cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Pudyastuti Kusumaningrum
Contact Email
mot.farmasi@ugm.ac.idm
Phone
-
Journal Mail Official
mot.farmasi@ugm.ac.id
Editorial Address
-
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
Arjuna Subject : -
Articles 594 Documents
 56   57   58   59   60 
Antibacterial, Antioxidant and Anticancer Evaluation of Ginger Water Extract from Mempawah Regency Dodi Iskandar; Donor Utomo Muhammad Susilo; Y. Erning Indrastuti; Rollando Rollando; Narsih Narsih; Adi Hermawansyah; Zaenal Muttaqin; Muhammad Hilmi Afthoni
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.103310

Abstract

This study evaluated the antibacterial, antioxidant, and anticancer activities of aqueous ginger extract (Zingiber officinale) obtained from Mempawah Regency. The extraction process was carried out by boiling ginger in distilled water until a concentrated paste was obtained. From 2 kg of raw material, the extraction yielded 197 g of extract (9.85%), which was subsequently used for further bioactivity testing. Antibacterial activity was assessed against Escherichia coli (E. coli) using the disc diffusion method, resulting in an average inhibition zone of 4.17 ± 0.29 mm. Antioxidant activity was determined using the Ferric Reducing Antioxidant Power (FRAP) method, showing a value of 33.74 mg Ascorbic Acid Equivalent per gram of extract (mg AAE/g). Meanwhile, anticancer testing against MCF-7 cells yielded an IC₅₀ value of 4,654 µg/mL.
A Narrative Review: Bioactive Components and Antifungal Effects of Curcuma xanthorrhiza Catur Aryanto Rahman; Djoko Santosa; Purwanto Purwanto; Eka Noviana
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.105031

Abstract

Invasive fungal infections (IFIs) pose a significant threat to morbidity and mortality, particularly due to the increasing resistance of fungal pathogens to conventional antifungal drugs. Curcuma xanthorrhiza has been recognized for its diverse bioactive compounds, which hold potential as alternative agents to address these challenges. This study aims to identify the bioactive components of C. xanthorrhiza with antifungal properties, evaluate the antifungal effects demonstrated in previous studies, and establish correlations between the bioactive components and their antifungal activities as reported in various studies. A comprehensive narrative review was conducted using reputable databases, collecting research articles published in the last 15 years. Data from the selected studies were analyzed descriptively to assess the frequency of active compounds and their antifungal effects. The analysis identified several key bioactive compounds, including xanthorrhizol and curcuminoids, with varying degrees of antifungal activity. Xanthorrhizol emerged as the most extensively tested compound, demonstrating inhibitory effects against Candida albicans. The study also categorized the efficacy of these compounds based on the extraction methods employed and the fungal species tested. These findings reinforce the significant antifungal potential of C. xanthorrhiza, particularly its key bioactive components, which may serve as promising alternatives to conventional antifungal therapies. The antifungal mechanisms of key bioactive compounds, particularly xanthorrhizol and curcuminoids, are summarized and illustrated in this review, providing insights into their therapeutic roles and supporting future research aimed at addressing the growing challenge of antifungal resistance.
Lycopodium cernuum L. in Traditional and Contemporary Medicine: A Review of Its Pharmacognostic Profiles Rollando Rollando; Dodi Iskandar; Viol Dhea Kharisma; Arif Nur Muhammad Ansori
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.106002

Abstract

Traditional medicinal plants continue to serve as important sources of therapeutic agents due to their diverse bioactive compounds and generally favorable safety profiles. This review aims to comprehensively summarize the ethnomedicinal uses, phytochemical constituents, and therapeutic activities of Lycopodium cernuum, highlighting its potential for drug development. A systematic search of major scientific databases and authoritative references was conducted with no a priori restriction on publication year or language, yielding 50 eligible articles published between 1948 and 2024. L. cernuum has been widely utilized in traditional medicine systems across Asia, Latin America, and other regions to manage conditions related to inflammation, metabolic disorders, infections, and cancer-associated symptoms. Phytochemical investigations have identified diverse secondary metabolites, particularly alkaloids, flavonoids, phenolics, and terpenoids, which are proposed to underlie its pharmacological effects. Preclinical evaluations indicate that L. cernuum exerts multi-target activities on inflammatory, oxidative, metabolic, infectious, and immune pathways, including anti-inflammatory, antioxidant, antimicrobial, anticancer, antiviral, antidiabetic, antiplatelet, and immunomodulatory effects, thereby providing mechanistic support for several of its traditional uses. Preliminary toxicological studies suggest a relatively wide safety margin at commonly tested doses. Nevertheless, the current evidence base is limited by a predominance of in vitro and animal studies, heterogeneous experimental designs, and a lack of standardized extracts and dose–response evaluations, while clinical data in humans are virtually absent. Collectively, these findings underscore the promising pharmacological potential of L. cernuum and highlight the need for rigorously designed studies, particularly well-controlled clinical trials and mechanistic investigations, to validate its efficacy and safety and to inform its rational development as a therapeutic agent.
Analyzing Antioxidant Properties of Caulerpa racemosa Harvested in Jepara Using ABTS and β-Carotene Bleaching Methods Ariyanti Ariyanti; Akhmad Kharis Nugroho; Triana Hertiani; Adhyatmika Adhyatmika; Eka Noviana
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.106166

