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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
Arjuna Subject : -
Articles 564 Documents
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Chemical Composition of Active Compounds in Standardized Cinnamon Simplicia (Cinnamomum verum) Sentot Joko Raharjo; Dewi Ratih Tirto Sari; Yanty Maryanty; Ita Tresnowati; Ernanin Dyah Wijayanti
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.100943

Abstract

Cinnamon (Cinnamomum verum) is widely recognized as a spice with a distinctive aroma that has a variety of applications in the culinary and health industries, due to its diverse active compounds. Standardization is essential to ensure the quality and uniformity of cinnamon raw materials. Previous studies primarily focused on identifying the most abundant compounds and bioactivity testing. However, a comprehensive analysis of the chemical composition of active compounds in different solvent extracts and essential oils has not been fully reported. This study aims to explore the chemical composition of active compounds in standardized cinnamon simplicia. Standardization parameters include water-soluble extractive, ethanol-soluble extractive, moisture content, ash content, microbial contamination levels, and qualitative and quantitative phytochemical analysis. Cinnamon was extracted using water, n-hexane, and steam distillation to obtain water extract, n-hexane extract, and essential oil, respectively, which were then analyzed by LC-MS and GC-MS. In general, all parameters set for the standardization of cinnamon simplisia met the applicable quality standards. The total phenolic content obtained was 3.99 ± 0.14 mgGAE/g, flavonoid content was 1.54 ± 0.10 mgQE/g, and total terpenoid content was 1.35 ± 0.13 mg/g. Furthermore, this study identified that the dominant active compounds in water extracts were polyphenols; n-hexane extracts contained major active compounds in terpenoids. At the same time, cinnamon essential oil showed the largest content of cinnamaldehyde. These findings provide important information regarding the chemical composition of cinnamon and its contribution to potential applications in the pharmaceutical and natural products industries.
In Vivo Antihyperlipidemic Activity of TD.HLM01 – A Vietnamese Traditional Remedy in Experimental Models Tung Thanh Tran; Ha Thi Thu Nguyen; Thuy Thanh Nguyen; Lien Huong Thi Nguyen; Van Hong Thi Nguyen; Hang Thi Thuy Nguyen; Quang Vinh Trinh; Hang Thi Thu Dinh; Duong Thuy Dau; Phong Xuan Pham; Nghia Trong Duong; Van Anh Thi Pham
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.101779

Abstract

One of the primary risk factors for cardiovascular disease nowadays is dyslipidemia. For many years, multi-herbal preparations have been the standard treatment approach for treating dyslipidemia. The purpose of this study was to assess the effects of TD.HLM01 hard capsule on experimental rodent models of endogenous and exogenous dyslipidemia. To create hyperlipidemia in the endogenous hyperlipidemia paradigm, mice were first given TD.HLM01 hard capsule therapy and intraperitoneal injections of poloxamer-407. In the exogenous model, rats were given a diet of oil-cholesterol mixture orally and treated with TD.HLM01 hard capsules for four consecutive weeks. Serum lipid parameters were evaluated in both experiments. The results indicated that TD.HLM01 significantly reduced TC, TG, and non-HDL-C levels in the experimental models of exogenous hyperlipidemia and endogenous hyperlipidemia. TD.HLM01 improved the serum LDH levels and ameliorated the elevated AST and ALT levels in cholesterol-induced hyperlipidemia rats. This study has demonstrated the potential efficacy of TD.HLM01 in hyperlipidemia experimental models in vivo.
The Effects of Imperata cylindrica Root Extract on Spermatozoa Membrane Integrity Using Hypo-Osmotic Swelling Test Silvani Permatasari; Febriana Dwi Nanda; Sigit Nurfianto; Septi Handayani; Margaretha Yayu Indah Anugerahny
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.102532

Abstract

High levels of reactive oxygen species (ROS) may trigger oxidative stress that harms the structural integrity of the sperm cell membrane. Concerning this case, ethanol extract from the alang-alang (Imperata cylindrica) root is considered capable of maintaining sperm quality. However, tests of spermatozoa membrane integrity in vitro have not been conducted. This research purposed to determine the effects of different concentrations of I. cylindrica root extracts on spermatozoa membrane integrity, analyzed by the hypo-osmotic swelling test. The I. cylindrica root extracts (concentrations of 1000 ng/mL, 2000 ng/mL, 3000 ng/mL, and 4000 ng/mL) were obtained through maceration extraction for 3 × 24 hours with 96% ethanol solvent. GC-MS analysis was then conducted to identify compounds in the extract. The sample used for the membrane integrity test was in vitro human spermatozoa. Priorly, it was washed, mixed with BWW medium, and incubated at 37℃ for 60 minutes with I. cylindrica root extracts and the control group. Furthermore, semen was added to the HOS solution. The yields exhibited that the highest compounds in the ethanol extracts of I. cylindrica root were hexadecanoic acid, palmitic acid, octadec-9-enoic acid, and stearic acid. Further, the spermatozoa membrane integrity increased significantly with the higher concentrations of the I. cylindrica extracts. Moreover, the extracts could maintain the membrane integrity more than the control group, where the most effective result was achieved at 1000 ng/mL I. cylindrica extracts, since its minimum concentration can induce a biological response.
Formulation and Wound Healing Evaluation in vivo of Ointment Based on Propolis, and Containing Curcumin Mariia Kozak; Kristina Sementsiv; Iryna Petruh
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.104987

Abstract

Antimicrobial drugs are widely used in commercial ointments to treat different types of wounds.  Unwise use of antimicrobials in ointment formulations only deepens the problem of antimicrobial resistance. Some natural products and plants (Aloe vera, honey, turmeric paste, garlic, and coconut oil) also possess antibacterial, anti-inflammatory and antioxidant properties. They are able to accelerate the healing of wounds. These wound-healing agents have the ability to suppress the development of pathogenic microflora on the wound surface, prevent the appearance of rotting of damaged tissues, and also have a weak analgesic effect. The aim of the study is to develop ointment formulations based on natural products and assess their physical properties, efficiency and safety for animals. Ointment formulations were prepared by fusion technique using animal fat, propolis, starch and curcumin. Physical evaluation of ointments pH, appearance, spreadability and stability was studied. Skin irritation and wound healing tests were applied on guinea pigs (Cavia porcellus). The first ointment contains 20% of Propolis and 5% of starch. The second ointment additionally hold 5% of curcumin. Ointments’ pH was within the optimal limits (6.5±1.3 and 5.6±0.13). Both ointments showed good stability and perfect spreadability (121±3.5 and 112.4±2.6). The microscopic observation confirms higher spreadability of the ointment with curcumin. The ointments caused no irritation for the skin. Propolis ointment enhanced wound closure in male guinea pigs.  Propolis+curcumin have great anti-inflammatory activity. The results showed that propolis and curcumin ointment is not irritable and can be used for wound treatment and healing.

Page 57 of 57 | Total Record : 564

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