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Global Medical and Health Communication

gmhc
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Published by Universitas Islam Bandung

ISSN : 23019123 EISSN : 24605441 DOI : https://doi.org/10.29313/gmhc

Core Subject : Health, Science,

Dentistry Health Professions Immunology & microbiology Nursing Public Health

Global Medical and Health Communication is a journal that publishes research articles on medical and health published every 4 (four) months (April, August, and December). Articles are original research that needs to be disseminated and written in English. Subjects suitable for publication include but are not limited to the following fields of anesthesiology and intensive care, biochemistry, biomolecular, cardiovascular, child health, dentistry, dermatology and venerology, endocrinology, environmental health, epidemiology, geriatric, hematology, histology, histopathology, immunology, internal medicine, nursing sciences, midwifery, nutrition, nutrition and metabolism, obstetrics and gynecology, occupational health, oncology, ophthalmology, oral biology, orthopedics and traumatology, otorhinolaryngology, pharmacology, pharmacy, preventive medicine, public health, pulmonology, radiology, and reproductive health.

Arjuna Subject : Kedokteran - Epidemilogi

Articles 422 Documents

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Evaluation on the Implementation of Rural-Based Program for Undergraduate Medical Student Nita Arisanti; Insi Farisa Desy Arya; Indah Amelia; Kuswandewi Mutyara; Elsa Pudji Setiawati
Global Medical & Health Communication (GMHC) Vol 6, No 2 (2018)
Publisher : Universitas Islam Bandung

Evaluation of a program is needed to determine whether the program could be implemented and generate inputs to improve the program. The objective of this study was to evaluate the implementation of community-based programs for medical clerkship students in rural areas. This research was a qualitative study using interpretivism paradigm and case study approach. Data collection method was focus group discussions with the head of publichealth center (puskesmas) and preceptor. Data were analyzed through transcription, coding, categorization, and generating theme. The study was conducted from August 2015 to November 2016 in Sukabumi and Cianjur, West Java. Triangulation method and member check were conducted to elicit valid and reliable data. Two focus group discussions were conducted with 11 informants comprises 5 heads of puskesmas and 6 preceptors. There were 7 themes generated from the discussion. The themes were socialized and disseminate the information; collaboration and local government involvement; integration of education and service; encourage lifelong learning; encourage the improvement of performance; skill enhancement; and sustainability. Implementation of community-based medical education curriculum in rural areas has been implemented. Sustainability of the curriculum is needed to contribute to the improvement of community health status.EVALUASI IMPLEMENTASI PROGRAM ILMU KESEHATAN MASYARAKAT DI DAERAH PEDESAAN UNTUK PROGRAM PROFESI DOKTER Evaluasi sebuah program dibutuhkan untuk mengetahui apakah program tersebut dapat dilaksanakan dan mendapatkan masukan yang akan digunakan dalam rangka memperbaiki program. Tujuan penelitian ini adalah melakukan evaluasi pelaksanaan program pendidikan kedokteran berbasis daerah pedesaan untuk mahasiswa profesi dokter. Penelitian ini merupakan penelitian kualitatif dengan paradigma interpretivism dan pendekatan studi kasus. Pengumpulan data dilakukan dengan diskusi kelompok terarah kepada kepala puskesmas dan preseptor lapangan. Pengambilan data dilakukan pada bulan Agustus 2015 sampai November 2016 di Sukabumi dan Cianjur, Jawa Barat. Analisis data hasil wawancara dilakukan melalui proses transkripsi, koding, kategorisasi, dan penyusunan tema. Triangulasi dan member check dilakukan untuk mendapatkan data yang valid dan reliabel. Dua diskusi kelompok terarah dilakukan kepada 11 informan yang terdiri atas 5 orang kepala puskesmas dan 6 orang preseptor. Berdasar atas hasil diskusi didapatkan 7 tema dalam evaluasi kurikulum pendidikan, yaitu sosialisasi dan diseminasi informasi; kolaborasi dan keterlibatan pemerintah setempat; integrasi pendidikan dan pelayanan; mendorong pembelajaran sepanjang hayat; mendorong peningkatan kinerja staf; pemahiran keterampilan; serta keberlanjutan. Pelaksanaan kurikulum pendidikan kedokteran berbasis komunitas di daerah pedesaan telah dilakukan dengan baik, hal ini terlihat dari beberapa manfaat yang dikemukakan oleh informan. Agar implementasi kurikulum ini memberikan hasil yang lebih baik untuk masyarakat dibutuhkan keberlanjutan program.

