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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Perbaikan Sifat Mekanik Deksibuprofen melalui Pembentukan Ko-Kristal Deksibuprofen-Kafein dengan Metode Ultrasound assisted Solution Co- crystallization Fikri Alatas; Titta H. Sutarna; Raisa Fakhrona Salman; Sundani Nurono Soewandhi
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.34713

Abstract

Kemampuan suatu bahan aktif farmasi untuk dapat dikempa langsung dipengaruhi oleh sifat-sifat mekaniknya, seperti daya alir dan tabletabilitas. Karakterisasi pembentukan ko-kristal meliputi morfologi kristal, difraktogram sinar-X serbuk, dan perilaku termal. Perbandingan sifat-sifat mekanik dilakukan terhadap ko-kristal DXI-CAF hasil USSC dengan DXI murni, meliputi daya alir (indeks kompresibilitas) dan tabletabilitas (tensile strength dan elastic recovery). Pengujian tabletabiltas dilakukan pada kekuatan kompresi 10-60 kg/cm2. Hasil karakterisasi menunjukkan hasil USSC memiliki habit kristal, difraktogram, dan titik lebur yang unik yang berbeda dengan DXI murni, dan hal ini mengindikasikan terbentuknya ko-kristal DXI-CAF. Indeks kompresibilitas ko-kristal DXI- CAF berada pada rentang kategori baik, sementara DXI murni berada pada rentang kategori buruk. Nilai tensile strength maksimum ko-kristal DXI-CAF adalah 1,526 MPa yang dicapai pada kekuatan kompresi 50 kg/cm2, sementara nilai tensile strength maksimum DXI murni hanya 0,853 MPa yang dicapai pada kekuatan kompresi 20 kg/cm2. Kurva elastic recovery menunjukkan persentase elastic recovery ko-kristal DXI-CAF lebih baik daripada DXI murni. Dari hasil-hasil ini dapat disimpulkan bahwa pembentukan ko-kristal DXI-CAF dengan metode USSC mampu memperbaiki sifat-sifat mekanik deksibuprofen.
Characterization of Nanosilver Biosynthesis by Citrus sinensis (L.) Osbeck and Peel-off Mask Formulation with Variation Polyethylene Glycol 400-Glycerin Concentration Dian Eka Ermawati; Agung P. Surya; Adi Yugatama
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.29875

Abstract

Sweet orange contains flavonoids and citric acid that have the potential as a capping agent in the nanosilver biosynthesis process. The antibacterial activity of silver can be increased in nanoparticles, then it can be applied to treat acne through a peel-off mask preparation. Glycerin and Polyethylene glycol 400 are humectants that combined to obtain good physicochemical properties of the preparation. This study aims to determine the character of nanosilver biosynthesis and the effect of humectant combination on the physicochemical properties of the preparation. The characterization of nanosilver was employed by UV-VIS Spectrophotometry, Particle Size Analysis, and Scanning Electron Microscope. The Glycerin- PEG 400 combination was F1 (0:100%); F2 (25:75%); F3 (50:50%); F4 (75:25%) and F5 (100:0%). The results of nanosilver biosynthesis have an absorption peak of nanoparticles at 421-423nm, rod shape, the particle size of 83.2±7.2nm. Statistical analysis showed that the combination of Glycerin- PEG 400 had a significant effect on organoleptic, viscosity, and dry time, but did not affect the pH of preparation. The combination of Glycerin-PEG 400 (75%:25%) is the best formula because it has stable viscosity, dry time, and pH value during storage for four weeks.Keywords: nanosilver, biosynthesis, Citrus sinensis, humectants, peel off mask
Uji Aktivitas Antibakteri Fraksi Umbi Allium cepa L. Melzi Octaviani; Nadilla Alfitri; Haiyul Fadhli
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.29474

