cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
pharmacon@ums.ac.id
Editorial Address
Jl. A. Yani 1 Pabelan Kartasura Surakarta 57162 INDONESIA
Location
Kota surakarta,
Jawa tengah
INDONESIA
Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
Arjuna Subject : -
Articles 345 Documents
 31   32   33   34   35 
Formulation and Characterization of Gels of Telang Flower Extract (Clitoria Ternatea L) with Variations of Carbopol Concentration and Antioxidant Activity Test Using DPPH Methods Nurwaini, Setyo; Fatimah, Mutiara Nurul
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23469

Abstract

Telang flower (Clitoria ternatea L) has antioxidant activity. Formulation in gel form provides convenience in the use of telang flower extract. This study aims to determine the effect of carbopol as a gelling agent on the physical properties of the gel and to determine the antioxidant activity of telang flower extract gel. Telang flower extract was obtained by maceration method. The gel was formulated with 3 variations of carbopol concentration, namely 0.5%, 1% and 2%. Characterization of Clitoria ternatea L. gel includes: organoleptic, homogeneity, pH, viscosity, spreadability and stickiness. Antioxidant activity test of telang flower (Clitoria ternatea L) using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The gel formulation of telang flower extract (Clitoria ternatea L.) from 3 formulas met the requirements. Gel with 2% carbopol concentration was the gel with the best characteristics: pH 5.82; viscosity 2,666 cP; spreadability 4.33 cm; stickiness 2.2 s. The Antioxidant activity test of telang flower extract gel showed strong category with an IC50 value of 97.72 ppm. Carbopol has an influence on the physical properties of telang flower extract (Clitoria ternatea L) gel and strong antioxidant activity of bay flower extract gel.
The Relationship of Sociodemographic Factors to The Level of Knowledge, Perceptions, and Attitudes of The Community About Pulmonary TB Disease in Barlingmascakeb, Central Java Muttaqin, Cecep Darwis; Samodra, Galih; Kusuma, Khamdiah Indah
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23307

Abstract

Pulmonary tuberculosis remains a significant health concern in Indonesia, holding the second position globally. Central Java province alone contributes to 44% of all pulmonary tuberculosis cases in the country. This research endeavors to explore the correlation between sociodemographic factors and the community's knowledge, perceptions, and attitudes toward tuberculosis (TB) in Barlingmascakeb, utilizing a Cross-sectional approach. The study employed an online-based questionnaire via the Google Forms platform, reaching 438 respondents throughout Barlingmascakeb. The analysis involved univariate methods to interpret the characteristics of the Barlingmascakeb community's awareness of pulmonary TB, presented in percentage form. Additionally, bivariate analysis was conducted to ascertain connections, with results Adjusted for a significance level of p 0.05. The results indicated significant connections between the knowledge level and various variables, such as gender (p = 0.006), age (p = 0.000), occupation (p = 0.001), and district (p = 0.000). Additionally, there were correlations between perception and age (p = 0.006), highest educational attainment (p = 0.010), and district (p = 0.001). Likewise, attitudes were associated with age (p = 0.009), highest educational attainment (p = 0.020), and district (p = 0.015). This emphasizes the importance of comprehending the interplay between sociodemographic factors and individual attitudes in addressing pulmonary TB within the community.
Active Antibacterial Fraction from Ethanolic Extract of Johar Leaves (Cassia siamea Lam.) against Staphylococcus epidermidis and Its Bioautography Munawaroh, Rima; Khoirunnisa, Khoirunnisa
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23298

