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Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 37 Documents
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Search results for , issue "Vol 13, No 1 (2024)" : 37 Documents clear
Ethnobotanical Study of Medicinal Plants in South Sumatera, Indonesia Asiandu, Angga Puja; Sari, Widya
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.73-82

Abstract

South Sumatra, a province in Indonesia, is inhabited by several tribes. The geographical landscape surrounded by primary and secondary forests is a natural resource for the local communities in dealing with medical problems. They use plants as traditional medicine from generation to generation. The used parts include roots, stems, leaves, and sap that are biologically active to treat some diseases from moderate to deadly diseases. Based on literature studies, there are 250 plant species from 79 families processed by local communities in South Sumatra in some ethnobotanical activities. The dominant plant families are Fabaceae (5.6%), Asteraceae (4.8%), Euphorbiaceae (4.4%), Poaceae (4.4%), Myrtaceae (3.6%), Rubiaceae (3.6%), Rutaceae (3.6%), Solanaceae (3.6%), and Piperaceae (3.2%). Among many methods, boiling is the most common method in processing medicinal plants as it is considered more effective in extracting the bioactive compounds.
Antimicrobial Potential of Selected Phytochemicals from Hygrophila schulli; Computational Insights Perera, Pasindu Dilshan; Lawan, Haritha
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.205-214

Abstract

The escalating global concern over antibiotic resistance has led to an intensified exploration of alternative therapeutic strategies, including the utilization of plant-derived secondary metabolites. In this in-silico study, we investigated the structural inhibition of bacterial DNA Topoisomerase IV complex by major secondary metabolites extracted from the medicinal plant Hygrophila schulli. The plant is renowned for its rich phytochemical composition, possessing bioactive compounds with diverse pharmacological properties. Using computational approaches, we conducted molecular docking simulations to explore the binding affinities and interactions between the identified secondary metabolites from Hygrophila schulli and the target bacterial DNA Topoisomerase IV complex. Our results unveil promising interactions, suggesting a potential inhibitory effect on the targeted protein. Furthermore, molecular dynamics simulations were employed to examine the dynamic behavior of the ligand-protein complexes, providing insights into the stability and conformational changes over time. This in-silico exploration contributes valuable information to the understanding of the molecular interactions between plant-derived secondary metabolites and Bacterial DNA Topoisomerase IV, laying the groundwork for future experimental validations. The findings from this study may pave the way for the development of novel antimicrobial agents derived from natural sources, offering a sustainable and effective approach in the ongoing battle against antibiotic-resistant bacterial infections.
Potential of Methane (CH4), Nitrogen (N2), and Carbon Dioxide (CO2) from Eco-Enzyme with the Addition of Cow Feces Starter Kamelia, Marlina; Ulmillah, Aulia; Pawhestri, Suci Wulan
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.35-42

Abstract

Eco-enzyme solutions are generally used in the manufacture of disinfectants, floor cleaners, liquid fertilizers, preservatives and others. In this study, eco-enzyme was used as the main ingredient in the manufacture of biogas fermentation with the addition of cow feces as an additional starter in the fermentation. The aim of this study was to determine the content of CH4, CO2, N2, pH, temperature, and pressure in eco-enzyme fermentation with the addition of cow feces starter.  his research is a quantitative research with the type of experimental research as well as direct observation data collection techniques and data analysis techniques using descriptive statistical analysis. The results showed that the treatment that produced the highest methane (CH4) gas was the P5 treatment with a concentration of 2.889%. 6,1. The highest volume pressure value was produced in the P5 treatment which was 70 ml. Nitrogen gas (N2) and carbon dioxide gas (CO2), the concentration of nitrogen gas (N2) from reactor P0 - P4 is in the range of 95.875-99.669 % and the concentration of carbon dioxide (CO2) from reactor P0 - P4 is in the range of 0.237 - 4.125 %.
Physical Characteristics of Immobilized Cells Acetobacter xylinum of Various Concentrations of Na-alginate Indraningtyas, Lathifa; Kustyawati, Maria Erna; Fitriah, Nafiatul
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.165-172

Abstract

Immobilization of Acetobacter xylinum cells by trapping technique is considered one way to maintain cell viability and can be used repeatedly. The purpose of this study was to determine the physical characteristics of immobilized cells in different concentrations of Na-alginate and apply them to the manufacture of nata de coco, as well as to see the surface and pore shape of immobilized cells after fermentation. This study used a descriptive method with visual observation. This study used one factor, namely various concentrations of Na-alginate, namely 2%, 3%, 4%, and 5% w/v. The immobilized cells applied to the manufacture of nata de coco had only a Na-alginate concentration of 3% resulting in a nata fiber layer close to that of a control. Immobilized cells with a Na-alginate concentration of 2% have a cracked, slightly pore surface with a size of 60.37 μm, while a Na-alginate concentration of 5%, have a smooth surface, many pores, with a size of 10.55 μm. Thus, the concentration affects the characteristics of immobilized cells. Application of immobilized cells with a Na-alginate concentration of 3% produces nata de coco with a fairly thick and stable fiber layer characteristic (close to control).
b-Glucan Comparison in the Mushrooms of Medicinal Fungal Species Totowiputro, Dicky Kurniawan; Sargowo, Djanggan; Tjokroprawiro, Askandar; Rifa'i, Muhaimin
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.285-289