Clinical Outcome of Cytomegalovirus Infection on Low Birth Weight Infants Ali Usman; Abdurachman Sukadi; Johanes Cornelius Mose
Global Medical & Health Communication (GMHC) Vol 2, No 2 (2014)
Publisher : Universitas Islam Bandung

Cytomegalovirus (CMV) is a DNA virus and a marker of the herpes virus groups. This virus was found only in human and the infection occurs for a long time. The transmission of CMV infection to fetus/neonates is via congenital infections or perinatal infections. Clinical manifestation of symptomatic CMV infection of the fetus has two presentations, early and second early manifestations. Diagnosis of neonatal CMV infection may be done by serologic test based on detection of IgM of CMV infection. The objective of this study is to asses clinical outcome of CMV infection of low birth weight infants delivery with long term sequelae. An observational study was conducted since March 2010 until December 2011 in Advent and Hermina Pasteur Hospital, all subjects were low birth weight infants (LBWI). The inclusion criterias are all LBWI who were delivered in those hospital or were a referred neonates. The exclusion criterias are major congenital defect, which is not related to congenital CMV infection and neonates’ death before one week of life. Every neonate was examine both their physical and peripher blood count, glucose, Ca. Liver function test done for neonates with acute hepatitis and titre IgG and IgM CMV serial, head ultrasound serial and head CT scan/MRI used for babies with intracranial bleeding and hydrocephaly. During the period of this study there were 50 cases of LBWI, consisted of 41 preterm babies, and 30 small for gestational age babies. Clinical manifestation of acute hepatitis were found in 20% subjects, all of them with the elevation of liver function test. Microcephaly which occured in the first untill three weeks of life were 8%. Ventricular dilatation were 10% in the first week of life and increased up to 48% after three weeks. Cases with intracranial haemorrhage were found in 6% and 10% with cerebral calcification on head while sensorineural hearing loss were 8%. All of LBWI have 100% serorespon immune IgG. IgM CMV reactive only in 12% cases but after 3 weeks increased up to 32%. During neonatal up to infancy period, the prevalence of CMV infection in Bandung is high (12+32%:44%) with long term sequelae which are serious and can be fatal. It is urgent and important to give information about this disease to new couples, every mother and healthcare providers in fetomaternal fields to prevent CMV infection. KELUARAN KLINIS INFEKSI CYTOMEGALOVIRUS PADA BAYI BERAT LAHIR RENDAH Cytomegalovirus (CMV) adalah virus DNA dan termasuk dalam kelompok virus herpes. Virus ini hanya menyerang manusia dan infeksinya berlangsung lama. Penularan CMV pada janin/neonatus dapat melalui infeksi kongenital atau infeksi perinatal. Manifestasi Infeksi CMV pada janin terdiri dari dua bentuk yaitu manifestasi awal dan lanjut. Diagnosis infeksi CMV neonatal ditegakkan dengan tes serologis berdasarkan deteksi IgM CMV. Tujuan penelitian ini adalah menilai keluaran klinis infeksi CMV pada bayi berat lahir rendah dengan gejala sisa. Penelitian observasional telah dilakukan sejak Maret 2010 sampai dengan Desember 2011 di RS Advent dan RS Hermina Pasteur pada semua bayi berat lahir rendah (BBLR). Kriteria inklusi adalah semua BBLR yang lahir di kedua RS maupun merupakan pasien rujukan. Kriteria eksklusi adalah adanya kelainan kongenital mayor yang tidak berhubungan dengan infeksi CMV kongenital dan bayi yang meninggal dalam minggu pertama. Setiap bayi dilakukan pemeriksaan fisik dan laboratorium (hitung darah tepi, kadar glukosa dan kalsium), tes fungsi hati dilakukan pada bayi yang menderita hepatitis akut, pemeriksaan kadar IgG dan IgM CMV serial, USG kepala dan CT-scan/MRI kepala pada kasus hidrosefalus dan perdarahan intrakranial. Selama penelitian terdapat 50 kasus BBLR yang terdiri atas 41 bayi prematur, 30 bayi kecil masa kehamilan. Hepatitis akut ditemukan sebanyak 20% yang semuanya disertai peningkatan tes fungsi hati. Mikrosefali yang terjadi sampai usia 3 minggu sebanyak 8%. Dilatasi ventrikular lateralis sebesar 10% pada minggu pertama dan meningkat sebanyak 48% setelah 3 minggu. Perdarahan intrakranial sebanyak 6% dan kalsifikasi serebral 10%. Gangguan pendengaran sebanyak 8%. IgG (+) pada semua BBLR (100%). IgM CMV reaktif hanya 12% tetapi meningkat sebesar 32% setelah usia 3 minggu. Simpulan, prevalensi infeksi CMV di Bandung cukup tinggi dengan gejala sisa neurologis yang berat dan fatal selama 6 bulan postnatal, sehingga perlu diberikan informasi mengenai penyakit ini kepada pasangan baru, setiap ibu, dan petugas kesehatan di bidang fetomaternal untuk mencegah infeksi ini.