Abstract

Caulerpa racemosa (Forsskal) J. Agardh, commonly known as sea grapes, is a green macroalga traditionally consumed as food. While previous studies have examined the antioxidant activity and chemical constituents of C. racemosa from various coastal regions, the species from Jepara, Indonesia, an ecologically distinct marine area, remains largely underexplored. This study aims to evaluate the antioxidant activity of C. racemosa ethanol extract using ABTS and β-carotene bleaching (BCB) assays, characterize its chemical profile through thin-layer chromatography (TLC) and Fourier-transform infrared (FT-IR) spectroscopy, and quantify the caulerpin content via high-performance liquid chromatography (HPLC). Extraction was performed with 96% ethanol, and phytochemical screening on TLC employed spray reagents: Dragendorff’s for alkaloids, anisaldehyde for terpenoids/steroids, and FeCl₃ for phenolics and flavonoids. The phytochemical characterization confirmed the presence of alkaloid compounds. The extract exhibited moderate antioxidant activity, with IC₅₀ values of 57.05 ppm (ABTS) and 63.75 ppm (BCB), compared to quercetin (11.87 ppm, ABTS) and BHT (26.35 ppm, BCB). Caulerpin content in the 1000 ppm extract was 26.86 ppm. These findings indicate that C. racemosa from Jepara is a promising source of natural antioxidant compounds with potential pharmaceutical applications and warrants further investigation.
Identification, Phytochemical, and Proximate Analysis of the Combination of a Black Cumin Seed Extract with Soursop or Celery Leaf Extracts Sri Wardatun; Trirakhma Sofihidayati; Ghifa Amelia Syam Marissa Azi; Wisnu Wisnu; Stefani Carisa Natasha Diningrat; Nafa Mutiara Ramadani
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.107268

Abstract

Combined extracts of black cumin (Nigella sativa L.) seeds and soursop (Annona muricata L.) or celery (Apium graveolens L.) leaves showed antioxidant and pharmacological activities, with phenolic and flavonoid phytochemicals as potential antioxidants. This study investigated the bioactive compounds, phytochemical contents, proximate analysis, and residual ethanol solvent contents of a black cumin seed extract, as well as its combination with soursop or celery leaf extracts. The ethanol extracts were prepared by maceration and analyzed by GC-MS to identify bioactive compounds and residual ethanol. The total polyphenol and flavonoid contents were measured using a UV-Vis spectrophotometer. A proximate assay was used to determine crude protein, fat, and fiber contents. Microbial contamination and heavy metal contamination (Pb, Cd, and Ag) were also assessed. The extracts were free from residual ethanol and contained several pharmaceutically active compounds, including thymoquinone, stigmasterol, and gamma-sitosterol. All extracts contained flavonoids and phenolics, with total flavonoid contents ranging from 1.5–16.16 mg quercetin equivalents/g and total phenolic contents ranging from 3.1–56.6 mg gallic acid equivalents/g. The crude protein content ranged from 4.61–13.37 %, while the crude fat ranged from 3.58–22.42% and the crude fiber ranged from 0.825–2.30%. All extracts except the soursop leaf extracts met microbial and heavy metal safety standards, suggesting their potential for further development as standardized herbal products but with concerns regarding handling, packing, and storage.
Nutritional, Medicinal, and Industrial Applications of Hyptis suaveolens, Plantago ovata, and Salvia hispanica: A Comprehensive Review Md. Solayman Ope; Sumaia Sultana; Samir Shakir; Md. Masudul Karim; M. Ashrafuzzaman
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.108844

