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Dental Journal (Majalah Kedokteran Gigi)
Published by Universitas Airlangga
ISSN : 19783728     EISSN : 24429740     DOI : -
Core Subject : Health,
Dentistry
The Dental Journal (Majalah Kedokteran Gigi) (e-ISSN:2442-9740; p-ISSN:1978-3728) is published by the Faculty of Dental Medicine, Universitas Airlangga. Its diciplinary focus is dental science and dental hygiene. The Dental Journal (Majalah Kedokteran Gigi) is published in English on a quarterly basis with each 50-60 page edition containing between nine and eleven scientific articles on research, study literature and case studies. Contributors to the Dental Journal (Majalah Kedokteran Gigi) included: dental researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries.
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Articles 15 Documents
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Search results for , issue "Vol. 58 No. 4 (2025): December" : 15 Documents clear
Caspase-3/-9 as tongue cancer cell apoptosis target induced by ibuprofen Supriatno; Rosanto, Yosaphat Bayu; Karina, Vincensia Maria
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p355-360

Abstract

Background: Tongue carcinoma is different from oral cancer in other areas because it has a high amount of cell growth, localized migration, and a higher rate of spreading to cervical lymphatic nodes. Therapeutic alternatives, particularly concerning recurrent malignancies, are notably constrained. Nevertheless, it is imperative to explore novel methodologies for refractory neoplasms, one of which may involve the application of ibuprofen. Purpose: The goal of this study was to look at how well caspase-3 and -9 break down proteins as possible targets for apoptosis in tongue cancer cells that were caused by ibuprofen. Methods: A controlled laboratory experiment employing a post-test-only design was executed. We used a colorimetric test for caspase-3 and -9 to check for the induction of apoptosis. The suppression of cellular invasion was verified through the Boyden chamber assay. Western blot analysis was utilized to identify the presence of caspase-3 and -9 proteins. The administered doses of ibuprofen were calibrated at 0, 5, 10, 25, 50, and 100 µg/mL. Data were subjected to analysis using two-way ANOVA followed by post-hoc Least Significant Different (LSD), with a significance threshold set at 95%. Results: It was established that ibuprofen at dosages ranging from 25 to 100 µg/mL significantly facilitated apoptosis in cells through an augmentation of the proteolytic activity of caspase-3 and -9. Notably, caspase-9 exhibited a superior proteolytic activity (1.85-fold) compared to caspase-3 (1.30-fold) (P = 0.038) at the 100 µg/mL concentration. The upregulation of caspase-3 and -9 proteins was observed in cells treated with ibuprofen. Ultimately, ibuprofen demonstrated an ability to inhibit the invasion of tongue carcinoma cells across various dosages. Conclusion: Ibuprofen has been shown to induce the proteolytic activities of caspase-3 and -9 in tongue carcinoma cells. However, the proteolytic activity of caspase-9 surpassed that of caspase-3, suggesting that targeting this protein may constitute a promising novel therapeutic strategy for this cancer variant.
Social determinants and oral health among cement industry workers Azzahra, R. E. Haura; Amalia, Rosa; Widhyharto, Derajad Sulistyo; Pramono, Dibyo; Priyono, Bambang
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p382-387

Abstract

Background: Cement industry workers are exposed to significant oral health risks due to hazardous conditions, but the role of social determinants in this context is not well understood. Purpose: This study investigates the association between social determinants and oral health among factory and office workers in the cement industry. Methods: A cross-sectional study was conducted at PT. Semen Padang, West Sumatra, Indonesia. A stratified random sample of 83 workers was selected. Social determinants were assessed using World Health Organization (WHO) 2013 and Perceived Stress Scale (PSS-10) questionnaires, while oral health was evaluated using decayed, missing, and filled teeth index (DMF-T), community periodontal index (CPI), and inspection. Ten calibrated dentists conducted dental examinations. Multiple linear regression was used for data analysis. Results: Factory workers exhibited higher rates of dental caries (95.83%), periodontal disease (87.50%), abrasion (91.67%), and attrition (87.50%), compared to office workers. Social determinants significantly associated with dental caries in factory workers included age, sugar intake, tooth-brushing frequency, and last dental check-up (r2 = 0.573), while only sugar intake was associated with caries in office workers (r2 = 0.290). For periodontal disease determinants associated with age, psychosocial factors, and smoking (r2 = 0.558) were significant in factory workers, whereas, in office workers, age, sugar intake, tooth-brushing frequency, last dental check-up, and smoking were significantly associated (r2 = 0.870). Age was the only significant determinant of abrasion and attrition in both groups. Conclusion: Social determinants influence oral health among cement industry workers, especially factory workers, due to physiological and psychological changes caused by working conditions. However, office workers also face oral health challenges due to poor oral health behaviors.
Level of knowledge and learning exposure on cleft lip and palate treatment among undergraduate Universitas Indonesia dental students Ariawan, Dwi; Utomo, Yudy Ardilla; Angriandananti, Nadya Deva; Latief, Mohammad Adhitya; Julia, Vera; Sulistyani, Lilies Dwi
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p342-346