Determinan Peresepan Polifarmasi pada Resep Rawat Jalan di Rumah Sakit Rujukan Yuke Andriane; Herry S. Sastramihardja; R. Ruslami
Global Medical & Health Communication (GMHC) Vol 4, No 1 (2016)
Publisher : Universitas Islam Bandung

Resep polifarmasi (≥5 jenis obat/resep) berpotensi meningkatkan interaksi obat, efek samping obat, dan masalah lain. Pasien yang berobat ke rumah sakit (RS) rujukan umumnya berpenyakit kronik, dengan komorbiditas dan komedikasi. Dilakukan penelitian potong silang untuk menganalisis determinan peresepan polifarmasi dari berbagai klinik rawat jalan di RS rujukan di Bandung. Analisis statistik menggunakan uji chi square dan dihitung rasio prevalensi (RP). Selama bulan Oktober 2012 terdapat 2.548 resep dari lima klinik rawat jalan dengan jumlah resep polifarmasi terbanyak. Prevalensi polifarmasi adalah 32% dan median jumlah jenis obat adalah 5 (rentang: 5–11). Terdapat perbedaan karakteristik pasien dalam hal usia ≥60 tahun (59,8% vs 44,8%; p<0,001), jenis kelamin laki-laki (57,1% vs 44,6%; p<0,001), peserta Askes (73,6% vs 56,1%; p<0,001), dan asal poliklinik: kardiovaskular (72,1% vs 33,1%; p<0,001) antara yang menerima resep polifarmasi dan tidak polifarmasi. Faktor dominan terhadap peresepan polifarmasi adalah dari klinik kardiovaskular (RP:8,80; IK95%: 6,35–12,19). Faktor lain dengan risiko polifarmasi >3 kali adalah dari klinik geriatri (RP:6,68; IK95%: 4,43–10,08) dan peserta Askes (RP:6,23; IK95%: 3,49–11,12). Prevalensi polifarmasi resep gabungan beberapa klinik (574 pasien) lebih besar, yaitu 59,8%. Simpulan, prevalensi peresepan polifarmasi di RS rujukan cukup tinggi, terlebih jika pasien menerima resep dari berbagai klinik. Determinan utama peresepan polifarmasi di RS rujukan adalah dari poli kardiovaskular, poli geriatri, dan peserta Askes.DETERMINANTS FOR POLYPHARMACY PRESCRIBING OF THE PRESCRIPTION IN THE OUTPATIENT CLINICS OF REFERRAL HOSPITALPolypharmacy prescription (≥5 drugs in one prescription) potentially increased drug-drug interaction, side effects, and other problems. Patients who come to referral hospital usually were with chronic diseases, comorbidities and comedications. A cross sectional study was performed to analyze the determinants for polypharmacy prescription from clinics in referral hospital in Bandung. Data were analyzed using chi-square test and prevalence ratio (PR) were calculated. During October 2012, there were 2,548 prescriptions from five clinics with highest number of prescription. Prevalence of polypharmacy prescription was 32%, the median number of drugs written were 5 (ranged: 5–11). The characteristics of the patients showed a difference in aged ≥60 years (59.8% vs 44.8%, p<0.001), gender: males (57.1% vs 44.6%, p<0.001), had health insurrance (73.6% vs 56.1%, p<0.001), and origin cardiovascular clinic (72.1% vs 33.1%, p<0.001) between those receiving polypharmacy prescriptions and those receiving non polypharmacy prescription. The dominant factor for polypharmacy prescription was treated at cardiovascular clinic (PR:8.80, 95%CI: 6.35–12.19), followed by treated at geriatry clinic (RP:6.68, 95%CI: 4.43–10.08) and had health insurrance (RP:6.23, 95%CI: 3.49–11.12). Polypharmacy of combined prescriptions (574 patients) was 59.8%. In conclusions, prevalence of polypharmacy prescription in referral hospital in Bandung is high, even higher in patients received combined prescriptions. Main determinants for polypharmacy prescription in referral hospitals are being treated at cardiovascular clinic, geriatry clinic, and having health insurance.

Kesiapan Masyarakat dalam Melaksanakan dan Memanfaatkan Posyandu Penyakit Tidak Menular di Desa Cilayung dan Cipacing, Kecamatan Jatinangor Yulia Sofiatin; Rully M.A. Roesli
Global Medical & Health Communication (GMHC) Vol 5, No 2 (2017)
Publisher : Universitas Islam Bandung