Abstract

Johar leaves (Cassia siamea Lam.) have been traditionally used to treat pruritus due to their antibacterial properties. This study aims to identify the active fraction of an ethanolic extract of Johar leaves against Staphylococcus epidermidis, as well as the active chemical class. The extraction process involved maceration with 96% ethanol. The liquid-liquid extraction method was used to separate the n-hexane, ethyl acetate, and water fractions. The resulting extract and fraction were assessed for antibacterial activity using the well diffusion method. Sample loadings of 4 mg, 2 mg and 1 mg per well were used, with DMSO as a negative control and 6 mg chloramphenicol as a positive control. The test results indicate that the ethyl acetate fraction is more effective than the extract. Specifically, the fraction produced an inhibition zone of 13.5 ± 0.5 mm at a loading of 4 mg/well, while the extract only produced an inhibition zone of 9.3 ± 1.2 mm at the same loading. Additionally, there was a significant difference in the diameter of the inhibitory zone between treatment groups at p 0.05. The TLC results indicate that the ethyl acetate fraction of Johar leaves contains alkaloid, phenolic, flavonoid, and steroid compounds when using silica gel 60 F254 stationary phase and chloroform:ethyl acetate:ethanol (7:2:1 v/v/v) mobile phase. Bioautography results showed that the phenolic and alkaloid compounds at Rf 0.22 and phenolic compound at Rf 0.42 are responsible for the antibacterial activity against Staphylococcus epidermidis.
Vol 20, No 2 (2023) Wahyuni, Arifah Sri
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23493

Abstract

Relationship Between Knowledge and Behaviour of Self-Medication in Cough Towards One Community in East Java Netta, Shella Naradewi; Hajma, lilla Prapdhani Agni
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23465

Abstract

Coughing is often considered a minor illness, but in reality it disrupts daily activities. In dealing with coughs, treatment can be done independently or known as self-medication. In Indonesia, the practice of self-medication tends to increase. However, improvement in self-medication practices is often not aligned with adequate knowledge. This research aims to determine the profile of self-medication in society, the level of self-medication knowledge, the level of self-medication behaviour, and analyze the relationship between knowledge and behaviour. Questionnaires that have been tested for validity and reliability on 30 respondents are used as instruments. The data collection method was carried out cross-sectionally using a purposive sampling technique in September-November 2023. Respondents in this study were community in one of the regions in East Java with the inclusion criteria. The total respondents in this study were 363 respondents. Univariate analysis was carried out on self-medication profile, level of knowledge, and level of behaviour. The relationship between level of knowledge and behaviour was analyzed using the Spearman Rank method. In this study, the average community knowledge score was 76.86% with a good level of knowledge (54.3%). In the behavioral variable, the average value is 77.39% with the good behaviour level category (59%). There is a relationship between the level of knowledge and cough self-medication behaviour in the community as evidenced by a sig. (2-tailed) 0.000. A positive correlation coefficient of 0.49 was obtained thus indicating that the strength of the relationship between knowledge level and behavior is moderate.
Antibacterial Potency of Jackfruit Leaf Extract (Artocarpus heterophyllus L.) Against Salmonella typhi Mawardika, Herlinda; Wahyuni, Dwi; Khasanah, Siti Ma’rifatul
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.20862

Abstract

Typhoid fever is a chronic disease caused by S. typhi bacterium. This disease can be transmitted via contaminated water or food, and close contact with an infected person. The symptomps of typhoid fever include high fever, stomach pain, headache, and constipation. Jackfruit (Artocarpus heterophyllus L.) leaves extract contain active compounds with antibacterial activity. This research aims to determine the inhibitory activity of jackfruit leaves extract against S. typhi. Jackfruit leaves were extracted by maceration using 70% ethanol as solvent. After that, organoleptic test, ethanol-free test and phytochemical screening of extract were carried out. Inhibitory activity of extract was conducted using well diffusion method, followed by determination of MIC and MBC. The results showed that jackfruit leaves extract contained flavonoid, tannins, saponin, and triterpenoid. Inhbitory activity of extract was found at concentration 20% (5.24 mm), 40% (6.78 mm), and concentration 60% (8.08 mm). The MIC value of extract was 12.5%. while the MBC could not be found. According to the results, ethanol extract of jackfruit leaves (70%) have potential compounds to inhibit the growth of S. typhi
Purification of Curcumin Derivate (1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on) Using Chromatotron Harimurti, Sabtanti; Fadhilah, Alfan; Widada, Hari; Damarwati, Vella Lailli
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23593