Abstract

Background: Cleft lip and palate are the most common congenital orofacial anomalies. Dental students must have a basic knowledge, understanding, and awareness of comprehensive cleft management. The Faculty of Dentistry Universitas Indonesia undergraduate program uses the problem-based learning (PBL) method to teach dental students about cleft management. Purpose: This study aims to determine the level of knowledge and exposure to learning with the PBL method regarding comprehensive cleft management. Methods: A cross-sectional design was used, and data were collected from 253 dental students using an online questionnaire via Google Forms. Results: Ten preclinical students (8.5%) had a low level of knowledge, 56 (47.5%) had a sufficient level of knowledge, and 52 (44.1%) had a high level of knowledge of comprehensive cleft management. Among the clinical students, 6 (4.4%), 65 (48.1%), and 64 (47.4%) demonstrated low, sufficient, and high levels of knowledge, respectively. Furthermore, most students were content with the lectures on comprehensive cleft management (46.24% satisfied and 20.55% very satisfied) and the supervision received during the lectures (43.48% agreed and 23.71% strongly agreed). Most students believed the lectures on cleft management could be applied when they graduate as dentists. The Chi-square test showed no significant relationship between learning exposure and the student’s knowledge level. Conclusion: Most Faculty of Dentistry Universitas Indonesia students who had learned about cleft lip and palate using the PBL method had sufficient knowledge about comprehensive cleft management. However, no significant relationship was observed between learning exposure and knowledge level.
Retention of CAD PEEK versus metallic partial denture frameworks in patients with mandibular Kennedy Class I Abdelaziz, Amr Magdy Ibrahim; ElKhashab, Mohamed Amr; Zaky, Azza Hussein
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p402-408

Abstract

Background: Traditionally, removable partial denture (RPD) frameworks have been made from metal alloys, with patients expressing dissatisfaction regarding esthetics, metallic taste, and weight. Several attempts have been made to introduce new materials suitable for RPD frameworks. Purpose: This study aims to compare the retention of polyetheretherketone (PEEK) and metallic computer-aided designed (CAD) removable partial dentures (RPD) in patients with mandibular Kennedy Class I. Methods: Twenty-four patients with Kennedy Class I partially edentulous mandibles were randomly assigned to two parallel groups. Computer-aided design of the RPD’s frameworks was used to produce a sacrificial resin pattern, then cast into cobalt chromium (Co-Cr) or pressed into PEEK to produce RPD frameworks. An acrylic resin denture base and teeth were attached to the framework, processed, finished, polished, and delivered to the patients. Retention in Newtons was measured for both groups by pulling the RPDs from their geographic center at the time of insertion, after one and three months. Results: At each time interval, a repeated measures ANOVA revealed statistically significantly higher mean retention values for the metal group compared to the PEEK group. Retention did not decrease significantly in the PEEK group, whereas a significant retention decrease was observed in the metal group. An independent student’s T-test revealed a significant difference between retention loss for the metal and PEEK groups. Conclusion: Within the limitations of this study, although metal RPD frameworks provide higher mean retention values than PEEK RPD frameworks, both show clinically acceptable retention levels. Nevertheless, PEEK maintains retention more than metal in the short term.
The effect of the ethanolic extract of African leaves (Vernonia amygdalina Delile) on the corrosion rate and microstructure of stainless steel orthodontic wire Bahirrah, Siti; Ilyas, Syafruddin; Narmada , Ida Bagus; Primasari, Ameta; Lestari, Widya; Indra; Sofyanti, Ervina
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p376-381

Abstract

Background: Stainless steel orthodontic wire is commonly used in orthodontic treatment but is prone to corrosion; therefore, an inhibitor is required. Purpose: This study aimed to evaluate the effectiveness of the ethanolic extract of African leaves (Vernonia amygdalina Delile) as a corrosion inhibitor for stainless steel wires. Methods: A laboratory experiment with a pre- and post-test control group design was conducted. Samples included one negative control (artificial saliva), one positive control (chlorhexidine), and two treatment groups (ethanolic extract of African leaves at 3.125 mg/mL and 6.25 mg/mL), totaling 28 samples. Immersion lasted 7 days at 37°C. Corrosion rates were measured by weight loss, and microstructural changes were analyzed using a scanning electron microscope. Results: The highest average corrosion rate was observed in the chlorhexidine group (0.98 ± 0.58 mils per year [mpy]), whereas the lowest was in the 6.25 mg/mL extract group (−0.04 ± 0.80 mpy). Scanning electron microscope analysis revealed notable microstructural differences: the artificial saliva group showed long scratches scattered across the surface and localized round porosity; the chlorhexidine group exhibited rough scratches and widespread porosity; in contrast, the African leaves groups displayed minor scratches and a thin layer presumed to be protective. Conclusion: The ethanolic extract of African leaves considerably affects corrosion rates and microstructural changes in stainless steel orthodontic wires.

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