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INDONESIA
Jurnal Farmasi Klinik Indonesia
Published by Universitas Padjadjaran
ISSN : 23375701     EISSN : 2337 5701     DOI : -
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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
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Articles 536 Documents
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Efek Kemoterapi Bleomisin, Vincristin, Mitomisin dan Karboplatin terhadap Massa Tumor dan Infiltrasi Parametrium pada Pasien Kanker Serviks: Studi Kasus di RSUP Sanglah Denpasar Suwiyoga, Ketut; Noviyani, Rini; Budiana, I Nyoman G.; Tunas, I Ketut; Indrayathi, Ayu; Niruri, Rasmaya
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (394.506 KB) | DOI: 10.15416/ijcp.2017.6.3.164

Abstract

Penggunaan regimen BOM-cisplatin untuk kemoterapi pasien kanker serviks masih belum memberikan hasil efektivitas yang memuaskan, sehingga dilakukan penggantian agen cisplatin dengan karboplatin. Kemoterapi BOM-karboplatin merupakan salah satu regimen terapi kanker serviks di RSUP Sanglah Denpasar. Informasi tentang efektivitas penggunaan BOM-karboplatin untuk kemoterapi kanker serviks masih sangat minim, maka dari itu penelitian ini dilakukan dengan melihat massa tumor dan infiltrasi parametrium. Penelitian ini merupakan penelitian studi kasus terhadap 9 pasien kanker serviks sel skuamosa stadium IIB–IIIB sebelum dan sesudah kemoterapi BOM-karboplatin di RSUP Sanglah dari bulan Februari hingga Agustus 2015 yang memenuhi kriteria. Pemeriksaan Massa Tumor dan Infiltrasi Parametrium (%CFS) dilakukan sebelum kemoterapi seri I dan sesudah kemoterapi seri III. Pengambilan sampel menggunakan consecutive sampling. Data penelitian dianalisis menggunakan uji normalitas yaitu uji Shapiro-Wilk, selanjutnya dianalisis menggunakan uji t berpasangan dengan taraf kepercayaan 95%, sedangkan data berdistribusi tidak normal ditranformasi ke bentuk fungsi logaritma lalu dianalisis dengan uji Wilcoxon. Berdasarkan analisis statistik diketahui bahwa terdapat penurunan bermakna pada massa tumor dan infiltrasi parametrium kiri sesudah 3 seri kemoterapi dengan nilai p<0,05 yaitu masing-masing p=0,001 dan p=0,025, tetapi tidak terdapat penurunan bermakna pada infiltrasi parametrium kanan dengan nilai p>0.05 yaitu p>0,083.Kata kunci: BOM-cisplatin, cancer free space, kanker serviks, RSUP Sanglah Effect of Chemotherapy Bleomycin, Vincristin, Mitomycin and Carboplatin by Tumor Mass and Infiltration Parametrial for Cervical Cancer Patients: Case Study in Sanglah General Hospital, DenpasarBOM-cisplatin regimen for chemotherapy for cervical cancer patients has not resulted high efficacy, hence a replacement of cisplatin with carboplatin is proposed. BOM-carboplatin chemotherapy is at present a treatment for cervical cancer patients in Sanglah Hospital in Denpasar. Information about the efficacy of using the BOM-carboplatin for cervical cancer chemotherapy is not provided, therefore this research performed by observing tumor mass and parametrial infiltration. This research was carried out using case study method on 9 patients with squamous cell cervical cancer stage IIB–IIIB before and after BOM-carboplatin chemotherapy at Sanglah Hospital from February until August 2015. Examination of tumor mass and parametrial infiltration (%CFS) conducted prior to chemotherapy series I and after chemotherapy series III. Sampling was done consecutively. The research data were analyzed using the normal distribution Shapiro-Wilk test continued by paired t-test with 95% confidence level, while data that is classified otherwise is transformed to logarithmic function and were analyzed using the Wilcoxon test. Based on statistical analysis, there is significant reduction in tumor mass and left parametrial infiltration after the third chemotherapy with (p<0.05) which are p=0.001 and p=0.025, but there is no significant reduction of right parametrial infiltration with p>0.05 that is p>0,083.Keywords: BOM-cisplatin, cancer free space, cervix cancer, Sanglah hospital
Penggunaan Suplemen Herbal sebagai Upaya Swamedikasi di Kota Bandung Destiani, Dika P.; Suwantika, Auliya A.
Indonesian Journal of Clinical Pharmacy Vol 4, No 1 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.92 KB) | DOI: 10.15416/ijcp.2015.4.1.71

