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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 706 Documents
 43   44   45   46   47 
TOXICITY OF ETHANOLIC EXTRACT OF FRUIT, SEED AND LEAVES OF MAKUTADEWA (Phaleria macrocarpa (Scheff.) Boerl.) TO Artemia salina Leach AND THIN LAYER CHROMATOGRAM PROFILE OF ACTIVE EXTRACT Indah Purwantini; Erna Prawita Setyowati; Triana Hertiani
Indonesian Journal of Pharmacy Vol 13 No 2, 2002
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.799 KB) | DOI: 10.14499/indonesianjpharm0iss0pp101-106

Abstract

A research has been done to determine the toxicity of ethanolic extract of fruit, seed and leaves of makutadewa (Phaleria macrocarpa (Scheff) Boerl.) using Brine Shrimp Lethality Test method. Extract were made by maceration of the materials for 24 hours. The bioassay has been done using 48 hour old Artemia saline Leach. The effect of ethanolic extract was identified by determining and analysing the shrimp death percentage and LC50 of each extract using probit analysis.The result showed that these ethanolic extract were toxic to the shrimp. The ethanolic extract of seed was the most active with the LC50 of 1.60 x 102 g/ml, whereas that of the fruit has the LC50 of 30.42 g/ml. The thin layer chromatogram profile of the active extract suggested that the extract contains alkaloids.Key words : toxicity, makutadewa, brine shrimp lethality test
Co-processing of the arrowroot-chitosan by spray drying Yudi Wicaksono; Yuli Witono; Herlina .; Nuri .
Indonesian Journal of Pharmacy Vol 21 No 3, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.49 KB) | DOI: 10.14499/indonesianjpharm0iss0pp171-177

Abstract

Starch is one of the most widely used excipient in the manufacture of solid dosage forms. One of few problems associated with starch is its poor flowability so  can’t  used  as  excipient  in  direct  compression  tablet.  The  purpose  of  these studies  was  to  develop  of  the  arrowroot  starch  for  use  as  excipient  in  direct compression  tablet.  The  arrowroot  starch  was  co-processing  with  chitosan  by spray  drying.  The  suspension  of  arrowroot  starch-chitosan  for  feed  in  spray drying were prepared with three different ratios (1:1, 2:1 and 3:1). The product of  co-processing  were  evaluated  for  morphology,  moisture  content,  viscosity, angle  of  repose,  flow  rate  of  granules,  bulk  density,  tapped  density  and  Carr’s index.  Results  showed  that  co-process  excipient  of  arrowroot  starch-chitosan have  spherical  in  shape,  moisture  content  in  the  range  of  4.70–5.10  % w/w, viscosity  in  the  range  of   1.77-2.17  mPas,  angle  of repose  was  found  to  be  < 380, flow rate of granules in the range of 1,5 – 4,0 g/s, bulk density in the range of  0.47-0.59 g/mL,  tapped  density  in  the  range of 0.59–0.79  g/mL  l and Carr’s index in the range of 19.03-25.08 %.Key words: arrowroot starch, co-process excipient, direct compression
Effect of the combination of curcuminoid and essential oil on the serum ureum and creatinine level of patientswith osteoarthritis Kertia, Nyoman; ., Danang
Indonesian Journal of Pharmacy Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (205.741 KB) | DOI: 10.14499/indonesianjpharm0iss0pp151-157

Abstract

The curcuminoid of Curcuma domesticaVal. rhizome and the essential oil of Curcuma xanthorrhizaRoxb. rhizome can be used for rheumatic treatment,but no enough  data  regarding  those  side  effects.   This  study  aimed  to  determine  the efect  of  curcuminoid  of  Curcuma  domestica Val.  combined  with  essential  oil  from Curcuma  xanthorriza Roxb.  to  the  serum  ureum  and  creatinine  level  of  patients with osteoarthritis. This treatment was compared tothat of piroxicam. This was a Prospective  Randomized  Open  end  Blinded  Evaluation  (PROBE),  involving  38 patients with knee osteoarthritis.The treatment group were given the combination of  15  mg  curcuminoid  of  Curcuma  domestica Val.  and  100  mg  essential  oil  of Curcuma xanthorrhizatwice daily for two weeks. The control group were given 10 mg piroxicam twice daily for two weeks. In the treatment group the serum ureum level  decreased  4.58±6.20%  mg,  while  in  the  control group  the  ureum  level increased  1.68±8.24%  mg.  In  the  treatment  group  the serum  creatinine  level decreased  0.12±0.36%  mg,  while  in  the  control  group the  creatinine  level increased  0.18±0.29%  mg.  Decreasing  of  serum  ureum  level  in  the  treatment group was significantly different compared to increasing of that level in the control group  (p<0.01).  Decreasing  of  the  creatinine  level  in  the  teatment  group  was significantly  different  compared  to  increasing  of  that  level  in  the  control  group (p<0.01).Key words: Curcuminoid, Essential Oil, Ureum, Creatinine, Osteoarthritis
Isolation and structure elucidation of main compound originated from sponge Axynissa aplysinoides Sumaryono, Wahono; Wibowo, Agung Eru; ., Chaidir
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.647 KB) | DOI: 10.14499/indonesianjpharm0iss0pp186-191

Abstract

Isolation of the main compound of sponge Axynissa aplysinoides collected from Lombok seawater, has been conducted. Methanol extract of dried sponge was fractionated into nonpolar, semipolar and polar fractions using hexane, ethyl acetate and buthanol. Identification and final purification of the main compound was done using column chromatography and high performance liquid chromatography (HPLC). Structure elucidation of the main compound was performed using mass spectrometry (EIMS), 1H- and 13C-NMR spectroscopies. The main compound was identified as (E)-(4-hydroxystyryl) trimethylammonium.Key words : isolation, structure elucidation, Axynissa aplysinoides
The anticancer compound identification from chloroform extract of Rhizopora mucronata stem bark Diastuti, Hartiwi; ., Warsinah
Indonesian Journal of Pharmacy Vol 21 No 4, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.963 KB) | DOI: 10.14499/indonesianjpharm0iss0pp266-271

Abstract

Previous  reasearch  reported  that  chloroform  extract  that  was  partitioned from etanol exctracts  of  R. mucronata  stem bark had sitotoxic against Myeloma cells  (Diastuti,  2008).  This  research  was  aimed  to  fractinate  the  chloroform extract  of  R.  mucronata  stem  bark  and  cytotoxicity  test  againts  Myeloma  cells, then  identification  the  cytotoxic  compounds.  The  ethanol  extracts  of R.  mucronata  steam  bark  was  partitioned  with  chloroform.  The  chloroform extracts was fractinated by coloum chromatography with gradient eluent were nhexane, chloroform, etilacetate  and methanol respectivelly. Cytotoxicity test the fraction  of  chloroform  extracts  were  conducted  on  Myeloma  cells  by  MTT methods.  Identification   the  compoud  of  fraction  that  had  a  highest  cytotoxic againts  Myeloma  cells  conducted  using  IR  spectrometer,  and  GCMS.  The  result showed  that  2b  fraction  of   R.  mucronata  stem  bark  had  a  highest  cytotoxic againts  Myeloma  cells,  having  IC50  equal  to  5.122   µg/mL.  Identification  of chemical compounds  showed that 2b fraction  contained two steroid compounds were 4 methyl- colest-24-en-3-ol and 4-methyl-stigmast-22-en-3-ol.Key words : R. Mucronata, anticancer, Myeloma cells, steroids
A BIOAVAILABILITY STUDY OF INDONESIAN GENERIC TABLET OF CAPTOPRIL IN HEALTHY VOLUNTEERS Nugroho, Agung Endro; Hakim, Arief Rahman; ., Purwantiningsih; Hakim, Lukman
Indonesian Journal of Pharmacy Vol 23 No 3, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (691.336 KB) | DOI: 10.14499/indonesianjpharm23iss3pp183-187

Abstract

Captopril  is  a  selective  inhibitor  of  angiotensin-converting enzyme  (ACE)  and  is  formulated  by  several  pharmaceutical companies in Indonesia. This study was conducted to compare the bioavailability  of  a  captopril  tablet  with  reference  products  in healthy  volunteers.  The  relative  bioavailability  of  captopril  was determined in single dose, randomized, crossover,  and  two-phase studies.  The  relative  bioavailability  of  the  test  product  (a  generic captopril 50 mg tablet) with respect to the reference product was determined. Twelve healthy volunteers in two groups took part in these  studies  and  took  either  the  test  or  reference  tablets  in  the first  phase  and  received  the  other  tablet  in  the  second  phase  of each  study.  The  bioavailability  parameters  include  the  peak concentration  of  captopril  in  serum  (Cmax);  the  time  to  achieve the  peak  concentration  (Tmax);  and  the  area  under  the  curve  of captopril  in  serum  versus  time.  Non-compartmental  analysis  on observed concentration versus time data has resulted in the mean value of Cmax of 545.26 ± 22.90 ng/mL (test product) and 548.91 ± 25.07 ng/mL (reference product) and mean Tmax of 1.13 ± 0.08 hours  (test  product)  and  1.08  ± 0.08  hours  (reference  product), mean  of  AUC0-7  value  of  1820.51  ± 75.31  ng.  hour/mL  (test product)  and  1822.09  ± 99.29  ng.  hour/mL  (reference  product), and  mean  of  AUC0-inf  value  of 1967.83  ±  95.65  ng. hour/mL  (test product)  and  1996.94  ± 124.52  ng.  hour/mL  (reference  product). Based on the data, it can be concluded that there is no significant difference  (p>0.05)  in  bioavailability  between  both  captopril Tablet (test and reference product).Key words: Bioequivalence, Captopril, HPLC, Human serum, Generic 
BIOACTIVITY SCREENING OF SPONGES COLLECTED FROM BUNAKEN, MENADO BY Brine Shrimp Lethality Test AGAINST Artemia salina Leach Astuti, Puji; Alam, Gemini; Wahyuono, Subagus
Indonesian Journal of Pharmacy Vol 14 No 1, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.569 KB) | DOI: 10.14499/indonesianjpharm0iss0pp238-243

Abstract

Indonesia is one of the countries rich of natural resources. Sponges are marine invertebrates widely found in Indonesia and known to have various bioactive compounds with unique chemical structures. This study was aimed to screen potentially bioactive extracts of sponges collected from Bunaken and identify on their toxicity level against larva Artemia salina Leach. Samples were macerated using acetone followed by partition using chloroform and methanol. The extracts were prepared at the concentration of 100, 250, 500 and 1000 mg/ml and their toxicity was tested using Brine shrimp Lethality Test. LC50 (mg/ml) of the extracts was calculated using probit analysis. From the 4 extracts tested, all of them showed toxicity to larva Artemia. Chloroform extract of MD-02 was found to be the most toxic with the LC50 of 48.15 mg/ml and considered as a potential candidate for new drug research. Further characterization is still needed for the development in the future. This active sponge was then identified as Petrosia sp.Key words: sponges, Bunaken, bioactivity, Artemia salina Leach
Three resveratrol’s oligomers from the stem bark of H. gregaria (dipterocarpaceae) and their toxicity and citotoxicity ., Sahidin; Hakim, Euis H.; Syah, Yana M.; Juliawaty, Lia D.; Achmad, Sjamsul A.; Latip, Jalifah
INDONESIAN JOURNAL OF PHARMACY Vol 17 No 3, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.948 KB) | DOI: 10.14499/indonesianjpharm0iss0pp109-115