Abstract

Bawang merah (Allium cepa L.) selain digunakan sebagai bumbu penyedap masakan, juga bisa digunakan sebagai obat oleh masyarakat Indonesia. Bagian tumbuhan yang dapat dimanfaatkan sebagai obat adalah bagian umbinya. Umbi bawang merah mengandung metabolit sekunder yaitu fenolik, flavonoid, dan terpenoid yang berkhasiat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri fraksi n-heksana, etil asetat, dan 1-butanol umbi bawang merah terhadapbakteri Gram positif Staphylococcus aureus dan bakteri Gram negatif Escherichia coli dengan metode difusi cakram. Fraksi umbi bawang merah dibuat dalam beberapa seri konsentrasi yaitu 25%; 12,5%; 6,25%; 3,125%; dan 1,5625%. Konsentrasi 25% memberikan daya hambat paling baik dalam menghambat bakteri Staphylococcus aureus dan Escherichia coli. Hasil analisisdata menggunakan uji one way ANOVA dan Kruskall-Wallis didapatkan hasil p <0,05 yang menandakan adanya perbedaan daya hambat yang signifikan yang diberikan antara seri konsentrasi masing-masing fraksi dengan kontrol positif dan kontrol negatif. Simpulan dari penelitian ini adalah fraksi etil asetat memiliki daya hambat yang lebih besar terhadap pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli dibandingkan fraksi n-heksana dan 1-butanol.
Formulation of Cinchona Extract (Cinchona succirubra) Cream and The Safety as Hair Fertilizer Hariyanti Hariyanti; Retno Wahyuningrum; Shintia Lintang Charisma
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36324

Abstract

Background: cinchona extract contains quinoline alkaloids, has telangiectatic activity, is practically insoluble in water so penetration into hair follicles is low and requires a delivery system, namely cream. Objective: to determine the formula of cinchona extract cream with good activity, physical stability and safety. Methodology: cinchona bark extraction (soxhletation method), phytochemical screening, cinchona extract dosage determination, optimization of cream formula using Design Expert software version 11. Evaluation: pH, adhesion, spreadability, viscosity and cycling test stability. Activity test using guinea pigs (Cavia porcellus) for 14 days, parameters of hair length/2 days, hair mass (14th day). Acute dermal irritation test using rabbit (Orycogalus cuniculus) by erythema and edema index parameters. Results: cinchona extract (13.32% yield) contained quinoline alkaloids, cinchona extract dosage was 20% (p<0.05). The optimum formula is F2 with characteristics: pH 6.48±0.07, adhesion 1.16±0.07, spreadability 4.99±0.85 and viscosity 3067±416.45, has good physical stability. Activity test: test area hair length 13.54 – 62.14% longer than normal control and 10.10 – 49.17% than negative control. The hair mass of test area was 122.91% heavier than normal control and 104.48% of negative control (p<0.05). Cinchona extract and excipients were non-irritant. Conclusion: Cinchona extract cream (20%) has hair fertilizer activity, good physical stability and safety.
Pembuatan Sabun Cairan Mengandung Susu Sapi dari Usaha Kecil Menengah di Kota Cimahi Titta Hartyana Sutarna; Wulan Anggraeni; Fikri Alatas; Regita Ayu Lestari; Faizal Hermanto; Elivas Simatupang; Afifah Bambang Sutjiatmo; Ririn Puspadewi; Lucky Rachmawan; Fahmy Ahsanul Haq; Suci Nar Vikasari
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.28901

Abstract

Kulit merupakan salah satu bagian tubuh yang sering terpapar benda asing dan membutuhkan nutrisi dan pembersihan rutin menggunakan sabun. Susu sapi mengandung protein dan lemak yang berkhasiat untuk melembabkan dan menutrisi kulit. Penelitian ini bertujuan untuk membuat sediaan sabun cair dari susu sapi yang berfungsi untuk meningkatkan kelembaban pada kulit. Penelitian dimulai dengan pengumpulan susu sapi dari usaha kecil menengah di kota Cimahi dan uji karakteristik secara organoleptik. Selanjutnya dibuat serangkaian seri formula sabun cair yang mengandung susu sapi sebanyak 0, 5, 10 dan 20%, kemudian dievaluasi meliputi evaluasi fisik (organoleptis, pH, viskositas, dan uji stabilitas) dan pengujian terhadap responden (pengujian daya emolien dengan alat skin analyzer, uji kesukaan, dan efektivitas pembersihan). Data yang diperoleh dianalisa statistik menggunakan uji t-berpasangan. Hasil evaluasi fisik menunjukkan bahwa formula sabun cair yang mengandung susu sapi stabil selama penyimpanan 28 hari. Hasil pengujian terhadap responden menunjukkan sediaan yang paling disukai adalah sabun cair yang mengandung susu sapi 15% dengan alasan nyaman digunakan, lembut dan tidak lengket pada kulit. Hasil pengujian efektivitas pembersihan juga menunjukkan sabun cair yang mengandung susu sapi 15% dapat membersihkan kotoran dan make up.
Total Phenolic and Flavonoid Contents and Antioxidant Activity of Kembang Bulan Leaves (Tithonia diversifolia (Hemsley) A. Gray) Noer Fauziah Rahman; Nursamsiar Nursamsiar; Megawati Megawati; Handayani Handayani; Christa A. M. Suares
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36900

