cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
-
Location
Kota semarang,
Jawa tengah
INDONESIA
Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Published by Universitas Wahid Hasyim Semarang
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Medicine & Pharmacology
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
Arjuna Subject : -
Articles 244 Documents
 21   22   23   24   25 
Search results for , issue "JURNAL ILMU FARMASI " : 244 Documents clear
Perceptions Aganist Disease And Medicine Consumption Adherence Of Stroke Patients At X Hospital In Central Java Wibowo, Sulistiyanto
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14062

Abstract

The increasing prevalence of stroke needs attention. Medication adherence and disease perception play an important role in stroke treatment. The research aimed to provide an overview of disease perception and medication adherence in stroke patients at Hospital X, Central Java Province. Quantitative research was conducted using cross-sectional. The study population was JKN stroke patients who received treatment during the study period. The sample used must meet the inclusion criteria such as being ≥18 years old, being willing to be a research subject, and having been diagnosed with stroke within 3 months. Adherence to medication using the Morisky Medication Adherence Scale questionnaire and understanding perceptions of illness using the Brief Illness Perception Questionnaire. Based on research data, the average respondent had experienced a stroke for 2.62 years with a history of diabetes mellitus, hypertension, cholesterol, heart disease, and gout. Perception of illness with a total score of 57.59 (> 40) which means the respondent has a positive perception. A total of 31 respondents had a high level of compliance, 45 respondents had a medium level of compliance, and 24 respondents had a low level of compliance. The research conclusion shows that the majority of patients have a good perception of the disease by carrying out pharmacological and non-pharmacological treatment such as adopting a healthy diet and living pattern, and regular exercise. Non-compliance with taking medication is caused by forgetting to take medication, stopping taking medication when side effects appear or feeling better, forgetting to bring medication when traveling, and still having difficulty remembering to use medication.
Antihyperuricemic Activity of n-Hexane, Ethyl Acetate, and Aqueous Fractions of Ethanol Extract of Chromolaena odorata Leaves in Mice: In Vivo Study Aisyiah, Aisyiah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14170

Abstract

Hyperuricemia is a metabolic disorder characterised by elevated uric acid levels in the blood, which may lead to complications such as gout, arthritis, kidney stones, and renal failure. In recent years, medicinal plants have gained increasing attention as alternative therapies for hyperuricemia. Chromolaena odorata, commonly known as kirinyuh, is one such plant suspected to have antihyperuricemic properties. This study aimed to evaluate the antihyperuricemic activity of the n-hexane, ethyl acetate, and aqueous fractions of C. odorata leaf ethanol extract in male Swiss Webster mice induced with chicken liver juice. The extract was obtained by maceration using 96% ethanol and subsequently fractionated using solvents with different polarities. The experiment employed a pretest-posttest control group design, involving 12 groups: a normal control, a negative control (0.5% Na-CMC), a positive control (allopurinol at 13 mg/kg body weight), and nine treatment groups that received each fraction at doses of 20, 40, and 80 mg/kg body weight. Uric acid levels were measured at three intervals: baseline (day 0), post-induction (day 7), and after treatment (day 14), using the Easy Touch GCU Multi-Function Monitoring System. The results demonstrated that all three fractions reduced uric acid levels, with the ethyl acetate fraction at 80 mg/kg body weight (BW) showing the most significant effect, achieving a 21.34% reduction. These findings suggest that Chromolaena odorata leaves, especially the ethyl acetate fraction, possess promising antihyperuricemic potential and could serve as a natural alternative for managing hyperuricemia.
Molecular Docking and ADMET Evaluation of Fluoro-Hydroxyxanthone Derivatives as Potential Estrogen Receptor Alpha Inhibitors Puspitasari, Anita Dwi
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14236