Abstract

Three resveratrol oligomers have been isolated from the stem bark of H. gregaria including a resveratrol trimer i.e. α-viniferin (1), and two resveratrol tetramers i.e. vaticanol B (2) and hopeaphenol (3). These structures were determined by spectroscopic evidence including UV, IR, 1H , 13C NMR and compared with that of the reported data in the literatures. Activities of the compounds were determined toward brine shrimp Artemia salina (toxicity) and murine leukemia P-388 cells (cytotoxicity). The compound 1 is the most active against A. salina (LC50 = 49,0 ± 5,8 μg/mL), and the compound 3 has very active level toward murine leukemia P-388 cells (LC50 = 5,7 ± 0,3 μM).Key words : Resveratrol oligomers, H. gregaria, toxicity, and cytotoxicity.
Active cutaneous anaphylaxis-inhibitory activity of Gamavuton-0 potassium (K-GVT-0) Agung Endro Nugroho; Nunung Yuniarti; Enade Perdana Istyastono; Supardjan .; Lukman Hakim
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (277.154 KB) | DOI: 10.14499/indonesianjpharm0iss0pp63-70

Abstract

Potassium Gamavuton-0 is a salt form of 1,5-bis(4’-hydroxy-3’-methoxyphenyl)-1,6-heptadiene-3,5 dione or gamavuton-0. Structure modification to a salt form is expected to result in a soluble compound which should have a better bioavailability. The purpose of this experimental study was to evaluate the inhibitory effects of potassium gamavuton-0 on active cutaneous anaphylaxis reaction induced by ovalbumin as an antigen.The study was performed using an active cutaneous anaphylaxis method followed by histopathological observation. The rats were subcutaneously sensitised by ovalbumin (OVA) and Al(OH)3 twice on the days of 0 and 7, and finally were challenged by ovalbumin on the day of 14 to induce active cutaneous anaphylaxis reaction. In order to determine the mast cells on the inflammation tissues, the specimens were stained with 0.1 % Alcian Blue (pH 0.3) and nuclear fast red. Under light microscopy, mast cells were identified as blue granules against a pale red backgound.The results showed that potassium gamavuton-0 at the doses of 20 and 40 mg/kg BW could inhibit the pigmentation area of vascular permeability on rats dorsal skin. It indicated that this compound has the inhibitory effect on active cutaneous anaphylaxis reaction with ED30 value of 28.26 mg/kg BW. Nevertheless, inhibitory effect of potassium gamavuton-0 was still lower than that of cromolyn sodium, a mast cell degranulation inhibitory drug. Histopathologically, the mechanism of inhibitory effect of potassium gamavuton-0 on active cutaneous anaphylaxis reaction is suggested through the inhibition on mast cell degranulation process responsible for releasing inflammation mediators such as histamine, serotonin.Key words: Gamavuton-0 potassium, anaphylaxis, mast cell, ovalbumin
Peroxide value and DPPH (diphenyl picril hydrazil hydrate) free radical scavenger activity of Knema laurina methanol extract ., Praptiwi; Dewi, Puspa; Harapini, Mindarti
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.416 KB) | DOI: 10.14499/indonesianjpharm0iss0pp32-36

Abstract

The aim of the study were to determine the peroxide value and anti DPPH free radical scavenger activity of Knema laurina (Myristicaceae) methanol extract as indicator og antioxidant properties. Peroxide value wasdetermined by iodometri-titration method while anti DPPH free radical was determined by spectrophotometry. Based on phytochemical screening, the chemical compounds of K. laurina were essential oil, sterol, triterpen, tannin, peroxide sugar, alkaloid and saponin. Peroxide value (POV) of K. laurina methanol extract was 158.07 peroxide/1kg sample, while POV of α- tocopherol was 363.96 peroxide/1kg sample. It mean that the inhibition of oxidation process of K. laurina methanol extract was better that that of α-tocopherol so the peroxide formed was lower. The IC50 of K. laurina methanol extract was 39.72 ppm, while IC50 of vitamin C was 12.20 ppm. The result showed that methanol extract of K. laurina at the concentration of 39.72 ppm inhibit 50% of free radical DPPH activity. Based on the peroxide value and IC50 of K. laurina methanol extract, it can be concluded that K. laurina methanol extract had potential activity as anti-DPPH free radical and could be acted as reductor in oxidation process.Key words : Knema laurina, peroxide value (POV), free radical DPPH

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