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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Formulasi dan Evaluasi Gel Nanopartikel Perak Citra Ariani Edityaningrum; Artika Tri Oktafiani; Lina Widiyastuti; Dewa Ayu Arimurni
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.35343

Abstract

Nanopartikel perak diketahui dapat menembus membran sel bakteri penyebab jerawat dan menyebabkan kerusakan struktural yang berakibat pada kematian sel bakteri. Nanopartikel perak perlu diformulasikan dalam bentuk gel agar memudahkan dalam penggunaannya. Penelitian ini dilakukan untuk mensintesis nanopartikel perak dan memformulasikannya dalam bentuk gel. Sintesis nanopartikel perak dilakukan menggunakan metode reduksi kimia dengan reduktor natrium sitrat dan penstabil gelatin. Nanopartikel perak kemudian diformulasikan dalam sediaan gel dengan variasi konsentrasi HPMC 7%, 10%, dan 15%. Hasil karakterisasi menunjukkan telah terbentuk nanopartikel perak berdasarkan panjang gelombang maksimal yang terbentuk yaitu 430,2 nm, absorbansi 0,297, ukuran partikel 157,73±15,03 nm, indeks polidispersitas 0,328±0,032, dan morfologi bulat. Berdasarkan hasil analisis, dapat disimpulkan bahwa formula 3 dengan konsentrasi HPMC 15% merupakan formula terbaik dengan sifat fisik berupa nilai viskositas 3931,75 ± 92,383 cps, diameter sebar 6,41 ± 0,06 cm dan daya sebar 22,78 ± 0,221 g.cm/detik, daya lekat 59,43 ± 1,158 detik, serta nilai pH 5,81 ± 0,04.
Rebusan Jahe Merah (Zingiber officinale var. rubrum) dalam Memperbaiki Gejala PPOK Amelia Lorensia; Devitya A. Sukarno; Rifaatul L. Mahmudah
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36460

Abstract

Penyakit paru obstruktif kronik (PPOK) merupakan masalah kesehatan global yang utama dan berdampak pada peningkatan biaya kesehatan dan penurunan produktivitas. Jahe merah infus (Zingiber officinale var. rubrum) merupakan salah satu tanaman obat yang banyak dikonsumsi di Indonesia. Penelitian ini bertujuan mengetahui perbaikan gejala PPOK dengan kuesioner CAT (COPD Assesment Test) dari terapi jahe merah. Metode penelitian yang digunakan adalah pre-post design pada bulan Mei-September 2021. Responden adalah pasien PPOK dewasa yang berdomisili di Kota Mojokerto. Penelitian dilakukan dengan mengukur gejala PPOK dengan kuesioner CAT. Selanjutnya, terapi seduhan jahe merah dosis 250 gram selama 4 bulan diaplikasikan pada pasien. Analisis data untuk menguji efektifitas perbaikan gejala PPOK pada infusa jahe merah menggunakan uji-t. Responden penelitian sebanyak 21 orang. Rata-rata usia responden adalah 53,24 tahun. sebagian responden mengalami peningkatan nilai CAT setelah terapi jahe merah sebanyak 66,67%. Berdasarkan uji beda, menunjukkan nilai P=0,028 (P<0,05), yang membuktikan ada perbedaan signifikan antara nilai CAT sebelum dan setelah terapi jahe merah selama 4 minggu. Rebusan jahe merah selama 4 minggu efektif memperbaiki gejala harian PPOK dibandingkan sebelum terapi. Oleh karena itu, terapi jahe merah perlu mendapatkan perhatian karena mungkin dalam membantu terapi penyakit PPOK.
Penambatan Molekuler Senyawa Bioaktif Daun Wungu (Graptophyllum Pictum (L) Griff) sebagai Inhibitor Tirosinase Abdul Aziz; Dimas Andrianto; Mega Safithri
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36219

Abstract

Melasma is a skin disorder characterized by hyperpigmentation of the skin in areas exposed to sunlight and is included in the dominant skin disorder category in several countries. Meanwhile, data from the Food and Drug Administration shows that cosmetic products have progressed from 0.01% to 57.4% in terms of registered products over the last six years. Currently, melasma treatment and cosmetic applications as a whitening agent were carried out by regulating tyrosinase activity through the use of compounds such as kojic acid which poses a health risk. Therefore, it was necessary to have other alternatives that can regulate tyrosinase activity without harming health. This study aimed to determine inhibitory effects of wungu leaf (Graptophyllum pictum (L) Griff) bioactive component as an agent to inhibit tyrosinase activity through a molecular docking approach. A total of 28 wungu leaves bioactive components as a result of the analysis of Gas Chromatography-Mass Spectrometry (GC-MS) and Gas Chromatography-Flame Ionization Detector (GC-FID) were tested for their inhibitory effects on tyrosinase activity. Linolenic acid and phytol were ligands that have the best inhibition on tyrosinase enzyme activity with affinity energies of -5.8 kcal/mol and -5.4 kcal/mol, respectively, and inhibition constants of 55.718 M and 109.489 M.
Radiochemical Purity Test of Fractionated Sestamibi Kit Labelled with Technetium-99m Hasna Chaerunisa; N. Elly Rosilawati; Muchtaridi Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.33332

