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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 494 Documents
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Preparasi Lotion Pelembab Mengandung Nanopartikel Serisin Ulat Sutera (Bombyx mori L.) Aulia Fikri Hidayat; Ratih Aryani; Indrawati Hannisah
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.30486

Abstract

Serisin yang merupakan salah satu protein yang terkandung dalam kepompong ulat sutera (Bombyx mori L.) diketahui memiliki kemampuan meningkatkan kelembaban kulit dalam sediaan kosmetik. Tujuan dari penelitian ini yaitu untuk menentukan formula lotion nanopartikel serisin dan efektivitas lotion nanopartikel serisin. Pembentukan nanopartikel serisin secara garis besar dilakukan dengan mekanisme pencampuran dan pengadukan menggunakan urea sebagai agen taut silang. Suhu dan kecepatan pengadukan dijaga konstan, sedangkan durasi pengadukan divariasikan. Nanopartikel serisin optimal yang diperoleh memiliki rata-rata ukuran 701 nm, yang diperoleh pada pengadukan 800 rpm dalam 30 menit di suhu ruang. Kemudian diformulasikan lotion nanopartikel serisin dengan konsentrasi nanopartikel sebesar 5% dan 10%. Hasil yang diperoleh mengindikasikan bahwa lotion dengan konsentrasi nanopartikel serisin 5% dan 10% mampu meningkatkan kelembaban kulit secara signifikan.
Formulation of Gel Hand Sanitizer of Nagasari Leaf Extract (Mesua ferrea L.) Tuti Sri Suhesti; M. Mudrik H. Rohman; Sunarto Sunarto
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36465

Abstract

Nagasari (Mesua ferrea L.) is one of the biodiversity to be developed as an antiseptic preparation. These plants are known to contain flavonoid compounds, tannins, and terpenoids that act as antibacterial. Hand sanitizer gel preparations can increase the effectiveness of topically. The physical properties of a good gel depend on a gelling agent, one of which is HPMC. The purpose of this study was to determine the effect of variations in HPMC levels on physical properties and antibacterial activity. Gels were prepared with various HPMC levels of 1%, 2%, and 3%. The gel was tested for physical properties and stability. All formulas produced preparations that met the requirements for good physical properties and stability. Testing of antibacterial activity against Staphylococcus aureus showed that an increase in HPMC levels could decrease the ability to release the active substance of the preparation. The diameter of the inhibition zone obtained was 10.0 mm (HPMC 1%); 9.5 mm (2% HPMC) and 8.0 mm (3% HPMC). Increasing the concentration of HPMC will increase the viscosity and adhesion but decrease the spreadability. The three formulas had antibacterial activity against Staphylococcus aureus with moderate criteria.Keywords: Extract of nagasari leaf, Gel, HPMC, Staphylococcus aureus
The Antiplaque Efficacy and Effectiveness of Activated Charcoal Toothpaste of Elaeis guineensis in Smokers Uce Lestari; Syamsurizal Syamsurizal; Yustika Trisna
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.32664

Abstract

Plaque on the teeth of smokers comes from cigarette smoke tar that settles on the surface of the teeth and roots of the teeth, causing the tooth surface to become rough and easier to stick with food debris and germs that will react making it easier for plaque to form. This study was aims to determine the safety and effectiveness of removing plaque in palm shell activated charcoal toothpaste with a concentration of 12% calcium carbonate combination of 25%. The content of calcium carbonate as an abrasive against the dental plaque of active smokers. The method used was measurement the plaque index score according to Turesky before and after using toothpaste on 20 panelists of active smokers. The decrease in plaque index in the use of toothpaste by using Wilcoxon's non-parametric statistical test, namely P = 0.000 (Sig <0.05). The results showed that toothpaste in the first week was able to reduce dental plaque by 59% compared to positive control by 45% and without activated charcoal by 34%. Toothpaste and positive control in the second week were able to remove dental plaque by 100%, while toothpaste without activated charcoal and calcium carbonate was only able to remove dental plaque by 68%. It can be concluded that palm shell activated charcoal toothpaste with a concentration of 12% combined with 25% calcium carbonate is safe and effective in removing plaque on the teeth of smokers.Keywords: dental plaque, efficacy, palm shells
Antidiabetic Potential Screening of Ulin Fruit Extract (Eusideroxylon zwageri) Against Streptozotocin-Induced Diabetic Rats Muhammad Rizani Faisal; Nada Widiasmira Amanda Oktia; Diana Aulia Mursidah; Dede Mahdiyah; Bayu Hari Mukti
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36621

