cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Pudyastuti Kusumaningrum
Contact Email
mot.farmasi@ugm.ac.idm
Phone
-
Journal Mail Official
mot.farmasi@ugm.ac.id
Editorial Address
-
Location
Kab. sleman,
Daerah istimewa yogyakarta
INDONESIA
Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
Arjuna Subject : -
Articles 579 Documents
 54   55   56   57   58 
Chemical Composition of Active Compounds in Standardized Cinnamon Simplicia (Cinnamomum verum) Sentot Joko Raharjo; Dewi Ratih Tirto Sari; Yanty Maryanty; Ita Tresnowati; Ernanin Dyah Wijayanti
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.100943

Abstract

Cinnamon (Cinnamomum verum) is widely recognized as a spice with a distinctive aroma that has a variety of applications in the culinary and health industries, due to its diverse active compounds. Standardization is essential to ensure the quality and uniformity of cinnamon raw materials. Previous studies primarily focused on identifying the most abundant compounds and bioactivity testing. However, a comprehensive analysis of the chemical composition of active compounds in different solvent extracts and essential oils has not been fully reported. This study aims to explore the chemical composition of active compounds in standardized cinnamon simplicia. Standardization parameters include water-soluble extractive, ethanol-soluble extractive, moisture content, ash content, microbial contamination levels, and qualitative and quantitative phytochemical analysis. Cinnamon was extracted using water, n-hexane, and steam distillation to obtain water extract, n-hexane extract, and essential oil, respectively, which were then analyzed by LC-MS and GC-MS. In general, all parameters set for the standardization of cinnamon simplisia met the applicable quality standards. The total phenolic content obtained was 3.99 ± 0.14 mgGAE/g, flavonoid content was 1.54 ± 0.10 mgQE/g, and total terpenoid content was 1.35 ± 0.13 mg/g. Furthermore, this study identified that the dominant active compounds in water extracts were polyphenols; n-hexane extracts contained major active compounds in terpenoids. At the same time, cinnamon essential oil showed the largest content of cinnamaldehyde. These findings provide important information regarding the chemical composition of cinnamon and its contribution to potential applications in the pharmaceutical and natural products industries.
In Vivo Antihyperlipidemic Activity of TD.HLM01 – A Vietnamese Traditional Remedy in Experimental Models Tung Thanh Tran; Ha Thi Thu Nguyen; Thuy Thanh Nguyen; Lien Huong Thi Nguyen; Van Hong Thi Nguyen; Hang Thi Thuy Nguyen; Quang Vinh Trinh; Hang Thi Thu Dinh; Duong Thuy Dau; Phong Xuan Pham; Nghia Trong Duong; Van Anh Thi Pham
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.101779

Abstract

One of the primary risk factors for cardiovascular disease nowadays is dyslipidemia. For many years, multi-herbal preparations have been the standard treatment approach for treating dyslipidemia. The purpose of this study was to assess the effects of TD.HLM01 hard capsule on experimental rodent models of endogenous and exogenous dyslipidemia. To create hyperlipidemia in the endogenous hyperlipidemia paradigm, mice were first given TD.HLM01 hard capsule therapy and intraperitoneal injections of poloxamer-407. In the exogenous model, rats were given a diet of oil-cholesterol mixture orally and treated with TD.HLM01 hard capsules for four consecutive weeks. Serum lipid parameters were evaluated in both experiments. The results indicated that TD.HLM01 significantly reduced TC, TG, and non-HDL-C levels in the experimental models of exogenous hyperlipidemia and endogenous hyperlipidemia. TD.HLM01 improved the serum LDH levels and ameliorated the elevated AST and ALT levels in cholesterol-induced hyperlipidemia rats. This study has demonstrated the potential efficacy of TD.HLM01 in hyperlipidemia experimental models in vivo.
The Effects of Imperata cylindrica Root Extract on Spermatozoa Membrane Integrity Using Hypo-Osmotic Swelling Test Silvani Permatasari; Febriana Dwi Nanda; Sigit Nurfianto; Septi Handayani; Margaretha Yayu Indah Anugerahny
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.102532