Abstract

Fluoro-hydroxyxanthone derivatives (X1–X10) were investigated as potential inhibitors of estrogen receptor alpha (ER-α) through molecular docking and in silico ADMET profiling. The docking protocol was validated through a redocking procedure, yielding a Root Mean Square Deviation (RMSD) of 0.81 Å, which confirmed the method's reliability.  Compounds X6–X10 demonstrated favorable binding affinities ranging from −7.32 to −7.46 kcal/mol, although these values remained lower than those of the native ligand, estradiol (−10.69 kcal/mol), and tamoxifen (−9.21 kcal/mol). These compounds formed key hydrogen bond interactions with Glu353 and Arg394, similar to estradiol, suggesting a correct binding orientation within the receptor's ligand-binding domain. Structural modifications, particularly the introduction of hydroxyl and fluoro substituents, contributed to the enhanced binding energies observed in these top-performing compounds. ADMET analysis further indicated that compounds X6–X10 complied with Lipinski's Rule of Five, had acceptable oral bioavailability, metabolic stability, and the ability to cross the blood–brain barrier. However, all derivatives were predicted to exhibit mutagenic potential and hepatotoxicity, which may limit their safety profiles. In conclusion, fluoro-hydroxyxanthone derivatives, especially X6–X10, represent promising molecular scaffolds for further optimization and development as potential anti-breast cancer agents targeting ER-α
Antibacterial Activity of Ethanol Extract of Red Ginger (Zingiber officinale Roscoe) Against Proteus mirabilis Arum Rafiqah, Jovita; Nuria, Maulita Cut
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14441

Abstract

Red ginger (Zingiber officinale Roscoe) has been extensively utilized in traditional medicine and is reported to possess a wide range of biological activities. Proteus mirabilis is a pathogenic bacterium that could cause Urinary Tract Infections (UTIs). Red ginger contains flavonoid compounds, phenolics, essential oils, and tannins that may contribute to its antibacterial properties. This study aimed to evaluate the differences in antibacterial activity of the ethanol extract of red ginger at various concentrations against Proteus mirabilis and to identify its phytochemical constituents. Red ginger simplicia was macerated using 96% ethanol and the macerate was evaporated with a rotary vacuum evaporator. Extracts were made in series concentrations of 20%, 40%, 60%, and 80% w/v for the antibacterial activity test. Ampicillin was used as a positive control, while dimethylsulfoxide was used as a negative control. Antibacterial activity was assessed based on the diameter of the inhibition zones, and the data were statistically analyzed using a one-way ANOVA test, followed by a post hoc Tukey test at a 95% confidence level. The results of this study showed that there were differences (p < 0.05) in the zone of inhibition values from all series of concentrations of the ethanol extract of red ginger against Proteus mirabilis. The extract was found to contain several classes of secondary metabolites, including terpenoids, alkaloids, phenolics, flavonoids, tannins, and saponins.

Page 25 of 25 | Total Record : 244

 21   22   23   24   25 

Filter by Year

2007 2025


Reset
Filter By Issues
All Issue Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis Vol 21, No 1 (2024): Jurnal Ilmu Farmasi & Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2 Vol 20, No 2 (2023) Vol 20, No 1 (2023): Jurnal Ilmu Farmasi & Farmasi Klinik 2023: [Special Edition] Jurnal Ilmu Farmasi & Farmasi Klinik Vol 19, No 2 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik Vol 18, No 01 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik Vol 18, No 2 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik Vol 17, No 2 (2020): Jurnal Ilmu Farmasi & Farmasi Klinik Vol. 17 N0. 02 Desember 2020 Vol 17, No 01 (2020): Jurnal Ilmu Farmasi & farmasi Klinik Vol 17 No. 01, Juni 2020 Vol 16, No 02 (2019): Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 02 Desember 2019 Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019 Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018 Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 1 Juni 2018 Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 2 Desember 2017 Jurnal Ilmu Farmasi & Farmasi Klinik Vol 14 No 1 juni 2017 Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine" Jurnal Ilmu Farmasi & Farmasi Klinik Vol 13 No 2 Desember 2016 JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016 Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015 Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015 JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014 JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014 Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013 Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013 Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012 Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif" JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 7 NO. 2 DESEMBER 2010 JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009 JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008 JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 1 JUNI 2008 JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007 More Issue