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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
Published by Universitas Wahid Hasyim Semarang
ISSN : 16937899     EISSN : 27163814     DOI : 10.31942
Core Subject : Health,
Medicine & Pharmacology
Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.
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Articles 251 Documents
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Search results for , issue "JURNAL ILMU FARMASI " : 251 Documents clear
Perceptions Aganist Disease And Medicine Consumption Adherence Of Stroke Patients At X Hospital In Central Java Wibowo, Sulistiyanto
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14062

Abstract

The increasing prevalence of stroke needs attention. Medication adherence and disease perception play an important role in stroke treatment. The research aimed to provide an overview of disease perception and medication adherence in stroke patients at Hospital X, Central Java Province. Quantitative research was conducted using cross-sectional. The study population was JKN stroke patients who received treatment during the study period. The sample used must meet the inclusion criteria such as being ≥18 years old, being willing to be a research subject, and having been diagnosed with stroke within 3 months. Adherence to medication using the Morisky Medication Adherence Scale questionnaire and understanding perceptions of illness using the Brief Illness Perception Questionnaire. Based on research data, the average respondent had experienced a stroke for 2.62 years with a history of diabetes mellitus, hypertension, cholesterol, heart disease, and gout. Perception of illness with a total score of 57.59 (> 40) which means the respondent has a positive perception. A total of 31 respondents had a high level of compliance, 45 respondents had a medium level of compliance, and 24 respondents had a low level of compliance. The research conclusion shows that the majority of patients have a good perception of the disease by carrying out pharmacological and non-pharmacological treatment such as adopting a healthy diet and living pattern, and regular exercise. Non-compliance with taking medication is caused by forgetting to take medication, stopping taking medication when side effects appear or feeling better, forgetting to bring medication when traveling, and still having difficulty remembering to use medication.
Antihyperuricemic Activity of n-Hexane, Ethyl Acetate, and Aqueous Fractions of Ethanol Extract of Chromolaena odorata Leaves in Mice: In Vivo Study Aisyiah, Aisyiah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14170

Abstract

Hyperuricemia is a metabolic disorder characterised by elevated uric acid levels in the blood, which may lead to complications such as gout, arthritis, kidney stones, and renal failure. In recent years, medicinal plants have gained increasing attention as alternative therapies for hyperuricemia. Chromolaena odorata, commonly known as kirinyuh, is one such plant suspected to have antihyperuricemic properties. This study aimed to evaluate the antihyperuricemic activity of the n-hexane, ethyl acetate, and aqueous fractions of C. odorata leaf ethanol extract in male Swiss Webster mice induced with chicken liver juice. The extract was obtained by maceration using 96% ethanol and subsequently fractionated using solvents with different polarities. The experiment employed a pretest-posttest control group design, involving 12 groups: a normal control, a negative control (0.5% Na-CMC), a positive control (allopurinol at 13 mg/kg body weight), and nine treatment groups that received each fraction at doses of 20, 40, and 80 mg/kg body weight. Uric acid levels were measured at three intervals: baseline (day 0), post-induction (day 7), and after treatment (day 14), using the Easy Touch GCU Multi-Function Monitoring System. The results demonstrated that all three fractions reduced uric acid levels, with the ethyl acetate fraction at 80 mg/kg body weight (BW) showing the most significant effect, achieving a 21.34% reduction. These findings suggest that Chromolaena odorata leaves, especially the ethyl acetate fraction, possess promising antihyperuricemic potential and could serve as a natural alternative for managing hyperuricemia.
Molecular Docking and ADMET Evaluation of Fluoro-Hydroxyxanthone Derivatives as Potential Estrogen Receptor Alpha Inhibitors Puspitasari, Anita Dwi
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14236

Abstract

Fluoro-hydroxyxanthone derivatives (X1–X10) were investigated as potential inhibitors of estrogen receptor alpha (ER-α) through molecular docking and in silico ADMET profiling. The docking protocol was validated through a redocking procedure, yielding a Root Mean Square Deviation (RMSD) of 0.81 Å, which confirmed the method's reliability.  Compounds X6–X10 demonstrated favorable binding affinities ranging from −7.32 to −7.46 kcal/mol, although these values remained lower than those of the native ligand, estradiol (−10.69 kcal/mol), and tamoxifen (−9.21 kcal/mol). These compounds formed key hydrogen bond interactions with Glu353 and Arg394, similar to estradiol, suggesting a correct binding orientation within the receptor's ligand-binding domain. Structural modifications, particularly the introduction of hydroxyl and fluoro substituents, contributed to the enhanced binding energies observed in these top-performing compounds. ADMET analysis further indicated that compounds X6–X10 complied with Lipinski's Rule of Five, had acceptable oral bioavailability, metabolic stability, and the ability to cross the blood–brain barrier. However, all derivatives were predicted to exhibit mutagenic potential and hepatotoxicity, which may limit their safety profiles. In conclusion, fluoro-hydroxyxanthone derivatives, especially X6–X10, represent promising molecular scaffolds for further optimization and development as potential anti-breast cancer agents targeting ER-α
Antibacterial Activity of Ethanol Extract of Red Ginger (Zingiber officinale Roscoe) Against Proteus mirabilis Arum Rafiqah, Jovita; Nuria, Maulita Cut
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14441