Abstract

High levels of reactive oxygen species (ROS) may trigger oxidative stress that harms the structural integrity of the sperm cell membrane. Concerning this case, ethanol extract from the alang-alang (Imperata cylindrica) root is considered capable of maintaining sperm quality. However, tests of spermatozoa membrane integrity in vitro have not been conducted. This research purposed to determine the effects of different concentrations of I. cylindrica root extracts on spermatozoa membrane integrity, analyzed by the hypo-osmotic swelling test. The I. cylindrica root extracts (concentrations of 1000 ng/mL, 2000 ng/mL, 3000 ng/mL, and 4000 ng/mL) were obtained through maceration extraction for 3 × 24 hours with 96% ethanol solvent. GC-MS analysis was then conducted to identify compounds in the extract. The sample used for the membrane integrity test was in vitro human spermatozoa. Priorly, it was washed, mixed with BWW medium, and incubated at 37℃ for 60 minutes with I. cylindrica root extracts and the control group. Furthermore, semen was added to the HOS solution. The yields exhibited that the highest compounds in the ethanol extracts of I. cylindrica root were hexadecanoic acid, palmitic acid, octadec-9-enoic acid, and stearic acid. Further, the spermatozoa membrane integrity increased significantly with the higher concentrations of the I. cylindrica extracts. Moreover, the extracts could maintain the membrane integrity more than the control group, where the most effective result was achieved at 1000 ng/mL I. cylindrica extracts, since its minimum concentration can induce a biological response.
Formulation and Wound Healing Evaluation in vivo of Ointment Based on Propolis, and Containing Curcumin Mariia Kozak; Kristina Sementsiv; Iryna Petruh
Majalah Obat Tradisional Vol 30, No 3 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.104987

Abstract

Antimicrobial drugs are widely used in commercial ointments to treat different types of wounds.  Unwise use of antimicrobials in ointment formulations only deepens the problem of antimicrobial resistance. Some natural products and plants (Aloe vera, honey, turmeric paste, garlic, and coconut oil) also possess antibacterial, anti-inflammatory and antioxidant properties. They are able to accelerate the healing of wounds. These wound-healing agents have the ability to suppress the development of pathogenic microflora on the wound surface, prevent the appearance of rotting of damaged tissues, and also have a weak analgesic effect. The aim of the study is to develop ointment formulations based on natural products and assess their physical properties, efficiency and safety for animals. Ointment formulations were prepared by fusion technique using animal fat, propolis, starch and curcumin. Physical evaluation of ointments pH, appearance, spreadability and stability was studied. Skin irritation and wound healing tests were applied on guinea pigs (Cavia porcellus). The first ointment contains 20% of Propolis and 5% of starch. The second ointment additionally hold 5% of curcumin. Ointments’ pH was within the optimal limits (6.5±1.3 and 5.6±0.13). Both ointments showed good stability and perfect spreadability (121±3.5 and 112.4±2.6). The microscopic observation confirms higher spreadability of the ointment with curcumin. The ointments caused no irritation for the skin. Propolis ointment enhanced wound closure in male guinea pigs.  Propolis+curcumin have great anti-inflammatory activity. The results showed that propolis and curcumin ointment is not irritable and can be used for wound treatment and healing.
The Effect of Biofertilizer under Drought: Vitamin C, Starch Content, Biomass and Root Anatomy of Shallot (Allium cepa L.) Siswanti, Dwi Umi; Lestari, Nurrisma Ika; Laksitorini, Marlyn Dian
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.98006

