Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Majalah Obat Tradisional

TradMedJ
Website

Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

Arjuna Subject : -

Articles 564 Documents

12 13 14 15 16

EVALUASI SIFAT FISIK DAN DAYA IRITASI SEDIAAN LOTION MINYAK ATSIRI BUNGA CENGKEH (SYZIQIUM AROMATICUM) DENGAN BERBAGAI VARIASI KONSENTRASI Fadzil Latifah; Nining Sugihartini; Tedjo Yuwono
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

In this study, the lotion contained essential oil of clove Syzigium a romaticum which contained eugenol as the active ingredient. Eugenol has been scientifically proven as anti-inflammatory. Because its activity, the study about development of dosage form is needed. Aims of this study was to know the physical properties of spreadibility, adhesivity, pH, viscosity and irritation index of lotion with variation concentration of essential oil.Thisstudywasstartedwithaformulationoflotionwith variationconcentrationofessentialoil5%(FI); 10% (FII); 15% (FIII). Lotion was evaluated physical properties with parameters spreadibility, adhesivity, viscosity and pH. The evaluation of iritation index was done using guinea pig test animals. Data were analyzed statistically with One Way Anova at confidence level of 95% to detect a significant difference between the treatment groups. The results of the study showed the variation consentration did not influence pH the increasing concentration caused a decreasing spredibility P<0.05 and increasing adhesivity P<0.05. The all of concentration did not irritated the skin of guinea pigs.

ANALISIS SIDIK JARI KROMATOGRAM Stevia rebaudiana SECARA HIERACHIAL CLUSTER ANALYSIS (HCA) DAN PRINCIPAL COMPONENT ANALYSIS (PCA) Yohanes Martono; Sugeng Riyanto; Sudibyo Martono; Abdul Rohman
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Bioactivity herbal plant is influenced by its active compounds and consistency. Stevia rebaudiana contains bioactive compounds, diterpene glycosides which have antidiabetes activity. The goal of this study was to develop fingerprints analysis of S. rebaudiana based on High Performance Liquid Chromatography (HPLC) chromatogram. S. rebaudina leaves were taken from different planting area, leave ages, and seeds source. S. rebaudiana leaves were analyzed using isocratic Reversed Phase High Performance Liquid Chromatography (RP-HPLC). Fingerprints analysis of S. rebaudiana was done using chemometrics of Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA). Peak marker “common peak” were identify using Cluster Observation in HCA analysis at each peaks retention time formed in chromatogram. Retention times giving similarity value more than 0,90 were identified as “common peak”. HCA analysis resulted in 5 “common peak” identification as peaks marker particularly at peak no 1, 2, 4, 6 and 7. HCA analysis was also clustered samples into 3 main cluster. PCA analysis was optimized by calculated peak area whose N > 2000 particularly peak no 4, 6, and 7. PCA analysis result can be used to classify chromatogram based on original seeds, planting area and leave ages. Fingerprints analysis developed can be used an alternative method for quality control of S. rebaudiana herbal plants based on its bioactive compounds systemic characteristics.

KETOKSIKAN AKUT EKSTRAK AIR Eupatorium riparium Reg. PADA TIKUS SPRAGUE-DAWLEY Nurlaila Nurlaila; Sita Rina Widyarini; Subagus Wahyuono; Lukman Hakim
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Eupatorium riparium Reg. is one of medicinal plant that might be used to cure a disease optimally. Some research reports and traditional uses in society show that this plant can be used as a diuretic, anti-inflammatory, hepatoprotective, immunostimulant, anti-malarial, and anti-infective agents. Therefore, it is necessary to evaluate its safety. The aim of this study is to determine the acute toxicity of the aqueous extract of E. riparium Reg. at Sprague-Dawley (SD) rats. The acute toxicity test was conducted using the method of OECD 423. Male SD rats were orally given aqueous extracts of E. riparium Reg. which was started with a dose of 2000 mg / kg. Observations were performed 24 hours after the administration with intensive observations on the first 4 hours. The result showed that there were no animals found in dead condition when treated with a dose of 2000 mg/kg; repeated testing is also showed that no animals died, so the observation was continued until 14 days. The dose was increased to 5000 mg/kg, and again there were no dead animals. From the results, it can be concluded that the potential for acute toxicity (LD50) (cut off) of aqueous extract of E. riparium Reg., in rats is > 5000 mg/kg. In addition, toxic symptoms such as restlessness, lick, hyperactivity, forced movement, paralysis of the legs, dyspnea were shown but these symptoms were disappeared after 14 days. Histopathological study showed that there was no change on animal’s organ compared to the normal control.