Abstract

Red ginger (Zingiber officinale Roscoe) has been extensively utilized in traditional medicine and is reported to possess a wide range of biological activities. Proteus mirabilis is a pathogenic bacterium that could cause Urinary Tract Infections (UTIs). Red ginger contains flavonoid compounds, phenolics, essential oils, and tannins that may contribute to its antibacterial properties. This study aimed to evaluate the differences in antibacterial activity of the ethanol extract of red ginger at various concentrations against Proteus mirabilis and to identify its phytochemical constituents. Red ginger simplicia was macerated using 96% ethanol and the macerate was evaporated with a rotary vacuum evaporator. Extracts were made in series concentrations of 20%, 40%, 60%, and 80% w/v for the antibacterial activity test. Ampicillin was used as a positive control, while dimethylsulfoxide was used as a negative control. Antibacterial activity was assessed based on the diameter of the inhibition zones, and the data were statistically analyzed using a one-way ANOVA test, followed by a post hoc Tukey test at a 95% confidence level. The results of this study showed that there were differences (p < 0.05) in the zone of inhibition values from all series of concentrations of the ethanol extract of red ginger against Proteus mirabilis. The extract was found to contain several classes of secondary metabolites, including terpenoids, alkaloids, phenolics, flavonoids, tannins, and saponins.
Antioxidant Activity of Facial Gel Moisturizer Formulation From Various Plants: A Literature Review mukti, adhitya ilham; karunia nining handaningrum; Rini rahmawati; Nina Salamah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12398

Abstract

Antioxidants are compounds that can neutralize free radicals, which can damage normal cells, fats, and proteins. Various methods, such as DPPH, ABTS, and FRAP, are used to evaluate the capacity of antioxidant compounds against reactive oxygen species (ROS). Skin ageing, caused by free radicals, pollution, and ultraviolet rays, can be mitigated by using antioxidants, one of which is found in cosmetic preparations such as moisturizers. This study aims to determine the antioxidant activity of various plant extracts in the formulation of a moisturizer gel. The method used is a literature review, with sources from the Google Scholar and PubMed databases, which includes articles from 2014 to 2024, resulting in 9 eligible articles out of 20 screened. The review result showed that plants such as star fruit leaf extract (Averrhoa bilimbi L.) and green tea leaf (Camellia sinensis) have potent antioxidant activity. Starfruit Wuluh (Averrhoa bilimbi L.) extracted with 70% ethanol had an IC50 value of 24.78 ppm, while green tea leaf extract (Camellia sinensis) with 70% ethanol showed an IC50 value of 5.62 ppm in the gel moisturizer preparation. A high IC50 indicates that the compound contains antioxidants that can protect the skin from free radicals, which are formulated into a moisturizing gel. In conclusion, star fruit leaf extract (Averrhoa bilimbi L.) and green tea leaf extract (Camellia sinensis) are highly effective ingredients in moisturiser gel products, as they provide significant antioxidant protection to the ski  
Efficacy of Sodium Hypochlorite (NaOCl) Against Gram Positive and Gram Negative Bacteria: A Systematic Literature Review Marlita, Jeli; Febriani, Yuyun; Fatmayanti, Baiq Risma; Ramadhan, Leny
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12508

Abstract

Sodium hypochlorite (NaOCl) is a chemical compound that acts as a strong oxidizer commonly used as an antibacterial, antiseptic, and disinfectant in various pharmaceutical and health applications. This systematic review aims to evaluate the antibacterial activity of NaOCl against various types of bacteria based on the PICO framework. Literature searches were conducted through the PubMed, ScienceDirect, and Scopus databases for publications from 2017 to 2024. Inclusion criteria included all types of bacteria, the use of NaOCl as an antibacterial or antimicrobial agent, and articles published within that time frame. The interventions reviewed were the use of NaOCl at various concentrations, while the control group referred to conditions without treatment or a comparative antibacterial agent. The results were determined based on antimicrobial activity against the bacteria tested. Two stages of independent literature searches were conducted according to the established inclusion and exclusion criteria. This review shows that NaOCl has significant antibacterial activity against various bacteria, with effectiveness depending on the concentration and characteristics of the target microorganisms.
Evaluation of Prescribing Patterns and Guideline Based on the Therapy Management of Ischemic Stroke Wardhani, Firdha; Kusumaningrum, Yunita Dyah
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.12690

Abstract

Stroke management requires a comprehensive approach to ensure that treatment addresses both the acute event and underlying comorbidities and risk factors. Adherence to clinical guidelines is essential to optimize outcomes in ischemic stroke patients. This cross-sectional study was conducted from January 2021 to January 2022 using medical record data. Based on sample size calculation, a minimum of 97 patients was required, and data from 111 patients were included. The majority were female (54.1%) with a mean age of 62.11 years. None of the patients received fibrinolytic therapy, although it is recommended as the first-line treatment for eligible ischemic stroke cases. Instead, all patients received antiplatelet therapy, predominantly clopidogrel (52.3%). The most commonly prescribed antihypertensive agent was an angiotensin receptor blocker (52.2%), while atorvastatin (43.2%) was the most frequent lipid-lowering agent. Overall, most prescribed therapies were consistent with guideline recommendations, although individualised considerations, such as delayed presentation, contraindications, and comorbidities, likely influenced therapeutic decisions.
Formulation of Spinach Leaf Extract (Amaranthus tricolor L.) Shampoo and Antifungal Activity Test Against Pityrosporum ovale Priamsari, Margareta Retno; Pinto, Marcia Angelica Vidigal Loi; Akbar, Nanda Dwi
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14276