Abstract

Many plants are used ethnomedicinally for the treatment of disease and restoration of health. One of these medicinal plants is Tithonia diversifolia. This study aims to determine the phenolic and flavonoid contents and antioxidant activity using the DPPH method from the leaves of T. diversifolia. Phenolic identification was carried out with FeCl3 reagent; the blackish green color formed indicates the presence of phenolic compounds. Identification of flavonoid was carried out using a reagent between magnesium powder and concentrated HCl; the orange-red color formed indicated the presence of flavonoid. Determination of phenolic and flavonoid contents from extract of T. diversifolia leaves was carried out colorimetrically using a UV-Vis spectrophotometer. The results showed that the Total Phenolic Contents (TPCs) of the ethyl acetate and ethanolic extract of the T. diversifolia leaves was 1.28 and 1.37% GAE, respectively, while the Total Flavonoid Contents (TFCs) was 2.21 and 3.41 mgQE/g, respectively. Better antioxidant activity was shown by the ethanol extract with an IC50 value of 84.018 µg/ml.Keywords: Antioxidant, flavonoid, phenolic, Tithonia diversifolia
Isolasi Fungi Tanah Muara dan Skrining Aktivitas Antibakteri Terhadap Staphylococcus aureus Afrian Rosyadi; Bawon Triatmoko; Ari Satia Nugraha
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.28834

Abstract

Penyakit infeksi merupakan salah satu penyebab kematian di dunia. Antibiotika sering digunakan dalam pengobatan infeksi bakteri namun saat ini mengalami resistensi. Berdasarkan hal tersebut, penelusuran alternatif antibiotika dari bahan alam perlu dilakukan, salah satunya dari fungi. Fungi merupakan mikrobe eukariotik sebagai sumber utama antibiotika yang tersedia saat ini termasuk penisilin. Penelitian ini dilakukan untuk mengetahui potensi aktivitas antibakteri ekstrak etil asetat hasil fermentasi isolat fungi tanah muara terhadap bakteri gram positif Staphylococcus aureus. Penapisan fitokimia ekstrak menggunakan metode KLT sedangkan pengujian aktivitas antibakteri penelitian ini menggunakan metode mikrodilusi. Aktivitas antibakteri dilaporkan dalam persen penghambatan. Hasil uji antibakteri ketujuh ekstrak memiliki aktivitas dengan persen penghambatan tertinggi dari kode isolate IS-IB-T2 sebesar 66,5 ± 1,1 % dan terendah dari kode isolate IS-IB-B2 sebesar 12,2 ± 0,7 % pada konsentrasi 100 μg/mL. Adanya terpenoid dalam tiap ekstrak diduga memiliki kontribusi dalam mekanisme antibakteri. Maka dari itu, fungi yang berasal dari tanah muara berpotensi untuk dieksplorasi senyawa antibiotiknya lebih jauh lagi.
Formulation And Antioxcidant Activity Test Of Clay Mask Extracted Ethanol Tamarillo (Solanum betaceum Cav.) Yessi Febriani; Sudewi Sudewi; Rosanna Sembiring
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36432