STANDARDISASI KUALITAS EKSTRAK BATANG BROTOWALI (Tinospora crispa) Harwoko Harwoko; Nur Amalia Choironi
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Brotowali (Tinospora crispa) has been traditionally used for the treatment of gout and scientifically reported as analgesic, anti-inflammatory, and antihyperuricemic agents. Tinospora crispa stem is one of herbal medicine material that its quality should be standardized. This study aims to determine the quality parameters of the T. crispa ethanolic extract included specific and non-specific parameters. Brotowali stem were macerated using ethanol 70%, then the non-specific parameters such as the water content, total ash, total contaminant number of bacteria and fungus were determined. The specific parameters including organoleptic properties, water soluble extract, ethanol soluble extract, and the thin layer chromatography (TLC) profile have also been determined. The parameter values were compared to the qualification of traditional medicine from Department of Health (Depkes R.I.). The result showed that T.crispa stem ethanolic extract has the water content was 8.12±0.06% and the total ash was 5.20 ± 0.12%. The microbiology results showed that the total contaminant of bacteria as much as 5 x 102 CFU/g and fungus as much as 5 x 103 CFU/g. This extract was brown viscous extract, bitter taste and characteristic odor with water soluble fraction was 45.09 ± 0.67% and ethanol soluble fraction was 14.19 ± 0.14%. The TLC profile of ethanolic extract indicates the existence of flavonoids and alkaloids. Total flavonoids of brotowali extract (32.65 ± 0.20%) rutin equivalent.

PENGARUH HIDROLISIS ASAM-BASA TERHADAP AKTIVITAS PENANGKAPAN RADIKAL 2-2’ DIFENIL-1-PIKRIL HIDRAZIL (DPPH) FRAKSI AIR DARI EKSTRAK ETANOLIK BUAH TALOK (Muntingia calabura L.) Tatang Irianti; Yosi Bayu Murti; Damiana Nitya Kanistri; Desi Riza Pratiwi; Kuswandi Kuswandi; Ratih Anggar Kusumaningtyas
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The investigation of talok fruits (Muntingia calabura L.) was shown the antioxidant activity of aqueous fraction of the ethanolic extract is relatively low. Hydrolysis treatment has increased the antioxidant activity by releasing the flavonoid aglycone from glycoside form. This study aims to determine the effect of acid and alkaline hydrolysis, and hydrolysis time on the antioxidant activity of aqueous fraction of calabura fruits ethanolic extract. The antioxidant activity of acid hydrolyzed aqueous fractions in 1 and 3h hydrolysis, respectively 9.5 and 1.5 times more potent than the aqueous fraction, while the alkaline in 1 and 3h hydro-lysis were 2.5 and 6.5 times. Flavonoid aglycone liberated on acid hydrolysis and alkaline had different anti-oxidant activity. The value of IC50 by acid hydrolyzed aqueous fraction in 1h and 3h hydrolysis of 20.55 and 97.88μg/mL, while the alkaline in 1h and 3h hydrolysis of 66.64 and 25.53μg/mL. One hour acid hydrolysis had antioxidant activity greater than 3h whereas in alkaline the greatest antioxidant activity is shown in 3h.

AKTIVITAS SITOTOKSIK HASIL PARTISI ETIL ASETAT EKSTRAK PETROLEUM ETER DAN EKSTRAK METANOL DAUN KAYU APU (Pistiae Folium) Sentot Joko Raharjo; Rahayu Wahyu Ningsih
Majalah Obat Tradisional Vol 20, No 3 (2015)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

This study aims to explore the cytotoxic test (LC50) towards Artemia salina L. larvae of the partition ethyl acetate fractions from methanol extracts and petroleum ether (PE) extracts of Pistiae folium. The leaves of Pistiae folium was extracted using solvents soxhletation with methanol solvent and petroleum ether solvent. Both extracts successively partitioned with n-hexane and ethyl acetate, respectively. Identification of secondary metabolites was using phytochemical screening method and TLC (Thin Layer Chromatography). TLC analysis was using the eluent chloroform: methanol 3: 1 by citroboric acid spot analysis. The cytotoxic activity was using Brine Shrimp Lethality Test (BSLT) method. The result of partition from methanol extracts was 6.25% and from PE extracts was 0.69%. The phytochemical screening test showed that it contained flavonoids, saponins and steroids. The TLC analysis identified flavonoid compounds. The cytotoxic activity (LC50) of the ethyl acetate partition from methanol extracts and petroleum ether extracts of Pistiae folium were 79.9298mg/mL and 51.7608mg/mL, respectively. The result showed that the cytotoxic activity of ethyl acetate fractions partitined from methanol extract of Pistiae folium was higher than the PE extracts.