Abstract

Curcumin derivate with IUPAC name 1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,4-pentadien-3-on is also known as Gamavuton-0 (GVT-0) reported has an activity as anti-inflammation and anti-cancer. GVT-0 can be synthesized using vanillin and acetone as starting material by aldol condensation. Purification process of GVT-0 after synthesis usually was done using maceration. This method resulting un-pure GVT-0, therefore, another separation technique of Chromatotron was chosen. This research aims to investigate the effectiveness of Chromatotron towards the purity of GVT-0. The study was started by GVT-0 synthesis. The synthesis was using 4.4 mole of vanillin and 1 mole acetone as the raw material. Microwave irradiation was used as the energy source. Isolation of GVT-0 using hot water maceration. Further, the purification of GVT-0 was conducted using Chomatotron. First step of purification using Chomatotron was preparing best ratio between hexane and chloroform as solvent to remove vanillin. Further, the best combination of solvent was used to separate all the vanillin remaining in the bulk of GVT-0. Last step after all vanillin was removed, the GVT-0 remining in the silica was elucidated using chloroform. The purity was evaluated using Melting-point analysis and Thin Layer Chromatography (TLC) with four different mobile phases. Based on the data of melting point and TLC, a pure GVT-0 was obtained. The Chomatotron may be recommended for purification of GVT-0, however this method consumes a lot of organic solvent that may need to be improved in the future with more environmentally process
Formulation And Evaluation Of Telang Flower (Clitoria Ternatea L.) Extract Gel Preparation With Tragacanth As Gelling Agent And Antioxidant Activity Test Nurwaini, Setyo; Amanda, Alifah Tasya
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23470

Abstract

Telang flower has antioxidant activity as a scavenger of free radicals. Formulation in gel form can facilitate its use as a cosmetic preparation. This study aims to determine the characteristics of telang flower extract gel at different concentrations of tragacanth as a gelling agent and its antioxidant activity.Gel formula of telang flower extract with different concentration levels of tragacanth, namely 3%, 4%, and 5%. Gel evaluation includes organoleptic test, homogeneity, pH, spreadability, stickiness, and viscosity. The best formula will be tested for antioxidant activity.Based on the gel characteristics of telang flower extract, F3 has good physical properties, namely pH value of 7.28 ± 0.06, viscosity of 2133.3 ± 23.09 cP, spreadability of 6.05 ± 0.13 cm, and stickiness of 1.17 ± 0.07 seconds. The telang flower extract exhibited an IC50 value of 71.125 ppm, classifying it as strong antixodant. The IC50 value of telang flower extract gel was 92.867 ppm
Optimization of Soursop (Annona muricata L.) Leaf Extract in Nanoemulgel and Antiacnes Activity Test Against Propionibacterium acnes, Staphylococcus aureus, Staphylococcus epidermidis Bacteria Asyhari, Hanif Fibiana; Cabral, Kibedi B; Wikantyasning, Erindyah R
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23308

