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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 345 Documents
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Efektivitas Agen Pendeplesi GSH pada Sitotoksisitas Cisplatin terhadap Sel Kanker: Systematic Literature Review Elisa Tri Oktaviyana; Wahyu Utami
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.16254

Abstract

Cisplatin is one of chemotherapy agent for long cancer, ovarium cancer, gastric cancer, breast cancer, head-neck cancer. However, in the fact, the role of cisplatin does not always provide an optimal effect because it often appears cancer cell resistance phenomenon to cisplatin. This resistance condition occurs partly due to the inactive metabolite cause of conjugation reaction between cisplatin and GSH in cancer cells. Therefore, gluthathione (GSH) has an important role in controlling cisplatin resistance. This study aims to analyze some combination of cisplatin and the depletion agent of gluthathione (GSH) as a support for cisplatin activity in several types of cancer cells within in vitro scope. This study is prepared using systematic literature review method. Library search were carried out on two accredited international journals databases, namely PubMed and Science Direct with interval years of publication in 2011-2020. From 10 selected journals, it was shown that the use of GSH depletion agents could enhance the cytotoxic effect of cisplatin. This was analyzed based on data of the number measured GSH cells and the number of living cells (% cell viability) which gave a significant decrease. The result of research are expected to be able to provide information for the development of therapeutic agents on cisplatin as chemotherapy.
Validasi Metode Analisis Matriks Patch Domperidon Maleat dengan Perbedaan Polimer Menggunakan Spektorfotometri UV-Vis Shesanthi Citrariana; Oktavia Indrati; Puspa Dwi Pratiwi; Ita Nurma Sari; Ari Wibowo
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.14576

Abstract

Uv-Vis spectrophotometry is an analytical method that can be used to determine the levels of domperidon maleate contained in transdermal patches with different polymers. The analysis method needs to be validated to prove that it can provide measurement results that match its designation. The purpose of this study is to prove that uv-vis spectrophotometry methods can provide the specificity, linearity, thoroughness, and precision that meet the requirements. In this study, linearity was known by calculating the r value on the curve of the relationship between levels and absorbance. Precision is obtained based on rsd value. Accuracy is calculated based on the return value. Selectiveity is known by means of identity confirmation that calculates the absorbance ratio at different wavelengths. The results showed that the method meets the requirements with a value of r=0.999; RSD precision results at a level of 10 ppm obtained RSD 0.236%. The accuracy values of 80%, 100%, and 120% in the matrix of transdermal domperidon maleate patches with PVA and PVP polymers respectively recovery was 99.50%, 101.15%, and 99.13%.. In the matrix of transdermal patches domperidon maleate with polymers HPMC and Na-CMC respectively recovery was 100.91%, 100.31%, and 100.67%. In the matrix of transdermal domperidon patches with HPMC and EC polymers respectively recovery was 98.00%, 98.00%, and 99.00%. The identity confirmation results on the transdermal domperidon patch matrix with PVA and PVP polymers, HPMC and Na-CMC, as well as HPMC and EC respectively have ratio value close to the standard solution with an average value of 0.800; 0,806; and 0.808. It can be concluded that the method of analyzing the levels of domperidone maleate in matrix of transdermal patches has qualified for good validity.
Evaluasi Ketepatan Antibiotik pada Pasien Sepsis Ambar Yunita Nugraheni; Mahyastuty Shintya Putri; Adi Yusron Saputro
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.16635

Abstract

The administration of early intravenous antibiotics was one of the fundamental procedures in sepsis. Inappropriate of antibiotics in septic patients has an impact on mortality and prolongs treatment. The purpose of this study was to evaluate the appropriateness of antibiotics therapy in hospitalized sepsis patients in Central Java based on the parameters right indication, right patient, right drug, and the right dose. This study was observational. Data collected retrospectively and analyzed descriptively. Sampling was done by purposive sampling. The inclusion criteria were inpatients diagnosed with sepsis who received antibiotics therapy with complete medical record data. The exclusion criteria were patients who died of sepsis. Antibiotics analyzed using the DIH 25th edition 2016, IONI 2014, Tata Laksana Sepsis Pada Anak IDAI 2016, Neofax 2014, Kepmenkes PNPK Tata Laksana Sepsis 2017, PPK RS, and SHC Antimicrobial Dosing 2017. Based on data from 108 patients who fulfilled the inclusion criteria obtained results right indication 100%, right patient 97.22%, right drug 90.74%, and the right dose 48.15%. The most used antibiotic was a combination of ampicillin and gentamicin (41.67%), while the single antibiotic was ceftriaxone (12.96%).
Aktivitas Antiinflamasi Ekstrak Etanol Echinometra mathaei pada Tikus Putih Jantan dengan Induksi Karaginan Angelica Kresnamurti; Hardiyono Hardiyono; Febriana Siswulandari; Iwan Sahrial Hamid
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.15021