Abstract

Empirical evidence of complementary medicine from one community in Kalimantan often uses Ulin fruit (Eusideroxylon zwageri) for medical therapy or as herbal drinks by people with diabetes mellitus. This research aims to identify the antidiabetic compound of Ulin fruit extract against Streptozotocin (STZ) induced diabetic rats. Extraction was performed by maceration method using 96% ethanol, phytochemical test of extracts, extract toxicity test on mice (50 mg/BW to 200 mg/BW), test antidiabetic extract in diabetic rats induced by STZ as much as 70 mg/kgBW with each extract dose of 150, 300, and 600 mg given for 14 days, positive control is Glibenclamide 0.25 mg/kg/day, and the negative control is CMC 1%. Phytochemical test results showed that the extract of Ulin contains alkaloids, tannins, flavonoids, phenolics, terpenoids, and steroids. Ulin fruit extract was not toxic to rats at 50, 150, and 200 mg for three days. Based on the Mann-Whitney test, there was an effect of giving the extract on changes in the average body weight and body temperature of rats during three days of administration (p = 0.000). The results showed novelty that the extract of Ulin fruit affected reducing blood glucose levels in diabetic rats during 14 days of administration (p=0.000).Keywords: Antidiabetic, Eusideroxylon zwageri, flavonoids, streprozotocin, diabetic rats
Aktivitas Antimikroba Fraksi n-Heksan dan Fraksi Air Clerodendrum paniculatum L. Terhadap Pseudomonas aeruginosa dan MRSA Dewi Pertiwi; Panal Sitorus; Ihsanul Hafiz
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.30659

Abstract

Ada banyak tanaman obat-obatan yang berasal dari alam terbukti memiliki senyawa antimikroba yang digunakan sebagai alternatif yang berpotensi secara efektif pada penanganan bakteri. Clerodendrum telah diteliti aktivitas antimikrobanya pada beberapa bakteri. Tujuan dari penelitian ini adalah untuk mengetahui aktifitas antimikroba dari fraksi n-heksan dan fraksi air dari daun pagoda (Clerodendrum paniculatum) terhadap bakteri Pseudomonas aeruginosa and Metichilin Resistant Staphylococcus Aureus (MRSA). Aktivitas antimikroba dari senyawa yang diisolasi diukur dengan metode difusi cakram. Fraksi n-heksan dari Clerodendrum paniculatum memiliki aktivitas antimikroba terhadap Pseudomonas aeruginosa dengan inhibisi 9,43 ± 0,057; 8,76 ± 0,057; 8,17 ± 0,115; 7,03 ± 0,057 dan terhadap MRSA 6,07 ± 0,057; 6,03 ± 0,057; 6,03 ± 0,115; 6,03 ± 0,057 pada konsentrasi 300 ppm, 200 ppm, 100 ppm dan 50 ppm. Fraksi air dari Clerodendrum paniculatum memiliki aktivitas antimikroba terhadap Pseudomonas aeruginosa dengan inhibisi 9,13 ± 0,057; 8,30 ± 0,100; 7,86 ± 0,057; 6,53 ± 0,057 dan terhadap MRSA 8.50 ± 0,100; 7,73 ± 0,057; 6,87 ± 0,057; 6,47 ± 0,057 pada konsentrasi 300 ppm, 200 ppm, 100 ppm dan 50 ppm. Hal ini menunjukkan fraksi n-heksan dan fraksi air dari Clerodendrum paniculatum memiliki potensi sebagai antimikroba yang baru.
Water Extract Influence of Stachytarpheta jamaicensis (L.) Vahl Leaves to Prevent Psoriasis Severity in Animal Model Encep Abdurahman; Nengdiana Permana; Grace S. Mardiana; Afifah B. Sutjiatmo; Anna Choirunnisa; Suci N. Vikasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36335