Pengendalian hipertensi dan penyakit tidak menular (PTM) memerlukan kerja sama pasien karena pilar utama pengendalian PTM adalah pengetahuan penderita dan kepatuhan dalam menjalankan upaya pengendaliannya. Sampai saat ini pemberian edukasi di sarana kesehatan tidak efektif sehingga diperlukan upaya lain seperti kelompok dukungan pasien dan peningkatan kemampuan masyarakat. Pos pelayanan terpadu (posyandu) PTM merupakan salah satu alternatif. Penelitian ini bertujuan menggali kesiapan kader posyandu dan pasien hipertensi mengenai kemungkinan pelaksanaan posyandu khusus PTM. Telah dilakukan diskusi kelompok terarah (DKT) terhadap dua kelompok (kader dan penderita) di Desa Cilayung dan Cipacing serta 1 (satu) sesi wawancara mendalam terhadap Kepala Puskesmas Kecamatan Jatinangor, Sumedang pada Maret–April 2017 dengan tingkat partisipasi peserta cukup baik. Keempat kelompok menyatakan kebutuhan terhadap posyandu PTM dengan aktivitas selain pemantauan tekanan darah dan berat badan yang dibutuhkan adalah penyuluhan mengenai perbaikan gaya hidup dan kepatuhan berobat. Kader Desa Cipacing siap melaksanakan penyuluhan jika telah mendapat pelatihan, tetapi kader Desa Cilayung menginginkan penyuluh dari luar lingkungan mereka. Terdapat kebutuhan kemudahan mendapatkan obat karena pengambilan obat di puskesmas dirasakan membutuhkan biaya transportasi yang cukup tinggi. Dapat disimpulkan bahwa masyarakat dan kader merasakan kebutuhan terhadap posyandu PTM, tetapi kesiapan mereka berbeda-beda.COMMUNITY READINESS TO RUN AND UTILIZE INTEGRATED HEALTH POST FOR NON-COMMUNICABLE DISEASE IN CILAYUNG AND CIPACING VILLAGES, JATINANGORThe main pilars of non-communicable diseases (NCDs) management are patient’s awareness, knowledge and compliance. At present, education by health provider in health facilities has been proven to be not effective that other measures such as patient support group and community empowerement are needed. The options is through integrated health post (posyandu) for NCD. The aim of this research was to explore the readiness of the community to run and utilize such post. Four sessions of focus group discussions with two groups of health cadres and two groups of people with high blood pressure in Cilayung and Cipacing villages and 1 (one) session of indepth interview towards the Head of Public Health Center (Puskesmas) at Jatinangor, Sumedang, Indonesia were held on March–April 2017 with high participations. Each group expresses the needs of patient support group and community empowerement through regular integrated health post for NCDs. Schedulled screening and mass education especially for life style modification and drug used are urgent. Health cadres of urban community are ready to lead the activities, while those from rural area ask for formal educators. Drug dispensing at public health center is favourable due to expensive transportation to primary health care. In conclusion, communities in Jatinangor need integrated health post for NCD to assist them to manage their blood pressure and other NCDs although their readinesses were vary.

The Effects of Physical Exercise on Spatial Learning and Serotonin Levels in the Brain of Adult Rats Annisa Rahmah Furqaani; Sri Redjeki; Dwirini Retno Gunarti
Global Medical & Health Communication (GMHC) Vol 6, No 2 (2018)
Publisher : Universitas Islam Bandung

Physical exercise can enhance tryptophan transport into the brain so that it will also increase serotonin levels in the brain. Therefore, it may influence many brain functions, such as learning and memory. This study aimed to determine the effect of physical exercise on spatial learning and serotonin levels in the brain of adult male Wistar rats. Biochemistry Laboratory of Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia was the study place which conducted in January–April 2013. Sixteen adult male rats randomly divided into two groups, the control group, and the treatment group. Physical exercise for the treatment group for four weeks using the animal treadmill at 15 m/min in speed for 15 minutes in the 1st week and 25 minutes for the next three weeks. Learning and memory test using water-E maze apparatus once a week. At the end of the exercised period, animals were sacrificed, and the brains were isolated. The measurement of serotonin and tryptophan levels was done using high-performance liquid chromatography (HPLC). The results showed that physical exercise improved animals performance in learning and memory test, exercised group made fewer errors at third and fourth week (p<0.05). Serotonin levels in the brain of exercised group was significantly higher than that in control group (p<0.05). These results indicated that the enhancement of serotonin levels in the brain induced by physical exercise is involved in improving spatial learning and memory. PENGARUH LATIHAN FISIK TERHADAP KEMAMPUAN BELAJAR SPASIAL DAN KADAR SEROTONIN PADA OTAK TIKUS DEWASALatihan fisik diketahui dapat meningkatkan transpor triptofan melewati sawar otak sehingga dapat meningkatkan kadar serotonin di otak. Oleh karena itu, latihan fisik berperan memengaruhi berbagai fungsi otak termasuk proses belajar dan memori. Penelitian ini bertujuan mengetahui pengaruh latihan fisik aerobik dengan intensitas yang ringan terhadap kemampuan belajar spasial serta kadar serotonin pada otak tikus Wistar dewasa. Penelitian ini dilakukan di Laboratorium Biokimia, Departemen Biokimia & Biologi Molekuler, Fakultas Kedokteran, Universitas Indonesia, Jakarta periode Januari–April 2013. Enam belas ekor tikus jantan dewasa dibagi secara acak menjadi dua kelompok, yaitu kelompok kontrol dan kelompok perlakuan. Latihan fisik diberikan kepada kelompok perlakuan selama 4 minggu menggunakan animal treadmill dengan kecepatan 15 m/menit selama 15 menit pada minggu pertama dan 25 menit pada 3 minggu berikutnya. Uji belajar dan memori dengan perangkat water-E maze dilakukan satu kali/minggu. Setelah masa latihan fisik selesai, hewan coba dikorbankan dan jaringan otak diisolasi. Pengukuran kadar serotonin dan triptofan pada otak dilakukan menggunakan kromatografi cair kinerja tinggi (KCKT). Hasil penelitian menunjukkan bahwa jumlah kesalahan yang dilakukan oleh kelompok perlakuan lebih sedikit secara signifikan pada uji belajar dan memori ke-3 dan ke-4 (p<0,05). Kadar serotonin lebih tinggi secara signifikan pada otak kelompok perlakuan (p<0,05). Hasil penelitian ini mengindikasikan bahwa peningkatan kadar serotonin pada otak yang diinduksi oleh latihan fisik aerobik intensitas ringan terlibat dalam meningkatkan kemampuan belajar dan memori spasial.