Abstract

Sea urchin (Echinometra mathaei) is one of the marine biota that contains high flavonoid and phenolic compounds that are potent as anti-inflammatory and antioxidant. This study aimed to measure the anti-inflammatory activity of the 70% ethanol extract of sea urchins in male white rats induced by carrageenan. Anti-inflammatory activity test using 5 groups of rats selected randomly, each group consists of 5 rats. Negative control group, positive control group, and 3 groups of extracts (doses of 100, 200, and 400mg/kgBW). Each group was induced using 1% carrageenan subplantarly and the volume of edema was measured using a mercury plethysmometer every 30 minutes for 3 hours. The data were statistically analyzed using one-way Anova. The results showed that the percentage of inflammatory inhibition in the positive control group, and the Echinometra mathaei ethanol extract group (dose of 100, 200, and 400 mg/KgBW) showed a significant difference (P0.05) with the negative control group with a percentage value of Inflammation inhibition was 61.11%, 85.19%, 85.19%, and 74.07%, respectively. The administration of sea urchin ethanol extract at all doses had a higher percentage of anti-inflammatory than diclofenac sodium, but increasing the extract dose did not significant increase inflammatory inhibition. This research concluded that 70% ethanol extract of Echinometra mathaei at doses of 100, 200, 400 mg/KgBW has strong anti-inflammatory activity potential.
Kajian Penggunaan Antibiotik pada Pasien Meningitis dan Ensefalitis Bakteri di Bangsal Rawat Inap Rumah Sakit Rujukan Utama Diyan Ajeng Rossetyowati; Ika Puspitasari; Tri Murti Andayani; Titik Nuryastuti
Pharmacon: Jurnal Farmasi Indonesia Vol 18, No 2 (2021)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v18i2.16861

Abstract

Inadequate antibiotic therapy for meningitis and bacterial encephalitis is one of the factors that can jeopardize patient safety and turn into a public health issue in a number of nations, including Indonesia. This phenomena has the potential to raise health-care expenses, which should be avoided in the era of the JKN program's implementation. The goal of this research was to describe the profile of antibiotic use and cost in hospitalized meningitis and bacterial encephalitis patients. This cross-sectional observational study took place from January to December 2019. As study materials, patient medical records and billing data were employed. To enhance the data obtained, confirmation with medical and pharmaceutical personnel is required. Antibiotic use and expenditures were described using descriptive analysis. A total of 71 patients, both children and adults, met the study's inclusion criteria. Antibiotics were given to all of the patients, and the results revealed that third generation cephalosporins (49.375%) were the most commonly recommended antibiotic class, either alone or in combination. Antibiotic use receives 46.94% of total medication funding. According to the length of stay category, the majority of patients (45.99 %) were hospitalized for 8-14 days consecutively with antibiotic medication. Antibiotics, which are typically administered to patients with meningitis and bacterial encephalitis, had no effect on the length of stay in the hospital. Antibiotic prescriptions must be carefully reviewed at top referrel hospital, taking into account the local germ map.
Front Matters Vol.19, No 1, 2022 Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18988

Abstract

Analisis Prevalensi dan Faktor-Faktor yang Mempengaruhi Swamedikasi Sebelum dan Selama Pandemi COVID-19: Studi pada Mahasiswa Kesehatan di Jawa Tengah Indriyati Hadi Sulistyaningrum; Arifin Santoso; Fildza Huwaina Fathnin; Dian Mila Fatmawati
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.17699

Abstract

Self-medication is defined as an attempt to treat using medicines purchased at pharmacies or drug stores without a doctor's prescription. There is currently a public health emergency due to the emergence of COVID-19. This study aimed to assess the prevalence of self-medication before and during the COVID-19 pandemic among health students in Central Java and its associated factors. This cross-sectional  survey  involved 384 respondents with teknik snowball sampling using an online questionnaire  that had been tested for validity and reliability. The data were analyzed with descriptive and inferential statistics, namely bivariate analysis and multivariate analysis. Bivariate analysis with Chi square and Wilcoxon to compare sociodemographic characteristics with self-medicating before and during the pandemic. Furthermore, multivariate analysis was carried out using logistic regression to see the factors that most influenced individual desires to self-medicate (p0.05). Based on the analysis, the results showed that the prevalence of self-medicating among health students in Central Java has increased from before the pandemic (58.6%) to (78.6%) during the pandemic. Self-medication was mostly done by women (84.4%), aged 18-40 years (99.2%). Places to buy drugs at pharmacies (91%) and considerations in choosing drugs by looking at drug brands (52%). Another factor of respondents doing self-medication is due to previous experience using similar drugs (49%), the factor of information sources from the internet (46%). The results of the study concluded that there were differences between age, gender, level of education, understanding of self-medication, experiencing pain in the last 3 months, physical activity and suggestions from others affecting individual desires for self-medication before and during the COVID-19 pandemic. Furthermore, it is necessary to conduct education and monitoring related to self-medication carried out by students so that the treatment carried out is appropriate and rational.
Development of Prasman Leaf Suspension in Combination With Pulvis Gummi Arabici and Hydroxyethylcellulose Using Simplex Lattice Design Method Dina Salwa Atiqi; Slamet Slamet; Wirasti Wirasti; Dwi Bagus Pambudi
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.15565