Abstract

Soursop leaf extract (Annona muricata L.) has antibacterial activity with active components of alkaloids, flavonoids, steroids, and saponins. This research aims to optimize the use of VCO, Tween 80, and PEG 400 in the nanoemulsion system, which will be added Carbopol 940 as a gelling agent to form a nanoemulgel and to determine antibacterial activity. By utilizing the simplex lattice design method in Design Expert 13.0, the nanoemulsion formula has been successfully optimized involving a mixture of VCO, Tween 80, and PEG 400. A total of 14 different nanoemulsion formulas were produced through this process. The process of making nanoemulsion is carried out by mixing extracts, oils, surfactants and cosurfactants, homogenized using a vortex, then sonicated. Evaluation of % transmittance, emulsification time, and pH were carried out to determine nanoemulsion physical properties. The nanoemulsion optimal formula was evaluated for particle size, polydispersity index, and zeta potential and made into nanoemulgel with the addition of Carbopol 940. The optimal formula has a composition of 10.86% VCO, 67.33% Tween 80, 21.81% PEG 400 form homogeneous and clear nanoemulsion with % transmittance of 91.97±1.11%, emulsification time of 56.42±0.72 seconds, and pH of 5.67±0.24. Particle size, polydispersity index, and zeta potential of the optimal formula were 229.47±38.79 nm, 0.41±0.10, and -39.13±0.19 mV, respectively. Evaluation of nanoemulgel physical properties showed homogeneous, pH value of 5.83±0.24, spreadability of 5.57±0.25 cm, adhesive force of 3.80±0.25 seconds, viscosity of 11479.33±167.49 cP, antibacterial activity against P. acnes, Staphylococcus aureus, and Staphylococcus epidermidis with inhibition zone diameters of 9.67±0.47 mm, 7.33±0.47 mm, and 5.67±0.47 mm. respectively. Nanoemulgel soursop leaf extract has suitable physical properties, and antibacterial activity is in the medium category.
Behaviour of Community Pharmacy Service Provider towards Self Medication Services: Study in Two Cities in West Java Roseno, Mohammad; Widyastiwi, Widyastiwi; Alifia, Sarah; Rahmadhani, Melly Shafira
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 2 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i2.23299

Abstract

Self-medication behavior is currently increasing in Indonesia. Community pharmacy service provider have an important role as the main source of information and recommendations for the community in self-medication. To be able to provide good self-medication services, good knowledge, attitudes, and practices are needed from pharmacists. This study was aimed to measure the knowledge, attitudes, and practices of pharmacists in providing self-medication services. The study was conducted with a cross-sectional design in pharmacies in Bandung City and Cianjur Regency in the period March-April 2021. A valid and reliable questionnaire was administered to 141 respondents who worked in pharmacies that were selected randomly, to measure the knowledge, attitudes, and practices related to self-medication. The inclusion criteria were community pharmacy service provider who worked permanently and were willing to fill out questionnaires. Exclusion criteria were intern worker and incomplete questionnaires. Results showed that community pharmacy service provider in Bandung City and Cianjur Regency had an average knowledge of 65.04% (moderate), attitudes 78.40% (good), and practice 85.59% (very positive) towards self-medication services. In self-medication behavior, knowledge of community pharmacy service provider was influenced by type of position (p0.05), self-medication attitude was influenced by type of pharmacies (p0.05), and self-medication service practice was influenced by location (p0.05). This study concludes that community pharmacy service provider in Bandung City and Cianjur Regency have a moderate knowledge, and good attitudes and very positive practices in self-medication services.

Page 33 of 35 | Total Record : 345

 31   32   33   34   35 

Filter by Year

2010 2024


Reset
Filter By Issues
All Issue Vol 21, Special Issue 1, 2024 Vol 20, No 2 (2023) Vol 20, No 1 (2023) Vol 19, No 2 (2022) Vol 19, No 1 (2022) Vol 18, No 2 (2021) Vol 18, No 1 (2021) Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG 2021 Vol 17, No 2 (2020) Vol 17, No 1 (2020) Vol 16, No 2 (2019) Vol 16, No 1 (2019) Vol 16, No 1 (2019) Vol 15, No 2 (2018) Vol 15, No 2 (2018) Vol 15, No 1 (2018) Vol 15, No 1 (2018) Vol 14, No 2 (2017) Vol 14, No 2 (2017) Vol 14, No 1 (2017) Vol 14, No 1 (2017) Vol 13, No 2 (2012) Vol 13, No 2 (2012) Vol 13, No 1 (2012) Vol 13, No 1 (2012) Vol 12, No 2 (2011) Vol 12, No 2 (2011) Vol 12, No 1 (2011) Vol 12, No 1 (2011) Vol 11, No 2 (2010) Vol 11, No 2 (2010) Vol 11, No 1 (2010) Vol 11, No 1 (2010) Edisi Khusus: RAKERDA, SEMINAR, PID IAI More Issue