Abstract

Psoriasis is an autoimmune disease that is characterized by the appearance of lesions on the skin. The current treatment aims to control the symptoms. The efficacy of Stachytarpheta jamaicensis (L.) Vahl’s for autoimmune rheumatoid arthritis and systemic lupus erythematosus has been tested in animal models. The aim of this research was to evaluate the effect of the water extract of S. jamaicensis leaves on psoriasis model animal (male Balb/c mice) induced topically by imiquimod. The water extract of S. jamaicensis leaves is made by boiling. The animal was divided into groups: normal, control, methotrexate 0.2 mg/kgBW, the extract (doses 25, 50 and 100 mg/kgBW). The measured parameters were the Psoriasis Area and Severity Index (PASI) score and skin histopathology. The results showed that all doses of the extract could reduce the PASI score when compared to the control group. Histological results showed that there was a decrease in keratin growth in test animals that were given the extract. Extracts at doses of 25 and 50 mg/kgBW can reduce the thickening of keratin in the epidermis of the back and ears. It can be concluded that the water extract of S. jamaicensis leaf has the most effective activity to prevent psoriasis recurrence in the dose range of 25 and 50 mg/kgBW.Keywords: Psoriasis, Stachytarpheta jamaicensis leaf water extract, PASI, keratin, imiquimod
Antidiabetic of Mango (Mangifera longipes Griff.) Leves: Methanol Extract, Water Fraction, and Ethyl Acetate Nur Rahayuningsih; Piranti Piranti; Diana S. Zustika
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36890

Abstract

Mango leaves (Mangifera longipes Griff.) are used for diabetic, malaria, gastrointestinal, kidney, as well as topical treatment of wounds. The aim of this study was to determine the antidiabetic activity of methanol extract, water fraction and ethyl acetate fraction from mango leaves (Mangifera longipes Griff.). Oral Glucose Tolerance Test (OGTT) on 24 rats divided into 6 groups, namely normal; negative; positive (given acarbose 1.8 mg/200 g BW rats); methanol extract (EM), water fraction (FA), ethyl acetate fraction (FEA) with a dose of 58.8 mg/200 g BW rats. Induction of 1.35 g/200 g BW of rats glucose was carried out 30 minutes before the dosage administration. Data analysis with Paired T Test (95% confidence level). Results: In crude extract standardization, the water content was 2%, the ash content was 12.6% and the water soluble extract content was 19.5%. In crude extract and EM, flavonoids, saponins, and phenols were identified; in FA identified saponins and phenols; FEA identified flavonoids and phenols. A significant decrease in blood glucose levels at T0 and T120 in all groups (significant 2-tailed <0.05). The percentage of decline in the positive and FEA groups compared to the negative was 85.5% and 16.9%, respectively. Discussion:. Flavonoids are thought to increase antioxidant activity and inhibit α-glucosidase enzymes. Conclusion: EM, FA and FEA have antidiabetic activity with the best percentage reduction in glucose levels was FEA (16.9%).Keywords: Antidiabetic, OGTT, Mangifera longipes Griff
Anti inflammatory Activity of the Ethanol Extract of Cinnamon (Cinnamomum burmannii) Bark using Membrane Stabilization Method and Protein Denaturation Annisa Shalihah; Fransiska M. Christianty; Fifteen Aprila Fajrin
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36323