Abstract

Swamedikasi menggunakan suplemen herbal di Indonesia belum terdokumentasi karena sebagian besar masyarakat yang mengonsumsinya tidak berkonsultasi dengan tenaga kesehatan. Penelitian retrospektif observasional ini dilakukan di salah satu pusat pelayanan kesehatan di Bandung pada tahun 2014 denganpengambilan data dari data penjualan suplemen herbal. Penjualan swamedikasi suplemen atau vitamin selama tahun 2014 mencapai 30.163 item dengan swamedikasi suplemen herbal untuk penyakit kronik dan degeneratif sebanyak 1.277 item. Berdasarkan kategori terapi, suplemen herbal yang paling banyak dikonsumsi adalah suplemen herbal untuk indikasi hiperlipidemia dengan kandungan bawang putih, lecithin, dan spirulina. Dari hasil penelitian ini dapat dilihat tingginya angka penggunaan swamedikasi suplemen herbal, akan tetapi tidak diketahui apakah masyarakat sudah memperoleh informasi yang benar dari apoteker mengenai cara penggunaannya.Kata kunci: Bandung, herbal, observasional, suplemen, swamedikasiThe Use of Herbal Supplements as One of Self Medications in BandungThe use of herbal supplements as one of self medications in Indonesia has not yet been well-documented since many people used these supplements in absence of medical consultation with pharmacist. This retrospective observational study was conducted at one of healthcare service centers in Bandung. Data related to the sale of herbal supplements during 2014 period was collected and analyzed. We found that 30.163 items of herbal supplements were sold in 2014. Approximately 1.277 sold items were specific supplements for chronic and degenerative diseases. Based on the category of therapy, the most sold item was a herbal supplement for hyperlipidemia with three major ingredients: garlic, lecithin, and spirulina. Despite the huge number of the use of herbal supplements in Indonesia, medical information from pharmacist about the use of herbal supplements is still scarce.Key words: Bandung, herbal, observation, self medication, supplement
Pengaruh Pelayanan Informasi Obat terhadap Keberhasilan Terapi Pasien Diabetes Melitus Tipe 2 Insani, Widya N.; Lestari, Keri; Abdulah, Rizky; Ghassani, Salma K.
Indonesian Journal of Clinical Pharmacy Vol 2, No 4 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

pemahaman mengenai instruksi pengobatan merupakan permasalahan utama dalam pengobatan DMT2. Ketidakpatuhan pasien terhadap regimen obat hipoglikemik oral yang kompleks serta ketidaktepatan dalam cara dan waktu pengonsumsiannya merupakan barrier tercapainya keberhasilan terapi DMT2. Hal ini sangat berkaitan dengan kualitas pelayanan kefarmasian yang diberikan kepada pasien, khususnya pelayanan informasi obat. Penelitian ini bertujuan untuk mengevaluasi pengaruh intervensi pelayanan informasi obat terhadap parameter keberhasilan terapi diabetes yaitu glukosa 2 jam postprandial, HDL dan trigliserida. Penelitian ini merupakan nonrandomized concurrent control trial secara prospektif. 14 subjek uji direkrut selama 4 bulan selama Mei–Agustus 2013 kemudian dibagi menjadi dua grup. Kedua grup mendapat terapi pengobatan diabetes berupa hipoglikemik oral. Grup intervensi mendapatkan pelayanan informasi obat dan edukasi mengenai diabetes, sedangkan grup kontrol tidak mendapatkannya. Data dianalisis menggunakan uji t independen dengan α 0,05. Walau belum berbeda signifikan, nilai keberhasilan terapi dengan intervensi pelayanan informasi obat pada parameter glukosa 2 jam postprandial, HDL dan trigliserida memberikan hasil yang lebih tinggi 17,01%; 6,73%; dan 6,31% untuk masing-masing parameter dibandingkan terapi tanpa pelayanan kefarmasian tersebut.Kata kunci: Pelayanan informasi obat, diabetes, obat hipoglikemik oral Effect of Pharmaceutical Information Care on Clinical Outcomes of Patients With Type 2 Diabetes MellitusPoor adherence to medication and lack of understanding about medication instructions are the main problems in the treatment of type 2 diabetes mellitus. Poor adherence to oral hypoglicemic drugs which have complex regiment and unappropriate consumption of them are the obstacles to reach good clinical outcomes. These problems are highly related to the quality of pharmaceutical care given to patients. The aim of this study was to evaluate the effect of pharmaceutical information care towards the outcome of type 2 diabetes mellitus including 2 hours postprandial glucose, HDL and tryglicerides. This study used nonrandomized concurrent control trial prospectively. 14 subjects were recruited during 4 months from May–August 2013 and were divided into two groups. Both of group were given oral hypoglycemic drugs. The intervention group received pharmaceutical information care and diabetes education, whilecontrol group did not receive these. Data were then analysed with independent t test using α 0,005. Although the difference were not significant yet, pharmaceutical information care intervention on diabetes treatment gave higher improvement by 17,01%; 6,73%; and 6,31% respectively in 2 hours postprandial glucose, HDL and tryglicerides parameters, compared with the treatment without pharmaceutical care.Key words: Pharmaceutical information care, diabetes, oral hypoglicemic drugs
Evaluasi Penggunaan Antibiotik dan Profil Kuman pada Seksio Sesarea di Rumah Sakit Umum Daerah Kabupaten Pasuruan Yulia, Rika; Herawati, Fauna; Jaelani, Abdul K.; Anggraini, Wirda
Indonesian Journal of Clinical Pharmacy Vol 7, No 2 (2018)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.967 KB) | DOI: 10.15416/ijcp.2018.7.2.69

Abstract

Infeksi Luka Operasi (ILO) adalah salah satu komplikasi pembedahan yang paling umum terjadi di dunia, terutama di negara berkembang. Penggunaan antibiotik profilaksis sebelum operasi yang tepat dapat mengurangi ILO. Penelitian ini bertujuan untuk mengetahui profil penggunaan antibiotik dan kesesuaian penggunaan antibiotik pada seksio sesarea dengan peta kuman rumah sakit, Pedoman Penggunaan Antibiotik (PPAB) 2016, Formularium Rumah Sakit (RS), Formularium Nasional (Fornas), serta mengidentifikasi profil kuman penyebab ILO pada luka pasien. Metode penelitian menggunakan metode cohort prospective melalui penelusuran data terhadap rekam medik pasien yang menjalani tindakan operasi seksio sesarea di salah satu rumah sakit di Kabupaten Pasuruan periode Maret–Mei 2017, yaitu data penggunaan antibiotik (jenis antibiotik, dosis, waktu pemberian) dan data peta kuman bulan Januari–Maret 2017 terkait resistensi antibiotik. Analisis data berupa deskripsi profil penggunaan antibiotik, kesesuaian penggunaan antibiotik pada pasien seksio sesarea dengan pedoman, dan profil kuman penyebab ILO. Hasil yang diperoleh dari penelitian ini menunjukkan bahwa penggunaan antibiotik pada pasien seksio sesarea adalah ampisilin/sulbaktam 37%, sefuroksim 34%, seftriakson 24%, sefazolin 5%, metronidazol 1%, dan gentamisin 1%. Kesesuaian berdasarkan jenis antibiotik secara berturut-turut 5% berdasarkan PPAB, 100% berdasarkan Formularium RS dan 63% berdasarkan Fornas. Hal ini disebabkan oleh pola sensitivitas sefazolin berdasarkan peta kuman bulan Januari–Maret 2017 semakin menurun. Kesesuaian berdasarkan dosis antibiotik 100% sesuai berdasarkan PPAB, Formularium RS dan Fornas. Kesesuaian berdasarkan dosis antibiotik dan waktu pemberian 92% sesuai berdasarkan PPAB. Kuman yang ditemukan pada luka pasien adalah bakteri Hafnia alvei.Kata kunci: Antibiotik profilaksis, Infeksi Luka Operasi, seksio sesarea Evaluation of Antibiotics Use and Bacteria Profile of Caesarean Section at Regional General Hospital, PasuruanAbstractSurgical Site Infection (SSI) is one of the most common surgical complications in the world, especially in developing countries. Proper use of prophylaxis antibiotics in appropriate intraoperative procedures may reduce SSI. The aim of this study was to determine the profile of antibiotic used and the adherence of antibiotic in caesarean section to Hospital Guideline 2016, Hospital Formulary, National Formulary, bacteria profile that cause SSI on the patient’s wound. Method used in this study was cohort prospective study design using record data of patients who underwent caesarean section surgery at Regional General Hospital of Pasuruan from March–May 2017, i.e. antibiotics usage data (type, dosage and time of delivery) and microbial pattern data about antibiotic resistance from January–March 2017. Data analysis was description of the profile of antibiotic use, adherence use of antibiotic of caesarean section inpatients to the guidelines, and profile of bacteria that cause SSI. The results showed that the use of antibiotics in caesarean section patients was ampicillin/sulbactam 37%, cefuroxime 34%, ceftriaxone 24%, cefazolin 5%, metronidazole 1%, and gentamycin 1%. Adherence by type of antibiotics was 5% based on Hospital Guideline, 100% based on Hospital Formulary and 63% based on National Formulary. This was due to a decrease of cefazolin sensitivity pattern from 20% to 0% in January–March 2017 period. Adherence of antibiotic dosage was 100% based on Hospital Guideline, Hospital Formulary and National Formulary. Adherence of time of delivery 92% was based on Hospital Guideline. Bacteria found in the wounds of patients was Hafnia alvei.Keywords: Caesarean section, prophylaxis antibiotic, surgical site infection
e-Prescription: An e-Health System for Preventing Adverse Drug Events in Community Healthcare Puspitasari, Irma M.; Soegijoko, Soegijardjo
Indonesian Journal of Clinical Pharmacy Vol 1, No 1 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