Abstract

Red spinach leaves contain flavonoid, tannin, alkaloid, saponin and terpenoid that have potential as antifungal compounds. This research is  experimental. The purpose of this reserach is is to find out extract red spinach leaves can inhibit the growth of Pityrosporum ovale and to find out that red spinach leaf extract can be formulated in shampoo. Extraction was carried out using the remaceration method with 70% ethanol solvent and then tested for phytochemical content. Antifungal activity testing of red spinach leaf extract using concentrations of 15; 30; 45; 60 and 75% using the well method with PDA media incubated at 37 for 3x24 hours. The results showed the average inhibition zone activity against Pityrosporum ovale at a concentration of 75% of 19.17 mm statistically showed a significant difference. Formulation of shampoo preparations was carried out on red spinach leaf extract at a concentration of 15% with variations in the formula of Cocamide DEA and CMC-Na. The physical characteristics of the shampoo preparation include organoleeptic test, homogeneity, pH, viscosity, adhesion, spreadability and foam height. The results of testing the antifungal activity of shampoo preparations in formula 1 (17.5 mm); formula 2 (17.83 mm); and formula 3 (16.83 mm), based on statistical tests of antifungal shampoo preparations with a p-value (> 0.05) variations in the concentration of Cocamide DEA and CMC-Na have no significant effect on antifungal activity.
Antihypertensive Activity of Herbal Medicine (Jamu) X on Male Wistar Rats Induced with Monosodium Glutamate Damayanti, Kiki
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14335

Abstract

Jamu X, which is available in the market, has a simple composition consisting of noni fruit (Morinda citrifolia L.), celery herb (Apium graveolens L.), cat's whiskers leaves (Orthosiphon aristatus), pule bark (Alstoniae scholaris), meniran herb (Phyllanthus niruri), gotu kola herb (Centella asiatica), sembung leaves (Blumea balsamifera), plantain leaves (Plantago major), and andrographis herb (Andrographis paniculata). Jamu X is claimed to help lower blood pressure. All plants in jamu X contain flavonoids. This study aims to confirm the presence of flavonoids and prove the antihypertensive effect of jamu X on rats induced with monosodium glutamate (MSG). The presence of flavonoids was determined through test tube and thin-layer chromatography (TLC) tests. The research method employed is a randomised controlled group pretest and posttest design. Hypertensive mice were induced by administering MSG 100 mg/kg body weight/day orally for 14 days. The hypertensive rats were divided into five treatment groups: Group I rats (negative control) received CMC Na 0.5% 12.5 mL/kg body weight. Group II rats (positive control) received captopril at a dose of 2.5 mg/kg body weight/day. Group III, IV, and V rats were given jamu X at doses of 0.09, 0.18 capsules/kg body weight, once a day, and 0.18 capsules/kg body weight, twice a day, respectively. The test substance was administered orally for 14 days. The significance of the difference between systolic and diastolic blood pressure was tested using a paired t-test at a 95% confidence level. Jamu X was declared to have antihypertensive activity if there was a decrease and a significant difference in systolic and diastolic blood pressure before and after the administration of jamu X. Flavonoids were declared to be contained in jamu X. Based on the tests performed, jamu X showed antihypertensive activity at all doses.  
The Use of Dragon Fruit and Pineapple as Food and Traditional Medicine, and Their Potential as Food to Prevent Stunting Yumni, Gharsina Ghaisani; Ulfa Filliana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14941

Abstract

Many tropical countries, including Indonesia, grow dragon fruit (Hylocereus polyrhizus) and pineapple (Ananas comosus). Both of them have a lot of vitamins, minerals, bioactive compounds, and fiber in their diets. Flavonoids, phenolics, betalain pigments (from dragon fruit), and the enzyme bromelain (from pineapple) are some of the bioactive compounds that give these foods their antioxidant properties and possible health benefits. Studies show that eating pineapple and dragon fruit, as well as foods made from them, can raise antioxidant levels, reduce inflammation, fight bacteria, and protect against some degenerative diseases. People have eaten both fruits a lot in the past as fresh food, drinks, jams, and dodol. They have also been used in traditional medicine for digestive problems, inflammation, and the immune system. Dragon fruit and pineapple contain bioactive compounds and antioxidants that may support children's gut health and nutrition, as oxidative stress, chronic inflammation, and nutritional imbalances can all lead to stunting. In this literature review, we examine the chemical composition, antioxidant characteristics, and customary applications of dragon fruit and pineapple. We also look into how these fruits could be used as functional foods to help stop stunting.

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