Abstract

Suspending agents affect the viscosity, storage, and re-dispersal of suspension preparations. This study aims to optimize the combination of suspending agent PGA and hydroxyethylcellulose to obtain the optimum suspension preparation. This suspension formulation uses a computer program design expert version 11 using the Simplex Lattice Design (SLD) method with 2 suspending agents, namely PGA and hydroxyethylcellulose. This SLD method produces 8 formulas. The parameters of these eight formulas were measured including their physical properties, such as organoleptic, pH, viscosity, sedimentation volume, and redispersibility of the preparation. Data were analyzed and produced a graphic equation of each response that gave the optimum suspension formulation. The formula I showed optimal parameters, i.e. physical stability, organoleptic stability, the pH of 5, the viscosity value of 59 cP, 0.04 mL sedimentation, and 95% redispersibility value with the concentration of the suspending agent is 6.25% of PGA and 0.775% of hydroxyethylcellulose, and the desirability value of 0.57. The results indicated that the suspension preparation had the characteristics of low viscosity, the particles settle quickly and are easily re-dispersed. Analysis of ANOVA statistical data on viscosity, sedimentation volume, and redispersibility of suspension preparations showed a p-value 5 or significant meaning that the use of the SLD method affected increasing and decreasing the response value.
Studi Docking Molekular Aktivitas Panghambatan Enzim Tirosinase Ubi Jalar (Ipomoea batatas L. Lam) Dwi Utami; Ryan Syahputra; Wahyu Widyaningsih
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18295

Abstract

Sweet potato (Ipomoea batatas L. Lam) is a plant source of carbohydrates with chemical content of catechins, quercetin, asam klorogenat, anthocyanins, beta-carotene. These phytochemical compounds have been shown to have antioxidant activity that is closely related to tyrosinase through the oxidative stress pathway. The purpose of this study was to develop sweet potato plants as anti-tyrosinase candidates for cosmetic preparations by molecular docking of these 4 compounds to tyrosinase protein (pdb:2Y9X) with kojic acid control. The research was done in 4 stages : (1) Preparation of proteins (receptors) and ligands with Biovia Discovery Studio (2) Optimization of geometry with Avogadro and Chem 3D (3) Validation of docking and molecular docking methods for proteins (2Y9X) with Autodock-4 (5) and (4) ADMET study with pkCSM and SwissADME websites. The test results obtained the highest affinity for 3 active compounds, namely beta-carotene with (ΔG) -6.05 kcal/mol (IC) 36.72 M and quercetin has (ΔG) -5.87 kcal/mol (IC) 45.30 M . While the control kojic acid has a lower affinity of (ΔG) -5.27 kcal/mol (IC) 380.37 M. ADMET predictions provide information that the four active compounds Ipomoea batatas L. Lam meet the requirements to be developed as natural tyrosinase inhibitors based on lipophilicity (logP), topology polar surface area (TPSA), skin permeability, skin sensitivity, logKP, CYP1A2 inhibitor, lipinski rule. and bioavailability. The molecular docking study and ADMET prediction indicate that the active compound of sweet potato (Ipomoea batatas L. Lam) has the potential to be developed as a natural cosmetic ingredient.
Studi In Silico Kandungan Senyawa Daun Srikaya (Annona squamosa L.)Terhadap Protein Dihydrofolate Reductase Pada Mycobacterium tuberculosis Nur Cholis Endriyatno; Muhammad Walid
Pharmacon: Jurnal Farmasi Indonesia Vol 19, No 1 (2022)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v19i1.18044

Abstract

Tuberculosis is caused by the Mycobacterium tuberculosis. Tuberculosis is one of the problems in the world, especially the problem of resistance which requires the search for new alternative drugs, one of which is from natural compounds.In silico studies with molecular docking method can be used as a preliminary test to assess the potency of a natural compound. In this study, the target proteins were Dihydrofolate Reductase: 4KL9 and 4KM2 with the original P33 and ATR ligands on Mycobacterium tuberculosis. Dihydrofolate reductase is a protein that has an important role in nucleotide biosynthesis, and has become a target for antibacterial drugs. The natural compounds tested were anonaine, asimilobine, and corypalmine contained in soursop leaves. The molecular docking results showed that the three compounds had docking score, especially for the 4KL9 target protein, which was lower than the original ligand. A lower value means that the binding of the ligand and target protein is stronger than that of the native ligand. The three compound ligands on the target protein 4KM2 have a higher docking score  than the original ligand, meaning that the binding of the three ligands is not as strong as the original ligand, but the values are not far apart. In addition, there are similar residues involved from the original ligand and the ligands of the three compounds to the target protein. Therefore, it can be concluded based on an in silico study of the content of anonaine, asimilobine, and corypalmine compounds that may have antituberculosis activity.

Page 28 of 35 | Total Record : 345

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