Abstract

Herbal plants have been traditionally valued for centuries across many cultures. Hyptis suaveolens, Plantago ovata, and Salvia hispanica are widely consumed in Bangladesh as mucilage-rich sherbet drinks which promote hydration and digestive health, yet no previous study has offered a comprehensive side-by-side comparison of their seed and husk profiles. The objective of this review is to systematically analyze their nutritional composition, medicinal properties, and industrial uses to identify complementary strengths and guide future research and commercialization efforts. A systematic literature search was conducted across major scientific databases, supplemented by local market collection of seeds and husks, experimental measurement of water-holding capacity, and photography of the plants. The findings indicate that P, ovata possesses the highest soluble fiber content offering superior benefits for gut health, cholesterol management, and applications in biodegradable packaging and drug delivery systems, while S. hispanica stands out for its rich omega three fatty acids and essential minerals that support cardiovascular and metabolic wellness and enable versatile incorporation into bakery items, beverages, and cosmetics, and H. suaveolens, although less studied globally, demonstrates notable anti-inflammatory, antimicrobial, antiviral, and insecticidal properties with promising roles as a natural herbicide and grain preservative in agriculture. In conclusion, S. hispanica emerges as the most nutritionally balanced with diversified commercial potential, whereas P. ovata and H. suaveolens contribute distinct digestive and agro-medicinal advantages, underscoring the need for further clinical trials, cultivation optimization, and industrial scale-up, particularly in Bangladesh.
Ethanol Extract of Frankincense: Study of Antifungal Potential Nora Susanti; Ruth Maria Meylisa Br Hutapea; Maria Aprina Br Surbakti; Muhammad Nizam; Marini Damanik
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.109042

Abstract

Natural products for phytopharmaca and cosmetics play a valuable role in the pharmaceutical industry. The sap of this plant contains secondary metabolic compounds, including alkaloids, flavonoids, and terpenoids, and has been proven to exhibit several biological activities such as antibacterial, antifungal, anti-inflammatory, and antimutagenic properties. Therefore, this research aimed to analyze the antifungal potential of the Indonesian indigenous frankincense (Styrax benzoin) extract before and after formulation as liquid soap. The result showed that both frankincense and the liquid soap formulations containing 2%, 4%, 6% and 8% extract exhibited strong growth inhibition against Candida albicans, Malassezia furfur, and Pityrosporum ovale using the disc paper method, comparable to the ketoconazole positive control. The lower frankincense concentration of 2% and 4% liquid soap maintained a stable appearance, acidity, and viscosity after storage.
Formulation and In Vitro Antibacterial Activity of Limonia acidissima Bark Patch against C.acnes and S.epidermidis Valentina Girsang; Anak Agung Pradnya Paramitha Vidiani; Anisa Devi Kharisma Wibowo; Silvy Aldila
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.109141

Abstract

Acne vulgaris is a common skin disorder, particularly among adolescents, often caused by the bacteria Cutibacterium acnes and Staphylococcus epidermidis. Antibiotic resistance in acne treatment necessitates the development of natural-based alternatives. This study aims to formulate and evaluate the antibacterial activity of acne patches based on kawista bark extract (Limonia acidissima L.) at varying concentrations of 25%, 50%, and 75%. Extraction was performed by maceration using 96% ethanol, and patches were formulated with a combination of HPMC and PVP polymers. Physical property tests included organoleptic evaluation, weight uniformity, drying shrinkage, thickness, folding endurance, and pH. Antibacterial activity was tested using the diffusion method against Cutibacterium acnes and Staphylococcus epidermidis. Results showed that all formulations met good physical patch standards, being : homogeneous, stable, thickness less than 1 mm, folding endurance greater than 300 times, and pH of 6. Antibacterial activity increased with higher extract concentration, with the largest inhibition zones observed at 75% concentration (15.16 mm for C. acnes and 18.05 mm for S. epidermidis), approaching the effectiveness of the positive control (clindamycin 10%). This study demonstrates that kawista bark extract acne patches have potential as an alternative topical acne therapy with strong antibacterial activity and physical characteristics that meet modern patch preparation standards.
Free Radical Scavenging Activity and Physical Properties of Lip Balm Formulated with Avocado Seed Oil, Virgin Coconut Oil, Tamanu Oil, and Olive Oil Agitya Resti Erwiyani; Khalisna Ocean; Muhammad Rafi Zhafran; Istianatus Sunnah; Dian Oktianti
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.109159

