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Kab. jember,
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INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 7 Documents
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Search results for , issue "Vol. 11 No. 2 (2025)" : 7 Documents clear
Computational Insights into Leucaena leucocephala Extract Shampoo as a Malassezia furfur Anti-Dandruff Agent Hibatulloh, Muhammad Farhan; Nafisa, Tsabita; Afnan, Muhammad Syifaul; Andriani, Made Prasanti; Widanto, Cika Abadi Laily; Wisudanti, Desie Dwi
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.24051

Abstract

Dandruff is a scalp condition characterized by excessive flaking resulting from colonization by the fungus Malassezia furfur. Chemical-based anti-dandruff shampoos frequently result in side effects, including irritation, resistance, and hair discoloration. This study investigates the efficacy of Leucaena leucocephala leaf extract as a natural treatment for dandruff using an in-silico methodology. This research employed molecular modeling and docking assays targeting the 14-alpha lanosterol demethylase enzyme (CYP51), the primary antifungal target in Malassezia furfur. The docking results indicated that the active compounds in Leucaena leucocephala leaves, namely squalene and lupeol, exhibit a competitive binding affinity for CYP51, similar to the mechanism of action of ketoconazole. Squalene engages in polar interactions akin to the natural ligands of CYP51, whereas lupeol demonstrates robust hydrophobic interactions, suggesting its potential as an enzyme inhibitor. The findings indicate that herbal compounds derived from Leucaena leucocephala may serve as a natural alternative for dandruff treatment, presenting a reduced risk of side effects relative to synthetic chemicals. Further in vivo studies are necessary to validate the effectiveness and safety of anti-dandruff topical formulations. Keywords: CYP51, Dandruff, Leucaena leucocephala, Malassezia furfur, Natural antifungal
Relationship between PLR Value and Severity of Dengue Infection in Pediatric Patients in the Aster Room at RSUD dr. Soebandi Jember Gianevan, Nicholas Jirezra; Riyanti, Rini; Shodikin, Muhammad Ali; Rachmania, Sheilla; Dewi, Rosita
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.50026

Abstract

Dengue infection is a disease caused by dengue virus infection and transmitted by the Aedes mosquito, and is a major health problem in children, especially in developing countries. The Platelet to Lymphocyte Ratio (PLR) is a novel inflammatory biomarker that has recently been frequently studied and plays a role in the assessment of viral infectious diseases, and the use of PLR in viral infectious diseases has previously found greater potential compared with the Neutrophil-Lymphocyte Ratio (NLR). It is hoped that PLR can become a new biomarker for predicting the severity of dengue infection which is suitable for use in developing countries because PLR ​​is a cheap biomarker and is available in all clinical conditions. This research is a correlative analytical observational study using a cross-sectional approach. This research design was carried out by collecting data from children diagnosed with dengue infection as well as data on platelets and lymphocytes on the first day of admission to the hospital. This research uses stratified random sampling. Data were analyzed using Spearman correlation with a confidence level of 99%. The results of Spearman's correlation analysis showed a strong significant relationship with p<0.01 (p=0.000) and a correlation coefficient of -0.753. In conclusion, there is a significant and strong relationship between the Platelet-to-Lymphocy Ratio (PLR) value and the severity of dengue infection in pediatric patients in the Aster ward of RSUD Dr. Soebandi Jember. If the PLR ​​value increases, the severity of dengue infection will be lower or decrease and vice versa. Keywords: PLR; dengue infection; children; platelets; lymphocytes
Children Under Five Years of Age: Factor Analysis of Tuberculosis Preventive Therapy's Success in Controlling Childhood Tuberculosis Wahyuningsih, dr. Rita; Syafriadi, Mei; Mufida, Diana Chusna
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53703

Abstract

Jember Regency is the 2nd Regency after Surabaya City in finding the highest number of TB cases in East Java Province, with 5,244 adult cases and 478 pediatric TB cases found. Finding TB cases in children is an important component in controlling TB because the number of children aged less than 14 years constitutes 12% of the population. The government's efforts to control childhood TB by providing TPT (TPT) as an effort to strengthen the management of latent tuberculosis infection (ILTB) are still low. Toddlers in close contact with Drug Sensitive Tuberculosis (TB SO) are a group at risk of being infected with TB so they need to get TPT. This study aims to determine and analyze the driving factors, enabling factors, reinforcing factors and the role of the Medication Supervisor (PMO) on medication adherence in the TPT program for toddlers in close contact with TB in Jember Regency. The method in this research uses the Explanatory Research type, which is a type of research that aims to analyze the relationship or influence between variables through hypothesis testing. The results of this research indicate that the success factors of the TPT administration program, namely driving factors, enabling factors, reinforcing factors and the role of the Medication Supervisor (PMO) are proven to influence medication adherence in the TPT administration program for toddlers in close contact. It’s known that the factors contributed mainly to the successness of Tuberculosis Prevention Therapy are family’s support and the rile of the the Medication Supervisor (PMO).
Ischemic Stroke Induced by Bee Sting in Agricultural Society – A Rare Complication of Bee Sting: A Case Report Navadz, Eqiel; Aprilianto Handoko, Eko; Taufiq, Kamilka; Gemawan, Taufiq; Hakiim, Arsyzilma; Handoko, Adelia; Fortuna Sari, Putri
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53705

Abstract

Abstract Introduction: Ischemic stroke is one of the highest causes of morbidity and mortality. One of the factors that triggers ischemic stroke which is quite rare is a bee sting. Pathomechanism of this condition remain unclear. This case report will describe a rare complication of bee sting and discuss it from a pathomechanism perspective. Case Report: A 40-year old woman came to the emergency room at Dr. Koesnadi Bondowoso with the main complaint of weakness in the right face. Referral patients from community health centers. The patient's complaint occurred 7,5 hours ago after being stung by a bee on the middle finger of his left hand. Physical examination showed facial angioedema, edema of digiti manus III sinsitra, and others normal. On neurological examination, it was found: Parasis Nervus XII and VII sinistra UMN type and hemiparasis sinistra. Laboratory examination showed increased neutrophils (90.4%) and eosinophilia (0.1%). A non-contrast CT scan examination showed a hypodense lesion in the right hemisphere. The patient was given antiplatelet, antihistamin, and neuroprotectan. Discussion: One of the rare complications of bee stings is ishemic stroke. This occurs due to the toxin from bee stings which contain vasoactive, pro-inflammatory agents, thrombogenic peptides, thromboxane A2, and leukotrienes which trigger platelet aggregation and vasoconstriction. This condition can trigger trombus formation and lead to ischemic stroke. Medical personnel, especially neurologists, must be aware of pathomechanism from the quite rare complications of ischemic stroke induced by bee stings, especially in rural areas Keywords: Ischemic Stroke, Bee sting, rural area.
An An Analysis Of The Incidence Of Sensorinural Hearing Loss Based On Type 2 Diabetes Mellitus And Obesity Factor: An Analysis Of The Incidence Of Sensorinural Hearing Loss Based On Type 2 Diabetes Mellitus And Obesity Factor Dilla, Natasya Salsa; Wirayudha, Yan; Kurniati, Yuni Prastyo; Soekiswati, Siti
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53711

Abstract

Indonesia ranks fourth in Southeast Asia with a 2.3% prevalence of sensorineural hearing loss, a condition that may result from various risk factors including diabetes mellitus (DM) and obesity. DM can impair cochlear vascularization, while obesity significantly affects vascular function, potentially impacting the auditory system. This study aims to analyze the relationship between type 2 DM and obesity with sensorineural hearing loss. An observational analytic study with a cross-sectional approach was conducted on 64 participants aged 18–60 years, selected via purposive sampling. Type 2 DM was diagnosed by internal medicine consultants, and obesity was assessed using waist-to-hip ratio measurements. Data analysis employed Fisher's exact test and logistic regression. The study was ethically approved by the Health Ethics Committee of RS PKU Muhammadiyah Surakarta (No. 05/KEPK/RS.PKU/X/2024). Results showed a significant correlation between type 2 DM and sensorineural hearing loss (p=0.037) and between obesity and sensorineural hearing loss (p=0.001). The odds ratio for type 2 DM was 12.031, while for obesity it was 58.059, indicating that obesity poses a substantially higher risk. In conclusion, type 2 DM and obesity are significantly associated with the occurrence of sensorineural hearing loss, suggesting that addressing these risk factors may help reduce its prevalence. Keywords: Diabetes Melitus Tipe 2, Obesitas, Gangguan Pendengaran Sensorineural, Faktor Risiko.
The Phytochemical Identification And Antibacterial Activity Test Of Leucas Lavandulifolia Against Escherichia Coli Nidya Meilani; Dianasari, Dewi; Indah Yulia Ningsih
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53717

Abstract

Diarrhea is defined as a condition where the stool changes or becomes softer or more liquid with a frequency of 3 or 4 times a day. Based on its etiology, diarrhea is caused by several microorganisms, one of which is bacteria. The bacteria that causes diarrhea most often found in Indonesia is Escherichia coli. One type of plant that has the potential as an antibacterial is the Leucas lavandulifolia or Lenglengan plant. Based on ethnopharmaceutical studies, lenglengan leaves are commonly used to treat insomnia, pinworms, coughs with phlegm, epilepsy and digestive disorders. This research was carried out using lenglengan leaf ethanol extract with concentrations of 2.5%, 5%, 10%, 20% and 40%. In this study, phytochemical screening was also carried out using the TLC method. Antibacterial testing was carried out using the well diffusion method. The results obtained were the formation of a clear zone around the well, which indicated activity inhibiting bacterial growth. The results of testing antibacterial activity against E.coli showed that the ethanol extract of langlengan leaves at concentrations of 2.5%, 5%, 10%, 20% and 40% had antibacterial activity with clear zone results of 1.04 ± 0.33 , 12.71 ± 0.34, 13.90 ± 0.60, 15.23 ± 0.36, and 19.32 ± 0.79 mm.  The results of the phytochemical screening showed that ethanol extract of lenglengan leaves contained alkaloids, saponins, flavonoids, terpenoids/steroids and polyphenols. It can be concluded, the ethanol extract of lenglengan leaves has antibacterial activity against E.coli where the greater  sample concentration, the greater  activity.
Evaluating the Effect of Outpatient Registration Systems on Patient Recommendations Using Value Stream Mapping and Path Analysis Malik Qilsi, Fatkhur Ruli; Bukhori, Saiful; Firman, Firman
Journal of Agromedicine and Medical Sciences Vol. 11 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ams.v11i2.53729

Abstract

Digital transformation in healthcare requires hospitals to adopt efficient and integrated information systems. This research aims to analyze the influence of outpatient registration information system types—conventional, Hospital Management Information System (HMIS), and Mobile JKN—on recommendations to others using Value Stream Mapping (VSM) and path analysis with SmartPLS. The study was conducted at Citra Husada Hospital Jember with 98 respondents selected through convenience sampling. The VSM results indicate that Mobile JKN has the shortest total service time (1 hour 32 minutes) and the highest efficiency value (8.6%). Statistical analysis shows that interaction with medical personnel, ease of access, ease of use, and data security significantly influence patient satisfaction. Medical information satisfaction and overall service quality are proven to be the main factors driving patient recommendations. Consequently, Mobile JKN is the most efficient registration system alternative and has the potential to improve hospital service quality. Optimization of system integration and user education is recommended to support digital-based healthcare service transformation.

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