Abstract

Agaricus blazei Murill has been known as a mushroom with medicinal properties, such as its efficacy in maintaining the immune system and other metabolic processes. The main polysaccharide found in A. blazei, is b-glucan. This study aims to quantify and compare b-glucan content in A. blazei compared with the medicinal mushrooms Ganoderma sp. and Pleurotus ostreatus. ?-glucan was extracted from each species using an alkaloid extraction method. The b-glucan content was determined using UV-Vis Spectrophotometer at a wavelength of 220 nm. The data showed that A. blazei contained the highest level of b-glucan, 6.99% (w/w), while the other mushrooms contained less than 2 %. This study obtained that A. blazei contain high levels of b-glucan compared with Ganoderma sp. and Pleurotus ostreatus. Thus, A. blazei has the potential as medicine, especially to maintain the balance of the immune system. To keep the body healthy and balance immune system patient can consume Agaricus blazei Muril.
Evaluation and Antibacterial Activity Test of Peel-off Mask Preparation from Combination of Pegagan Leaves (Centella asiatica (L) Urb.) and Charcoal Powder Utari, Fadhilla Dwi; Hilaliyati, Najmi; Afriani, Tika
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.127-133

Abstract

Pegagan leaf (Centella asiatica (L) Urb.) is a plant that contains flavonoids, tannins, triterpenoids, and saponins that function as antibacterials. Pegagan leaf is combined with activated charcoal powder, which has the job of absorbing facial oil, so that it is formulated in the form of a peel off mask to produce a synergistic effect. This study aims to formulate, evaluate, and test the antibacterial effectiveness of the peel-off mask preparation of pegagan leaf extract at concentrations of 1.5%, 2%, and 2.5%. This study uses an experimental method by testing the parameters of the physical evaluation requirements and testing antibacterial activity with the disc method on the peel off mask preparation. The results were evaluated for 28 days, and the results of the organoleptic test were stable, homogeneity stable, pH (5.6–6.2), dry time (16–25 minutes), dispersion (6.1-6.4 cm), and irritation (2 respondents). The effectiveness test against the bacteria Propionibacterium acnes has inhibitory power of 12.3 mm in the strong category. So, it can be concluded that the peel off mask produced has stable physical characteristics and can be used as an antibacterial mask.
The Effect of Use of Local Organic Microorganism Fertilizers on Rice Media, Banana Sticks, And Tongol Fish on The Growth of Arabika Coffee Plants (Coffea arabica L.) in The Gunung Karang Garden, Pandeglang District Suyamto, Suyamto; Hujaji, M.; Susilo, Hadi; Oktavia, Swastika; Mu'jijah, Mu'jijah
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.251-258

Abstract

Arabica coffee plants (Coffea arabica L.) are plantation commodities with high economic value. Efforts that can be made in farming without using chemicals that will damage the environment is by utilizing local microorganisms (MOL). For farmers who demand the use of cheap and practical fertilizers, they can be directed to use local microorganism organic fertilizers made from rice, banana stems, and tuna. This study aims to determine the effect of using local microorganism organic fertilizers made from rice, banana stems, and tuna on the growth of C. arabica plants. The type of research to be carried out is experimental research. This research method uses a Completely Randomized Factorial Design (CRFD) consisting of 2 factors and 3 replications. The first factor is the source material consisting of 3 levels, namely: M1 = stale rice, M2 = banana stem, and M3 = tuna. The second factor is the fermentation period consisting of: H1 = 2 weeks fermentation and H2 = 4 weeks fermentation. The measured parameters of C. arabica plants are height, number of leaves, and stem diameter. The results showed that rice, banana stem, and tuna can be made into MOL fertilizers. The use of MOL organic fertilizers (stale rice, banana stem, and tuna) affects the growth of C. arabica, which can be seen from the parameters of plant height, number of leaves, and stem diameter. M3H2 MOL organic fertilizer (tuna fermented for 4 weeks) provides optimal growth of C. arabica in terms of plant height, number of leaves, and stem diameter.
Analysis of Heavy Metal Cadmium (Cd) and Lead (Pb) in Eggplant (Solanum melongena L.) in Pontianak City by Using Atomic Absorption Spectrophotometry (AAS) Nugraha, Fajar; Oktaviani, Syila Malinda; Luliana, Sri
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.83-90