Abstract

The lips have fewer layers of corneocytes than the skin and do not contain sebaceous glands and hair follicles, so they are prone to drought. Lip care can be done with the use of lip balm that can protect and maintain lip moisture. The purpose of the study was to evaluate the physical characteristics of lip balm preparations, antioxidant activity as well as GC-MS testing to see the bioactive components in the oil. The results of the qualitative analysis of the oil contain flavonoids, alkaloids, tannins and saponins. Quantitative analysis of GC-MS of avocado seed oil found that the dominant fatty acids were oleic acid, VCO contained the dominant fatty acids of lauric acid, the bioactive tamanu oil was predominant beta-myrcene and olive oil contained the dominant fatty acids of oleic acid. All lip balm formulas have yellowish-white organoleptics, soft and homogeneous texture, have a pH value ranging from 5.07 – 6.88, and melting point ranging from 51 – 52.6 °C.  Lip balm with a ratio of VCO and tamanu oil has moderate antioxidant activity.
Blood Sugar-Lowering Activity and Acute Toxicity of Eleutherine bulbosa Bulbs Extract from Lampo Donggala, Central Sulawesi, Indonesia Syariful Anam; Yusriadi Yusriadi; Aisyah Eka Putri; Siti Amina; Yonelian Yuyun; Asriana Sultan; David Pakaya
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.111400

Abstract

Eleutherine bulbosa is a medicinal plant with pharmacological properties, including antidiabetic properties. Therefore, this study aims to determine the effect of administering 150 mg/kg body weight (BW) of crude and purified extract of E. bulbosa bulbs from Lampo, Central Sulawesi, Indonesia, on blood glucose reduction in streptozotocin-induced rats, and the acute toxicity of the extract. The maceration method was used to perform extraction with 50% methanol to obtain the crude extract. Subsequently, the purified extract was derived through column chromatography and liquid-liquid partition methods. Blood glucose levels were measured before induction (H0), 3 days post-induction (H3), and 28 days post-extract administration (H31) using a glucometer. A total of 20 male rats, divided into 5 groups, were observed for symptoms of acute toxicity in 24 hours, and the number of dead subjects was recorded. Meanwhile, the percentage reduction in blood glucose levels in the negative control, positive control, water column extract, purified extract, and crude extract groups was 0%, 82.1%, 66.8%, 72.7%, and 69.3%, respectively. The purified extract was not significantly different from glibenclamide as a positive control, with p<0.05. The acute toxicity test of the purified extract of E. bulbosa showed that there was no record of deaths. The LD50 was approximately 2000 mg/kgBW, representing a criterion of practical non-toxicity.

Page 59 of 60 | Total Record : 594

 56   57   58   59   60 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Vol 31, No 2 (2026) Vol 31, No 1 (2026) Vol 30, No 3 (2025) Vol 30, No 2 (2025) Vol 30, No 1 (2025) Vol 29, No 3 (2024) Vol 29, No 2 (2024) Vol 29, No 1 (2024) Vol 28, No 3 (2023) Vol 28, No 2 (2023) Vol 28, No 1 (2023) Vol 27, No 3 (2022) Vol 27, No 2 (2022) Vol 27, No 1 (2022) Vol 26, No 3 (2021) Vol 26, No 2 (2021) Vol 26, No 1 (2021) Vol 25, No 3 (2020) Vol 25, No 2 (2020) Vol 25, No 1 (2020) Vol 24, No 3 (2019) Vol 24, No 2 (2019) Vol 24, No 1 (2019) Vol 23, No 3 (2018) Vol 23, No 2 (2018) Vol 23, No 1 (2018) Vol 22, No 3 (2017) Vol 22, No 2 (2017) Vol 22, No 1 (2017) Vol 21, No 3 (2016) Vol 21, No 2 (2016) Vol 21, No 1 (2016) Vol 20, No 3 (2015) Vol 20, No 3 (2015) Vol 20, No 2 (2015) Vol 20, No 2 (2015) Vol 20, No 1 (2015) Vol 20, No 1 (2015) Vol 19, No 3 (2014) Vol 19, No 3 (2014) Vol 19, No 2 (2014) Vol 19, No 2 (2014) Vol 19, No 1 (2014) Vol 19, No 1 (2014) Vol 18, No 3 (2013) Vol 18, No 3 (2013) Vol 18, No 2 (2013) Vol 18, No 2 (2013) Vol 18, No 1 (2013) Vol 18, No 1 (2013) Vol 17, No 3 (2012) Vol 17, No 3 (2012) Vol 17, No 2 (2012) Vol 17, No 2 (2012) Vol 17, No 1 (2012) Vol 17, No 1 (2012) Vol 16, No 3 (2011) Vol 16, No 3 (2011) Vol 16, No 2 (2011) Vol 16, No 2 (2011) Vol 16, No 1 (2011) Vol 16, No 1 (2011) Vol 15, No 3 (2010) Vol 15, No 3 (2010) Vol 15, No 2 (2010) Vol 15, No 2 (2010) Vol 15, No 1 (2010) Vol 15, No 1 (2010) More Issue