae better than the seven other compounds, because it has OH and CH3 groups which play a role in the interaction with around the active side of the α-glucosidase enzyme.Keywords: Columbin, In Silico, α-Glucosidase
Gastroprotective Effect of Green Algae Extract (Ulva lactuca L) on Gastric Rats Wahyu Widyaningsih; Siti Nurasih Afdaliah
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.22416

Abstract

Gastric ulcer is a disease of the digestive tract characterized by mucous damage to secretion of gastric acid and pepsin. One of the potential gastroprotector plants is green algae. The purpose of this study was to examine the gastroprotective effect of ethanol extract of green algae (EEGH) Ulva lactuca L on the gastric of ethanol-induced rats. This study used 36 rats, divided into 6 groups. Group I is a normal group. Group II negative control, ethanol 96% induced. Group III positive control, given comparison of ranitidine dose of 15.75 mg/kgBW. Groups IV, V and VI were given multilevel EEGH, namely 125, 250 and 500 mg/kgBW. The treatment was carried out for 14 days, on the 14th day ethanol 96% was induced and then dissected. Research data on gastric ulcer index and protection ratio were analyzed using One Way ANOVA with a confidence level of 95%. The results of the EEGH statistical test dose of 500 mg/kgBW with negative controls showed a significant difference with p value of 0.013 (p<0.05). The EEGH 500 mg/kgBW has the ability as an effective gastroprotector, as seen from the gastric ulcer index value of 0.5 and the protection ratio of 78.94%.Keywords: Ethanol, gastroprotector, protection ratio, ulcer index, Ulva lactuca L.78,94%. 
Study of Physicochemical Characteristics of Kaolin from Belitung Regency Nurul Izzah Pasi; Marline Abdassah Bratadireja; Anis Yohana Chaerunnisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.25675

Abstract

Kaolin is one of the abundant clay minerals on earth which has been widely used in various industries. kaolin as a raw material in drugs manufacturing must comply several requirements in Pharmacopoeia such as not exceeding the heavy metal content limits. In this study the analysis of heavy metal content (Pb, Sn, and As) was carried out on natural kaolin obtained from 3 different locations in Belitung regency. Testing of the brightness and particle size is also carried out to increase the value of kaolin as a pharmaceutical excipient. The highest recovery from kaolin was obtained in sample 3 which was 67.78%, while kaolin 1 and 2 which was 66.54, and 64.20%. Based on the results of heavy metal testing it is known that kaolin 1, 2, and 3 have a Pb content of 55.2, 0.0458 and 44.0 ppm, and As content of 1.05, 78.3, and 0.761 ppm. Whereas the Sn mean metal is only found in kaolin 2 which is 0.0034. White degree test results show that kaolin 1, 2 and 3 have a high brightness, namely 92.94%, 93.00%, 91.16%. From the results of particle size testing shows that all kaolin samples have size <2 μm.Keywords: Characterization of Minerals, Heavy Metals, Kaolin
Characterization of Imprinted Polymer of Diazepam With Methacrylic Acid and Hydroxyethyl Methacrylate Monomer in Chloroform for Selective Adsorption of Diazepam Michelle Ferdinand; Rimadani Pratiwi; Aliya Nur Hasanah
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.26230

Abstract

Diazepam is a benzodiazepine class usage is regulated nationally or globally. These drugs can be used to regulate sleep patterns or sedative-hypnotic drugs because it has a calming effect. Monitoring the abuse of diazepam requires a sensitive analysis methods that required the preparation of selective methods. One of the methods that are currently developing is Moleculary Imprinted Polymer-Solid Phase Extraction (MI-SPE). In this research, step being performed include determination of the association constant, synthesis sorbent of Imprinted Polymer (IP) diazepam by bulkpolymerization method with diazepam as a template, chloroform as porogen, two kind of monomer methacrylic acid (MAA) and hydroxyethyl methacrylate (HEMA) as functional monomer. Templates extracted from polymer followed by evaluation of adsorption ability test, a test of capacity and selectivity of the polymer, and also the characterization of the IP using Fourier Transform Infra-Red (FTIR),and Scanning Electron Microscope (SEM). The results showed that IP diazepam with MAA monomer has 7.95 x 10-5 mg/g of capacity, it is better than capacity of IP diazepam monomer HEMA with 7.47x 10-6 mg/g. Selectivity of IP diazepam MAA monomer has an IF value which is 2.13, which is better than IP HEMA with 1.21. In addition, IP diazepam MAA monomer more heterogenous than its Non Imprinted Polymer (NIP).Keywords: Chloroform, Diazepam, HEMA, Methacrylic acid, MI-SPE.
Method Validation of Chloramphenicol Analysis in the Shrimp Based on Diazotization Reaction Abdul Wafi; Ganden Supriyanto; Tjitjik Srie Tjahjandarie
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.26520

Abstract

A simple, rapid and precise spectrophotometric method has been developed and validated for the determination of Chloramphenicol (CAP) in the shrimp based on diazotization reaction at room temperature. The CAP was reduced by zinc powder and the diazotization reaction was carried out in the presence of NaNO2, bismuth nitrate pentahydrate as catalyst. The 2-napthol used as coupling agent to form a red-violet solution and the absorbance of azo dye solution was measured by UV-Vis spectrophotometer at 554 nm. The method validation parameters including linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) have been investigated. The correlation coefficient (R2) was 0.996 for concentration range 0.70 – 4.65 µg/mL. The LOD and LOQ were 0.36 µg/mL and 1.19 µg/mL. Accuracy and precision of the method were performed by spiking of CAP in the shrimp sample at concentration 1.16; 2.33; 3.49 µg/mL. Analysis result showed that the accuracy and precision of the method were 92.77-97.37 % and 0.21-2.39 % respectively.Keywords : Chloramphenicol, diazotization, shrimp, spectrophotometry, method validation.

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