Abstract

Coronary Heart Disease (CHD) is a heart disorder caused by blockage of blood vessels. CHD can bedetected by Myocardial Perfusion Imaging (MPI). MPI is performed by injecting a radiopharmaceuticalinto the patient's body. 99mTc-sestamibi is a radiopharmaceutical that is commonly used in MPI.Sestamibi is available in the form of a multidose vial, but the cost of the examination will be expensiveif it is only used for one patient. Cost effectiveness can be increased by fractionating the sestamibi kitbefore labelled by 99mTc. 99mTc-sestamibi needs to be tested for quality control before it is administeredto the patients. One of the tests is the radiochemical purity test. The aim of this study was to determinethe radiochemical purity of the fractionated sestamibi kit labelled by 50 mCi 99mTc. 2 vials of sestamibikit were fractionated by adding 5 mL of 0.9% NaCl solution to each vial and divided into 10 new vials.Radiochemical purity was measured using the thin layer chromatography (TLC) method. The resultsof this study indicated that all samples had radiochemical purity of 100% up to 6 hours after labelling.
Pembuatan dan Karakterisasi Self Emulsifying Drug Delivery Systems(SEDDS) Ibuprofen Secara Oral Fitrianti Darusman; Frida Anggita Amalia; Sani Ega Priani
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.31508

Abstract

Self emulsifying drug delivery systems (SEDDS) dikembangkan sebagai metode untuk meningkatkan kelarutan obat lipofilik seperti ibuprofen, serta untuk meningkatkan absorpsi dan laju disolusi obat. Oleh karena itu penelitian ini bertujuan untuk mengembangkan formulasi SEDDS ibuprofen yang memenuhi syarat secara farmasetik dan meningkatkan bioavailabilitas ibuprofen. Formula SEDDS diperoleh dari uji kelarutan ibuprofen dan optimasi formula pada berbagai konsentrasi minyak, surfaktan dan kosurfaktan. Asam oleat, cremophor RH 40 dan propilenglikol masing-masing terpilih sebagai minyak, surfaktan dan kosurfaktan dengan perbandingan fase minyak : (surfaktan + kosurfaktan) 1:9 dan pebandingan surfaktan : kosurfaktan (3:2). Formula SEDDS optimum dievaluasi meliputi pengukuran persen transmitan, pengujian dispersibilitas, pengujian robustness, pengujian stabilitas (sentrifugasi, heating cooling cycle, freeze thaw cycle), penentuan ukuran partikel dan uji laju disolusi. Formula SEDDS ibuprofen terbaik memenuhi persyaratan persen transmitan (99,7% ± 0,872), waktu dispersibilitas (41,48 detik ± 1,3), stabil pada pengujian robustness, tidak terjadi pemisahan fasa pada pengujian stabilitas, serta memiliki ukuran globul dalam kisaran mikrometer yaitu 114,7 ± 0,692 nm. Hasil uji laju disolusi in vitro pada menit ke-10 menunjukkan bahwa sediaan SEDDS ibuprofen lebih tinggi dibandingkan dengan serbuk ibuprofen murni, yaitu masing-masing sebesar 90,04 ± 1,764% dan 59,30 ± 1,638%.
Antibacterial Activity of Mangosteen Leaf and Bark Fraction Against Salmonella spp Causes Diabetic Ulcers Salmah Wilujeng Anggraini; Susanti Erikania; Vevi Maritha
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.33709

Abstract

Diabetes mellitus is a degenerative disease due to impaired cell function β-pancreas in insulin production causing hyperglycemics accompanied by microvascular complications such as diabetic ulcers. This condition is aggravated by bacterial contamination, one of which is Salmonella spp. The use of natural ingredients that have the potential for the treatment of diabetic ulcers is the mangosteen plant (Garcinia mangostana L.), so the identification of Salmonella spp in diabetic ulcers and testing the antibacterial activity of ethyl acetate and n-hexan leaves and mangosteen stem skins is carried out. The method started from the stage of bacterial identification using selective media, gram staining, biochemical testing, and antibacterial activity tests by diffusion of discs. Results showed that Salmonella spp was positif in SSA-specific media, biochemical tests, red bacteria, rod-shaped. Antibiotic sensitivity tests obtained by ciprofloxacin had the strongest activity of 30.20±1.37mm. The largest antibacterial activity result at a concentration of 100% obtained the ethyl acetate fraction of mangosteen leaves is 17.30±0.5mm compared to the fraction of n-hexane leaves of 8.81±0.32mm, ethyl acetate fraction and n-hexan mangosteen stem skin of 13.28±0.95mm, 7.42±0.45mm
Interactions of Perisbivalvin, Apioside, and Pelargonidine 3-Sambubioside Against PTGS2 Receptors Ketut Agus Adrianta; Puguh Santoso; Putu Windra Gunawan; Dewa Ayu Ika Pramitha
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.34765