Abstract

Shallots (Allium cepa L.) is a plant that requires sufficient water and is susceptible to drought stress. The use of biofertilizer is employed because it contains microorganisms to enhance nutrient availability and assist plant growth under abiotic stress. The biofertilizer used in this study is the Siswanti formula (EnWie Biofertilizer) which contains Bacillus sp., Lactobacillus sp., Saccharomyces sp., Streptomyces sp., Pseudomonas, Azospirillum, Azotobacter, Rhizobium and Trichoderma sp. This study aims to analyze the physiological and anatomical responses of shallot bulbs following the application of biofertilizer under drought stress. The doses of biofertilizer used were 10 L/ha, 15 L/ha, and 20 L/ha with field capacity levels of 25%, 50%, 75%, and 100%. Parameters tested included vitamin C content, starch content, cortex thickness anatomy and dry weight of shallot roots. The method used to determine the vitamin C content was UV-VIS spectrophotometry, while the starch content research used the Nelson-Smogy method. The method used in making shallot root specimens was the embedding method. The results of this study showed that the application of biofertilizer affects the physiology and anatomy of Allium cepa L. under drought stress. The application of 15 L/ha biofertilizer increases vitamin C content, starch content, and cortex thickness. Meanwhile, 10 L/ha biofertilizer increases root dry weight.
Optimization of Span 80-Croduret 50-Propylene Glycol as Emulsifier of Dried Strawberry Juice (Fragaria vesca L.) Emulgel and Permeation Test Through Shed Snakeskin Membrane Ermawati, Dian Eka; Martodihardjo, Suwaldi; Sulaiman, TeukuNanda Saifullah
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.98265

Abstract

Strawberry is a natural source of antioxidants with potential to inhibit melanin production in the skin. However, its application in topical formulations is limited by factors such as stability, skin permeability, and effective delivery, necessitating the development of an appropriate delivery system. This has led to the selection of double emulsion due to the water solubility of the active ingredient. To produce a stable emulsion, it is required to combine emulsifier with different hydrophilic-lipophilic balance values. This study aimed to obtain the optimal proportion of emulsifier combinations for formulating an emulgel containing dried strawberry. Antioxidant activity was evaluated using the DPPH assay, while the content of active compounds was quantified using the UV-Vis spectrophotometric method. The optimization of emulsifier proportions was carried out using the simplex lattice design (SLD), with globule size, viscosity, and separation ratio as response parameters. The optimized emulsion system was then incorporated into a hydrogel. Physicochemical stability of the emulgel was assessed based on organoleptic properties, pH, viscosity, spreadability, and phase separation. Permeation studies were conducted using Franz diffusion cells with shed snakeskin membrane as the diffusion barrier. The study successfully demonstrated that dried strawberry juice possesses antioxidant activity, with an IC₅₀ value of 0.331 mg/mL. The levels of key active compounds, namely quercetin (23.3% w/w) and anthocyanins (13.23% w/w), supporting its potential use in topical antioxidant applications. The most effective emulsifier system was determined to be a Span 80:Croduret 50:Propylene Glycol ratio of 1:2:1. This emulsifier composition yielded an emulsion with favorable droplet size, viscosity, and stability characteristics. Incorporation into a 1.5% Polygel CA hydrogel resulted in an emulgel formulation with excellent physicochemical stability, as indicated by consistent pH, spreadability, viscosity, and absence of phase separation during storage. Permeation studies using Franz diffusion cells showed that the optimized emulgel was capable of delivering 117.14 μg/cm² of flavonoids across shed snakeskin membrane within 5 hours, with a permeability coefficient of 2.84×10⁻⁵ μg/cm² and a flux rate of 6.6×10⁻⁵ μg/sec, indicating good skin permeation potential.
Evaluation of Antidiabetic Properties of a Polyherbal Extract (ACCBN) on Alloxan-induced Diabetic Rats Uroko, Robert Ikechukwu; Chike-Ekwughe, Amarachi; Nweje-Anyalowu, Paul Chukwuemeka; Aguwamba, Chinedu
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99354