Abstract

In Indonesia, eggplant is a favored vegetable with substantial production. The main objective of this study is to investigate the level of safety of eggplants marketed in traditional wholesale markets in Pontianak City against possible contamination of the heavy metals cadmium (Cd) and lead (Pb), which are commonly discovered in water waste, vehicle exhaust, and excessive pesticide and fertilizer use. Alizarin Red S for Cd metal and Dithizon for Pb metal were used in qualitative assays. Cd and Pb levels were measures using an Atomic Absorption Spechtrophotometer (AAS) instrument. The analytical method has been verified for linearity, accuracy, precision, limit of detection, and limit of quantification. The qualitative test results showed that all samples had positive results for Cd and Pb. The quantitative test results revealed that the Cd and Pb metal contents in the FB (Flamboyan) sample were 0.056 mg/kg and 3.5066 mg/kg, consequently, while they were 0.0986 mg/kg and 3.957 mg/kg, consequently, in the PR (Puring) sample. In keeping with BPOM standard No. 5 of 2018, Cd metal levels in FB samples are at a safe threshold, while Cd metal levels in PR samples and Pb metal levels in FB and PR samples exceed the maximum thresholds that have been set.
Levels of Oxidative Stress in Rats Treated with Calorie Restrictive Treatment and 50% Sucrose Solution Mukhtar, Diniwati; Amsaka, Azha Azzuna; Pd, Fanny Ratnasari; Royhan, Aan; Ridwan, Karina Ajeng
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.215-220

Abstract

This study aims to analyze the level of stress oxidative with treatment calorie restrictions and administration of sucrose solution. This study was a laboratory experimental study with 12 male white rats (Wistar strain) as subjects for caloric restrictive treatment and 12 rats for 50% sucrose solution. Where each group of rats is determined by the dependent and independent variables. Using the pre-posttest control design, the dependent variable of caloric restriction, and the independent variable malondialdehyde. The dependent variables used were body weight using a scale, fasting blood glucose using a glucometer, and MDA using a UV-Vis spectrophotometer. The independent variable used was the administration of 50% sucrose solution. The data were statistically analyzed by T-test analysis. There was no significant decrease in MDA levels in the caloric restriction treatment rats (p = 0.060), besides that there was a significant difference in body weight in both the control and sucrose groups (p <0.05). There was no significant difference in fasting blood sugar in the control group (p > 0.05) and there was a significant difference in the sucrose group (p < 0.05). There was no significant difference in serum MDA levels in either the control or sucrose groups (p > 0.05). There is an effect of calorie restriction on MDA levels. Also, administration of 50% sucrose solution for 4 weeks had a significant effect on the rats' body weight and blood glucose but did not have a significant effect on serum MDA levels.
Therapeutic Azithromycin Mitigated Monosodium Glutamate-Related Dysfunction in Rats’ Body Weight and Serum, Liver, Kidney and Heart Antioxidant Defense Bioindicators Egbuonu, Anthony Cemaluk Chinedum; Alaebo, Prince Ogochukwu; Onuoha, Udumma Nsofor; Njoku, Chinomso Juliet; Eze, Obioma Benedeth; Odoemelam, Francisca Ugochi; Edum, Michael Eberechukwu; Obi, Ojichukwu Boniface; Ukaegbu, Mmesoma Joy; Nwaogwugwu, Sandra Uchechi; Orji, Marvellous Chinonso; Ndukwe, Clara Ngozika; Opara, Prosper; Oyoyo, Chinagorom; Joe-Eme, Chika Blessing; Okwoigwe, Cheluchiaka Jecinta
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.43-50

Abstract

Monosodium glutamate (MSG) mediates body weight gain (BWG) and oxidative stress. Azithromycin (AZT), may be abused and co-consumed with MSG to present unknown outcomes on BWG and oxidative stress. This study evaluated the effect of AZT and MSG in rats’ BWG and antioxidant bioindicators. Thirty rats assigned to five groups were orally exposed for seven consecutive days to groups A, control (distilled water, 1 ml/kg), B, MSG (MSG 8000 mg/kg), C, therapeutic AZT, TAZ (AZT 82.5 mg/kg), D, overdose AZT, OAZ (AZT 412.5 mg/kg) and E, TAZ + MSG (AZT 82.5 mg/kg + MSG 8000 mg/kg). MSG-treated rats exhibited a significantly (p < 0.05) increased BWG; serum, liver, kidney and heart reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and malondialdehyde (MDA) but decreased catalase (CAT) and zinc (Zn) levels compared to control. Co-treated TAZ + MSG rats significantly (p < 0.05) decreased BWG, GSH, GPX, SOD, Zn; increased CAT and non-significantly (p > 0.05) decreased MDA compared to MSG and control. Thus, TAZ significantly mitigated BWG, and malfunction in the metabolism of antioxidant defense bioindicators in MSG rats via probable anorexigenic, anti-inflammatory and antioxidant responses. This suggests that TAZ could be useful in managing MSG-related dysfunction in BWG and metabolic activity of the antioxidant defense apparatus in rats.

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