Abstract

Inflammation is a normal protective response to tissue injury that involves various physiological processes in the body. Perisbivalvin, apioside, and pelargonidine 3-sambubioside are anthocyanin compounds found in magenta plants. The purpose of this study was to obtain a candidate for a new compound as an anti-inflammatory agent targeting the PTGS2 receptor before in vivo testing. Molecular docking in silico with PDB code 5IKR was carried out by optimizing 2 and 3-dimensional chemical structures, method validation, and docking between perisbivalvin compounds and the comparison compound mefenamic acid. The results obtained were docking perisbivalvin -7.63 kcal/mol, apioside -0.77 kcal/mol, and pelargonidine -5.74 kcal/mol, while the bond energy of the comparison compound was -7.52 kcal/mol through hydrogen bonding with amino acids TYR 385A and SER 530A. The prediction results of the test compounds and comparison compounds were classified as class 4 toxicities. Perisbivalvin compounds have anti-inflammatory potential because they can bind to the PTGS2 protein.
Authentication of Lemongrass Oil By Gas Chromatography-Mass Spectroscopy (GC-MS) Combination Chemometrics Any Guntarti; Husnun Khairunnisa Pratiwi; Laela Hayu Nurani; Ibnu Gholib Gandjar
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.32558

Abstract

The addition of something foreign to lemongrass essential oil has been done since ancient times. One way is to add turpentine oil which aims to increase the volume and grade of the smell. The purpose of this study was to determine the authentication of citronella oil using the gas chromatography-mass spectrometry (GC-MS) method combined with multivariate PCA analysis. Fragrant lemongrass oil was isolated by distillation of water and using simplicia in the form of powdered dried Cymbpogon citratus leaves. The oil obtained was treated with anhydrous Na2SO4. The results of the characteristics and quality requirements of citronella oil are compared with the SNI. The results of GC-MS analysis were the relative levels of essential oils. The results of the characteristic test meet the quality requirements of SNI 06-3953-1995, except for the yield requirements. The results of analysis by GC-MS, the essential content of citronella oil was citronella (37.47%), geraniol (25.03%), trans-caryophilene (3.69%), citronellol (11.68%), and delta cadinene. (2.44%). Chemometric principle component analysis (PCA) can group samples of fragrant lemongrass oil, turpentine oil and lemongrass oil products on the market.
Virtual Screening of Flavonoid Compounds as A Main Protease Inhibitor for Anti-Sars-Cov-2 Candidates Saeful Amin; Fadhilah Utami; Selvira Anandia Intan Maulidya
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.33682

Abstract

In 2019, the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was discovered in Hubei Province, China. After one year, no drug therapy has been approved, necessitating the development of SARS-CoV-2 drugs. To screen new drug candidates from natural product databases, the in-silico method, a drug discovery process based on computer simulations, can be utilized. Flavonoid is one of the most common compounds found in nature. They are secondary metabolites compounds contains phenolic functional group that can be virtually screened by predicting antiviral activity, drug likeness prediction, pharmacokinetic prediction, toxicity prediction, and molecular docking simulation Virtual screening is used in molecular docking simulations to design drugs based on activity prediction, compound similarity with oral drugs based on similar physical properties, pharmacokinetic profiles that include absorption and distribution, toxicity, and interactions of compounds with targets. The main protease used by target receptors is an enzyme that is important in determining SARS-CoV-2 survival. The structure of SARS-CoV-2 main protease code ID PDB 5RL4, 5R7Y and 7BUY is used in molecular docking simulation. The results of virtual screening of 80 flavonoid compounds showed that there are two most potential compounds, namely naringin and rutin that have lower ∆G values than the three native ligands, predictions of toxicity and good activity and a fairly good distribution profile.
Identification of Antibiotic-Producing Isolates from the Soil of Pesantren Darul Aman Gombara, Makassar Fhahri Mubarak; Wahyu Hendrarti; Hamdayani Lance Abidin; Arfan Abu Bakar
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 3, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i3.32257

Abstract

One source of antibiotics-producing microorganisms that are now widely used as a treatment for infections comes from the soil. Soil is an excellent medium for the growth and development of various microorganisms. The search for new antibiotics is currently urgently needed, because their use is not following the instructions, causing disease resistance. This study aims to get antimicrobial-producing microbial isolates that can inhibit the test microbes and identify the type of isolates. The first stage of microbial isolation was the dilution of the soil sample from 10-1 to 10-5 using the method of pouring on Nutrient Agar (NA) and Potato Dextrose Agar (PDA) medium. It carried further testing of antimicrobial activity against several test microbes out. The results of the isolation got 4 isolates of bacteria and 4 isolates of fungi with different identification of each isolate. In the test microbe, Escherichia coli isolates that gave activity were isolates IB1, IB2, IB3. In the Staphylococcus aureus test bacteria, the isolate that produces activity is the isolate IB1, IB2, IB3, IB4, IJ2, Meanwhile, for the test fungus Candida albicans was inhibited by isolates IB1, IJ1, IJ2, IJ3 and IJ4.

Page 27 of 50 | Total Record : 494

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