Labu Kuning (Cucurbita moschata Durch.) untuk Penurunan Kadar Glukosa Darah Puasa pada Tikus Model Diabetik Rahmi Fathonah; Anita Indriyanti; Yuktiana Kharisma
Global Medical & Health Communication (GMHC) Vol 2, No 1 (2014)
Publisher : Universitas Islam Bandung

Diabetes melitus didefinisikan sebagai penyakit metabolik yang ditandai dengan hiperglikemia akibat defisiensi insulin atau penurunan efektivitas insulin dan dapat menimbulkan berbagai komplikasi akut maupun kronik. Salah satu obat tradisional yang mempunyai efek anti diabetik adalah labu kuning (Cucurbita moschata Durch.) yang mengandung flavonoid, beta-karoten, vitamin C, dan vitamin E. Tujuan penelitian ini adalah untuk mengetahui efek dan rentang dosis efektif ekstrak air labu kuning terhadap penurunan kadar glukosa darah puasa pada tikus model diabetik. Penelitian ini bersifat eksperimental laboratorik dengan menggunakan disain rancangan acak lengkap terhadap 28 ekor tikus putih jantan galur Wistar yang terbagi dalam empat kelompok yaitu kelompok I (diet biasa, induksi aloksan), kelompok II (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 56 mg/200 gBB/hari per oral), kelompok III (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 112 mg/200 gBB/hari per oral), dan kelompok IV (diet biasa, induksi aloksan, ekstrak air labu kuning dosis 224 mg/200 gBB/hari per oral). Pengukuran kadar glukosa darah puasa dilakukan setelah masa adaptasi, setelah diinduksi aloksan, hari ke-7, dan hari ke-14 perlakuan. Data dianalisis dengan menggunakan uji repeated analysis of varians (ANOVA) lalu dilanjutkan dengan uji post-hoc Tamhane’s T2. Hasil penelitian menunjukan bahwa pemberian ekstrak air labu kuning dengan rentang dosis 56 mg/200 gBB/ hari per oral sampai 112 mg/200 gBB/hari per oral selama 14 hari dapat menurunkan kadar glukosa darah puasa dengan bermakna. Penurunan kadar glukosa darah puasa diduga karena labu kuning mengandung flavonoid, beta-karoten, vitamin C dan vitamin E. PUMPKIN (CURCUBITA MOSCHATA DURCH.) TO DECLINE OF BLOOD GLUCOSE FASTING LEVELS IN DIABETIC MICEDiabetes mellitus defined as syndrome of metabolic diseases characterized by hyperglycemia due to insulin deficiency or decreased effectiveness of insulin that cause various acute and chronic complications. One of the traditional medicines which have anti-diabetic effect is pumpkin (Cucurbita moschata Durch.) which contains flavonoids, beta-carotene, vitamin C, and vitamin E. The purpose of this study is to determine the effects and the effective dose range of pumpkin water extracts to the decline of blood glucose fasting levels in diabetic mice. This study was an experimental research with complete randomized design using 28 white male wistar mice divided into four groups i.e. group I (normal diet, alloxan induce), group II (normal diet, alloxan induce, water extract of pumpkin at the dose 56 mg/200 gBW/day orally), group III (normal diet, alloxan induce, pumpkin water extract with the dose of 112 mg/200 gBW/day orally), and group IV (normal diet, alloxan induce, pumpkin water extract orally with the dose of 224 mg/200 gBW/day). Measurement of blood glucose fasting levels done after the adaptation period, after alloxan induced, on day 7th and day 14th of treatment. Data was analyzed using repeated ANOVA test followed by post-hoc test. The results showed that administration of pumpkin water extract with dose ranges of 56 mg/200 gBB/day orally to 112 mg/200 gBB/day orally for 14 days can lower blood glucose fasting levels. The decrease in blood glucose fasting levels presumably was because pumpkin contains flavonoid, beta-carotene, vitamin C and vitamin E which known to have those effects.