The paper describes development activities of an e-health system for community health center (Puskesmas) with integrated adverse drug events e-prescription module, consist of system design and development, human resource development, e-health system realization, laboratory and implementation test of e-health system. Some e-readiness evaluations were conducted, through a number of field visits and questionnaires. The results had been used in the e-health system design and development, installation of the internet access infrastructure, and implementation of the education and hands-on training for the medical and administrative staff of the healthcare units. After completing the e-health system design and development as well as system realization and laboratory tests stages, a series of field implementation and experiments have been successfully conducted at Puskesmas Babakansari in Bandung. A number of users feed back have been obtained and used for further improvements on both of the software and hardware modules. The e-health system with integrated e-prescription module has successfully developed and shown its expected functions in: patient registration, medical record, paperless prescription, producing the required reports and preventing possible adverse drug events.Key words: Adverse drug events, community health center, e-health, e-prescription  e-Prescription: Sistem e-Health untuk Pencegahan Adverese Drug Event di PuskesmasAbstrakArtikel ini mendeskripsikan pengembangan sistem e-health untuk puskesmas dengan modul e-prescription yang terintegrasi adverse drug event. Modul ini terdiri dari desain sistem dan pengembangan, pengembangan sumber daya manusia, realisasi sistem e-health, laboratorium dan tes implementasi sistem e-health. Beberapa evaluasi kesiapan penggunaan elektronik (e-readiness) dilakukan melalui kunjungan lapangan dan kuesioner. Hasil evaluasi digunakan dalam desain dan pengembangan sistem e-health, instalasi akses internet, implementasi pendidikan dan pelatihan bagi staf medis dan administrasi. Setelah sistem e-health selesai dan dikembangkan sesuai dengan realisasi dan tahapan tes laboratorium, sejumlah implementasi dan eksperimen telah sukses dilakukan di Puskesmas Babakansari di Bandung. Respon yang diperoleh digunakan untuk pengembangan modul lebih lanjut dari segi software dan hardware. Sistem e-health yang terintegrasi dengan modul telah sukses dikembangkan sesuai dengan fungsi yang diharapkan: registrasi pasien, medical record, resep tanpa kertas, pelaporan dan pencegahan kemungkinan adverse drug events.Kata kunci: Adverse drug events, pusat kesehatan masyarakat, e-health, e-prescription
Improving Outpatient’s Quality of Life Through Patient Adherence of Antihypertensive Therapy Using “Mobile Phone (SMS) and Brief Counseling‑5A” in Polyclinic of Internal Medicine at PKU Muhammadiyah Bantul Hospital, Yogyakarta Saputri, Ginanjar Zukhruf; Akrom, Akrom; Darmawan, Endang
Indonesian Journal of Clinical Pharmacy Vol 6, No 2 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (619.418 KB) | DOI: 10.15416/ijcp.2017.6.2.67