UJI TOKSISITAS AKUT EKSTRAK ETANOL KELOPAK ROSELLA (Hibiscus sabdariffa L.) PADA TIKUS Sprague Dawley Fita Sari; Nurkhasanah Nurkhasanah; Moch. Saiful Bachri
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Roselle (Hibiscus sabdariffa L.) was used as a traditional medicine because it has antioxidant activity. Traditional medicine used to treat a disease should consider the safety aspects through the toxicity tests. This study aims to determine the acute toxicity of the ethanolic extract from the calyx of Hibiscus sabdariffa L., activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and hepar histopathology in Sprague Dawley (SD) rats. Acute toxicity tests was done by orall administration of single dose ethanolic extract at dose 40, 200, 1000 and 5000 mg/kg BB. The test was observed during 14 days post treatment. The activity of AST, ALT and ALP were measured by specthrophotometer UV-Vis Diasys® method. The results showed that LD50 of ethanolic extract of calyx roselle was found at 850,90 mg/kg BW, the activity of AST, ALT, ALP did not different significantly in the treatment to be and control group (p <0.05) and histopathological data found structural change and tissue in hepar. Tthe delayed toxic effects until day 14 was also not found. These research found that ethanolic extract of calyx roselle was toxic SDrats.

KANDUNGAN VITAMIN C, VITAMIN A DAN ALPHA HYDROXY ACID DALAM BENGKOANG (Pachyrhizus Erosus) Ardian Widyatmoko; Dwi Hastutik; Ari Sudarmanto; Endang Lukitaningsih
Majalah Obat Tradisional Vol 21, No 1 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Bengkoang or Pachyrhizus erosus has been used as a traditional cosmetic material since many years ago. Until now, many cosmetic preparations using bengkoang as a main material have been produced by cosmetic industries, mainly for skin care, whitening and sunscreen preparation. However, content of vitamin A, vitamin C and alpha hydroxyl acid has not been discovered yet. These compounds are essential in skin care process because of their activities in cell regeneration, antioxidant as well as peeling of dead skin cell layer. The aim of this research is to provide information about the content of three compounds in bengkoang. Vitamin A has been analysed by spectrophotometer, vitamin C analysed using titration method and alpha hydroxyl acid analysed using gas chromatography. The result showed that concentrations of vitamin A and vitamin C are 179.21 ± 8.19 ppm and 0.31 ± 0.06 %, respectively. Meanwhile the content of alpha hydroxyl acid was 0.80 ± 0.01% (measured as glycolic acid).

POTENSI PENANGKAPAN RADIKAL 2,2-difenil-1-pikril hidrazil (DPPH) OLEH BUAH PISANG SUSU (Musa paradisiaca L. “Susu”) DAN PISANG AMBON (Musa paradisiaca L. “Ambon”) Anjar Hermadi Saputro; Sudarsono Sudarsono
Majalah Obat Tradisional Vol 19, No 1 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Nutrients including vitamin A and C on milk banana and ambon banana predicted potential as an antioxidant. This study aims to determine the radical potential of pisang susu and pisang ambon with synthetic vitamin C as a comparison so we get how much antioxidant power of ambon banana and milk banana produced in the fruit if desired pengonsumsian antioxidant power of vitamin C produced by pure at certain levels. This study consisted of measuring the antioxidant activity by the method of 2,2-Diphenyl-1-Pikrilhidrazil (DPPH) so that the data obtained antioxidant activity and Inhibitory Concentration50 (IC50) of milk banana, ambon banana and vitamin C synthetic. From the research results can be concluded that as much as 2418.84g of milk banana as an antioxidant potential equivalent to the antioxidant potential of 1g of vitamin C when measured with 0.4 mM DPPH reagent, while the total of 9229.79g of ambon banana as an antioxidant potential equivalent to the potential antioxidants vitamin C 1 gram when measured with 0.4mM DPPH reagent.