Abstract

Diabetes mellitus emanates from a dysfunctional metabolic process and it affects human population globally, and causes a decline in the quality of life and increase in mortality rate due to its complications and adverse effects of the available antidiabetic drugs, thus, there is a need for a better antidiabetic agent. This study assessed the antidiabetic properties of a polyherbal extract (ACCBN) on alloxan-induced diabetic rats to validate its antidiabetic claims in traditional medicine. The diabetic study had 6 groups including normal control, diabetic rats deprived of treatment, diabetic rats administered 5 mg/kg Glibenclamide, and diabetic rats administered 400 and 800 mg/kg ACCBN-extract accordingly and normal rats administered 800 mg/kg ACCBN-extract only. The rats were successfully made diabetic by the administration of alloxan monohydrate intraperitoneally whereas and the rats were treated with either Glibenclamide or ACCBN-extract orally for 28 consecutive days. The acute study of ACCBN-extract indicated lethal dose above 5000 mg/kg. The diabetic rats deprived of treatment showed significantly elevated acute and sub-acute blood glucose levels including significantly elevated glycated haemoglobin concentration and significant decline in the C-peptide and insulin levels relative to the normal control. Diabetic rats administered ACCBN-extract displayed a marked decline in the acute and sub-acute blood glucose levels in comparison to the diabetic rats deprived of treatment. The diabetic rats administered ACCBN-extract displayed a remarkable decline in glycated haemoglobin level and significantly elevated C-peptide and insulin concentrations compared to the diabetic rats deprived of treatment. The outcome revealed that ACCBN-extract possesses sufficient antidiabetic properties and could be effective in the management of diabetes.
Secondary Metabolites Analysis and Anti-Cancer Potential of Lansium parasiticum Extract Mutiah, Roihatul; Safina, Nilna Amalia Nur; Briliana, Malich Septi Diajeng
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99979

Abstract

Cancer is a non-communicable disease characterized by uncontrolled growth of malignant cells. The leaves and stems of Lansium parasiticum have been recognized for their potential as an anti-cancer agent. However, research reporting secondary metabolite profiles and anti-cancer activity in these plants remains limited. This study aimed to identify compounds, compare compound profiles, and predict the anti-cancer activity of secondary metabolites present in the leaves and stem bark of Lansium parasiticum. The secondary metabolite profile was analyzed using UPLC-MS/MS (Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry) chromatogram data interpretation, while the prediction of anticancer activity was made by referencing the Probability Activity value obtained through the PASS (Prediction of Activity Spectra for Substances) Server. The results revealed 24 bioactive compounds successfully identified from the Lansium parasiticum leaf extract, with Emindole Sb as the major compound comprising 19.3% of the total chromatographic area. Meanwhile, the analysis identified 23 bioactive compounds in the stem bark extract of Lansium parasiticum, with Moronic Acid as the major constituent, representing 14.29% of the total chromatographic area. The examination of the anticancer potential utilizing a probability activity method suggests that both the leaves and stem bark of Lansium parasiticum demonstrate antineoplastic, chemopreventive, and apoptosis-inducing activities.
Antidiabetic and Antidyslipidemic Activity of Ethyl Acetate Fraction of Binahong Leaves in Streptozotocin (STZ)-induced Diabetic Rats Mulyani, Yani; Hasimun, Patonah; Apriliyanti, Nida Putri
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.100960

Abstract

Diabetes mellitus (DM) is a disease characterized by hyperglycemia and impaired glucose, protein, and fat metabolism due to insulin deficiency or resistance. In type 2 DM, insulin resistance potentially causes dyslipidemia through increased lipolysis and glucose production in the liver as well as reduced glucose absorption into cells. According to previous reports, the prevalence of dyslipidemia is relatively high, ranging from 72-85%. One of the plants that has the potential for antidiabetic and antidyslipidemic is binahong (Anredera cordifolia (Ten.) Steenis). Therefore, this research aims to determine the antidiabetic and antidyslipidemic activity as well as the effective dose of ethyl acetate fraction from ethanol extract of binahong leaves to reduce blood sugar levels, total cholesterol, triglycerides, LDL, IAP, increase HDL levels, and improve the histological profile of the pancreas and aorta. The experiment was conducted curatively using 30 rats divided into 5 treatment groups, namely normal (Na-CMC 0.5%), diabetic group (Streptozotocin 35 mg/kgBW), positive control (Simvastatin 10 mg/kgBW), and the test group given ethyl acetate fraction of ethanol extract at dose 1 (100 mg/kgBW) and 2 (150 mg/kgBW). All groups except normal received streptozotocin induction for 3 days until a diabetic rat model was formed, then the test drug treatment was given for 28 days. Blood sugar levels were measured on days 0, 3, 14, and 28 using a glucometer, and lipid profile levels were measured on days 0 and 28 enzymatically using a microlab 300. The results showed that the ethyl acetate fraction of binahong leaves ethanol extract at a dose of 100 mg/kgBW demonstrated antidiabetic and antidyslipidemic effects. It reduced blood glucose and lipid levels by 36–62% compared to the diabetic group and showed similar results to the positive control. This dose also improved the histological structure of the pancreas and aorta.
Hepatoprotective Effects of Milkfish (Chanos chanos) Oil and Silymarin Against Isoniazid–Rifampicin-Induced Liver Injury in Rats Sasongko, Heru; Hovhanness, Mikael; Sawitri, Arinda Handiyah; Maharani, Aulia Hanundita; Hedianti, Delia Putri; Hutasoit, Josua Arianto; Asyraq, Lathyfa; Safitri, Listiyana Ika; Zai, Lois Elda; Sutarno, Sutarno
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.101531