Abstract

 The Health-Related Quality of Life (HRQoL) is one of the important psycho-social characteristics that can affect patient’s ability to manage therapy. Poor of knowledge of hypertension and the changing lifestyle can affect the quality of life of patients. One of the pharmacist’s interventions in hypertension management is to conduct counseling. Motivational counseling helps health service to assess patient’s understanding and patient’s readiness to change patient’s behavior. Some motivational counseling methods still need to be developed. Therefore, this study aims to find the influence of the "brief counseling-5A" and "motivational SMS" by a pharmacist on the quality of life and blood pressure control in hypertension patients in the internal disease polyclinic, PKU Muhammadiyah Bantul Hospital, Yogyakarta. The study has been done by using the quasi-experimental method with prospective data collection during the period of January until April 2013. Sixty patients have met inclusion criteria and were divided into two groups. Thirty patients (50%) received "brief counseling-5A" and "motivational SMS" as intervention group and the other thirty patients (50%) received usual care as a control group. The data collection was done by interviewing patients. Medication adherence and QoL were assessed by using Morisky Medication Adherence Scale (MMAS) and SF-36. The values of blood pressure are taken from patient’s medical records. Patient’s quality of life showed a good improvement during post study. It is shown in 8 different domains including pain, fatigue, physical function, emotional function, social function, role physical, mental health, and general health. In intervention group, physical function, emotional function, and pain showed highly significant improvement (p<0.05). Systolic and diastolic blood pressure in the intervention group decreased significantly (p<0.05) (systolic p=0.001 and diastolic p=0.018) in the post study. From this study, it is concluded that the "brief counseling-5A by pharmacist" and "motivational SMS" had a positive impact on patient’s QoL and patient’s blood pressure, hence, the therapy outcome has been achieved.
N-MID Osteocalcin (N-MID Oc) dan β-Crosslaps (β-CTx) sebagai Penanda Biokimia Bone Turn Over pada Wanita Menopause Halimah, Eli; Rositawati, Wiwik; Pratiwi, Irma
Indonesian Journal of Clinical Pharmacy Vol 5, No 1 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (364.494 KB) | DOI: 10.15416/ijcp.2016.5.1.67

Abstract

  Osteocalcin merupakan senyawa penanda untuk pembentukan tulang sedangkan β-CrossLaps (β-CTx) merupakan fragmen hasil pemecahan kolagen tipe 1. Tujuan penelitian ini yaitu untuk menentukan N-MID osteocalcin (N-MID Oc) dan β-CTx sebagai penanda biokimia Bone Turn Over untuk deteksi dini osteoporosis pada wanita menopause. Nilai N-MID Oc dalam serum ditentukan dengan pereaksi Elecsys N-MID Osteocalcin kit dan nilai β-CTx dalam serum ditentukan dengan pereaksi Elecsys β-CROSSLAPS kit yang bekerja berdasarkan prinsip Electrochemiluminescence Immunoassay (ECLIA). Data yang diperoleh diuji dengan menggunakan Uji-T. Sampel yang dikumpulkan berasal dari wanita normal, osteopenia, dan penderita osteoporosis pada wanita menopause. Hasil penelitian menunjukkan terdapat perbedaan nilai N-MID Oc pada wanita menopause normal dengan wanita menopause osteopenia, wanita menopause normal dengan wanita menopause penderita osteoporosis dan wanita menopause osteopenia dengan wanita menopause penderita osteoporosis (α=0,05), sedangkan pada nilai β-CTx terdapat perbedaan antara wanita menopause normal dengan wanita menopause osteopenia, wanita menopause osteopenia dengan wanita menopause osteoporosis, tetapi antara wanita menopause osteopenia dengan wanita menopause osteoporosis tidak menunjukkan perbedaan (α=0,05). Penelitian ini menunjukkan bahwa N-MID Oc dan β-CTx dapat dijadikan parameter untuk deteksi dini osteoporosis.Kata kunci: N-MID Osteocalcin (N-MID Oc), Osteoporosis, β-CrossLaps (β-CTx) N-MID Osteocalcin (N-MID Oc) and β-Crosslaps (β-CTx) as Biochemical Markers of Bone Turnover in Menopausal Women Osteocalcin is a marker compound for bone formation while the β-crosslaps a fragment split from collagen type 1. The aims of this study were to determined of the value of N-MID osteocalcin (N-MID Oc) and β-CTx as a biochemical marker of Bone Turn Over as early detection of osteoporosis in postmenopausal women. The value of N-MID Oc in serum was determined by reagent Elecsys N-MID Osteocalcin kit and the value of β-CTx in serum was determined by reagent Elecsys β-Crosslaps kit which works with the principle of Electrochemiluminescence Immunoassay (ECLIA). The data obtained were examined using T-test. The sample collected from normal, osteopenia, and osteoporotic in menopausal women. There were a significant difference N-MID Oc between normal, osteopenia, and osteoporotic in menopausal women (α=0,05). There were significant differences of β-CTx between normal and osteopenia, normal and osteoporosis but between osteopenia and osteoporotic menopausal women not showed any difference (α=0,05). N-MID Osteocalcin (N-MID Oc) and β-CTx can be used as parameter for early detection of osteoporosis.Key words: N-MID Osteocalcin (N-MID Oc), Osteoporosis, β-CrossLaps (β -CTx)
Effect of Attapulgite on the Oral Bioavailability of Ciprofloxacin Izzah, Zamrotul; Gratia, Veronica; Aryani, Toetik; Suharjono, Suharjono
Indonesian Journal of Clinical Pharmacy Vol 2, No 2 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

As a result, this drug-drug interaction may reduce ciprofloxacin bioavailability. This study was aimed to determine the effect of attapulgite on the bioavailability of a single orally-administered ciprofloxacin. Six New Zealand white rabbits received each of the following treatments in a randomized, three-way crossover sequence, separated by a 7-day washout period: (i) ciprofloxacin (23 mg/kgBW) alone; (ii) ciprofloxacin (23 mg/kgBW) given simultaneously with attapulgite (28 mg/kgBW); (iii) ciprofloxacin(23 mg/kgBW) given 2 hours after attapulgite (28 mg/kgBW). Blood samples (1 mL) were collected from the marginal ear vein up to 240 minutes postdose. The plasma concentrations of ciprofloxacin were determined by a validated high-performance liquid chromatography method. The maximum concentration and oral bioavailability (AUC0-240 min) of ciprofloxacin were significantly decreased by 49% and 32% when administered concomitantly with attapulgite (p<0.001). Attapulgite appeared to have no significant effect on the bioavailability of ciprofloxacin when administered 2 hours before ciprofloxacin. In conclusion, the oral bioavailability of ciprofloxacin is markedly reduced when administered concomitantly with attapulgite. This drug-drug interaction may decrease clinical efficacy and promote microbial resistance to ciprofloxacin. However, the interaction could be minimized by separating the adminsitration of these drugs at least 2 hours.Key words: Attapulgite, bioavailability, ciprofloxacin, drug-drug interactionPengaruh Atapulgit pada Ketersediaan Hayati Siprofloksasin OralKemampuan absorpsi atapulgit dapat menghambat absorpsi siprofloksasin pada pemberian per oral. Sebagai hasilnya, interaksi obat-obat ini dapat menurunkan ketersediaan hayati siprofloksasin. Penelitian ini bertujuan untuk  mendeterminasi efek atapulgit pada ketersediaan hayati obat siprofloksasin yang diberikan secara oral. Sebanyak 7 kelinci putih Selandia Baru menerima perlakuan secara random dengan desain three-way crossover sequence, yang dipisahkan dengan periode washout 7 hari. (i) siprofloksasin (23 mg/kgBB); (ii) siprofloksasin (23 mg/kgBB) diberikan secara simultan dengan atapulgit (28 mg/kgBB); (iii) siprofloksasin (23 mg/kgBB) diberikan 2 jam setelah pemberian atapulgit (28 mg/kgBB. Sampel darah (1 mL) dikumpulkan pada marginal ear vein setelah 240 menit pemberian obat. Konsentrasi siprofloksasin plasma dihitung dengan metode kromatografi cair kinerja tinggi tervalidasi. Konsentrasi maksimum dan ketersediaan hayati oral (AUC0-240 min) siprofloksasin secara signifikan berkurang 49% dan 32% ketika dikombinasikan bersamaan dengan atapulgit (p< 0,001). Atapulgit tidak memiliki pengaruh signifikan pada ketersediaan hayati ketika diberikan 2 jam sebelum siprofloksasin. Ketersediaan hayati siprofloksasin berkurang secara signifikan ketika diberikan bersamaan dengan pemberian atapulgit. Interaksi obat dengan obat ini dapat mengurangi efikasi obat dan meningkatkan resistensi mikrob terhadap siprofloksasin. Namun, interaksi dapat dikurangi dengan pemberian obat pada jarak waktu minimal 2 jam.Kata kunci: Atapulgit, interaksi obat dengan obat, ketersediaan hayati, siprofloksasin
Terapi Kanker dengan Radiasi: Konsep Dasar Radioterapi dan Perkembangannya di Indonesia Fitriatuzzakiyyah, Nur; Sinuraya, Rano K.; Puspitasari, Irma M.
Indonesian Journal of Clinical Pharmacy Vol 6, No 4 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (818.8 KB) | DOI: 10.15416/ijcp.2017.6.4.311

Abstract

Kanker merupakan salah satu penyakit yang menyebabkan kematian yang tinggi di dunia. Berdasarkan data WHO, pada tahun 2015 terdapat 8,8 juta kematian yang diakibatkan oleh penyakit kanker. Berdasarkan data riskesdas tahun 2013, prevalensi kanker di Indonesia mencapai 1,4% atau sekitar 347.792 orang. Berbagai metode telah dikembangkan untuk mengobati kanker, salah satunya dengan menggunakan terapi radiasi atau radioterapi. Berdasarkan International Agency for Research on Cancer (IARC), dari 10,9 juta orang yang didiagnosis menderita kanker di seluruh dunia setiap tahun, sekitar 50% membutuhkan radioterapi. Penggunaan radiasi untuk terapi kanker belum banyak digunakan dan masih terbatas di Indonesia. Tujuan penulisan review ini adalah untuk memaparkan konsep dasar terapi kanker dengan radiasi dan perkembangan radioterapi di Indonesia melalui penelusuran pustaka. Metode penelusuran pustaka dalam artikel review ini adalah penelusuran pustaka pada mesin pencari Google, Google Scholar dan PubMed basis data dengan kata kunci “basic radiotherapy” “radiation therapy in Indonesia” “novel radiotherapy in Indonesia” serta peraturan perundang-undangan Republik Indonesia yang berkaitan dengan radioterapi. Hasil penelusuran pustaka menunjukkan bahwa teknologi radiasi telah ada di Indonesia sejak tahun 1927. Sampai tahun 2013, terdapat 29 pusat pelayanan radioterapi di Indonesia. Radioterapi telah menjadi salah satu terapi yang penting dalam pengobatan kanker di Indonesia. Pemerintah Indonesia mendukung kemajuan teknologi ini dengan menerbitkan peraturan tentang standar pelayanan radioterapi di rumah sakit. Semakin banyak dan berkembangnya fasilitas radioterapi diharapkan dapat mengurangi prevalensi penyakit kanker di Indonesia.Kata kunci: Kanker, radioterapi, regulasi, terapi radiasi Cancer Therapy with Radiation: The Basic Concept of Radiotherapy and Its Development in IndonesiaCancer is one of the leading causes of death worldwide. According to WHO, 8,8 million deaths in 2015 was caused by cancer. In Indonesia, based on basic health research data in 2013, the prevalence of cancer was 1.4% or 347.792 people in Indonesia suffer from cancer. Various methods have been developed to treat cancer, one of them is by using radiation therapy or radiotherapy. According to International Agency for Research on Cancer (IARC), from 10.9 million people diagnosed with cancer, about 50% require radiotherapy. The use of radiation for cancer therapy has not been widely used and is still limited in Indonesia. This review article was aimed to describe the basic concept of cancer therapy with radiation and its development in Indonesia. Literature review was conducted from Google search engine, Google Scholar and PubMed database with keyword “basic radiotherapy” “radiation therapy in Indonesia” “novel radiotherapy in Indonesia” and radiotherapy regulations in Indonesia. The results revealed that radiation technology has been availabe in Indonesia since 1927. Until 2013, 29 radiotherapy centers were available in Indonesia. Radiotherapy has become one of important modalities for cancer treatment in Indonesia. Indonesian government supports the development of this technology, by issuing regulations on radiotherapy service standards in hospitals. More technology development and radiotherapy facilities are expected to reduce the prevalence of cancer in Indonesia.Keywords: Cancer, radiation therapy, radiotherapy, regulation
Studi Penggunaan Antibiotik Berdasarkan ATC/DDD dan DU 90% di Bagian Bedah Digestif di Salah Satu Rumah Sakit di Bandung Mahmudah, Febrina; Sumiwi, Sri A.; Hartini, Sri
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (506.209 KB) | DOI: 10.15416/ijcp.2016.5.4.293

Abstract

  tidak tepat dapat menimbulkan berbagai masalah, di antaranya pengobatan akan lebih mahal, efek samping lebih toksik, meluasnya resistensi dan timbulnya kejadian superinfeksi yang sulit diobati. Tujuan penelitian ini adalah untuk mengetahui pola penggunaan antibiotik pada pasien bedah digestif di salah satu rumah sakit di Bandung. Data penggunaan antibiotik diperoleh dari Instalasi Rekam Medis pada Juli–Desember 2013. Data diperoleh dengan metode ATC/DDD dan DU 90%. Penelitian ini merupakan penelitian deskriptif dengan studi retrospektif yang diambil dari catatan medik untuk menilai kuantitas dan kualitas penggunaan antibiotik. Sampel diambil dengan cara simple random sampling. Hasil penelitian menunjukkan bahwa dari 208 catatan medik didapatkan total penggunaan antibiotik 17,9 DDD/100 hari rawat dan antibiotik yang masuk dalam DU 90% yaitu seftriakson (8,77 DDD/100 hari rawat), metronidazol (4,61 DDD/100 hari rawat), sefiksim (1,09 DDD/100 hari rawat), sefepim (0,85 DDD/100 hari rawat), siprofloksasin (0,73 DDD/100 hari rawat), dan meropenem (0,42 DDD/100 hari rawat). Hasil penelitian menunjukkan bahwa secara kuantitas penggunaan antibiotik yang paling banyak adalah seftriakson sebesar 8,77 DDD/100 hari rawat dan antibiotik yang masuk dalam segmen 90% yaitu seftriakson, metronidazol, sefiksim, sefepim, siprofloksasin, dan meropenem.Kata kunci: ATC, DDD, kuantitas, studi penggunaan antibiotikStudy of the Use of Antibiotics with ATC/DDD System and DU 90% in Digestive Surgery in Hospital in Bandung Abstract Antibiotics are the most widely prescribed medicines in the hospital. Improper use of antibiotics can cause various problems, such as treatment will be more expensive, more toxic side effects, and the emergence of widespread resistance superinfection events that are difficult to treat. The objective of this study was to determine quantity and pattern of antibiotic usage in hospitalized patients at one hospital in Bandung. Sample were taken by simple random sampling method. The quantity of antibiotics usage was assessed by counting the Defined Daily Dose (DDD)/100 patient days and DU 90%. Based on 208 patient medical records, it was found that total antibiotic usage was 17.9 DDD/100 patient days and antibiotics were included in the DU 90% is ceftriaxone (8.77 DDD/100 patient days), metronidazole (4.61 DDD/100 patient days), cefixime (1.09 DDD/100 patient days), cefepime (0.85 DDD/100 patient days), ciprofloxacin (0.73 DDD/100 patient days) and meropenem (0.42 DDD/100 patient days. The results showed that the use of antibiotics in quantity at most is ceftriaxone for 8.77 DDD / 100 days of hospitalization and antibiotics included in segment 90% were ceftriaxone, metronidazole, cefixime, cefepime, ciprofloxacin, and meropenem.Keywords: ATC, DDD, quantity, study of the use of antibiotics

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