Abstract

Tamarillo (Solanum betaceum Cav.) is a plant that is spread in Java, Bali and North Sumatra, which is rich in nutrients and contain flavonoid as antioxidants that can prevent cell damage due to oxidative stress. Clay-based face masks have a firming and cleansing effect on the skin. Tamarillo was extracted by maceration method using 96% ethanol extract, phytochemical screening was carried out. Clay mask formulation with extract concentration of 1.5%, 2%, 2.5% and blanks. Physical quality test of clay mask preparations included homogeneity test, stability test, pH test, dry time test, irritation test, effectiveness test of clay mask preparation on volunteers using the Skin Analyzer Checkher (Aram), preference test and antioxidant test using the DPPH method. The results showed that the ethanol extract tamarillo contained alkaloids, flavonoids, saponins and could be formulated into a clay mask preparation that was homogeneous, stable, met the pH requirements, and dried time. The results of the effectiveness test using a checkher skin analyzer give the effect of reducing blemishes, reducing pores, moisturizing, not causing irritation to the skin. The antioxidant activity of the ethanol extract tamarillo were in the moderate category with an IC50 value of 201 g/mL and the clay mask preparation of the ethanol extract tamarillo with a concentration of 2.5% was in the medium category with an IC50 value of 221 g/mL.
Variasi Volume Sari Buah dan Infusa Kulit Buah Jeruk (Citrus sinensis) Terhadap Karakteristik dan Aktivitas Antibakteri Nanosilver David Sarono Putro; Dian E. Ermawati; Adi Yugatama
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.29870

Abstract

Biosintesis nanosilver dengan buah jeruk (C. sinensis) sebagai bioreduktor diketahui dapat menghasilkan perak berukuran nano. Penelitian ini bertujuan melihat pengaruh variasi volume kombinasi sari buah dengan infusa kulit buah jeruk terhadap karakteristik dan aktivitas antibakteri nanosilver. Sintesis nanosilver dilakukan dengan mencampur larutan AgNO3 1 mM dengan kombinasi sari buah – infusa kulit buah jeruk dengan perbandingan (v/v), 3:0; 1,5:1,5; 1:2; 0,5:2,5 dan 0:3 padapenangas air bersuhu 60˚C selama 45 menit. Perubahan warna larutan mengindikasikan telah terbentuknya nanosilver    dan konfirmasi dilakukan dengan spektrofotometer UV/Vis serta analisis TEM. Hasil penelitian menunjukkan penambahan sari buah pada bioreduktor kombinasi dapat mempercepat terjadinya perubahan warna dan karakterisasi nanosilver dengan spektrofotometer UV/Vis mengkonfirmasi puncak SPR direntang 438-459 nm. Pengujian stabilitas memperlihatkan nanosilver hasil reduksi dengan kombinasi sari buah – infusa kulit buah jeruk 0,5:2,5 (v/v) memiliki stabilitas paling memenuhi syarat dan pengujian zona hambat dengan metode difusi terhadap bakteri S.aureus (19,50 mm) dan S.epidermidis (18,09 mm) yang dihasilkan lebih besar daripada nanosilver hasil reduksi kombinasi formula lainnya, yang mengindikasikan responhambat sedang. Analisis TEM menunjukkan nanosilver berukuran 30-56 nm berbentuk bulat.
Microscopic Identification and Determination of Total Flavonoid Content of Moringa Leaves Extract and Ethyl Acetate Fraction (Moringa oleifera L.) Annisa Fatmawati; Depita Sucianingsih; Riza Kurniawati; Muhammad Abdurrahman
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36337

Abstract

This research was conducted to identify simplicia microscopically, phytochemical screening and determination of total flavonoid content of extract and ethyl acetate fraction from Moringa (Moringa oleifera L.) leaves using UV-Visible Spectrophotometry method. The experimental design used in this study was to perform microscopic identification of Moringa leaf powder simplicia, make 96% and 70% ethanol extract and ethyl acetate fraction of Moringa leaves from 70% ethanol extract, then carry out phytochemical screening and determination of total flavonoid content with quercetin standards. Phytochemical screening on the ethyl acetate fraction of Moringa leaves included tests for the content of flavonoids, saponins, tannins and alkaloids. The results of microscopic identification of Moringa leaf simplicia showed the presence of calcium oxalate crystals in the form of rosettes, mesophyll and stomata. The result of determination of total flavonoid content in 96% ethanol extract was 16.69 ± 0.74% (w/w), 70% ethanol extract was 10.84 ± 0.49% (w/w), Moringa leaf ethyl acetate fraction 14 .45 ± 0.90% (w/w). The highest total flavonoid content was found in the 96% ethanol extract of Moringa leaves in accordance with the 2017 Indonesian Herbal Pharmacopoeia, that the thick extract of Moringa leaves containing no less than 6.30% (w/w) total flavonoids was calculated as quercetin.

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