Abstract

The objectives of the present research were to assess the hepatoprotective activities of milkfish oil (MFO) and silymarin (SL) against rifampicin (RFP) and isoniazid (INH) induced hepatotoxicity. Rats were divided into seven groups: normal control, negative control (INH+RFP), silymarin alone (50 mg/kg BW/day), low-dose MFO (MFO-L), high-dose MFO (MFO-H), low-dose combination (SL+MFO-L), and high-dose combination (SL+MFO-H). Rats receiving RFP and INH showed raised liver enzymes and typical signs of hepatotoxicity. Analyzed parameters comprised proinflammatory mediators (tumor necrosis factor-alpha and interleukin-6), antioxidant markers (catalase, glutathione, malondialdehyde, and superoxide dismutase), cytochrome P450, total protein, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin and bilirubin. Treatment with a combination of MFO plus SL remarkably decreased hepatic enzyme activities, oxidative stress and inflammation, and suggested a prevention effect against the drug-induce liver injury.

Page 57 of 58 | Total Record : 579

 54   55   56   57   58 

Filter by Year

2010 2026


Reset
Filter By Issues
All Issue Vol 31, No 1 (2026) Vol 30, No 3 (2025) Vol 30, No 2 (2025) Vol 30, No 1 (2025) Vol 29, No 3 (2024) Vol 29, No 2 (2024) Vol 29, No 1 (2024) Vol 28, No 3 (2023) Vol 28, No 2 (2023) Vol 28, No 1 (2023) Vol 27, No 3 (2022) Vol 27, No 2 (2022) Vol 27, No 1 (2022) Vol 26, No 3 (2021) Vol 26, No 2 (2021) Vol 26, No 1 (2021) Vol 25, No 3 (2020) Vol 25, No 2 (2020) Vol 25, No 1 (2020) Vol 24, No 3 (2019) Vol 24, No 2 (2019) Vol 24, No 1 (2019) Vol 23, No 3 (2018) Vol 23, No 2 (2018) Vol 23, No 1 (2018) Vol 22, No 3 (2017) Vol 22, No 2 (2017) Vol 22, No 1 (2017) Vol 21, No 3 (2016) Vol 21, No 2 (2016) Vol 21, No 1 (2016) Vol 20, No 3 (2015) Vol 20, No 3 (2015) Vol 20, No 2 (2015) Vol 20, No 2 (2015) Vol 20, No 1 (2015) Vol 20, No 1 (2015) Vol 19, No 3 (2014) Vol 19, No 3 (2014) Vol 19, No 2 (2014) Vol 19, No 2 (2014) Vol 19, No 1 (2014) Vol 19, No 1 (2014) Vol 18, No 3 (2013) Vol 18, No 3 (2013) Vol 18, No 2 (2013) Vol 18, No 2 (2013) Vol 18, No 1 (2013) Vol 18, No 1 (2013) Vol 17, No 3 (2012) Vol 17, No 3 (2012) Vol 17, No 2 (2012) Vol 17, No 2 (2012) Vol 17, No 1 (2012) Vol 17, No 1 (2012) Vol 16, No 3 (2011) Vol 16, No 3 (2011) Vol 16, No 2 (2011) Vol 16, No 2 (2011) Vol 16, No 1 (2011) Vol 16, No 1 (2011) Vol 15, No 3 (2010) Vol 15, No 3 (2010) Vol 15, No 2 (2010) Vol 15, No 2 (2010) Vol 15, No 1 (2010) Vol 15, No 1 (2010) More Issue