Efektivitas Penurunan Malondialdehyde dengan Kombinasi Suplemen Antioksidan Superoxide Dismutase Melon dengan Gliadin Akibat Paparan Asap Rokok Rivan Virlando Suryadinata; Bambang Wirjatmadi; Merryana Adriani
Global Medical & Health Communication (GMHC) Vol 5, No 2 (2017)
Publisher : Universitas Islam Bandung

Jumlah perokok di Indonesia makin meningkat setiap tahunnya hingga mencapai hampir 40% dari total penduduk. Terapi antioksidan dapat menurunkan radikal bebas akibat asap rokok yang dapat menyebabkan kerusakan dan kematian sel dalam tubuh. Antioksidan superoxide dismutase ekstrak melon dengan kombinasi gliadin berpotensi menurunkan radikal bebas dengan menurunkan malondialdehyde (MDA) dalam darah. Penelitian ini bertujuan mengetahui efektivitas suplemen superoxide dismutase-gliadin (SOD-gliadin) dalam menurunkan kadar MDA akibat paparan asap rokok terhadap tikus Wistar. Penelitian menggunakan metode ekperimental dengan post-test control group design di Laboratorium Fakultas Kedokteran, Universitas Airlangga. Pemberian suplemen SOD-gliadin dengan paparan asap rokok dua batang per hari dilakukan selama 28 hari (5 April 2016 sampai 12 Mei 2016) dengan menggunakan kelompok kontrol negatif, kelompok kontrol positif, dan tiga kelompok perlakuan dengan dosis ekstrak melon yang berbeda. Selanjutnya, pengukuran kadar MDA dilakukan dengan mengambil serum darah pada semua kelompok. Hasil penelitian, suplemen SOD-gliadin berpengaruh terhadap penurunan kadar MDA serum (ANOVA, p=0,000). Uji least significant difference (LSD) menunjukkan kelima kelompok memberikan hasil yang signifikan terhadap penurunan kadar MDA pada tikus Wistar yang terpapar asap rokok (p<0,05). Penurunan kadar MDA terendah terjadi pada dosis ketiga dibanding dengan dosis SOD-gliadin lainnya. Simpulan, pemberian suplemen SOD-gliadin dapat mengurangi radikal bebas akibat paparan asap rokok.EFFECTIVENESS DECREASE COMBINED WITH SUPPLEMENTS MALONDIALDEHYDE ANTIOXIDANT SUPEROXIDE DISMUTASE GLIADING MELON WITH DUE TO EXPOSURE TO CIGARETTEThe number of smokers in Indonesia was increasing every year to reach nearly 40% of the total population. Antioxidants superoxide dismutase of melon extract able to reduce free radicals in the body. The decrease of free radicals in the body can be measured from malondialdehyde (MDA) levels in the blood. This research aims to determine the effectiveness of melon extract for lowering malondyaldehyde level of cigarette smoke exposure on Wistar rats. Research using experimental methods with posttest control group design in Laboratory Medical Faculty, Airlangga University. Melon extract intake with exposure two cigarettes per day for 28 days (5 April 2016 until 12 May 2016) was done by using a negative control group, positive control group and 3 groups experiment with different doses of melon extract. The measurement of MDA level done by taking a blood serum in all groups after 28 days. The results showed SOD-gliadin effect of decreased levels of serum MDA (ANOVA, p=0.000). Least significant difference (LSD) test showed all groups significant results to decreased levels of MDA in Wistar rats were exposed to smoke (p<0.05). The third dose was decreased levels of MDA lowest compared to other doses of SOD-gliadin. The conclusion of the research, SOD-gliadin supplementation can reduce free radical role in the body as a result of exposure to cigarette smoke.

Hubungan Durasi Tidur dengan Kejadian Obesitas pada Anak Usia 3–8 Tahun Puput Septiana; Irwanto Irwanto
Global Medical & Health Communication (GMHC) Vol 6, No 1 (2018)
Publisher : Universitas Islam Bandung

Prevalensi obesitas pada anak meningkat secara global baik di negara maju maupun di negara berkembang termasuk Indonesia. Obesitas terjadi karena ketidakseimbangan asupan energi dan keluaran energi dalam jangka waktu yang lama dan dapat diketahui dari nilai indeks massa tubuh (IMT). Penelitian ini bertujuan mengetahui hubungan durasi tidur dengan kejadian obesitas. Jenis penelitian yang digunakan adalah observasional analitik dengan rancangan cross-sectional study. Subjek penelitian adalah semua anak usia 3–8 tahun yang bersekolah di Raudhatul Athfal (RA) Al Muawanah, SDN Rengasdengklok Selatan I, dan SDN Rengasdengklok Selatan II, Kecamatan Rengasdengklok, Karawang yang memenuhi kriteria inklusi periode bulan Maret–April 2017. Penelitian ini menggunakan total sampling dan uji statistik Spearman. Hasil penelitian diperoleh 440 anak ikut dalam penelitian ini. Anak dengan riwayat durasi tidur selama 7–9 jam 64,8% dan 10–12 jam 34,3%. Status gizi anak usia 3–8 tahun berdasar atas indeks massa tubuh menurut usia (IMT/U) 30,2% memiliki status gizi normal dan 64% memiliki status gizi gemuk–obesitas. Didapatkan hubungan durasi tidur dengan kejadian obesitas berdasar atas status gizi IMT/U (p<0,05). Simpulan, terdapat hubungan durasi tidur dengan kejadian obesitas pada anak usia 3–8 tahun. ASSOCIATION OF SLEEP DURATION AND OBESITY IN CHILDREN AGED 3 TO 8 YEARS OLDPrevalence of obesity in increasing worlwide, both in developed and developing countries, including Indonesia. Obesity develops due to imbalance of energy intake and expenditure in a long period of time and can be measured in values of body mass index (BMI). The purpose of this study was to discover the association sleep duration and obesity prevalence in children aged 3 to 8 years old. This cross-sectional study uses total sampling technique and involves 440 respondents that meet the inclusion criteria at Raudhatul Athfal (RA) Al Muawanah, SDN Rengasdengklok Selatan I and SDN Rengasdengklok Selatan II, Rengasdengklok sub-district, Karawang in March to April 2017. Data were analysed using Spearman's test. The result of descriptive study from 440 respondents showed that 64,8% children sleep 7 to 9 hours per day, and as many as 34,3% sleep 10 to 12 hours per day. Nutritional status of children aged 3 to 8 years old based on BMI/age showed that 30,2% had normal nutritional status and 64% were overweight-obese. Statistical analysis was conducted (p<0.05) was found sleep duration and prevalence of obesity based on BMI/age. In conclusion, there was an association between sleep duration and prevalence of obesity in children aged 3 to 8 years old.