OPTIMASI KOMPOSISI SUKROSA DAN ASPARTAM SEBAGAI BAHAN PEMANIS PADA FORMULA TABLET-EFFERVESCENT EKSTRAK ETANOLIK BUAH MENGKUDU Galih Pratiwi; Triana Hertiani; Mufrod Mufrod
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Mengkudu (Morinda citrifolia L.) has been widely used as traditional medicine. Its unpleasant smell and flavor urge a more acceptable dosage formulation. The aim of this research was to optimize the composition of sucrose and aspartame as sweetening agent in effervescent tablet formulation by using Simplex Lattice Design method. Effervescent tablets were produced by fusion method in five (5) different formulas, i.e. formula I (100% sucrose), II (suucrose-aspartame=75%:25%), III (sucrose-aspartame=50%:50%), IV (sucrose-aspartame=25%:75) dan V (100% aspartame). Effervescent granules were evaluated for mass density, flowing time, tapping index and compactibility characteristics. The effervescent tablets were tested for weight uniformity, hardness, friability, and disintegration time characteristics as well as TLC profile chromatogram. Data was analyzed by one way ANOVA, Scheffe method and Kruskall-Wallis with significance level 95%. The tablet acceptability was tested among 30 respondents. The results showed that the different composition of sucrose-aspartame influence the physical characteristics of granules and tablets effervescent produced. More sucrose content will increase the hardness, lower the friability but prolong the disintegration time. 70% respondents chose formula III as the best formula. Evaluation of SLD data recommended sucrose and aspartame in 42:58 proportion as the most optimum formula.

Page 14 of 57 | Total Record : 564

12 13 14 15 16

Filter by Year

2010 2025

Filter By Issues

All Issue Vol 30, No 3 (2025) Vol 30, No 2 (2025) Vol 30, No 1 (2025) Vol 29, No 3 (2024) Vol 29, No 2 (2024) Vol 29, No 1 (2024) Vol 28, No 3 (2023) Vol 28, No 2 (2023) Vol 28, No 1 (2023) Vol 27, No 3 (2022) Vol 27, No 2 (2022) Vol 27, No 1 (2022) Vol 26, No 3 (2021) Vol 26, No 2 (2021) Vol 26, No 1 (2021) Vol 25, No 3 (2020) Vol 25, No 2 (2020) Vol 25, No 1 (2020) Vol 24, No 3 (2019) Vol 24, No 2 (2019) Vol 24, No 1 (2019) Vol 23, No 3 (2018) Vol 23, No 2 (2018) Vol 23, No 1 (2018) Vol 22, No 3 (2017) Vol 22, No 2 (2017) Vol 22, No 1 (2017) Vol 21, No 3 (2016) Vol 21, No 2 (2016) Vol 21, No 1 (2016) Vol 20, No 3 (2015) Vol 20, No 3 (2015) Vol 20, No 2 (2015) Vol 20, No 2 (2015) Vol 20, No 1 (2015) Vol 20, No 1 (2015) Vol 19, No 3 (2014) Vol 19, No 3 (2014) Vol 19, No 2 (2014) Vol 19, No 2 (2014) Vol 19, No 1 (2014) Vol 19, No 1 (2014) Vol 18, No 3 (2013) Vol 18, No 3 (2013) Vol 18, No 2 (2013) Vol 18, No 2 (2013) Vol 18, No 1 (2013) Vol 18, No 1 (2013) Vol 17, No 3 (2012) Vol 17, No 3 (2012) Vol 17, No 2 (2012) Vol 17, No 2 (2012) Vol 17, No 1 (2012) Vol 17, No 1 (2012) Vol 16, No 3 (2011) Vol 16, No 3 (2011) Vol 16, No 2 (2011) Vol 16, No 2 (2011) Vol 16, No 1 (2011) Vol 16, No 1 (2011) Vol 15, No 3 (2010) Vol 15, No 3 (2010) Vol 15, No 2 (2010) Vol 15, No 2 (2010) Vol 15, No 1 (2010) Vol 15, No 1 (2010) More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Pudyastuti Kusumaningrum

Contact Email
mot.farmasi@ugm.ac.idm

Phone
-

Journal Mail Official
mot.farmasi@ugm.ac.id

Editorial Address
-

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Pudyastuti Kusumaningrum

Contact Email mot.farmasi@ugm.ac.idm

Phone -

Journal Mail Official mot.farmasi@ugm.ac.id

Editorial Address -

Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Pudyastuti Kusumaningrum

Contact Email
mot.farmasi@ugm.ac.idm

Phone
-

Journal Mail Official
mot.farmasi@ugm.ac.id

Editorial Address
-

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA