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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 345 Documents
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Front Matters Vol 16 No 2 (2019) Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9785

Abstract

Penetapan Kadar Flavonoid Total Ekstrak Buah Gambas (Luffa acutangula(L.) Roxb.) dengan Metode Spektrofotometri UV-Vis Suharyanto Suharyanto; Tutik Nur Hayati
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 1 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i01.10916

Abstract

Gambas or Oyong fruit has various benefits, namely it can overcome enlarged lymph nodes, diuretics, laxatives, antioxidants, hepatoprotective, inhibiting the growth of fungi and bacteria. The purpose of this study was to determine the levels of total flavonoid compounds in gambas (Luffa acutangula (L.) Roxb). Extraction methode using soxhletation with 96% ethanol as solvent. The extract obtained was used for qualitative and quantitative analysis. Phytochemical analysis of the flavonoid content in the sample using the Shinoda test, 10% NaOH solution, and concentrated H2SO4 solution, obtained positive results containing flavonoids. Quantitative analysis using UV-Vis Spectrophotometry with the maximum wavelength obtained is 429.5 nm and operating time is 30 minutes. The average total flavonoid content obtained was 9.897±0.11 mg/gram extract with %KV 1.14%.
Formulasi dan Karakterisasi Sediaan Nanoemulgel Serbuk Lidah Buaya (Aloe Vera L.) Teguh Imanto; Roseh Prasetiawan; Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 1 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i1.8114

Abstract

Aloe vera L. contains antiseptic saponins and anthraquinone complexes as antibacterial. This research was conducted to formulate aloe vera powder into nanoemulgel, characterize and test its physical properties, and to know the effect of gelling agent concentration (carbopol and chitosan) on nanoemulgel. Emulsion type used is oil in water (O / W) with surfactant tween 80 and co-surfactant propylene glycol. Nanoemulsion is characterized by percent of transmittance with UV-Vis spectrophotometer, also potential droplet and zeta size distribution with Particle Size Analyzer. Hydrogels consist of 4 combination formulas of carbopol 0.5%; 1%; 1.5%; 2% and 0.3% chitosan. The formula is tested for physical properties including organoleptic, pH, spreadability, adhesion, viscosity and stability with freeze thaw method. The results showed that the nanoemulsion droplet size was 65.05nm ± 13.49 with zeta potential of -0.1mV and the percent of transmittance above 98%. The result of physical properties of the four formulas shows that the different gelling agent concentration gives different physical properties of viscosity and spreadability. Overall, formula 3 has the best physical properties and physical stability compared to formula 1, 2 and 4.
Faktor-Faktor yang Mempengaruhi Kepatuhan Pengobatan pada Pasien Diabetes Mellitus Rawat Jalan di RSUD Sukoharjo Tri Yulianti; Lusi Anggraini
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 2 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i2.12261

Abstract

Diabetes mellitus is a chronic metabolic with high prevalence and it can increase the risk of the complications, if it not handled properly. Medication adherence is one of the determining factor to achive therapeutic outcome. This research aims to determine the affecting factors of adherence in  diabetes mellitus type 2 outpatient at RSUD Sukoharjo in 2020. This research type is  cross sectional with a purposive sampling technique. A total of 85 patients diabetes mellitus type 2 outpatient at RSUD Sukoharjo with inclusion criteria received OAD therapy (Oral Antidiabetic Drugs) or a combination of OAD with insulin for at least 1 month, recruited in this study. The data was collected from medical records and questionnaires. Adherence was measured by using the MARS 5 questionnaire (Medication Adherence Report Scale 5). Factors contributing to medication adherence was analyzed by using chi-square test. The results showed that 37 respondents (43.5%) were obedient. The significant factors of medication adherence are monthly income (p-value = 0.018 and OR = 2.887), Medication (p - value = 0.007 and OR = 3,551), the frequency of treatment (p-value = 0.006 and OR = 3,529) and blood glucose level (p-value = 0.006 and OR = 3,529).
Optimasi Konsentrasi Amylum Sagu (Metroxylon rumphii) sebagai Co-Processed pada Pembuatan Tablet Teofilin Nor Laili; Annisa' Meyndra Komala; Hidayaturrizqika Maulida; Suprapto Suprapto
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 2 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i2.6422

Abstract

Tablet preparations are widely used many people for treatment, so the level of production of tablet preparations is quite large and always develops in its formulation. Excipients are generally used in the form of 95% imported materials which are relatively expensive so that production costs will affect the price of tablet preparations which will be more expensive. Based on these considerations, this study uses Indonesian natural excipient with a relatively low cost in the form of sago amylum. This study combines sago amylum and Avicel pH 101 with 5 concentration variations, 90%: 10% (formula 1), 80%: 20% (formula 2), 70%: 30% (formula 3), 60%: 40% (formula 4), and 50%: 50% (formula 5) which produces a co-processed excipient. This co-processed was applied in the manufacture of the Theophylline tablet as a filler, binder and shredder with the direct compression method and tested based on parameters in the Indonesian Pharmacopoeia V. Data analysis using Design Expert® version 11 software to obtain the optimum formula. The co-processed characterization produced has optimum flow properties which are 11.11 g / sec, compressibility = 3.0%, and the stationary angle = 32.0 ° and evaluation of tablet quality uniformity CV = 10.3, hardness x̅ = 6 , 2 kg, fragility = 1.8%, and 46.2 seconds destroyed time. Based on the analysis by Simplex Lattice Design method, it is proved that the more amylum sago concentration increases friability and decreases hardness, while more of Avicel pH 101 decreases friability  and increases hardness. It is concluded with the Design Expert software analysis, the optimum co-processed formula was obtained in the form of a combination of 50% sago amylum; 18,18% pasta amylum sago and 31.82% Avicel pH 101.
Pandangan Konsumen Ibu PKK di Semarang terhadap Kehadiran Apoteker dalam Pelayanan Kefarmasian di Apotek Rosid Sujono; Farrah Bintang Sabiti
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PID IAI
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.10109

Abstract

The existence of pharmacies is needed by the community, considering the higher number of morbidity which has an impact on the need for drugs. These phenomena make the pharmacists have to continue to exist and the community continues to visit and receive pharmaceutical services. The aim of this study was to describe the views and expectations of consumers towards the presence of Pharmacists in pharmacy services in Semarang. The descriptive survey research involved respondents from PKK with age of 40 - 60 years, who could read and write, consumers had visited the Pharmacy to redeem prescriptions or bought medicine and without distinguishing the respondent from the first time or the customer often visited the Pharmacy. The study was conducted in the city of Semarang with a total of 55 respondents. The results showed that almost all respondents (94.5%) visited the Pharmacy more than three times a month, with the biggest goal being to redeem recipes for children or families by 92.7%. Consumers’ views on the presence of mandatory pharmacists in pharmacies are 94.5% and pharmacists' expectation of providing pharmaceutical services 67.2%. Consumer expectations for the presence of pharmacists in pharmacies are 92.7%, expectation of meeting Pharmacists at 70.9%. Consumer experience about pharmaceutical services in the form of information on drug use amounts to (80%), side effects (65.4%) as well as how to store and dispose of drugs (52.7%.). Consumers expect the presence and can meet the Pharmacist at the Pharmacy so that they will get direct services in the form of consultation and counseling about drugs by the Pharmacist.
KORELASI KANDUNGAN FENOLIK DAN AKTIVITAS ANTIRADIKAL EKSTRAK ETANOL DAUN EMPAT TANAMAN OBAT INDONESIA (Piper bettle, Sauropus androgynus, Averrhoa bilimbi, dan Guazuma ulmifolia) Ika Trisharyanti Dian Kusumowati
Pharmacon: Jurnal Farmasi Indonesia Vol 13, No 1 (2012)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v13i1.19

Abstract

Fenolik merupakan senyawa yang memiliki kemampuan untuk merubah atau mereduksi radikal bebas. Penelitian ini dilakukan untuk melihat korelasi antara kadar fenolik total terhadap aktivitas penangkap radikal ekstrak etanol daun Piper betle (Sirih), Sauropus androgynus (Katuk), Averrhoa bilimbi (Belimbing Wuluh), dan Guazuma ulmifolia (Jati belanda). Penentuan aktivitas antiradikal dilakukan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil) terhadap ekstrak etanol daun keempat spesies. Absorbansi dibaca pada λ 517,6 nm pada waktu 30 menit. Penelitian dilanjutkan dengan penetapan kadar fenolik total dengan metode Follin Ciocalteu yang dinyatakan dalam Gallic Acid Equivalent. Hasil penelitian menunjukkan bahwa ekstrak etanol daun Sirih (IC50 = 22,067 µg/mL; GAE = 210,11 mg/g sampel) mempunyai aktivitas antiradikal lebih besar dibandingkan ekstrak etanol daun Jati Belanda (IC50 = 126,29 µg/mL; GAE = 95,465 mg/g sampel), ekstrak etanol daun Belimbing Wuluh (IC50 = 112,82 µg/mL; GAE = 64,84 mg/g sampel), dan ekstrak etanol daun Katuk (IC50 = 310,82 µg/mL; GAE = 42,79 mg/g sampel). Koefisien korelasi dari persamaan regresi linier antara IC50 dan kadar fenolik total dalam GAE menunjukkan 64,9% aktivitas antiradikal ekstrak disumbangkan oleh kandungan fenolik totalnya. Kata kunci: Piper betle, Sauropus androgynus, Averrhoa bilimbi, Guazuma ulmifolia, antiradikal, fenolik, DPPH.
Willingness to Pay Pelayanan Konseling Apoteker di Apotek di Kecamatan Polokarto Tahun 2016 Mariska Sri Harlianti; Tri Murti Andayani; Diah Ayu Puspandari
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 1 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i1.7247

Abstract

Counseling is one part of the clinical pharmacy service at the pharmacy that is the responsibility of the pharmacist to achieve therapeutic goal. Community needs for counseling have increased so that the active participation of pharmacists is needed through the provision of professional services. This research needs to be done to find out the amount of counseling services by pharmacists who are willing to be paid by patients with a WTP (Willingness to Pay) value parameter. In addition, the value of WTP can also describe the indirect benefits felt by the community towards counseling services by pharmacists at the pharmacy. This research is a descriptive observational research through a survey. The study was conducted at the pharmacy in the Polokarto sub-district of Sukoharjo regency in January – February 2016 with pharmacy visitor respondents who received counseling services by pharmacists. A total of 82 patients participated in this study. The amount of WTP is determined based on the average WTP value chosen by the patients with the payment card method. The result showed that the average WTP value of pharmacist counseling services at pharmacies in Sukoharjo regency was Rp. 15,892. 
Aktivitas Sitotoksik Ekstrak Heksan, Ekstrak Etil Asetat, Ekstrak Etanol Buah Mengkudu (Morinda citrifolia L ) Terhadap Sel T47D Maryati Maryati; Ahmad Novian Nur Anas; Muhammad Nur Khairudin
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10761

Abstract

Noni fruit (Morinda citrifolia L) is one of the natural ingredients commonly used as traditional medicine to overcome various diseases, such as cancer. Noni fruit contains anthraquinone and coumarin which have anticancer effects. This study aims to determine the cytotoxic effects of n-hexane, ethyl acetate and ethanol extract of noni fruit and to determine the presence of anthraquinone and coumarin in the extract. Extraction was carried out by maceration method using n-hexane, followed by ethyl acetate and ethanol. The cytotoxic activity on T47D cells was carried out by the MTT method. The presence of anthraquinone and coumarin was identified using thin layer chromatography (TLC). Results showed that n-hexane extract had moderate cytotoxic effect on T47D cells with IC50 value of 582.13 ± 61.64 µg/mL, while the ethanol and ethyl acetate extract did not have cytotoxic effect on T47D cells. TLC results indicated that n-hexane extract of noni fruit contains anthraquinone and coumarin.
DOCKING KURKUMIN DAN SENYAWA ANALOGNYA PADA RESEPTOR PROGESTERON: STUDI INTERAKSINYA SEBAGAI Selective Progesterone Receptor Modulators (SPRMs) Edy Meiyanto
Pharmacon: Jurnal Farmasi Indonesia Vol 13, No 2 (2012)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v13i2.10

Abstract

Kurkumin merupakan suatu kandungan dari Curcuma longa L.,yang telah dibuktikan efek sitotoksiknya secara in vitro terhadap sel kanker payudara. Senyawa analog kurkumin: PGV-0, PGV-1, HGV-0, dan HGV-1, hasil modifikasi dari kurkumin, diperkirakan memiliki aksi yang sama. Penelitian ini bertujuan untuk mengetahui afinitas dan interaksi dari kurkumin dan analognya sebagai Selective Progesterone Receptor Modulators (SPRMs) dalam mengadakan inhibisi kompetitif dengan hormon progesteron. Optimasi geometri struktur kurkumin dan analognya dilakukan dengan software Hyperchem 7.5. Konformasi optimum PGV-0 dan PGV-1 dihasilkan melalui metode AM1 sedangkan kurkumin, HGV-0, dan HGV-1 dengan metode PM3. Kemudian dilakukan proses docking senyawa uji dengan bindingsite hormon progesteron pada reseptor progesteron (IA28) menggunakan software Arguslab 4.01, dalam kondisi ada dan tanpa air. Proses ini dilakukan dengan metode GAdock. Dari proses docking diperoleh nilai (Gibbs free energy)DG terendah pada senyawa kurkumin bentuk keto baik dengan maupun tanpa air. Afinitas terbesar turunan kurkumin ditunjukkan oleh PGV-1 pada keadaan ada air dan  HGV-1 tanpa air pada reseptor progesteron. 'font-family: "Arial","sans-serif";mso-ansi-language:IN'Kata kunci: kurkumin dan analognya, SPRMs, docking, reseptor  progesteron IA28 -language:IN'Antiradikal, DPPH, IC50, fenolik total, Elephantopus schaber L., Ocimum basilicum L.forma citratum Back., Graptophylum pictum Griff, Gynura procumbens Merr. 

Page 26 of 35 | Total Record : 345

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