Perbandingan Kadar C-Reactive Protein Kuantitatif dengan Hasil Deteksi Antigen Cryptococcus neoformans pada Penderita Human Immunodeficiency Virus Maenaka Smaratungga Hendrajaya; Agnes Rengga Indrati; Ahmad Rizal Ganiem
Global Medical & Health Communication (GMHC) Vol 1, No 2 (2013)
Publisher : Universitas Islam Bandung

Infeksi Cryptococcus neoformans merupakan salah satu infeksi oportunistik pada penderita HIV yang dapat menyebabkan meningitis kriptokokus dan dapat dideteksi secara dini melalui antigen yang terdapat pada kapsul polisakarida. Ketersediaan pemeriksaan antigen ini sangat terbatas sehingga dibutuhkan parameter lain untuk mendeteksi secara dini kemungkinan terjadi meningitis kriptokokus. Parameter tersebut adalah C-reactive protein (CRP). Penelitian ini bertujuan untuk membandingkan kadar CRP kuantitatif dengan hasil deteksi antigen C. neoformans pada penderita infeksi HIV. Serum diambil dari penderita HIV di Klinik Teratai RSUP Dr. Hasan Sadikin Bandung yang baru pertama kali terdeteksi, CD4+ <100 sel/mm3, belum diterapi, serta tidak didiagnosis meningitis kriptokokus. Dilakukan deteksi antigen menggunakan Cryptococcal antigen latex agglutination system (Meridian Diagnostics), dan pemeriksaan CRP kuantitatif. Desain penelitian analitik komparatif dengan analisis statistik menggunakan statistical product and service solutions (SPSS ver.13), uji Mann-Whitney, dan dilakukan perhitungan sensitivitas dan spesifisitas serta penentuan cut-off CRP kuantitatif dengan kurva ROC. Hasil penelitian menunjukkan perbedaan bermakna kadar CRP kuantitatif pada hasil CALAS positif dan negatif. Kadar CRP pada CALAS positif lebih tinggi dibandingkan dengan dengan negatif (p<0,05). Dari kurva ROC didapatkan sensitivitas 84,3% dan spesifisitas 42,4%, serta cut-off CRP >5,8197 mg/dL. Dari 14 sampel dengan CALAS positif, 12 (85,7%) dengan CRP > 5.8197 mg/dL dan 2 (14,3%) dengan CRP ≤5,8197 mg/dL. Simpulan, CRP kuantitatif dapat dipertimbangkan sebagai salah satu parameter untuk mendeteksi secara dini kemungkinan terjadi meningitis kriptokokus pada pasien HIV, dengan menyingkirkan kemungkinan lain yang dapat mengakibatkan peningkatan CRP COMPARISON OF QUANTITATIVE C-REACTIVE PROTEIN CONCENTRATION AND CRYPTOCOCCUS NEOFORMANS ANTIGENS DETECTION RESULTS IN HUMAN IMMUNODEFICIENCY VIRUS PATIENTSCryptococcus neoformans infection is one of the opportunistic infections in HIV patients, it caused cryptococcal meningitis, which can be detected earlier using the antigen contained in the polysacharide capsule. The availability of this antigen test is very limited that other parameter are needed for early detection of cryptococcal meningitis. That parameter is C-reactive protein (CRP). The aim of this study was to compare the levels of quantitative CRP with the C. neoformans antigen detection in HIV patients. This was a comparative analytical study design using serum taken from HIV patients who came to the Teratai Clinic RSUP Dr. Hasan Sadikin Bandung. The inclusion criteria was subject on their first detection, having CD4 + <100 cells/mm3, have never been treated before, and was not diagnosed with cryptococcal meningitis. Cryptococcal antigen detection using antigen latex agglutination system (Meridian Diagnostics) and quantitative CRP examination was performed. Data analysis used statistical product and service solutions (SPSS) ver. 13 to calculate sensitivity and specificity and the determination of CRP cut-off by ROC curve. Results showed that there was significant differences in the levels of quantitative CRP from positive and negative CALAS results. CRP levels in CALAS positive results was higher than negative result (p<0.05). From ROC curve, the CRP had 84.3% sensitivity and 42.4% specificity, and the cut-off was >5.8197 mg/dL. Of 14 samples with positive CALAS result, 12 (85,7%) having CRP >5.8197 mg/dL and 2 (14,3%) with CRP ≤5.8197 mg/dL. In conclusion, quantitative CRP could be considered as a parameter for early detection of cryptococcal meningitis in HIV patients, by eliminating the possibilities that can lead to increased level of CRP.