Abstract

Inflammation is the body's reaction to infection, irritation, or foreign substances, as an effort to defend the body's defenses. Inflammatory mediators such as bradykinin, prostaglandins, fluid extravasation, and tissue damage are essential to protect our body as an inflammatory response. One of the plants in Indonesia which is the potential to develop is Cinnamomum burmanii. These plants are identified to contain some substances such as flavonoid, tannin, and saponin. This study was aimed to determine the anti-inflammatory effect of the Cinnamomum burmanii extract using in vitro method compared with diclofenac sodium. Cinnamon bark was extracted using 96% of ethanol, and phytochemical screening was determined. Anti-inflammatory test in vitro using two methods, membrane stabilization using red blood cell suspension and protein denaturation inhibition using bovine serum albumin. After an anti-inflammatory test using the membrane stabilization method, the IC50 of the extract was 84.45 ± 3.55 g/mL, while in the protein denaturation method, the IC50 of the extract was 57.412 ± 0.718µg/mL. Even though the IC50 of the extract was lower, it is still higher than diclofenac sodium as drug control. Our result showed that cinnamon has potential as an antiinflammation and needs to develop further
Isoniazid Microencapsulation With HPMCP HP-50 and HPMCP HP- 55 (2:3) Coating Using Solvent Evaporation Method Hestiary Ratih; Gladdis Kamilah Pratiwi; Fikri Alatas; Mia Agustin; Bella Dewinta Saraswati
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.36678

Abstract

The combination formulation of tuberculosis drugs may cause interactions if these drugs are givensimultaneously. Rifampin (RIF) decomposes in the stomach when given concurrently with isoniazid(INH), which results in a decrease in the bioavailability of RIF. The purpose of this study is to makeINH microcapsules using HPMCP HP-50 and HP-55 coatings to prevent these interactions. Theprocess of making INH: HPMCP HP-50 and HP-55 (2:3) microcapsules was done by using solventevaporation method. The entrapment efficiency of INH: HPMCP HP-50 and HP-55 (2:3) were 83.21%and 91.57%, respectively. The dissolution test of INH: HPMCP HP-50 and HP-55 microcapsules metthe requirements of the Indonesian Pharmacopoeia Edition V. The FTIR results showed that there wasno change either in the chemical composition of isoniazid or in the coating of the microencapsulation.Scanning Electron Microscopy (SEM) showed the active substance was well coated. This studyproduces microcapsules that can provide a delayed release effect, so it is expected that INH: HPMCPHP-50 and HP-55 (2:3) microcapsules can be released in the intestines without interacting with RIF.Keywords: HPMCP HP 50, HPMCP HP-55, isoniazid, microcapsules, solvent evaporation method
Potensi Antiobesitas Ekstrak Cabai Pada Tikus Putih Jantan Siska Siska; Tahyatul Bariroh
Indonesian Journal of Pharmaceutical Science and Technology Vol 9, No. 2, 2022
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v9i2.35928

Abstract

Obesitas merupakan epidemik global untuk penyakit tidak menular yang ditandai dengan body mass index lebih dari 30 kg/m2. Data epidemiologis menunjukkan bahwa mengonsumsi makanan yang mengandung capsaicin yang merupakan senyawa aktif utama yang terkandung pada cabai dan menyebabkan rasa pedas berkaitan dengan penurunan prevalensi obesitas. Penelitian ini bertujuan untuk mengetahui pengaruh konsumsi cabai terhadap profil lipid tikus yang diberi pakan tinggi lemak dan potensinya sebagai anti obesitas. Penelitian dilakukan pada 24 ekor tikus Sprague Dawley jantan yang dibagi menjadi 6 kelompok yaitu kelompok normal (N) yang diberi pakan standar dan kelompok yang diberi pakan tinggi lemak (PTL) yang dibagi menjadi PTL yang diberikan obat simvastatin (PTLO), ekstrak alkohol 70% cabai merah (PTLM), cabai hijau (PTLH), dan cabai rawit (PTLR) dengan dosis 0,5 g/kg BB. Setiap 14 hari perlakuan, berat badan tikus ditimbang dan diambil darahnya secara retro orbitalis untuk didapatkan serumnya. Serum diuji kadar kolesterol total, trigliserida, LDL, dan HDL menggunakan spektrofotometer klinikal. Hasil yang didapat menunjukkan terdapat penurunan berat badan, kadar LDL, peningkatan kadar HDL (p<0.05), penurunan kadar kolesterol total dan trigliserida (p>0.05). Hal ini menunjukkan ekstrak cabai memiliki potensi sebagai antiobesitas dengan parameter pengukuran profil lipid dan berat badan namun perlu penyesuai dosis dan waktu pemberian ekstrak. 

Page 26 of 50 | Total Record : 494

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