The Use Reproductive Health Game (KEPO Game) on Female Adolescent’s Five Dimensions Satisfaction Susilawati, Sri; Husin, Farid; Wirakusumah, Firman Fuad; Dhamayanti, Meita; Herman, Herry; Anwar, Ruswana; Sekarwana, Nanan
Global Medical & Health Communication (GMHC) Vol 7, No 1 (2019)
Publisher : Universitas Islam Bandung

The adolescent’s reproductive health is the major problem that should take into consideration. To solve this problem, it needs an alternative strategy by using a media, reproductive health/kesehatan reproduksi (KEPO) game, in Android smartphone. The aim is analyzing the effect of KEPO game on the five dimensions of female adolescent’s satisfaction. The research method was quasi-experiment, and the research design used pre-test post-test with control group design. The sampling technique used simple random sampling. The subject was 64 respondents of female student age of 12−15 years old in public junior high school in Bandung city. The respondents divided into two groups, the first one treated by KEPO game is 32 students of Public Junior High School 50 Bandung, while the control group was 32 students of Public Junior High School 8 Bandung, get counseling from Ujungberung Indah Public Health Center; the entire research conducted in April−May 2017. Research result shows the percentage differential of satisfaction average score improvement on both groups. The treatment group produces percentage of content 14.6%, display 23.6%, accuracy 11.4%, easiness 12.4%, and correctness 17%. In the other hand, control group produces content 5%, display 3%, accuracy 4.3%, easiness 2.8%, and correctness 4.7% with a p value for each indicator was p<0.05 on the intervention group and p<0.05 on the control one. Entirely, it known that adolescent’s satisfaction from those five aspects in using KEPO game has a matter differential p<0.05, with satisfied percentage, was 84%. In conclusion, there was an effect of KEPO game on the five dimensions of female adolescent’s satisfaction. PENGARUH PENGGUNAAN GIM KESEHATAN REPRODUKSI (KEPO) TERHADAP LIMA DIMENSI KEPUASAN REMAJA PEREMPUANKesehatan reproduksi remaja merupakan masalah utama yang harus diperhatikan sehingga untuk mengatasi ketidakpuasan remaja, diperlukan strategi alternatif, yaitu gim kesehatan reproduksi (KEPO) menggunakan smartphone Android. Tujuan penelitian ini adalah menganalisis pengaruh gim KEPO terhadap lima dimensi kepuasan remaja perempuan. Metode penelitian adalah quasi-experiment dan desain penelitian menggunakan pre-test post-test with control group design. Teknik pengambilan sampel menggunakan simple random sampling. Subjek penelitian adalah 64 responden siswa perempuan usia 12–15 tahun SMP Negeri di Kota Bandung. Responden dibagi menjadi dua kelompok, yaitu kelompok perlakuan menggunakan gim KEPO sebanyak 32 siswa SMP Negeri 50 Bandung, sedangkan kelompok kontrol menerima penyuluhan dari Puskesmas Ujungberung Indah sebanyak 32 siswa SMP Negeri 8 Bandung. Penelitian dilaksanakan pada bulan April–Mei 2017. Hasil penelitian menunjukkan perbedaan persentase peningkatan nilai rerata kepuasan pada kedua kelompok. Kelompok perlakuan menghasilkan persentase konten 14,6%, tampilan 23,6%, akurasi 11,4%, kemudahan 12,4%, dan ketepatan 17%. Di sisi lain, kelompok kontrol menghasilkan konten 5%, tampilan 3%, akurasi 4,3%, kemudahan 2,8%, dan ketepatan 4,7% dengan nilai p untuk setiap indikator sebesar p<0,05 pada kelompok intervensi dan p>0,05 kelompok kontrol. Secara keseluruhan, diketahui bahwa kepuasan remaja dari kelima aspek kepuasan dalam menggunakan gim KEPO memiliki perbedaan yang bermakna p<0,05 dengan persentase puas 84%. Simpulan, terdapat pengaruh penggunaan gim KEPO terhadap lima dimensi kepuasan remaja perempuan.

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Home Page

OAI Link

Editorial Team

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Contact Name Agus Chalid

Contact Email gulid.p@gmail.com

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Editorial Address Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location Kota bandung, Jawa barat INDONESIA

Abstract

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Contact Name
Agus Chalid

Contact Email
gulid.p@gmail.com

Phone
+6285220013654

Journal Mail Official
gmhc.unisba@gmail.com

Editorial Address
Jalan Hariangbanga No. 2, Tamansari, Bandung 40116

Location
Kota bandung,

Jawa barat

INDONESIA